Vitamin D Trends During 12 Months After Bariatric Surgery Introduction
Abstract Objectives To assess serum vitamin D trend from baseline to 12 months after gastric bypass surgery. Methods In this observational cohort analysis of longitudinal data, we assessed the trend of serum vitamin D, and its associations with anthropometric, and biochemical measurements. All participants were on >800 IU/day vitamin D supplementation. Results Vitamin D, lipid profile, creatinine and albumin levels significantly improved at 12 months post-surgery. Vitamin D concentrations significantly increased from 26.52 ± 12.32 ng/mL to 54.52 ± 27.90 ng/mL at 12 months; however, we did not observe significant changes in ferritin, HbA1C or FBS at 12 months post-bariatric surgery versus baseline. The correlations between vitamin D concentrations and weight, BMI, TG, HDL-C, LDL-C, ferritin, HbA1c, FBS, and albumin were not significant. In addition, the correlations between vitamin D and PTH, vitamin D receptor, calcium, phosphorus, LBM, SLM, TBW, and basal metabolic rate (BMR) did not reach the threshold of statistical significance at 12 months following bariatric surgery. However, there was a significant correlation between body weight and LBM (r = 0.833, P = 0.000), SLM (r = 0.811, P = 0.000), TBW(r = 0.834, P = 0.000) and BMR (r = 0.762, P = 0.000) at 12 months. Conclusions Our results showed that supplementation of vitamin D with dosage of > 800 IU/day is sufficient for prevention of vitamin D deficiency within 12 months after Roux-en-Y surgery. Funding Sources The ethical committee of Shahid Beheshti University of Medical Sciences approved this study. (1,399,215/787).