Autologous pure platelet-rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient-reported outcomes to support antiaging effects

Abstract Background Many therapeutic options are currently available for facial skin rejuvenation, but little evidence exists about the efficacy of combining such procedures. Objectives To assess and investigate the synergic effect of HA and a-PRP injections on facial skin rejuvenation. Methods For this randomized controlled prospective study, 93 eligible patients were enrolled and randomized into three intervention groups to undergo a series of three treatments sessions with either a-PRP, HA or Cellular Matrix-BCT-HA (PRP-HA) injected on facial cheeks. Results A total of 93 patients were included. Treatment with Cellular Matrix BCT-HA led to a very significant improvement in the overall facial appearance compared to groups treated with a-PRP and HA alone (p<0.0001). Participants treated with Cellular Matrix showed a 20%, 24% and 17% increase in FACE-Q score at 1 month, 3 months and 6 months post-treatment, respectively. For the HA group, the improvement of FACE-Q score was 12%, 11% and 6% at 1, 3- and 6-months post-treatment, respectively, while the a-PRP group showed a 9% improvement in FACE-Q score at 1 month and 11% and 8% improvement at 3- and 6-months post-treatment, respectively.Biophysical measurements showed significantly improved skin elasticity for the group Cellular BCT-HA compared to a-PRP and HA alone. No serious adverse events were reported. Conclusions Combining a-PRP and HA seems to be a promising treatment for facial rejuvenation with a very significant improvement in facial appearance and skin elasticity compared to a-PRP or HA alone.

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Prospective, Randomized, Comparative Study of the Cutaneous Effects of a Topical Body Treatment Compared to a Bland Moisturizer

Aesthetic Surgery Journal ◽

10.1093/asj/sjab161 ◽

2021 ◽

Author(s):

Jean Carruthers ◽

Gyasi Bourne ◽

Michaela Bell ◽

Alan Widgerow

Keyword(s):

Patient Reported Outcomes ◽

Skin Thickness ◽

Skin Rejuvenation ◽

Recoil Velocity ◽

Thickness Skin ◽

Patient Reported ◽

Skin Retraction ◽

Topical Treatments ◽

Over Time

Abstract Background Over time human skin thins and loses elasticity, and topical treatments attempt to reverse this process. Objectives Assess the efficacy of TransFORM Body Treatment (TFB) in skin rejuvenation compared to a bland moisturizer on the extensor and volar forearms. Methods Blinded participants were given two products to apply on the designated forearms with follow-up at 4, 8 and 12 weeks. Measurements included skin thickness, photography, dermatopathology, cutaneous elasticity by two separate devices, and patient reported outcomes. All were compared to baseline. Results Change in roughness: extensor -0.09 mm for bland moisturizer and -0.26 mm for TFB (P = 0.174); volar 0.01mm for bland moisturizer and -0.23 mm for TFB (P = 0.004). Change in recoil velocity: volar -56 degree/s for bland moisturizer and -24 degree/s for TFB (p = 0.61); extensor -95 degree/s for bland moisturizer and -63 degree/s for TFB (p = 0.57). Change in retraction speed: volar -3.25 ms for bland moisturizer and -20.08 ms for TFB (p = 0.33); extensor -2.17 ms for bland moisturizer and -10.83 ms for TFB (p = 0.66). Histology: TFB showed an increase in mucopolysaccharide content, new collagen and increase in elastin fibers in the papillary dermis. Change in Rao-Goldman score: volar -0.17 for bland moisturizer and -0.33 for TFB (p = 0.25); extensor -0.08 for bland moisturizer and -0.17 for TFB (p = 0.36). Conclusions Histology showed production of new collagen and elastin. Quantification of changes using skin thickness, skin retraction speed and skin recoil velocity showed trends that agree with the visual data.

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FACE-Q Skin Cancer Module for measuring patient-reported outcomes following facial skin cancer surgery

British Journal of Dermatology ◽

10.1111/bjd.16671 ◽

2018 ◽

Vol 179 (1) ◽

pp. 88-94 ◽

Cited By ~ 29

Author(s):

E.H. Lee ◽

A.F. Klassen ◽

S.J. Cano ◽

K.S. Nehal ◽

A.L. Pusic

Keyword(s):

Skin Cancer ◽

Patient Reported Outcomes ◽

Cancer Surgery ◽

Facial Skin ◽

Cancer Module ◽

Patient Reported ◽

Skin Cancer Surgery

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Platelet-Rich Plasma Augmentation for Isolated Arthroscopic Meniscal Repairs Leads to Significantly Lower Failure Rates: A Systematic Review of Comparative Studies

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120964534 ◽

2020 ◽

Vol 8 (11) ◽

pp. 232596712096453

Author(s):

Kyle R. Sochacki ◽

Marc R. Safran ◽

Geoffrey D. Abrams ◽

Joseph Donahue ◽

Constance Chu ◽

...

Keyword(s):

Systematic Review ◽

Odds Ratio ◽

Patient Reported Outcomes ◽

Platelet Rich Plasma ◽

Meniscal Repair ◽

Activity Level ◽

Failure Rates ◽

Significant Difference ◽

Patient Reported ◽

Variable Data

Background: Studies have reported relatively high failure rates of isolated meniscal repairs. Platelet-rich plasma (PRP) has been suggested as a way to increase growth factors that enhance healing. Purpose: To compare (1) meniscal repair failures and (2) patient-reported outcomes after isolated arthroscopic meniscal repair augmented with and without PRP. Study Design: Systematic review; Level of evidence, 3. Methods: A systematic review was performed using the PRISMA (Preferred Reporting Items for Systematic Meta-Analyses) guidelines. Multiple databases were searched for studies that compared outcomes of isolated arthroscopic meniscal repair augmented with PRP versus without PRP in human patients. Failures and patient-reported outcome scores were reported for each study and compared between groups. Study heterogeneity was assessed using I 2 for each outcome measure before meta-analysis. Study methodological quality was analyzed. Continuous variable data were reported as mean and standard deviation from the mean. Categorical variable data were reported as frequency with percentage. All P values were reported with significance set at P < .05. Results: Five articles were analyzed (274 patients [110 with PRP and 164 without PRP]; 65.8% male; mean age, 29.1 ± 4.6 years; mean follow-up, 29.2 ± 22.1 months). The risk of meniscal repair failure ranged from 4.4% to 26.7% for PRP-augmented repairs and 13.3% to 50.0% for repairs without PRP. Meniscal repairs augmented with PRP had significantly lower failure rates than repairs without PRP (odds ratio, 0.32; 95% CI, 0.12-0.90; P = .03). One of the 5 studies reported significantly higher outcomes in the PRP-augmented group versus the no-PRP group for the International Knee Documentation Committee (IKDC), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee injury and Osteoarthritis Outcome Score (KOOS) ( P < .05 for all). The remaining 4 studies reported no significant difference between groups with regard to outcomes for the IKDC, Lysholm knee scale, visual analog scale for pain, or Tegner activity level. Conclusion: Although the studies were of mostly of low quality, isolated arthroscopic meniscal repairs augmented with PRP led to significantly lower failure rates (10.8% vs 27.0%; odds ratio, 0.32; P = .03) as compared with repairs without PRP. However, most studies reported no significant differences in patient-reported outcomes.

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The Treatment of Bone Marrow Lesions Associated with Advanced Knee Osteoarthritis: Comparing Intraosseous and Intraarticular Injections with Bone Marrow Concentrate and Platelet Products

January 2018 - Pain Physician ◽

10.36076/ppj.2021/24/e279 ◽

2021 ◽

pp. E279-E288

Author(s):

Ehren Dodson

Keyword(s):

Bone Marrow ◽

Knee Osteoarthritis ◽

Patient Reported Outcomes ◽

Platelet Rich Plasma ◽

Intraarticular Injection ◽

Bone Marrow Concentrate ◽

Bone Marrow Lesions ◽

Treatment Groups ◽

Patient Reported ◽

Intraosseous Injection

Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated with advanced osteoarthritis of the adjacent joint. Injection of autologous orthobiologic products, including bone marrow concentrate and platelet-rich plasma, have demonstrated safety and efficacy in treating both advanced osteoarthritis (via intraarticular injection) and associated bone marrow lesions (via intraosseous injection). The relative efficacy of intraarticular versus intraosseous injection of orthobiologics has not been evaluated at the present time. Objectives: The objective was to evaluate differences in orthobiologic bone marrow lesions treatment, either as a collateral result of intraarticular injection with bone marrow concentrate and platelet products alone, or intraosseous plus intraarticular injection as measured by patient reported outcomes. Study Design: This study employed a prospective case-matched cohort design. Setting: This study took place at a single outpatient interventional orthopedic pain clinic. Methods: Using data from a prospective orthobiologic treatment registry of knee patients, a population of knee osteoarthritis with bone marrow lesions patients who had undergone only intraarticular knee injections of bone marrow concentrate and platelets (for symptomatic advanced osteoarthritis) were age, gender, and disease severity case-matched to a series of advanced osteoarthritis and bone marrow lesions patients who underwent intraosseous plus intraarticular injections. Self-reported patient outcomes for Numeric Pain Scale, International Knee Documentation Committee, lower extremity functional scale, and a modified single assessment numeric evaluation were compared between the 2 treatment groups. Results: Eighty patients were included, 40 in each group. Although pain and functional outcome scores were significantly improved in both treatment groups, there was no statistically significant differences in patient reported outcomes based on the type of treatment. Limitations: There are several limitations to this study, including multiple providers performing the injections, varying onset of symptoms to treatment, and additional injections after their initial treatment, that were not controlled. In addition, increasing the sample size may be beneficial as well, particularly with the large bone marrow lesions group, which did suggest possible improvement with intraosseous plus intraarticular over the intraarticular, although was not statistically significant in our sample. Limited data availability for this cohort as well as some missing data are other limitations to consider. Conclusion: Treating knee bone marrow lesions with intraosseous bone marrow concentrate and platelet products did not affect patient reported outcomes. Key words: Intraosseous, intraarticular, bone marrow concentrate, bone marrow lesion, bone marrow edema, knee osteoarthritis, platelet-rich plasma, injection

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Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Experimental and Therapeutic Medicine ◽

10.3892/etm.2020.8531 ◽

2020 ◽

Author(s):

Rina Du ◽

Tiechi Lei

Keyword(s):

Platelet Rich Plasma ◽

Facial Skin ◽

Skin Rejuvenation ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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The use of biologics to improve patient-reported outcomes in hip preservation

Journal of Hip Preservation Surgery ◽

10.1093/jhps/hnab028 ◽

2021 ◽

Author(s):

Spencer W Sullivan ◽

Oluwatobi M Aladesuru ◽

Anil S Ranawat ◽

Benedict U Nwachukwu

Keyword(s):

Patient Reported Outcomes ◽

Platelet Rich Plasma ◽

Hip Osteoarthritis ◽

The United States ◽

Clear Understanding ◽

Biologic Treatment ◽

Relieve Pain ◽

Femoroacetabular Impingement Syndrome ◽

Patient Reported ◽

Improve Patient

Abstract Despite lack of clear understanding, the use of biologic treatment methods has increased in the United States. Therapeutic methods, including platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC) and hyaluronic acid (HA) among other biologics, are commonly associated with relief of pain in a number of different orthopedic conditions. Within the past two decades, hip preservationists have investigated the roles of these biologic treatments in both non-operative and surgical management of common hip conditions. The purpose is to review the published literature surrounding the application and efficacy of biologics, most notably PRP, BMAC and HA, in the clinical management of hip conditions. The hip conditions examined in this review include hip osteoarthritis, femoroacetabular impingement syndrome and associated labral tear pathology, avascular necrosis of the femoral head and gluteal/hamstring tendinopathy. While our review of the literature suggests that there is support for the implementation of biologics to relieve pain and improve function for hip conditions. Through further research efforts, it is important to stay updated with the clinical efficacy of biologics in hip preservation.

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Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation

Dermatologic Surgery ◽

10.1097/dss.0000000000001083 ◽

2017 ◽

Vol 43 (6) ◽

pp. 826-835 ◽

Cited By ~ 22

Author(s):

Norma Cameli ◽

Maria Mariano ◽

Iole Cordone ◽

Elva Abril ◽

Serena Masi ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Facial Skin ◽

Skin Rejuvenation

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Novel assessment of leukocyte-rich platelet rich plasma on functional and patient reported outcomes in knee osteoarthritis: a pilot study

Regenerative Medicine ◽

10.2217/rme-2021-0032 ◽

2021 ◽

Author(s):

Prathap Jayaram ◽

Gu Eon Kang ◽

Brett L Heldt ◽

Olumide Sokunbi ◽

Bo Song ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Patient Reported Outcomes ◽

Platelet Rich Plasma ◽

Early Time ◽

Therapeutic Effects ◽

Timed Up And Go ◽

End Points ◽

Time Points ◽

Gait Parameters ◽

Patient Reported

Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patient with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time-points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II–III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient reported outcomes at early time points in patients with KOA.

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