scholarly journals Association Between Executive Functioning and Functional Impairment Among Pediatric Cancer Survivors and Controls

2018 ◽  
Vol 34 (5) ◽  
pp. 599-609 ◽  
Author(s):  
Sarah J Erickson ◽  
Sarah Hile ◽  
Rebecca E Rieger ◽  
Natalia C Moss ◽  
Sarah Dinces ◽  
...  
Keyword(s):  
Executive Functioning ◽  
Executive Functions ◽  
Cancer Survivors ◽  
Functional Impairment ◽  
Pediatric Cancer ◽  
Treatment Intensity ◽  
Neurocognitive Deficits ◽  
Cross Sectional ◽  
Pediatric Cancer Survivors ◽  
The Impact

Abstract Objective To examine the impact of cancer treatment upon neurocognitive and functional impairment; and to explore the relationship between these constructs in pediatric cancer survivors compared to controls. Method A cross-sectional cohort of survivors (n = 26) and controls (n = 53) was included. Survivors were off treatment an average of 6.35 years (SD = 5.38; range 1–15 years) and demonstrated an average “medium” Central Nervous System (CNS) treatment intensity score. Participants completed measures of neurocognitive functions including intellectual assessment (RIST) and executive functions (NIH Examiner), while parents reported on children’s functional impairment (BIS). Results Survivors were similar to controls in neurocognitive ability, including intellectual and executive functions, and functional impairment. Regardless of group membership, NIH Examiner performance and functional impairment increased with age. Increased impairment was associated with different neurocognitive variables for survivors versus controls. Conclusions Research regarding functional impairment of cancer survivors and the association between neurocognitive deficits and functional impairment has been limited. Our results demonstrate that, while low treatment intensity may confer relative sparing of neurocognitive and executive functioning among survivors, functional impairment continues to be a potential risk. In conclusion, pediatric cancer survivors should be screened for functional difficulties, particularly in the areas of interpersonal relations and self-care.

Neurocognitive Deficits and IEP Monitoring of Pediatric Cancer Survivors

2006 ◽  
Author(s):  
Irene Delgado ◽  
Maria L. Goldman ◽  
Mary Whitney Ward ◽  
Monica Bocanegra ◽  
Erin O'Callaghan ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Neurocognitive Deficits ◽  
Pediatric Cancer Survivors

scholarly journals Quality of life in pediatric cancer survivors: contributions of parental distress and psychosocial family risk

2018 ◽  
Vol 25 (1) ◽  
pp. 41 ◽  
Author(s):  
N.M. Racine ◽  
M. Khu ◽  
K. Reynolds ◽  
G.M.T. Guilcher ◽  
F.S.M. Schulte
Keyword(s):  
Quality Of Life ◽  
Psychological Distress ◽  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Psychosocial Risk ◽  
Family Risk ◽  
Pediatric Cancer Survivors ◽  
Low Levels ◽  
The Impact

Background Pediatric survivors of childhood cancer are at increased risk of poor quality of life and social-emotional outcomes following treatment. The relationship between parent psychological distress and child adjustment in pediatric cancer survivors has been well established. However, limited research has examined the factors that may buffer this association. The current study examined the associations between psychosocial family risk factors, parental psychological distress, and health-related quality of life (hrql) in pediatric cancer survivors.Methods Fifty-two pediatric cancer survivors (34 males, 18 females, mean age = 11.92) and their parents were recruited from a long-term cancer survivor clinic. Children and their parents who consented to participate completed the Pediatric Quality of Life Inventory 4.0. Parents completed a demographic information form, the Psychosocial Assessment Tool (pat 2.0) and the Brief Symptom Inventory (bsi). The Intensity of Treatment Rating (itr-3) was evaluated by the research team.Results Multiple regression analyses revealed that parental psychological distress negatively predicted parent reported hrql, while treatment intensity, gender, and psychosocial risk negatively predicted parent and child-reported hrql. Psychosocial risk moderated the association between parent psychological distress and parent-reported child hrql (p = 0.03), whereby parents with high psychological distress but low levels of psychosocial risk reported their children to have higher hrql.Conclusion Low levels of family psychosocial risk buffer the impact of parent psychological distress on child hrql in pediatric cancer survivors. The findings highlight the importance of identifying parents and families with at-risk psychological distress and psychosocial risk in order to provide targeted support interventions to mitigate the impact on hrql.

scholarly journals Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 224 ◽  
Author(s):  
Thinh H. Nguyen ◽  
Monish Ram Makena ◽  
Siddhartha Yavvari ◽  
Maninder Kaur ◽  
Teresia Pham ◽  
...  
Keyword(s):  
Literature Review ◽  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Population Analysis ◽  
Large Population ◽  
Primary Cancer ◽  
Second Cancer ◽  
Pediatric Cancer Survivors ◽  
The Impact

The majority of pediatric patients are cured of their primary cancer with current advanced developments in pediatric cancer therapy. However, survivors often experience long-term complications from therapies for primary cancer. The delayed mortality rate has been decreasing with the effort to reduce the therapeutic exposure of patients with pediatric cancers. Our study investigates the incidence of sarcoma as second cancer in pediatric cancer survivors. We present a 9-year-old male who survived embryonal hepatoblastoma diagnosed at 22 months of age. At 4.5 years of age, he presented with a non-metastatic primitive neuroectodermal tumor (PNET) of the left submandibular area. He has no evidence of recurrence of either cancer for 51 months after finishing all chemotherapy and radiotherapy. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify the current rate of second sarcomas in pediatric cancer survivors. Our literature review and large population analysis emphasize the impact of sarcoma as a second malignancy and provide help to physicians caring for pediatric cancer survivors.

scholarly journals Cancer-Related Fatigue On Daily Living Activities in Pediatric Cancer Survivors

2021 ◽  
Author(s):  
Müberra Tanrıverdi ◽  
Fatma Betül Çakır
Keyword(s):  
Cancer Survivors ◽  
Pediatric Cancer ◽  
Daily Living ◽  
Treatment Modalities ◽  
Tumor Type ◽  
Daily Living Activities ◽  
Cancer Related Fatigue ◽  
Pediatric Cancer Survivors ◽  
The Impact ◽  
Total P

Abstract Aim Cancer-related long term complications such as cardiovascular disease, fatigue, weight-related problems, and emotional disturbances are found to be increased in pediatric cancer survivors (PCS). The relationship between daily living activities (DLA) and such complications is still being investigated. Our aim in this study was to investigate the impact of cancer-related fatigue on DLA in PCS. Methods Cancer-related fatigue was assessed by “PedsQL Multidimensional Fatigue Scale (MFS)”, “Visuel Analogue Scale (VAS)” and “Borg Fatigue Scale”. The DLA was evaluated by WeeFIM. Results There were 77 PCS (44 boys) with a mean age of 10.76 ± 4.49 years. The mean value of fatigue scales were VAS 2.48 ± 1.48, Borg 0.61 ± 1.00 and MFS total score 71.14 ± 18.74. There was a statistically significant negative relationship between age and VAS scores of PCS (p = 0.047). The girls were found more tired than boys (VAS; p = 0.031). A positive correlation was established between the type of tumor and MFS total score (p = 0.048). WeeFIM total result was 118.64 ± 11.37. While there was a statisticially significant relationship between VAS Fatigue Score and WeeFIM total (p = 0.07), there was no such correlation between MFS total and WeeFIM total (p = 0.080) and Borg Fatigue Scale and WeeFIM total (p = 0.449). Conclusions It is established that there is a relationship between level of fatigue and DLA. Risk factors like tumor type or treatment modalities for fatigue should be investigated in larger samples of specific survivor groups. Fatigue and its association with DLA should be screened clinically as a routine surveillence in PCS and treatment options be planned.

scholarly journals The Impact of Idiopathic Generalized Epilepsy on Executive Functions

2021 ◽  
pp. 097275312096875
Author(s):  
Haritha Koganti ◽  
Shasthara Paneyala ◽  
Harsha Sundaramurthy ◽  
Nemichandra SC ◽  
Rithvik S Kashyap ◽  
...  
Keyword(s):  
Executive Functions ◽  
Executive Dysfunction ◽  
Cross Sectional Study ◽  
Idiopathic Epilepsy ◽  
Idiopathic Generalized Epilepsy ◽  
Word Fluency ◽  
Cross Sectional ◽  
Generalized Epilepsy ◽  
Multiple Domains ◽  
The Impact

Background: Idiopathic generalized epilepsy is defined as seizures with a possible hereditary predisposition without an underlying cause or structural pathology. Assessment of executive dysfunction in idiopathic generalized epilepsies based on standard Indian battery is not available in the literature. Aims and Objectives: To assess specific executive functions affected in patients with idiopathic epilepsy and their association with various variables. Materials and Methods: Type of observational cross-sectional study, where clinical profile of all idiopathic epilepsy patients attending the neurology OPD was studied and their executive higher mental functions were assessed using the NIMHANS battery. Results: A total of 75 idiopathic generalized epilepsy patients were included in the study. Executive functions that were commonly found abnormal in our study were word fluency ( P ≤ .001), category fluency ( P < .001), verbal n-back ( P < .001), Tower of London ( p < 0.01), and Stroop test ( P < 0.01). Executive functions showed a significant correlation with age at symptom onset, duration of epilepsy, and in those with uncontrolled seizures. Conclusion: Patients of idiopathic generalized epilepsy according to the present study were found to have significant executive dysfunction in multiple domains. This necessitates the screening for executive dysfunctions, which if detected should prompt the clinician to initiate cognitive retraining.

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