CD36 Polymorphism (rs1761667) Was Associated with Fatty Liver in a Japanese Population

Abstract Objectives Nonalcohol fatty liver disease (NAFLD) is one of the considerable health problems in the world. NAFLD is a representative phenotype in the liver reflecting individual's lifestyle. Previous studies suggested that a single nucleotide polymorphism (SNP) in the CD36 gene was associated with dietary fat intake and fat metabolism. Therefore, we hypothesized that this SNP may be associated with fatty liver (FL) and NAFLD. We conducted this cross-sectional study to examine the association between two CD36 polymorphisms (rs1761667 and rs1527483) and FL and NAFLD in a Japanese population. Methods A total of 525 local residents participated in the health check-up in Yakumo town, Hokkaido, Japan. This cross-sectional study was conducted based on clinical information collected in this health check-up. Among all participants, 57 people were excluded due to the inadequate informed consent, clinical history of liver disease. Genotyping of two polymorphisms in the CD36 gpgbrkkene was performed by using the PCR-CTPP method. Ultrasound examination was performed by four qualified ultrasonographers. In this present, NAFLD was defined as 1) presence of FL and 2) a daily alcohol consumption <10 g in women and <20 g in men. Multivariable regression analysis was performed after adjusting for age, sex, waist circumference, medicine for dyslipidemia. Results The mean age of participants was 63.4 (10.0). The minor allele frequency of rs1761667 and rs1527483 was 0.26 and 0.21, respectively. The presence of FL and NAFLD was 90 (19.2%) and 67 (14.3%), respectively. Multiple regression analyses showed a significant association between rs1761667 and presence of FL (P = 0.04), and FL grade (P = 0.03). However, rs1761667 was not significantly associated with NAFLD (P = 0.11). No significant associations were found between rs1527483 and FL and NAFLD. Conclusions A polymorphism (rs1761667) in the CD36 gene was associated with the presence of FL, but we did not find a significant association between this SNP and NAFLD. Funding Sources This study was supported by the Mishima Kaiun Memorial Foundation.

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Correlation Between Anthropometric Measurements and Non-alcoholic Fatty Liver Disease in Individuals With Obesity Undergoing Bariatric Surgery: Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-021-05470-2 ◽

2021 ◽

Author(s):

Silênio Souza Reis ◽

Guilherme Hoverter Callejas ◽

Rodolfo Araújo Marques ◽

Martinho A. Gestic ◽

Murillo P. Utrini ◽

...

Keyword(s):

Bariatric Surgery ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Anthropometric Measurements ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Association between soil heavy metals and fatty liver disease in men in Taiwan: a cross sectional study

BMJ Open ◽

10.1136/bmjopen-2016-014215 ◽

2017 ◽

Vol 7 (1) ◽

pp. e014215 ◽

Cited By ~ 12

Author(s):

Yen-Chih Lin ◽

Ie-Bin Lian ◽

Chew-Teng Kor ◽

Chia-Chu Chang ◽

Pei-Yuan Su ◽

...

Keyword(s):

Heavy Metals ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Soil Heavy Metals

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Outcomes of Nonalcoholic Fatty Liver Disease In Covid Positive Diabetic Patients: Cross Sectional Study

10.53350/pjmhs2115123241 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3241-3243

Author(s):

Azhar Hussain ◽

Mehwish Iftikhar ◽

Amna Rizvi ◽

Muhammad Latif ◽

Muhammad Javed Ahmed ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Statistical Significance ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver

Background: SARS-CoV-2 principally invades the respiratory system. ACE receptor are also abundant throughout the hepatobiliary system and their increased expression on hepatocyte make patients with NAFLD more vulnerable. Aim: To see outcomes of COVID positive diabetic patients suffering from Nonalcoholic fatty liver disease (NAFLD). Study design: Cross Sectional Study. Methodology: 150 diabetic and COVID PCR positive were recruited from COVID ward of Services Hospital in Lahore. Clinical parameters like BMI, SpO2, Hepatomegaly and lab parameters like HbA1C, AST ALT were noted in spreadsheet. Statistical analysis was done using SPSS v.25. Statistical significance for difference in proportions is calculated using Pearson’s Chi-Squared test. P less than 0.05 was considered statistically significant. Results: Around 84(56%) were males and 66(44%) females, smoked were 27(18%), mean age (years) was 59.7333 ±11.35023, mean BMI (kg/m²) was 30.1425±7.30673, 87(58%) patients had NAFLD, who experienced sever disease (53.2%; x^2=0.010) and more mortalities (60.2%;x^2=0.453) as compared to those who do not had condition. Conclusion: We concluded that NAFLD makes COVID-19 infected patients more fragile. Such patients experienced sever disease and more mortalities however need of mechanical ventilation remains almost equal between those who has NAFLD and those who didn’t had. Keywords: Nonalcoholic fatty liver disease, COVID-19, Diabetes, Mortality and Severity.

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Lifestyle predictors of obese and non-obese patients with nonalcoholic fatty liver disease: A cross-sectional study

Clinical Nutrition ◽

10.1016/j.clnu.2017.08.018 ◽

2018 ◽

Vol 37 (5) ◽

pp. 1550-1557 ◽

Cited By ~ 6

Author(s):

Joo Hee Kwak ◽

Dae Won Jun ◽

Seung Min Lee ◽

Yong Kyun Cho ◽

Kang Nyeong Lee ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Obese Patients ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver

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Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in China: A Cross-Sectional Study

10.21203/rs.3.rs-208721/v1 ◽

2021 ◽

Author(s):

Yuling Chen ◽

Hao Li ◽

Shu Li ◽

Zhou Xu ◽

Shen Tian ◽

...

Keyword(s):

Risk Factors ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Metabolic Disorders ◽

Menopausal Status ◽

Cross Sectional Study ◽

Health Examination ◽

Sectional Study ◽

Cross Sectional

Abstract BackgroundMetabolic associated fatty liver disease (MAFLD) is a new definition for liver disease associated with known metabolic dysfunction. Based on new diagnostic criteria, we aim to investigate its prevalence and risk factors in Chinese.MethodsThis cross-sectional study was implemented on 139170 subjects who participated in health examination.Results Among 139170 subjects, prevalence of MAFLD was 26.1% (males: 35.4%; females: 14.1%), and it was significantly higher before 65-year-old in males than that in females (36.2% vs. 12.2%, P<0.001), however significantly lower after 65 (28.2% vs. 33.0%, P<0.001). The prevalence in different female menopausal status (premenopause, perimenopause, postmenopause) was 6.1%,16.8%, and 30.2%, in BMI groups (underweight, normal, overweight and obese), it was 0.1%, 4.0%, 27.4% and 59.8%. Proportions of abnormal metabolic features in MAFLD group were significantly higher than those in non-MAFLD group, so as the proportion of elevated alanine aminotransferase (ALT) (42.5% vs. 11%, P<0.001). Prevalence of metabolic syndrome (MS), dyslipidemia, and hyperuricemia in MAFLD group (53.2%, 80.0%, and 45.0%) was significantly higher than that in non-MAFLD group (10.1%, 41.7%, and 16.8%). Logistic regression revealed that age, BMI, waist circumference, ALT, triglyceride, fasting glucose, uric acid and platelet count were associated with MAFLD.ConclusionsMAFLD is prevalent in China, its prevalence varies among different groups of age, gender, BMI, and female menopausal status. MAFLD was related to metabolic disorders especially obesity. People with MAFLD suffer high prevalence of MS, dyslipidemia, hyperuricemia, and elevated liver enzymes. Metabolic disorders should be paid attention to improve management of MAFLD.

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Gender differences in the prevalence of nonalcoholic fatty liver disease in the Northeast of Thailand: A population-based cross-sectional study

F1000Research ◽

10.12688/f1000research.12417.1 ◽

2017 ◽

Vol 6 ◽

pp. 1630 ◽

Cited By ~ 8

Author(s):

Ueamporn Summart ◽

Bandit Thinkhamrop ◽

Nittaya Chamadol ◽

Narong Khuntikeo ◽

Metha Songthamwat ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver ◽

Prevalence Difference ◽

Post Menopausal

Background. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. A large number of studies have strongly described larger proportions of men being afflicted with NAFLD than women; however, recent studies investigating the role of gender and NAFLD have exposed the contrary. Methods. This cross-sectional study utilized data from the baseline survey of an ongoing cohort study called the Cholangiocarcinoma Screening and Care Program (CASCAP), conducted in the northeastern region of Thailand between March 2013 and September 2015. Information regarding socio-demographic, including gender, was collected using a standardized self-administered questionnaire. NAFLD was diagnosed with ultrasonography by board-certified radiologists. A binomial regression was used for estimating the prevalence differences, odds ratios (OR) and the 95% confidence intervals (CI) of NAFLD between men and women. Results. A total of 34,709 participants (27,073 females and 7,636 males) were recruited. The prevalence of NAFLD in women was 22.9% (95% CI: 22.5 to 23.5), whereas it was only 18.3% (95% CI: 17.4 to 19.2) in men. After adjusting for age and presence of diabetes mellitus and other underlying diseases, the prevalence was significantly higher in women, with adjusted prevalence difference of 4.2% (95% CI: 3.2 to 5.2) and adjusted OR of 1.3 (95% CI: 1.2 to 1.4). Women had a higher prevalence of NAFLD than men in all age groups and the largest difference was found in those aged 56-60 years (prevalence = 27.4% versus 21.2%; adjusted prevalence difference = 9.4%; 95% CI: 7.9 to 10.9; adjusted OR = 1.8; 95% CI: 1.8 to 2.0). Conclusion. NAFLD is more likely to affect women more than men, in particular, among the population 56-60 years of age, which is the post-menopausal transitional period. Therefore, post-menopausal women should be the target for interventions or further investigation for NAFLD.

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