scholarly journals Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian Mother and Child Cohort

2018 ◽  
Vol 107 (5) ◽  
pp. 789-798 ◽  
Author(s):  
Christine L Parr ◽  
Maria C Magnus ◽  
Øystein Karlstad ◽  
Kristin Holvik ◽  
Nicolai A Lund-Blix ◽  
...  

ABSTRACT Background Western diets may provide excess vitamin A, which is potentially toxic and could adversely affect respiratory health and counteract benefits from vitamin D. Objective The aim of this study was to examine child asthma at age 7 y in relation to maternal intake of vitamins A and D during pregnancy, infant supplementation with these vitamins, and their potential interaction. Design We studied 61,676 school-age children (born during 2002–2007) from the Norwegian Mother and Child Cohort with data on maternal total (food and supplement) nutrient intake in pregnancy (food-frequency questionnaire validated against biomarkers) and infant supplement use at age 6 mo (n = 54,142 children). Linkage with the Norwegian Prescription Database enabled near-complete follow-up (end of second quarter in 2015) for dispensed medications to classify asthma. We used log-binomial regression to calculate adjusted RRs (aRRs) for asthma with 95% CIs. Results Asthma increased according to maternal intake of total vitamin A [retinol activity equivalents (RAEs)] in the highest (≥2031 RAEs/d) compared with the lowest (≤779 RAEs/d) quintile (aRR: 1.21; 95% CI: 1.05, 1.40) and decreased for total vitamin D in the highest (≥13.6 µg/d) compared with the lowest (≤3.5 µg/d) quintile (aRR: 0.81; 95% CI: 0.67, 0.97) during pregnancy. No association was observed for maternal intake in the highest quintiles of both nutrients (aRR: 0.99; 95% CI: 0.83, 1.18) and infant supplementation with vitamin D or cod liver oil. Conclusions Excess vitamin A (≥2.5 times the recommended intake) during pregnancy was associated with increased risk, whereas vitamin D intake close to recommendations was associated with a reduced risk of asthma in school-age children. No association for high intakes of both nutrients suggests antagonistic effects of vitamins A and D. This trial was registered at http://www.clinicaltrials.gov as NCT03197233.

Thorax ◽  
2019 ◽  
Vol 74 (10) ◽  
pp. 977-985 ◽  
Author(s):  
Christos Stefanidis ◽  
Adrian R Martineau ◽  
Chinedu Nwokoro ◽  
Christopher J Griffiths ◽  
Andrew Bush

IntroductionVitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1α-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze.MethodsWe review here the literature concerning the relationships between circulating 25-hydroxyvitamin D (25(OH)D) concentration and secondary prevention of acute wheeze attacks in preschool and school-age children.ResultsEpidemiological data suggest that vitamin D insufficiency (25(OH)D <75 nmol/L) is highly prevalent in preschool and school-age children with wheeze. Preschool age children with a history of wheeze attacks and circulating 25(OH)D <75 nmol/L are at increased risk and frequency of future acute wheeze. However, no consistent association between low vitamin D status and risk of acute wheeze is reported in school-age children. Seven randomised controlled trials (RCTs) with relatively small sample sizes (30–430) and variable quality showed inconsistent results regarding the effect of oral vitamin D supplementation during childhood on the risk of asthma attacks, asthma symptom control, inhaled corticosteroid requirements, spirometry and unscheduled healthcare attendances for wheeze. A RCT showed that vitamin D supplementation had no effect on the frequency of unplanned healthcare attendances due to acute wheeze in 22 preschool children.DiscussionAn evidence-based recommendation for the use of vitamin D as a preventive therapy for wheeze attacks cannot be made until results of further trials are available. The assessment of circulating 25(OH)D concentration and the optimisation of vitamin D status to prevent acute respiratory tract infections, and to maintain skeletal and general health in preschool and school-age children with acute wheeze is worthwhile in its own right, but whether this will reduce the risk of acute wheeze attacks is unclear.


Author(s):  
Geereddy Bhanuprakash Reddy ◽  
Tattari Shalini ◽  
Santu Ghosh ◽  
Raghu Pullakhandam ◽  
Boiroju Naveen Kumar ◽  
...  

1990 ◽  
Vol 90 (3) ◽  
pp. 426-428
Author(s):  
Joyce M. Merkel ◽  
Susan J. Crockett ◽  
Rebecca Mullis

2017 ◽  
Vol 22 (3) ◽  
pp. 358-377 ◽  
Author(s):  
Patricia M Crittenden ◽  
Katrina Robson ◽  
Alison Tooby ◽  
Charles Fleming

Aims: We explored the relation between mothers’ protective attachment strategies and those of their school-age children. Methods: In total, 49 child–mother dyads participated in a short longitudinal study when the children were 5.5 and 6.0 years old. Their strategies were first assessed with the Preschool Assessment of Attachment (PAA) and then with the School-age Assessment of Attachment (SAA). Mothers were assessed with the Adult Attachment Interview (AAI). The Dynamic-Maturational Model of Attachment and Adaptation (DMM) was used to classify the assessments. Results: The validity and precision of the DMM-AAI were supported: Mothers’ AAI classifications were related to their referral group (normative or clinical) and measures of stress and distress. The DMM categories were more associated with risk than the Ainsworth categories. Types A, C and A/C were differentiated by trauma, triangulation and depression. Mothers’ and children’s protective attachment strategies were related, with B mothers having B children and A or C mothers having children using the same or opposite strategy. Children whose classification changed from the PAA to the SAA had mothers with complex traumas. Conclusion: When psychosocial treatment is needed, knowing whether mother and child use the same or different strategies and whether mothers have complex trauma can affect treatment success.


2014 ◽  
Vol 33 (3) ◽  
pp. 509-512 ◽  
Author(s):  
Dogus Vuralli ◽  
Leyla Tumer ◽  
Alev Hasanoglu ◽  
Gürsel Biberoglu ◽  
Hatice Pasaoglu

2015 ◽  
Vol 145 (4) ◽  
pp. 791-798 ◽  
Author(s):  
Trudy Voortman ◽  
Edith H van den Hooven ◽  
Annemieke C Heijboer ◽  
Albert Hofman ◽  
Vincent WV Jaddoe ◽  
...  

2021 ◽  
Vol 2 (121) ◽  
pp. 11-20
Author(s):  
Ana Lilić ◽  
Emilija Petković ◽  
Siniša Karišik ◽  
Ljiljana Bjelojević ◽  
Novica Gardašević ◽  
...  

Background. Today, it is very speculative  to talk about the percentage of obese children in the world because these figures change significantly from day to day, and there are even significant differences between respondents in the same country, according to geographical area and place of residence. A constant decline in the level of physical activity of children on a global level can be reported from the age when they start school. Energy intake of food is largely from energy consumption, which leads to an increase in body weight and obesity. Factors of overweight and obesity are associated with a sensitive comparison of health: a significantly increased risk of diabetes, disorders of the locomotor system, and increased social and psychological rights. Methods and results. During the systematization of the research on the topic, the aim of the paper was to determine whether the influence of physical activity on anthropometric parameters in school-age children is reviewed by previous research. Nineteen types of studies were collected. The following electronic databases were used to search the literature: MEDLINE, SCOPUS, Web of Science SPORTS DISCUS in the period from 2004 to 2016. The respondents included in the research were school-age children. Conclusion. The positive impact of various physical activity programs is aimed at reducing the parameters of anthropometric characteristics and obesity prevention. Keywords: physical activity, school program, morphology, anthropomeric data, exercises.  


2017 ◽  
Vol 6 (1) ◽  
pp. 55-62
Author(s):  
Meilanny Budiarti Santoso ◽  
Megawati B

Mother possesses a central role in the process of educating children. Mother spends more time with children at home than in the school. Thus, the attachment between the child and the mother becomes a benchmark as having required the ability to perform interaction within constructed social relations of school-aged children. This study was conducted using an explorative study that focused on the ‘eyecatching’ of information and issues that obtained in the process of this study. Interview, observation and documentation techniques are applied. The results show that the attachment between mother and child is built on the basis of the various skills that must be owned by school-aged children. This also means the role and function of the mother in educating school-aged children, expecially teaching process, that is caring, willingness to share, respect, politeness and responsibility. Providing good role models is the best way to instill values   in children, thus becoming the foundation for good attachment building between mother and child. Keywords: attachment, mother, children, school-age children.


2015 ◽  
Vol 7 (16) ◽  
pp. 47-56
Author(s):  
Desy Kumaladewi ◽  
Sugeng Maryanto ◽  
Galeh Septiar Pontang

Stunting is one of the effects of lack of nutrients that lasts a long time. Stunting can occur due to deficiency of macronutrients and macronutrients that play a role in the growth, such as energy, protein, vitamin A and zinc (Zn). The aim of this study was determine the relationship between the intake of energy, protein, vitamin A and zinc (Zn) and the incidences of stunting in children of school age in Candirejo Village This research was The study correlation with cross sectional approach. The population in this study were all first year students in Candirejo village. It obtained 56 children with total sampling method. Method of data taking used microtoise, digital scale and FFQ. Bivariate analysis used Pearson product moment and alternative test of Spearman rho (α=0,05) The average energy intake in children was 86.5% RDA. The average protein intake in children was 106.3% RDA. The average intake of vitamin A in children was 111.9% RDA. The average intake of zinc in children was 64.4% RDA. From 56 childs 37,5% was stunting and 62,5% no stunting. There was no relationship between the intake of energy, protein and vitamin A with the incidences of stunting (p = 0.129, p = 0.139, p = 0.200), and there was a correlation between zinc intake with the incidences of stunting (p = 0.014) There was no relationship between the intake of energy, protein and vitamin A with the incidences of stunting in children of school-age in Candirejo village. There was a relationship between zinc intake with the incidences of stunting in school-age children in the Candirejo village.


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