scholarly journals Radio-activity and Normal Physiological Function

1920 ◽  
Vol os-34 (3) ◽  
pp. 299-302 ◽  
Author(s):  
V. H. Blackman
2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Kamisha T. Woolery ◽  
Patricia A. Kruk

Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late stage when ovarian cancer (OC) has already spread beyond the ovary. Ovarian epithelial cancer cells are shed into intraperitoneal ascites and easily disseminate throughout the peritoneal cavity with preferential metastasis to the omentum, peritoneum, and local organs. Understanding how ovarian epithelial cells interact with and modulate their microenvironment can provide insight into the molecular mechanism(s) involved with malignant transformation and progression which may eventually identify novel diagnostic, prognostic, and therapeutic targets. The objective of this paper is to provide a brief consideration of ovarian surface epithelial-stromal interactions in regard to normal physiological function and tumor progression as influenced by two potentially key interleukins, interleukins-1 (IL-1) and -6 (IL-6), present in the microenvironment. Lastly, we will consider the clinical implications of IL-1 and IL-6 for OC patients.


1989 ◽  
Vol 9 (3) ◽  
pp. 1346-1350 ◽  
Author(s):  
J M Croop ◽  
M Raymond ◽  
D Haber ◽  
A Devault ◽  
R J Arceci ◽  
...  

The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.


2012 ◽  
Vol 550-553 ◽  
pp. 1043-1047
Author(s):  
Jian Guang Cai ◽  
Da Zhong Yin ◽  
Hui Tang

Taurine (Tau) was widely used in adjusting body normal physiological function and enhancing the ability of resisting all kinds of stress in clinical medicine and sports nutrition. This article collected the literatures of recent 20 years about the application of taurine in animal and human being. According to the chemical structure, amino acids in taurine’s molecular structure played a main role in regulating physiological function. Amino was the key and even the only functional group in biochemical reaction. Schiff’s Reaction between amino and carbonyl in reactive carbonyl compounds was that taurine played a variety biological function of molecular basis in cells.


1989 ◽  
Vol 9 (3) ◽  
pp. 1346-1350
Author(s):  
J M Croop ◽  
M Raymond ◽  
D Haber ◽  
A Devault ◽  
R J Arceci ◽  
...  

The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.


1970 ◽  
Vol 118 (3) ◽  
pp. 427-431 ◽  
Author(s):  
R. Bickerstaffe ◽  
C. E. West ◽  
E. F. Annison

A procedure for the perfusion of the isolated chicken liver was developed. The preparation satisfied many of the criteria of normal physiological function, e.g. oxygen consumption and the absence in the perfusion medium of enzymes indicative of cell damage, and retained its capacity to synthesize lipids from glucose, acetate and long-chain fatty acids. Part of newly synthesized triglyceride was released into the perfusion medium as lipoprotein.


1986 ◽  
Vol 109 (2) ◽  
pp. R5-R8 ◽  
Author(s):  
M. F. Knapp ◽  
M. N. Hicks ◽  
R. J. Linden ◽  
D.A.S.G. Mary

ABSTRACT To determine whether natriuresis attributable to atrial natriuretic peptides (ANP) is obtained in response to atrial stretch after blockade of the afferent input and reflex diuresis from atrial receptors, urine flow and sodium excretion were measured in response to distension of a balloon in the left atrium with the vagi at 37 and 9°C. It is known that during such a distension ANP plasma concentration is increased by the same amount whether or not the afferent vagal fibres are intact. In 11 chloralose anaesthetized dogs 22 distensions with the vagi at 37°C increased urine flow 117.5% and increased sodium excretion 28.7%. In 11 distensions with the vagi at 9°C, urine flow did not change but sodium excretion decreased significantly (−20.9%). Thus natriuresis could not be demonstrated in response to atrial stretch in anaesthetised dogs after blockade of the atrial receptor reflex. These results imply that under these conditions, in which ANP is reportedly released into plasma, ANP is not acting as a hormone. The results must call into question the suggestion that ANP is released into plasma in a concentration capable of causing a natriuresis as its normal physiological function.


Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 15
Author(s):  
Eduardo Fuentes-Lemus ◽  
Per Hägglund ◽  
Camilo López-Alarcón ◽  
Michael J. Davies

Covalent crosslinks within or between proteins play a key role in determining the structure and function of proteins. Some of these are formed intentionally by either enzymatic or molecular reactions and are critical to normal physiological function. Others are generated as a consequence of exposure to oxidants (radicals, excited states or two-electron species) and other endogenous or external stimuli, or as a result of the actions of a number of enzymes (e.g., oxidases and peroxidases). Increasing evidence indicates that the accumulation of unwanted crosslinks, as is seen in ageing and multiple pathologies, has adverse effects on biological function. In this article, we review the spectrum of crosslinks, both reducible and non-reducible, currently known to be formed on proteins; the mechanisms of their formation; and experimental approaches to the detection, identification and characterization of these species.


2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Stephen J. Genuis ◽  
Kasie L. Kelln

Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the surge of recent research confirming widespread exposure and bioaccumulation of chemical toxicants. Evidence from sources such as the Centers for Disease Control reveals that most people have accrued varying degrees of assorted toxic pollutants including heavy metals, flame retardants, and pesticide residues within their bodies. It has been well established that many of these toxicants have neurodegenerative as well as neurodevelopmental impact as a result of various pathophysiologic mechanisms including neuronal mitochondrial toxicity and disruption of neurotransmitter regulation. Elimination of stockpiled toxicants from the body may diminish adverse toxicant impact on human biology and allow restoration of normal physiological function. Incorporating a review of medical literature on toxicant exposure and dementia with a case history of a lead-exposed individual diagnosed with dementia, this paper will discuss a much overlooked and potentially widespread cause of declining brain function and dementia.


Author(s):  
Michelle Ellinson ◽  
Tommy Rampling

Normal nutritional function requires a healthy diet. Healthy eating incorporates a variety of nutrients that are essential for energy expenditure, prevention of disease, and maintenance of normal physiological function. An unhealthy diet can result in malnutrition, and this contributes to illness and death throughout the world. The core principle of healthy eating is obtaining an adequate balance, and the diseases resulting from overnourishment differ greatly from those resulting from undernourishment. In the third world, diets tend to rely heavily on staple crops, and can be very seasonal. Energy sources are predominantly cereals, whereas meat and fish are limited. Malnutrition tends to occur from a lack of essential nutrients, leading to conditions such as vitamin deficiencies, kwashiorkor, and iodine deficiency syndromes. In first-world countries, people have more freedom to choose what they eat. Thus, diets tend to be high in fat and dense in energy. Obesity, diabetes, coronary heart disease, cancer, and hypertension are major contributors to morbidity and mortality. A healthy diet should contain adequate proportions of carbohydrates, fats, proteins, vitamins, and trace elements. The intake of these constituents is sporadic, with meals constituting major boluses of potential energy. Energy expenditure, conversely, is continuous. The human body has, therefore, developed complex mechanisms directing nutrients into storage when in excess, and mobilizing these stores as they are needed, and it is essential that sufficient energy is always available to maintain the basal metabolic rate, which is the amount of energy expended while at rest in a neutrally temperate environment. This energy is sufficient only for the functioning of the vital organs, such as the heart, the lungs, the liver, the kidneys, and the CNS.


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