Mixed Neuroendocrine-Nonneuroendocrine Carcinoma Arising in the Gallbladder: A Rare Case of a Three-Component Composite Neoplasm

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S121-S121
Author(s):  
Mouyed Alawad ◽  
Scott Schoninger ◽  
Raavi Gupta
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Treatment Guidelines ◽  
Specific Treatment ◽  
Neuroendocrine Neoplasms ◽  
Mitotic Figures ◽  
Adenocarcinoma Component ◽  
Gross Examination

Abstract Introduction Neuroendocrine gallbladder neoplasms are rare, comprising 0.5% of all neuroendocrine cancers and about 2% of gallbladder cancers. Interestingly, those neoplasms can also be observed along with other malignant components of epithelial origin, mostly adenocarcinomas. Herein we report an unusual case of a patient with a gallbladder neoplasm composed of a neuroendocrine carcinoma, a squamous cell carcinoma, and an adenocarcinoma. Methods The patient was a 62-year-old woman who presented with right upper quadrant abdominal pain with a positive Murphy’s sign on physical examination. She was clinically diagnosed with acute cholecystitis and underwent cholecystectomy. Gross examination showed a 5-cm exophytic mass at the gallbladder fundus. Histopathologic examination of the mass showed an infiltrating squamous cell carcinoma and an adjacent high-grade neuroendocrine carcinoma; each of these two components composed more than 30% of the neoplasm and infiltrated into the perimuscular connective tissue with no serosal involvement. Additionally, a superficial adenocarcinoma component was also seen composing 10% of the neoplasm. The squamous cell carcinoma showed moderate differentiation with areas of keratinization; it was positive for Ck7, p40, and p63. The neuroendocrine carcinoma showed areas of geographic necrosis, and the cells had inconspicuous nucleoli and granular chromatin, with numerous mitotic figures; it was positive for synaptophysin and chromogranin. The adenocarcinoma showed gland formation with mucicarmine stain, highlighting the mucin within the neoplastic cells; it was positive for Ck7 but negative for p40. Subsequently, the patient underwent resection of the liver bed, which was negative for metastasis, and was then referred for chemotherapy. Conclusion Our review of the literature revealed seven documented cases of three-component gallbladder neuroendocrine neoplasms. Generally, patients with these tumors have a poor prognosis, and due to their rarity, no specific treatment guidelines have yet been established. It has been suggested that a multipotent common stem cell is the origin of these tumors.

scholarly journals Tatalaksana karsinoma sel skuamosa kanalis akustikus eksternus

2019 ◽  
Vol 49 (1) ◽  
pp. 73
Author(s):  
Ratna Dwi Restuti ◽  
Iman Pradana Maryadi ◽  
Rangga Rayendra Saleh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Guidelines ◽  
Early Stage ◽  
Surgical Techniques ◽  
Specific Treatment ◽  
Treatment Modalities ◽  
Cancer Center ◽  
Literature Study

Latar belakang: Keganasan pada kanalis akustikus eksternus (KAE) merupakan kasus yang jarang terjadi, kurang dari 0,2 % dari seluruh keganasan pada regio kepala dan leher. Secara histologis, karsinoma sel skuamosa merupakan jenis karsinoma terbanyak, terjadi pada 80% kasus. Karsinoma sel skuamosa KAE masih menjadi tantangan bagi praktisi medis dalam mendiagnosis dan menatalaksana. Tujuan: Hingga saat ini, belum ada algoritma yang spesifik dalam menatalaksana kasus ini, sehingga membutuhkan pengetahuan yang mendalam mengenai anatomi dan teknik pembedahan, serta ditunjang dengan adanya tim multidisiplin dalam menangani kasus keganasan KAE. Laporan kasus: Tulisan ini melaporkan 4 kasus pasien karsinoma sel skuamosa KAE yang menjalani bermacam modalitas tatalaksana dengan keluaran yang bervariasi. Metode: Telaah literatur berbasis bukti mengenai tatalaksana karsinoma sel skuamosa KAE melalui database Cochrane dan Pubmed Medline. Berdasarkan kriteria inklusi dan ekslusi didapatkan satu jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Karsinoma sel skuamosa liang telinga terutama ditatalaksana dengan terapi pembedahan. Modalitas tambahan yang dapat diberikan adalah kemoterapi dan radioterapi. Terapi pembedahan seringkali meninggalkan defek yang besar sehingga memerlukan tindakan rekonstruksi. Kesimpulan: Tatalaksana karsinoma sel skuamosa KAE seringkali membutuhkan pendekatan multidisiplin dan kompleks terutama pada kasus stadium lanjut. Angka harapan hidup yang lebih baik akan dicapai dengan mendiagnosis dan menatalaksana kasus ini secara dini. Background: Cancer of the external auditory canal (EAC) is a rare tumor, representing less than 0.2% of all head and neck cancers. Histologically, squamous cell carcinoma comprises more than 80% of cases. Squamous cell carcinoma (SCC) of the EAC is still a therapeutic challenge for medical specialists in its diagnosis and management. Purpose: Up to date, there is no specific treatment guidelines available due to SCC low incidence. The attending physician must have asubstantial knowledge of literatures as well as anatomy and surgical techniques, supported by an appropriate cancer center with adequate multidisciplinary team to offer the best therapy in accordance with the needs of the cancer clinical stages. Cases: This paper reports 4 cases of squamous cell carcinoma of the EAC which underwent various treatment modalities, and yielded also various outcomes. Method: Evidence based literature study about squamous cell carcinoma of EAC was performed through Cochrane and Pubmed Medline database. Based on inclusion and exclusion criteria, one study was found relevant to these cases. Results: The particular choice of SCC management of EAC is surgery, yet SCC of the EAC requires additional modalities such as chemotherapy and radiotherapy. Surgery often leaves a large defect which requires a reconstructive procedure. Conclusion: Cancer of EAC management requires a multidisciplinary approach, especially it is more complex in the advanced stage of SCC. An early stage diagnosis and prompt management will lead to a better survival rate. 

scholarly journals Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098154
Author(s):  
Xiangyu Wang ◽  
Wenjing Li ◽  
Yan Kong ◽  
Xiangyu Liu ◽  
Zhumei Cui
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Tumor Size ◽  
Treatment Guidelines ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Clinical Analysis ◽  
Palpable Mass

Objective This study aimed to examine the clinicopathological characteristics, treatment, and prognostic factors in 12 cases of malignant transformation of mature cystic teratoma of the ovary (MCTO). Methods We performed a retrospective study of 12 patients with malignant transformation of MCTO who were admitted to the Affiliated Hospital of Qingdao University from 2003 to 2019. We examined case records, clinical parameters, and biological assessments. Results The median age of the patients was 56.5 years and seven of them were postmenopausal. The average tumor size was 18.5 cm. All patients had pelvic masses at their first hospital visit. Nine of the patients had discomfort in the lower abdomen, two presented with a lower abdominal palpable mass, and three were complicated by fever. The median follow-up time was 73 months (12‒193 months). Ten patients survived with a disease-free status and two died. Conclusions There is a low incidence of malignant transformation of MCTO, and its most common histological type is squamous cell carcinoma. Age and tumor size are important factors in malignant transformation of teratomas. While there is a lack of treatment guidelines for malignant transformation of MCTO, early diagnosis and treatment may be beneficial for these patients.

Feulgen stain as a special stain for mitotic figures and apoptotic bodies in oral squamous cell carcinoma

2018 ◽  
Vol 9 (4) ◽  
pp. 164
Author(s):  
Sankari Radhakrishnan ◽  
Ramesh Venkatapathy ◽  
PD Balamurali ◽  
KarthikShree V Prashad ◽  
B Premalatha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Apoptotic Bodies ◽  
Special Stain ◽  
Mitotic Figures

scholarly journals Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412

2020 ◽  
Vol 16 (18) ◽  
pp. 1235-1243 ◽  
Author(s):  
Jean-Pascal Machiels ◽  
Yungan Tao ◽  
Barbara Burtness ◽  
Makoto Tahara ◽  
Lisa Licitra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Treatment Guidelines ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Phase Iii ◽  
Advanced Head ◽  
Double Blind

Current treatment guidelines for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) recommend multimodal treatment, including chemoradiation therapy (CRT) or surgery followed by radiation, with or without chemotherapy. The immune checkpoint inhibitor pembrolizumab has previously demonstrated antitumor activity in recurrent and/or metastatic HNSCC in large Phase III trials. For patients with locally advanced disease, Phase Ib data on the use of pembrolizumab in combination with chemoradiation have shown the approach to be safe and feasible. We describe here the design and rationale for KEYNOTE-412, a randomized, double-blind, Phase III trial investigating pembrolizumab or placebo administered concurrently with CRT and as maintenance treatment in patients with locally advanced HNSCC. Clinical Trial Registration: NCT03040999 ( ClinicalTrials.gov ).

Hypopharyngeal Squamous Cell Carcinoma and Laryngeal Neuroendocrine Carcinoma Colliding in the Aryepiglottic Fold: A Case Report

2017 ◽  
Vol 103 (1_suppl) ◽  
pp. S1-S4 ◽  
Author(s):  
Roberta Marangoni ◽  
Simone Mauramati ◽  
Giulia Bertino ◽  
Antonio Occhini ◽  
Marco Benazzo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Neck Region ◽  
Collision Tumor ◽  
Small Cell ◽  
Head And Neck Region

Purpose A collision tumor consists of 2 different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck region they are rare, with only 4 cases reported in the larynx. Case report A 60-year-old heavy smoker complained of a left submandibular lesion in October 2014. The lesion was excised and showed a poorly differentiated carcinoma, suggestive for adenocarcinoma. After a positron emission tomography-computed tomography scan showed increased metabolic activity in the left laterocervical region and right vocal cord, the patient underwent endoscopic biopsy of the lesion of the left piriform sinus, which was positive for moderately differentiated squamous cell carcinoma (SCC). He was then submitted to circular pharyngolaryngectomy, reconstruction with a radial forearm free flap, and bilateral neck dissection. The histopathologic examination showed an in situ and microinvasive SCC of the left pyriform sinus colliding with a high-grade, non-small-cell neuroendocrine carcinoma of the larynx. Conclusions To our knowledge, this is the first case described of laryngeal collision tumor comprising a neuroendocrine component. The choice of treatment of this kind of lesion is difficult because of the presence of 2 different histologies and of the controversial prognostic correlation of non-small-cell neuroendocrine neoplasms of the head and neck region.

scholarly journals Advanced Composite of Large Cell Neuroendocrine Carcinoma and Squamous Cell Carcinoma: A Case Report of Uterine Cervical Cancer in a Virgin Woman

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ryusuke Murakami ◽  
Iemasa Kou ◽  
Kenjiro Date ◽  
Hirofumi Nakayama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Neuron Specific Enolase ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Hpv Test

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is very rare and aggressive. The prognosis is very poor despite multimodal treatment. We report a virgin woman with FIGO stage 4b LCNEC of uterine cervix coexisting with squamous cell carcinoma. An early thirties virgin woman presented with 2-month history of abdominal pain. A chest X-ray showed multiple lung metastatic tumors. A vaginal smear showed malignant cells, and a biopsy specimen had features of LCNEC. The tumor showed trabecular patterns. Tumor cells possessed a moderate amount of cytoplasm, prominent nucleoli, and large nuclei. The tumor cells are stained positive for synaptophysin, chromogranin A, and neuron specific enolase (NSE). The invasive tumor cells in connection with cervical squamous epithelium were focally positive for 34bE12. We made a diagnosis of composite LCNEC and nonkeratinizing squamous cell carcinoma. High-risk HPV test was negative with hybridized captured method 2.

scholarly journals Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature

ISRN Oncology ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ayushi Jain ◽  
Deepti Mittal ◽  
Arpita Jindal ◽  
Ranjana Solanki ◽  
Suman Khatri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Renal Pelvis ◽  
Relevant Literature ◽  
Case Series ◽  
Advanced Stages ◽  
One Year ◽  
Suspicious Nodule ◽  
Gross Examination

Squamous cell carcinoma of the renal pelvis is a rare neoplasm, often unsuspected clinically due to its rarity and ambiguous clinical and radiological features, and hence patients present at advanced stages resulting in poor prognosis. We report here four cases of incidentally diagnosed primary renal squamous cell carcinoma, treated at our hospital over a short span of one year, and review the relevant literature. Mean age of the patients (3 males, 1 female) was 60 years. All suffered from staghorn stones. Interestingly, renal carcinoma was unsuspected clinically in all patients. In one case, a computerised tomography scan showed a suspicious nodule. All underwent nephrectomy for nonfunctioning kidney. In just two cases, tumor was identified on gross examination, while the other two only showed thickened pelvis. Our series emphasises the need for pelvicalyceal biopsy during treatment for long-standing nephrolithiasis, and thorough sampling of the renal pelvis in nephrectomy specimen of such patients.

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