High Prevalence and Its Influencing Factors of Vitamin D Deficiency Among Women of Reproductive Age in Central China (P10-119-19)

Abstract Objectives To examine the prevalence and its influencing factors of vitamin D deficiency. among women of reproductive age in central China. Methods A total of 1151 women of reproductive age were from an established Women's Reproductive Health Cohort Study, and their exposure factors, blood samples were collected between 2009 and 2010 in four counties of Henan Province, China. Pregnancy outcomes were followed up and a nested case control study was performed reproductive to estimate prevalence and its influencing factors of vitamin D deficiency according to serum 25-hydroxyvitamin D [25(OH)D] < 26.0 ng/mL. Results The prevalence of Vitamin D deficiency among women of reproductive age in central China was 61.5%. Significant determinants of serum 25(OH)D deficiency among women of reproductive age in central China were nutrition supplement (aOR 0.53, 95% CI 0.40–0.71), intake frequency of eggs (aOR 1.61, 95%CI 1.11–2.33) and fruits (aOR 2.50, 95% CI 1.43–4.37), Hemoglobin (aOR 2.25, 95% CI 1.38–3.66), gravidity (aOR 1.79,95% CI:1.27–2.51), family annual income (aOR 1.48, 95% CI 1.11–1.98) and passive smoking (aOR 1.56, 95% CI :1.20–2.03). Conclusions Vitamin D deficiency among women of reproductive age in central China should have high degree of concern, we should pay more attention on the nutritional status improvement and health education of women of reproductive age in central China. Funding Sources National Natural Science Foundation of China; Dietary Nutrition Research and Education Fund of Danone Nutrition Center. Supporting Tables, Images and/or Graphs

Download Full-text

Determinants of Vitamin D Status of Women of Reproductive Age in Dhaka, Bangladesh: Insights from Husband–Wife Comparisons

Current Developments in Nutrition ◽

10.1093/cdn/nzz112 ◽

2019 ◽

Vol 3 (11) ◽

Author(s):

Joo-Hyun Jeong ◽

Jill Korsiak ◽

Eszter Papp ◽

Joy Shi ◽

Alison D Gernand ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Reproductive Age ◽

Vitamin D Status ◽

Second Trimester ◽

Women Of Reproductive Age ◽

Hydroxyvitamin D ◽

Vitamin D Supplements ◽

Trial Participants

ABSTRACT Background Vitamin D deficiency is common among women of reproductive age (WRA) in Bangladesh, but the causes remain unclear. Objective To explain the high prevalence of vitamin D deficiency in WRA in Dhaka, Bangladesh, we compared the vitamin D status of pregnant women with that of their husbands and between pregnant and nonpregnant states. Methods This study was an observational substudy of the Maternal Vitamin D for Infant Growth trial conducted in Dhaka, Bangladesh. Women (n = 1300) were enrolled in the second trimester of pregnancy and randomly assigned to 1 of 5 arms consisting of different doses of vitamin D supplements or placebo, with 1 arm continuing supplementation until 6 mo postpartum. A subgroup of trial participants and their husbands with plasma 25-hydroxyvitamin D [25(OH)D] concentration measurements (n = 84), and placebo-group trial participants with serum 25(OH)D measured in the second trimester of pregnancy and 6 mo postpartum (n = 89) were studied using linear mixed-effects regression models. Results The mean ± SD plasma 25(OH)D in pregnant women in the second trimester was 23 ± 11 nmol/L. Adjusting for age and season, 25(OH)D of pregnant women was 30 nmol/L lower (95% CI: −36, −25 nmol/L) than that of men. Only 9% of total variance in 25(OH)D was explained by factors shared by spousal pairs. Selected nonshared factors (BMI, time spent outdoors, involvement in an outdoor job, sunscreen use) did not explain the association of sex with 25(OH)D. Adjusting for age, season, and BMI, 25(OH)D was similar during pregnancy and 6 mo postpartum (mean difference: −2.4 nmol/L; 95% CI: −5.3, 0.4 nmol/L). Conclusions In Dhaka, WRA have substantially poorer vitamin D status than men. Variation in 25(OH)D is not greatly influenced by determinants shared by spouses. Measured nonshared characteristics or pregnancy did not account for the gender differential in 25(OH)D. This trial was registered at clinicaltrials.gov as NCT01924013.

Download Full-text

Vitamin D deficiency in women of reproductive age, options for correction

Medical Council ◽

10.21518/2079-701x-2018-7-18-22 ◽

2018 ◽

pp. 18-22 ◽

Cited By ~ 1

Author(s):

A. Z. Khashukoeva ◽

T. N. Savchenko ◽

M. I. Agaeva ◽

Z. A. Agaeva ◽

G. O. Andreasyan ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Reproductive Age ◽

Women Of Reproductive Age

Download Full-text

Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

Archives of Endocrinology and Metabolism ◽

10.1590/2359-3997000000216 ◽

2017 ◽

Vol 61 (1) ◽

pp. 21-27 ◽

Cited By ~ 10

Author(s):

Vinicius Medina Lopes ◽

Joaquim Roberto Costa Lopes ◽

Jean Pierre Barguil Brasileiro ◽

Ingrid de Oliveira ◽

Ricardo Peclat Lacerda ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Reproductive Age ◽

Women Of Reproductive Age

Download Full-text

The Prevalence of Hypovitaminosis D and Its Associated Risk Factors Among Women of Reproductive Age in Saudi Arabia: A Systematic Review and Meta-Analysis

Clinical Medicine Insights Women s Health ◽

10.1177/1179562x18767884 ◽

2018 ◽

Vol 11 ◽

pp. 1179562X1876788 ◽

Cited By ~ 1

Author(s):

Riyadh A Alzaheb

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Saudi Arabia ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Hypovitaminosis D ◽

Reproductive Age ◽

Vitamin D Status ◽

Women Of Reproductive Age ◽

Associated Risk Factors

Vitamin D deficiency is currently a worldwide epidemic. Middle Eastern countries, including Saudi Arabia, have high vitamin D deficiency prevalence, most prominently among women, despite their plentiful year-round sunshine. Previous research investigating vitamin D status among Saudi women of reproductive age (15-49 years) is scarce, and no study has used a nationally representative sample, so this review quantified overall hypovitaminosis D prevalence among women in Saudi Arabia and explored the associated risk factors. The Web of Science, Scopus, and Medline databases were searched for prior studies in Saudi Arabia exploring vitamin D status among women of reproductive age, published between January 1, 2000 and May 25, 2017. Data were extracted from the identified studies, and a random effects model meta-analysis established the overall hypovitaminosis D prevalence. The initial search yielded 223 possibly relevant articles; 13 were confirmed as eligible, with samples totaling 2877 women aged between 15 and 49 years. Meta-analysis revealed a mean serum 25-hydroxyvitamin D, 25(OH)D, level of 13.1 ng/mL (95% confidence interval [CI]: 11.6-14.6) and an overall prevalence of hypovitaminosis D, defined as 25(OH)D < 30 ng/mL, of 77.4% (95% CI: 63.2-87.3), mostly due to insufficient sunlight exposure and low dietary vitamin D intake. There is therefore a need for a national strategy to raise vitamin D levels among women in Saudi Arabia by advising them on natural vitamin D sources, and recommending the timing and duration of sun exposure, while also defining a national approach to vitamin D fortification and supplementation.

Download Full-text

The influence of vitamin D deficiency and its correction on urogenital health indicators and the frequency of relapses of chronic cystitis in women of reproductive age [pilot study)

Фармакология & Фармакотерапия ◽

10.46393/2713-2129-2021-2-46-52 ◽

2021 ◽

pp. 46-53

Author(s):

O.I. BRATCHIKOV ◽

D.V. KONOVALOV ◽

A.V. SMIRNOV ◽

I.A. TYUZIKOV

Keyword(s):

Vitamin D ◽

Pilot Study ◽

Vitamin D Deficiency ◽

Health Indicators ◽

Reproductive Age ◽

Chronic Cystitis ◽

Women Of Reproductive Age

Download Full-text

Is Food Insecurity Associated With Iron Deficiency Anemia and Vitamin D Deficiency Among Women of Reproductive Age?

Topics in Clinical Nutrition ◽

10.1097/tin.0000000000000218 ◽

2020 ◽

Vol 35 (3) ◽

pp. 240-247

Author(s):

Ali Kazemi ◽

Seyed Jamal Ghaemmaghami Hezaveh ◽

Leila Nikniaz ◽

Zeinab Nikniaz

Keyword(s):

Vitamin D ◽

Iron Deficiency ◽

Food Insecurity ◽

Vitamin D Deficiency ◽

Iron Deficiency Anemia ◽

Reproductive Age ◽

Deficiency Anemia ◽

Women Of Reproductive Age

Download Full-text

SAT-017 Relationship Between Vitamin D Levels and Signs of Polycystic Ovary Syndrome

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.1063 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Anastasia Smykalova ◽

Svetlana Kalinchenko ◽

Aigul Safi ◽

Mekan Orazov ◽

Alexander Nizhnik

Keyword(s):

Vitamin D ◽

Waist Circumference ◽

Vitamin D Deficiency ◽

Polycystic Ovary ◽

Serum Vitamin ◽

The Body ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

Serum Vitamin D ◽

Vitamin D Levels

Abstract An analysis of the structure of the causes of infertility shows that up to almost 25% of women of reproductive age ovulation disorders are observed. Hormonal disorders leading to the absence of ovulation, began to play a leading role in the etiology of infertility, special vitamin D deficiency, while today it has been established that its D receptors (VDR) are localized in most organs, including reproductive ones. VDR affect the expression of 1000 genes and play a crucial role in the implementation of sex hormones function. The aim of the study was to assess the vitamin D level in women of reproductive age, depending on the presence of signs of PCOS and waist circumference (WC). 71 women from 19 to 44 years old were examined of these, 41 patients were diagnosed with PCOS and impaired ovulatory function, in 30 patients the ovulatory cycle was preserved, and signs of PCOS were not detected. The level of vitamin 25 (OH) D3 in the serum of the subjects was evaluated by tandem chromato-mass spectrometry at the ArchiMed clinic of new medical technologies, Moscow. In the recommendations of the Canadian “The Vitamin D society”, 40-60 ng/ml the optimal level of serum vitamin D, a concentration of 20-40 ng/ml insufficiency, <20 ng/ml as a deficiency. Vitamin D deficiency was detected in 57% of women in both groups, with a pronounced deficiency (<10 ng/ml) in 17%, insufficiency was observed in 43% of cases, a sufficient level was not detected in any of the subjects. The average level of vitamin D in patients with PCOS was 18.2 (2 to 32.3) ng/ml, the value in patients without signs of PCOS was 18.5 (6.8 to 31) ng/ml. Comparison of the vitamin D value with WC showed that in women with PCOS with an WC <80 cm the value of this indicator was 18.8 ng/ml, and for WC ≥ 80 cm it was statistically significantly lower - 13.3 ng/ml (p<0.05). Conclusion. High prevalence of vitamin D deficiency among patients of reproductive age, with no differences in the magnitude of this indicator depending on the presence of signs of PCOS and persistent ovulation. Difference was established between the levels of vitamin D in patients with PCOS depending on the waist circumference - its insufficiency increases with an increase in WC. The results of the study suggest that the deficiency of vitamin D in the body increases with the aggravation of hormonal dysfunction in PCOS, which should be taken into account by specialists during the management of this category of patients and the treatment of infertility.

Download Full-text

Myo-inositol supplementation in women of reproductive age with subclinical hypothyroidism and obesity on the background of vitamin D deficiency

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.17.5.2021.241525 ◽

2021 ◽

Vol 17 (5) ◽

pp. 443-447

Author(s):

N.V. Pasyechko ◽

V.M. Kulchinska ◽

S.V. Kadubets

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Negative Correlation ◽

Autoimmune Thyroiditis ◽

Subclinical Hypothyroidism ◽

Thyroid Diseases ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

The Impact ◽

Basic Treatment

Background. In recent years, thyroid diseases occupy the top places in the structure of the endocrine pathology. There exists a tight functional relationship between the thyroid and reproductive systems, which leads to a high probability of the development of combined disorders in one of these links of homeostasis. The problem of reproductive health disorders is of particular concern around the world and is relevant to the study of the impact of thyroid diseases on both fertility and pregnancy, especially in conditions of comorbidity. The purpose of the study was to investigate the effect of myo-inositol on the reproductive function of women with subclinical hypothyroidism on the background of autoimmune thyroiditis and obesity. Materials and methods. The study included 98 patients aged 18–40 years with subclinical hypothyroidism, overweight, or obesity on the background of autoimmune thyroiditis. They were randomly subdivided into two groups. Patients of the first group (n = 49) before the basic treatment received myo-inositol at a dose of 2000 mg/day and cholecalciferol at a dose of 2000 IU/day. Patients of the second group (n = 49) before the basic treatment received only cholecalciferol at a dose of 2000 IU/day. Results. Vitamin D deficiency was observed in 90.81 % of women with subclinical hypothyroidism, and vitamin D insufficiency in 9.19 %. A negative correlation was found between the level of 25(OH)D and the level of TPO-Ab (r = –0.189; p < 0.05). There was a weak negative correlation between the level of 25(OH)D and the level of the HOMA-IR (r = –0.168; p < 0.05). The administration of myo-inositol together with vitamin D led to a significant increase in the content of 25(OH)D, as well as to a decrease in the titer of TPO-Ab. Conclusions. The positive effect of myo-inositol drugs together with vitamin D on the functional state of the thyroid gland, on the level of TPO-Ab and HOMA-IR in women of reproductive age with subclinical hypothyroidism and obesity has been established.

Download Full-text