The effects of vitamin C, vitamin B6, and vitamin B12 supplementation on the breast milk and maternal status of well-nourished women

1979 ◽  
Vol 32 (8) ◽  
pp. 1679-1685 ◽  
Author(s):  
M R Thomas ◽  
J Kawamoto ◽  
S M Sneed ◽  
R Eakin
Keyword(s):  
Breast Milk ◽  
Vitamin C ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Vitamin B12 Supplementation ◽  
Maternal Status

PERBAIKAN KADAR ALBUMIN PASIEN POST AMPUTASI ET CAUSA LUKA BAKAR LISTRIK 25% DERAJAT III DAN STATUS GIZI KURANG DENGAN PEMBERIAN ASUPAN TINGGI PROTEIN

2018 ◽  
Vol 1 (1) ◽  
pp. 18-25
Author(s):  
Diane Paparang ◽  
Nurpudji A. Taslim ◽  
Haerani Rasyid ◽  
A. Yasmin Syauki
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Vitamin B1

Pendahuluan Proses penyembuhan luka post amputasi dan luka bakar dengan luas 25% dan kedalaman derajat III serta hipoalbuminemia sedang (albumin 2,6g/dL) dan status gizi kurang memerlukan terapi gizi spesifik tinggi protein. Laporan Kasus Tn.I, laki-laki, 28 tahun dikonsul oleh bagian bedah dengan luka post amputasi dan  luka bakar listrik derajat III luas 25%. Keluhan utama asupan makan kurang sejak 16 hari terakhir karena nafsu makan kurang akibat nyeri pada luka post amputasi dan luka bakar. Ada nyeri ulu hati dan demam menggigil. Asupan 24 jam 1000kkal. Pasien didiagnosis dengan status gizi kurang (LLA=80,7%), status metabolik anemia normositik normokrom (Hb 9.7 g/dl), deplesi sedang sistem imun (TLC 940/µL), hipoalbuminemia (albumin 2,6g/dL) dan status gastrointestinal fungsional. Terapi nutrisi dengan energi 2500 kkal, protein 2 gr/kgBBI/hari (23%), karbohidrat 57% dan lemak 20 %, melalui oral berupa makanan biasa 1250 kkal, ONS glutamine 2.5g/hari, suplementasi 6 butir putih telur (protein 31,5g/hari), vitamin C 1g/24jam, vitamin A 6.000IU/12jam, vitamin B1-100mg, vitamin B6-200mg, vitamin B12-200mg, Zinc 50mg/24jam, selenium 55µg, Curcuma 400mg/8jam dan ekstrak ikan gabus 2 kapsul/8 jam. Setelah perawatan 30 hari, terjadi perbaikan dalam penyembuhan luka, peningkatan LLA menjadi 23,5cm, peningkatan hemoglobin 9.3g/dl, peningkatan sistem imun (TLC 2064/µL), peningkatan albumin 3.9g/dL. Kesimpulan Terapi nutrisi spesifik dengan protein 2 gr/kgBBI dapat meningkatkan kadar albumin dan mempercepat penyembuhan luka pada pasien luka bakar.

PENGARUH GIZI TERHADAP RESPON TERAPI PASIEN CHRONIC MYELOCYSTIC LEUKIMIA (CML)

2018 ◽  
Vol 1 (1) ◽  
pp. 57-66
Author(s):  
Asrini Safitri ◽  
Haerani Rasyid ◽  
Agussalim Bukhari ◽  
Mardiana Madjid
Keyword(s):  
Vitamin C ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Vitamin B1 ◽  
Optimal Monitoring

Latar Belakang Penyakit kanker darah atau yang sering disebut dengan leukemia adalah salah satu penyakit yang mematikan. Penyakit ini merupakan kurangnya sel darah merah pada system produksi darah di tubuh manusia dan memproduksi sel darah putih dengan jumlah yang berlebihan. Laporan Kasus Tn I, Laki-laki, 37 tahun dikonsul oleh bagian Interna dengan Chronic Myelocystic Leukimia. Keluhan utama Asupan makan berkurang dialami sejak 5 bulan yang lalu dan memberat dalam 2 bulan terakhir karena nafsu makan menurun, mual  , tidak muntah, riwayat muntah ada, Ada gangguan menelan  ,rasa cepat kenyang , ada demam ,ada riwayat demam , batuk, tidak  sesak, penurunan berat badan ada tetapi besarnya tidak diketahui. Asupan 24 jam 550 Kkal. Pasien didiagnosis dengan status gizi buruk ( LLA = 59,32%), status metabolik anemia normositik normokrom (Hb 7,9 g/dl ),  Hipoalbuminemia  ( Albumin 2,9 gr/dl ), Hipoglikemia ( GDS 67 mg/dl ), leukositosis ( 53.550 /uL ) , dan status gastrointestinal fungsional. Penatalaksanaan Nutrisi dengan pemberian Energi 1600 Kkal yang diberikan secara bertahap sesuai toleransi pasien dan manajemen peningkatan berat badan dilakukan bertahap jika kebutuhan energi telah tercapai. Protein diberikan 1,5 gram/KgBBI/ hari ( 19%), Karbohidrat 50% dan lemak 31%. Pemberian asupan via oral berupa makanan lunak, formula peptisol, buah, dan putih telur 3 butir / hari. Suplementasi diberikan berupa zinc 20 mg/24 jam, Curcuma 40 mg/8 jam, ekstrak ikan gabus 2 kapsul/8 jam, Vitamin B1 100 mg, Vitamin B6 200 mg, Vitamin B12 200 mg, Vitamin C 100 mg/24 jam. Setelah perawatan selama 16 hari, terjadi peningkatan LLA dari 17,5 cm menjadi 19 cm, Hb 7,9 gr/dl menjadi 11,9 gr/dl dengan transfusi PRC 3 kantong. Kadar sel darah putih saat masuk rumah sakit adalah 53.550/uL dan saat dipulangkan 29.000/uL . Pada saat awal di rawat, kadar albumin pasien adalah 2,9 g/dL. Kemudian turun menjadi 2.5 g/dL. Pada saat albumin turun menjadi 2.5 g/dL, pasien di anjurkan untuk mengkonsumsi makanan yang tinggi protein, memberikan formula tinggi protein dan pemberian ekstra putih telur dan setelahnya kadar albumin pasien naik menjadi 3.2 g/dL sebelum dipulangkan untuk rawat jalan. Kesimpulan Malnutrisi pada penderita kanker secara negatif berpengaruh terhadap respon terapi, komplikasi, kualitas hidup dan survival penderita. Intervensi nutrisi yang optimal, monitoring serta edukasi gizi menunjukkan perbaikan status gizi serta perbaikan status metabolik.

scholarly journals Breast milk Vitamin B12 Concentration and Incidence of Diarrhea and Respiratory Infections among Infants in Urban Tanzania: a prospective cohort study

2020 ◽  
Author(s):  
Omar Ndano Lweno ◽  
Christopher R Sudfeld ◽  
Ellen Hertzmark ◽  
Karim P Manji ◽  
Anne Marie Darling ◽  
...  
Keyword(s):  
Cohort Study ◽  
Breast Milk ◽  
Vitamin B12 ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Respiratory Infections ◽  
Recent Trial ◽  
Indian Children ◽  
Childhood Infections ◽  
Vitamin B12 Supplementation

Abstract Objective: A recent trial of vitamin B12 supplementation among Indian children 6-30 months found no effect on the incidence of diarrhea and respiratory infections. These results differ with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania. Results: A prospective cohort study was undertaken to determine the association of breast milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had breast milk vitamin B12 inadequacy (<310 pmol/L). Using generalized estimating equations, we found no overall association of milk vitamin B12 concentration with incident diarrhea and acute respiratory infections in infants. Studies measuring longitudinal changes of breast milk B12 concentration over time are needed to clarify the role of breast milk vitamin B12 in childhood infections.

scholarly journals Profiles of Nutrition and Non – Nutrition Factors Related to Anemia Status Among Lactating Mothers in Jakarta

2019 ◽  
Vol 3 (1) ◽  
pp. 29
Author(s):  
Reisa Melisa Wijaya ◽  
Diana Aulia ◽  
Saptawati Bardosono
Keyword(s):  
Vitamin C ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Family Income ◽  
Deficiency Anemia ◽  
Public Health Centre ◽  
Major Health Problem ◽  
Level Of Education ◽  
Lactating Mothers ◽  
Prevalence Of Anemia

Background and Objective: Anemia is a major health problem affecting every phase of life. However less attention given to lactating mothers where anemia can give bad impacts to the mothers themselves and their babies. Less knowledge also known about nutrition and non-nutrition factors related to anemia. Therefore, this study aims to profile nutrition and non-nutrition factors related to anemia status among lactating mothers.Method: This cross-sectional study was conducted in Grogol Petamburan and Cilincing Public Health Centre in Jakarta in February–April 2019. Seventy fours lactating mothers aged 20–35 years old who delivered within the last 3–6 months recruited using consecutive sampling method. Nutrition factors examined were energy, protein, iron, folate, vitamin B6, vitamin B12, vitamin C intakes, and body mass index (BMI). Non-nutrition factors examined were level of education and family income. Basic characteristic data was collected by interview and dietary intake was assessed using a semiquantitative-food frequency questionnaire and 24-hours food recall for two non-consecutive days. BMI and laboratory assessments (haemoglobin, ferritin serum, and c-reactive protein) were done.Results: Anemia prevalence was 8% and 11% was iron deficient. Prevalence of iron deficiency anemia was 3% (37.5% from prevalence of anemia). Based on Indonesia Recommended Dietary Allowance, around 58% subjects had low iron intake, 39% with low vitamin B6 intake, 27% with low vitamin B12 intake, 40% with low vitamin C intake, and no subject with low folate intake. Around 53% of subjects had BMI < 22.9 kg/m2. Almost 70% of the subjects had middle level of education and 50% had family income lower than regional minimum wage.Conclusion:  Prevalence of anemia among lactating mothers in Jakarta was 8%. Non-nutrition factors had higher proportion compared to nutrition factors related to anemia status. Further studies are needed to determine the possible causes of anemia in lactating mothers.

scholarly journals Breast milk Vitamin B12 Concentration and Incidence of Diarrhea and Respiratory Infections among Infants in Urban Tanzania: a prospective cohort study

2020 ◽  
Author(s):  
Omar Ndano Lweno ◽  
Christopher R Sudfeld ◽  
Ellen Hertzmark ◽  
Karim P Manji ◽  
Anne Marie Darling ◽  
...  
Keyword(s):  
Cohort Study ◽  
Breast Milk ◽  
Vitamin B12 ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Respiratory Infections ◽  
Childhood Infections ◽  
Increased Risk ◽  
Vitamin B12 Supplementation

Abstract Trials of vitamin B12 supplementation in children 6-30 months have shown an increased risk of diarrhea and respiratory infections among participants. These results are not consistent with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania. A prospective cohort study was undertaken to determine the association of milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had vitamin B12 concentrations less than the value used to define adequate intake (<310 pmol/L) in breast milk. Using generalized estimating equations, we found no overall association of milk vitamin B12 concentration with incident diarrhea and ARI in infants. Prospective studies that perform longitudinal evaluations of milk B12 concentration over time are needed to clarify the role of milk vitamin B12 in childhood infections.

Diagnostik und Therapie der Homocystinurie

2009 ◽  
Vol 09 (05) ◽  
pp. 289-293
Author(s):  
B. Reulecke ◽  
J. Denecke
Keyword(s):  
Vitamin B12 ◽  
Vitamin B6 ◽  
Sich Eine ◽  
Diagnostik Und Therapie

ZusammenfassungDie Homocystinurie ist eine seltene angeborene Erkrankung des Methioninstoffwechsels, die mit einer pathologischen Erhöhung der nicht proteinogenen Aminosäure Homocystein und der Ausscheidung ihres Disulfids Homocystin über den Urin einhergeht. Mehrere biochemische und genetische Defekte können zu einer deutlichen Homocysteinerhö-hung führen, darunter Störungen des Vita-min-B6-, Folsäure- und Vitamin-B12-Stoffwechsels, sodass der Terminus Homocystinurie eine Erkrankungsgruppe zusammenfasst. Die häufigste Ursache der Homocystinurie, auch klassische Homocystinurie oder Homo-cystinurie Typ I genannt, stellt die hereditäre Cystathionin-β-Synthase-Defizienz dar, die mit einer Erhöhung von Homocystein und Methionin im Blut einhergeht. Die Diagnose wird durch Bestimmung von Homocystein im Plasma gestellt und kann biochemisch und genetisch gesichert werden. Unbehandelt zeigen sich eine erhebliche Morbidität und Mortalität, die durch Ausschöpfung der therapeutischen Optionen, bestehend aus Vitamin B6, Folsäure, Vitamin B12, Betain und einer Proteinrestriktion mit Aminosäuresupplementie-rung, erheblich reduziert werden können.

Vitamin B12 Deficiency an Unusual Cause of Fever: A Case Report

2019 ◽  
Vol 4 (02) ◽  
Author(s):  
Shyama . ◽  
P. Kumar ◽  
Surabhi .
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Unusual Case ◽  
Vitamin B12 Deficiency ◽  
Bone Marrow Aspiration ◽  
Microcytic Anemia ◽  
Peripheral Smear ◽  
Erythroid Hyperplasia ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

Introduction: An unusual case of a 19 year old female, presenting with fever, pallor and hepatosplenomegaly for one month. She had microcytic anemia on peripheral smear examination but her bone marrow aspiration & biopsy revealed a hypercelluar marrow with megaloblastic erythroid hyperplasia. Resolution of fever within 48 hours of Vitamin B12 supplementation, initiated in view of the megaloblastic bone marrow picture & low serumVitamin B12 level, suggests a causal association. Conclusion: Vitamin B12 deficiency seems to be an unusual cause of PUO (Pyrexia of unkown origin) which should be ruled out in every case of PUO.

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