Statistical tests of genetic association for case-control study designs

Abstract Case-control studies are an important part of the epidemiologic literature, yet confusion remains about how to interpret estimates from different case-control study designs. We demonstrate that not all case-control study designs estimate odds ratios. On the contrary, case-control studies in the literature often report odds ratios as their main parameter even when using designs that do not estimate odds ratios. Only studies using specific case-control designs should report odds ratios, whereas the case-cohort and incidence-density sampled case-control studies must report risk ratio and incidence rate ratios, respectively. This also applies to case-control studies conducted in open cohorts, which often estimate incidence rate ratios. We also demonstrate the misinterpretation of case-control study estimates in a small sample of highly cited case-control studies in general epidemiologic and medical journals. We therefore suggest that greater care be taken when considering which parameter is to be reported from a case-control study.

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Analysis of secondary outcomes in nested case-control study designs

Statistics in Medicine ◽

10.1002/sim.6231 ◽

2014 ◽

Vol 33 (24) ◽

pp. 4215-4226 ◽

Cited By ~ 7

Author(s):

Ryung S. Kim ◽

Robert C. Kaplan

Keyword(s):

Case Control Study ◽

Case Control ◽

Secondary Outcomes ◽

Study Designs ◽

Nested Case Control ◽

Control Study

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A comparison of the test-negative and the traditional case-control study designs for estimation of influenza vaccine effectiveness under nonrandom vaccination

BMC Infectious Diseases ◽

10.1186/s12879-017-2838-2 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 16

Author(s):

Meng Shi ◽

Qian An ◽

Kylie E. C. Ainslie ◽

Michael Haber ◽

Walter A. Orenstein

Keyword(s):

Influenza Vaccine ◽

Case Control Study ◽

Case Control ◽

Vaccine Effectiveness ◽

Study Designs ◽

Control Study

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Genetic Association of KCNE1G38S Polymorphism in Postoperative Atrial Fibrillation of North Indian Population: A Case-Control Study

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1202 ◽

2017 ◽

Vol 10 (3) ◽

pp. 1055-1060 ◽

Cited By ~ 1

Author(s):

Surabhi Yadav ◽

Salman Akhtar ◽

Surendra K Agarwal ◽

Gauranga Majumdar ◽

Suman Vimal

Keyword(s):

Atrial Fibrillation ◽

Genetic Association ◽

Indian Population ◽

Case Control Study ◽

Case Control ◽

Postoperative Atrial Fibrillation ◽

North Indian Population ◽

Control Study

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The Effect of Family Room Lighting on Incidence of Positive AFB Lung TB in Serdang Bedagai Regency

Britain International of Exact Sciences (BIoEx) Journal ◽

10.33258/bioex.v2i1.130 ◽

2020 ◽

Vol 2 (1) ◽

pp. 210-219

Author(s):

Ika Dewi Purba ◽

Rahayu Lubis ◽

Nurmaini

Keyword(s):

Multivariate Analysis ◽

Case Control Study ◽

Case Control ◽

Pulmonary Tb ◽

The Family ◽

Study Designs ◽

Control Study ◽

Room Lighting

The aims of the study is to find out the effect of lighting in family room. This type of research uses observational analytic studies with case-control study designs. The result of the study shows that there is the effect of lighting in the family room (p = 0.010, OR = 4.125, 95% CI = 1,473 - 11,555), lighting in the room (p = 0.009, OR = 3.167, 95% CI = 1,398-7,174) with the incidence of pulmonary TB, while the incidence of pulmonary TB disease, whereas occupancy density had no effect (p = 0.263). The result of multivariate analysis showed that lighting in the family room had the strongest influence with TB disease (p = 0.001 and Exp (B) of 24.560).

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