scholarly journals Piezoelectric Micro-dosing System for Spiking Quality Samples in Occupational Hygiene Laboratories

2019 ◽  
Vol 63 (9) ◽  
pp. 1061-1069
Author(s):  
Yvonne Giesen ◽  
Franziska Nürnberger ◽  
Krista Gusbeth ◽  
Ann-Kathrin Mühlberg ◽  
Nils Lamm ◽  
...  
Keyword(s):  
Quality Control ◽  
Reference Materials ◽  
Health And Safety ◽  
Cost Effective ◽  
Internal Quality ◽  
Inorganic Acids ◽  
Quartz Fibre ◽  
Limited Scale ◽  
Assembly Unit ◽  
Comparison Of The Results

Abstract Quality control is crucially important in the arena of chemical analysis. Reference materials are essential for calibration and quality control processes, and for verification of the accuracy and reliability of the analytical results obtained. Owing to the complexity of their manufacture, reference materials for chemical agents occurring at workplaces are expensive and available only on a limited scale and for a small number of substances. Therefore, their cost-effective and fast production is an important aim. The Institute for Occupational Health and Safety (IFA) of the German Social Accident Insurance (DGUV) currently pursues different strategies for the production of reference materials. One strategy entails the use of a piezoelectric micro-dispensing system for non-contact spiking of extremely small quantities of substances with high reproducibility. The dispensing system is coupled to a semi-automated assembly unit for loading high numbers of samples. It is used for spiking phosphoric and sulphuric acid onto quartz fibre filters. Comparison of the results obtained on different days shows higher variability than results observed on the same day. However, after daily adjustment of the number of droplets to the current droplet volume, highly reproducible series with an adequate number of samples (>500) could be realized. The results of the internal quality control were verified in an interlaboratory comparison. Furthermore, storage stability was investigated systematically over a period of 2 years. The samples produced are suitable for use as reference materials for both inorganic acids.

scholarly journals Microbiological reference material (bacterial and fungal domains): Definition, production rules, use and need for establishment in Brazil

2019 ◽  
Vol 22 ◽  
Author(s):  
Carla de Oliveira Rosas ◽  
Janaína Marques Rodrigues ◽  
Marcus Henrique Campino de la Cruz ◽  
Silvia Maria dos Reis Lopes ◽  
Aline da Silva Soares Souto ◽  
...  
Keyword(s):  
Quality Control ◽  
Reference Materials ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Proficiency Tests ◽  
Culture Collections ◽  
Test Items ◽  
Incentive Policies ◽  
Reference Strains ◽  
Practical Recommendations

Abstract Reference materials are crucial for laboratory quality assurance. They are widely used for the internal quality control of analytical tests, in the validation of methodologies and as test items in proficiency tests. Microbiological reference materials are represented mainly by reference strains, whose use in laboratory internal quality control is unquestionable and recommended by several microbiological manuals. In Brazil, the practice of producing microbiological reference materials has advanced in recent years in the development of specific materials for proficiency testing. However, the same did not occur with the establishment of reference strains due to a lack of incentive policies, maintaining the country dependant on the use of international reference strains. This article aims to emphasize the importance of the use of microbiological reference materials in laboratory quality control and discuss the need for the development of such materials in Brazil. The paper presents a brief explanation of microbiological reference materials and points out questions concerning the country’s dependence on the acquisition of international biological materials. It also describes quality standards related to the production of these materials and the situation of culture collections and Brazilian reference laboratories that supply reference strains. The study also mentions practical recommendations on the subcultures of reference strains.

scholarly journals PENGGUNAAN BAHAN ACUAN BERSERTIFIKAT OYSTER TISSUE 1566b SEBAGAI INTERNAL QUALITY CONTROL UNTUK MENENTUKAN KADAR TIMBAL TOTAL DALAM TEPUNG IKAN MARLIN DENGAN ELECTROTHERMAL ATOMIC ABSORPTION SPECTROMETRY

2015 ◽  
Vol 17 (2) ◽  
pp. 131-137
Author(s):  
Willy Cahya Nugraha ◽  
Yohanes Susanto Ridwan
Keyword(s):  
Quality Control ◽  
Reference Materials ◽  
Certified Reference Materials ◽  
Electrothermal Atomic Absorption Spectrometry ◽  
Absorption Spectrometry ◽  
Lead Content ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Oyster Tissue ◽  
High Level

Lead is widely knows as one of the harmful pollutants for humans. Contaminated fishery built by lead may endanger the consumption body. Therefore, contamination monitoring for the fishery products is necessary to be conducted. To ensure the validity of data, Oyster Tissue 1566b certified reference material was used as Internal Quality Control. Marlin fish powder and certified reference materials were analyzed with the same method, personnel, duration or time, equipment and environmental conditions. As the results, it was found that the lead contained in CRM was 0.306 mg.kg-1 with 11.9 % rsd, which is within range of lead content in  the certificate. The method was applied for Marlin Fish. Lead content obtained in this study (1.821 mg.kg-1 with 11.06 % rsd) can be reported with high level of confidence.Keywords: Lead, Certified Reference Materials, Marlin fish

scholarly journals Study on the production of Reference Material (RM) for Vitamin B1, B2, B6 in health supplements

2021 ◽  
Vol 4 (4) ◽  
pp. 307-314
Author(s):  
Hang Nguyen Thi ◽  
Phuong Thao Le Thi ◽  
Huu Cuong Dang ◽  
Huyen Trang Luu Thi ◽  
Hong Hao Le Thi ◽  
...  
Keyword(s):  
Quality Control ◽  
Reference Material ◽  
Reference Materials ◽  
Vitamin B1 ◽  
Assessment Method ◽  
Internal Quality ◽  
Standard Samples ◽  
Mandatory Requirement ◽  
The Cost ◽  
Health Supplements

Vitamins are essential nutrients commonly found in food products in general and health supplements in particular. In order to accurately evaluate product quality, laboratories need to use reference material in analysis, proficiency assessment, method validation and ensure the validity of the results. The use of reference materials plays an important role in the quality control of test results and is a mandatory requirement for laboratories wishing to demonstrate appropriate competence as required by ISO/IEC 17025:2017. The need to provide reference materials for laboratories is huge. However, at present, there are very few domestic organizations that can produce reference materials, while the cost of buying reference materials from reputable firms in the world is expensive. In this study, we introduced the procedure and production reference materials for the analysis of B-group vitamins (B1, B2, B6). These reference materials were evaluated for homogeneity and stability in 322 days. The certified values are consistent with the concentrations of substances present in normal samples in practice. The measurement uncertainty ranges from 14.5 - 23.3 %. The reference materials can be used for internal quality control for domestic laboratories and is also a premise for further research on standard samples with different matrix and analytical criteria.

scholarly journals Efficacy of Pooled Serum Internal Quality Control in Comparison with Commercial Internal Quality Control in Clinical Biochemistry Laboratory

2020 ◽  
Vol 12 (03) ◽  
pp. 191-195
Author(s):  
Sweta Kulkarni ◽  
Shema Alain Pierre ◽  
Ramachandran Kaliaperumal
Keyword(s):  
Quality Control ◽  
Density Lipoprotein ◽  
Cost Effective ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Serum Samples ◽  
Commercial Sample ◽  
Effective Measure ◽  
Clinical Biochemistry Laboratory ◽  
Better Than

Abstract Introduction With increasing automation in clinical laboratories, the requirements for quality control (QC) material have greatly increased in order to monitor performance. The constant use of commercial control material is not economically feasible for many countries because of nonavailability or the high-cost of those materials. Therefore, preparation and use of in-house QC serum will be a very cost-effective measure with respect to laboratory needs. Materials and Methods In-house internal quality control from leftover serum samples of master health checkup subjects, which have been screened negative for HIV, HCV and HBsAg antibodies was pooled in a glass jar with ethanediol as preservative and kept in deep freezer at − 20°C. From the pooled serum, 100 microliter thirty aliquots were prepared. Every day along with commercial internal QC (IQC), one aliquot of pooled serum was analyzed for 30 days for the following parameters: plasma glucose, blood urea, serum creatinine, total cholesterol, triglycerides (TGL), high-density lipoprotein, calcium, total protein, albumin, total bilirubin, AST, ALT, ALP, amylase. After getting 30 values for each parameter, mean, standard deviation (SD) and CV% were calculated for both IQC commercial sample and pooled serum sample. Results The mean, SD, and CV% of glucose, cholesterol, TGL, calcium, alanine aminotransaminase (ALT), aspartate aminotransferase (AST), amylase, and alkaline phosphatase (ALP) were statistically significant between pooled serum and commercial QC. Conclusion In-house QC prepared from pooled serum is better than commercial internal QC. The biochemical parameters were stable in pooled serum due to less matrix effect; also, variation was less in pooled serum IQC.

Quality control of lipid measurements in epidemiological studies: the U.S. Air Force HEART program.

1985 ◽  
Vol 31 (2) ◽  
pp. 261-263 ◽  
Author(s):  
A Hainline ◽  
P Hill ◽  
L Garbaczewski ◽  
C Winn
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Air Force ◽  
Reference Materials ◽  
Internal Control ◽  
Density Lipoprotein ◽  
Quality Assurance Program ◽  
Internal Quality ◽  
Surveillance Program ◽  
The U.S

Abstract A special standardization and quality assurance program, similar to that created for the Lipid Research Clinics Program (LRC), was developed for the American Health Foundation Laboratory by the Centers for Disease Control (CDC) to assure the quality of lipid measurements in the U.S. Air Force Health Evaluation and Risk Tabulation (HEART) Program. This study was designed to test the feasibility of reducing the incidence of heart disease in active-duty U.S. Air Force personnel through life-study intervention. During the 18-month study, CDC provided serum calibrators and reference materials for internal control and an external surveillance program for measurements of total cholesterol (TC) and high-density-lipoprotein cholesterol (HDLC). The Laboratory, using an automated enzymic method to measure cholesterol, achieved an overall goal for accuracy of less than 2% error (av systematic error, -30.6 mg/L) for TC, as measured on nine reference pools for which values were assigned by CDC. The average bias of measurements of HDLC with heparin-manganese to separate the lipoproteins in five CDC reference pools was -4.6 mg/L. Bias was estimated relative to the values assigned to the reference materials by the CDC reference methods for TC and HDLC. The average CV for TC was 0.89%, for HDLC 2.66%. Accuracy of cholesterol measurements can be assured over time with a standardization and quality-assurance program that incorporates accurately labeled reference materials for calibration, internal quality control, and external surveillance.

Regulatory and sustainability initiatives lead to improved polyaminopolyamide epichlorohydrin (PAE) wet-strength resins and paper products

TAPPI Journal ◽  
2018 ◽  
Vol 17 (09) ◽  
pp. 519-532 ◽  
Author(s):  
Mark Crisp ◽  
Richard Riehle
Keyword(s):  
Health And Safety ◽  
Cost Effective ◽  
Worker Safety ◽  
Regulatory Requirements ◽  
Wet Strength ◽  
The Past ◽  
Consumer Safety ◽  
Federal Institute ◽  
Sustainability Initiatives ◽  
The Impact

Polyaminopolyamide-epichlorohydrin (PAE) resins are the predominant commercial products used to manufacture wet-strengthened paper products for grades requiring wet-strength permanence. Since their development in the late 1950s, the first generation (G1) resins have proven to be one of the most cost-effective technologies available to provide wet strength to paper. Throughout the past three decades, regulatory directives and sustainability initiatives from various organizations have driven the development of cleaner and safer PAE resins and paper products. Early efforts in this area focused on improving worker safety and reducing the impact of PAE resins on the environment. These efforts led to the development of resins containing significantly reduced levels of 1,3-dichloro-2-propanol (1,3-DCP) and 3-monochloropropane-1,2-diol (3-MCPD), potentially carcinogenic byproducts formed during the manufacturing process of PAE resins. As the levels of these byproducts decreased, the environmental, health, and safety (EH&S) profile of PAE resins and paper products improved. Recent initiatives from major retailers are focusing on product ingredient transparency and quality, thus encouraging the development of safer product formulations while maintaining performance. PAE resin research over the past 20 years has been directed toward regulatory requirements to improve consumer safety and minimize exposure to potentially carcinogenic materials found in various paper products. One of the best known regulatory requirements is the recommendations of the German Federal Institute for Risk Assessment (BfR), which defines the levels of 1,3-DCP and 3-MCPD that can be extracted by water from various food contact grades of paper. These criteria led to the development of third generation (G3) products that contain very low levels of 1,3-DCP (typically <10 parts per million in the as-received/delivered resin). This paper outlines the PAE resin chemical contributors to adsorbable organic halogens and 3-MCPD in paper and provides recommendations for the use of each PAE resin product generation (G1, G1.5, G2, G2.5, and G3).

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