Is Food Insecurity Associated With Iron Deficiency Anemia and Vitamin D Deficiency Among Women of Reproductive Age?

Objectives: Iron deficiency anemia (IDA) is most frequent in children under five years old. Many studies have shown a high prevalence of vitamin D deficiency (VDD) in similar age group. An association between IDA and VDD was reported. The objective of our study was to determine whether there is an association of VDD with IDA in Turkish children under 5 years old. Methods: Children, ages between four months-five years were included in a case–control study. Two groups were constituted: children with IDA (group I) and healthy control children without IDA (group II). Serum 25(OH) vitamin D levels lower than 20 ng/mL were considered as deficiency. Results: Mean age of group I (n=211, 24.8±17.5 months, 45% males) and group II (n=149, 26.4±17.7 months, 44% males) were comparable (p>0.05). Median vitamin D level in group I (22.5 ng/ml) was lower than group II (32.3 ng/mL) (p=0.001). The frequency of VDD was 38.5% in group I and 14.5% in group II (p<0.001). Sixteen children had subclinical rickets signs (All <36 months old); 14 of these were in group I (p=0.034). Conclusions: VDD is more frequent in small children with IDA than healthy controls. Most of the children presenting subclinical rickets signs had concurrent IDA. Physicians should note that VDD or even subclinical rickets may associate to IDA in children younger than 36 months old.

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Prevalence of Anemia Among Women of Reproductive Age in Rural Haryana, India

Current Developments in Nutrition ◽

10.1093/cdn/nzab045_081 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 699-699

Author(s):

Lorraine Yeung ◽

Mona Duggal ◽

Reena Das ◽

Jorge Rosenthal ◽

Swati Bhardwaj ◽

...

Keyword(s):

Public Health ◽

Iron Deficiency ◽

Wheat Flour ◽

Iron Deficiency Anemia ◽

Reproductive Age ◽

Deficiency Anemia ◽

Women Of Reproductive Age ◽

Lactating Women ◽

Iron Deficient ◽

Prevalence Of Anemia

Abstract Objectives Anemia is a public health problem in women of reproductive age in many low- and medium-income countries including India. Maternal anemia can cause low birth weight, impaired fetal growth, and preterm birth. We assessed the baseline prevalence of anemia, iron deficiency (ID), iron deficiency anemia (IDA), and inflammation using c-reactive protein (CRP) among non-pregnant, non-lactating women of reproductive age living in the Ambala District, Haryana, India prior to the start of a wheat flour fortification program. Methods We conducted a multistage cluster probability household and biomarker survey and analyzed venous blood samples from non-pregnant, non-lactating women aged 18–49 years residing in rural areas of two subdistricts in the Ambala District. Factors of interest were: anemia, hemoglobin < 12.0 g/dL; ID, serum ferritin < 15μg/L; IDA, presence of both anemia and iron deficiency; inflammation, CRP > 5 mg/L. We used the BRINDA regression adjustment for ferritin to account for inflammation. Prevalence and 95% confidence intervals (CI) for anemia, ID, IDA, and CRP were estimated. Results Among 775 non-pregnant, non-lactating women of reproductive age, 54.3% (95% CI; 50.7, 58.0) had anemia, 86.9% (95% CI; 84.3, 89.2) were iron deficient, and 15.1% (95% CI; 12.5, 18.1) had inflammation. Among those with anemia, 58.2% (95 CI; 54.3, 62.0) had iron deficiency anemia. Conclusions Anemia, iron deficiency, and iron deficiency anemia among non-pregnant, non-lactating women of reproductive age in Haryana are significant public health concerns. The findings from the survey helped quantify the burden of inadequate iron intake and informed the Haryana government's prevention strategy aimed at reducing micronutrient deficiencies through a wheat flour fortification program. Funding Sources Centers for Disease Control and Prevention.

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Prevalence and risk factors for vitamin D deficiency in children with iron deficiency anemia

Korean Journal of Pediatrics ◽

10.3345/kjp.2012.55.6.206 ◽

2012 ◽

Vol 55 (6) ◽

pp. 206 ◽

Cited By ~ 19

Author(s):

Jung Won Yoon ◽

Sung Woo Kim ◽

Eun Gyong Yoo ◽

Moon Kyu Kim

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Iron Deficiency ◽

Vitamin D Deficiency ◽

Iron Deficiency Anemia ◽

Deficiency Anemia

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THE STATE OF THE RED BLOOD CELL MEMBRANE IN IRON DEFICIENCY ANAEMIA IN WOMEN OF REPRODUCTIVE AGE

Periódico Tchê Química ◽

10.52571/ptq.v16.n32.2019.489_periodico32_pgs_471_477.pdf ◽

2019 ◽

Vol 16 (32) ◽

pp. 471-477

Author(s):

Leila I. ARYSTAN ◽

Gulmira M. MULDAEVA ◽

Leila S. HAYDARGALIEVA ◽

Damira K. PAKHOMOVA ◽

Yernar B. ISKAKOV

Keyword(s):

Iron Deficiency ◽

Cell Membrane ◽

Blood Cell ◽

Iron Deficiency Anemia ◽

Red Blood Cell ◽

The State ◽

Reproductive Age ◽

Deficiency Anemia ◽

Women Of Reproductive Age ◽

Red Blood Cell Membrane

The problem of iron deficiency is urgent in many countries, regardless of the socio-economic standards of living. Among biomedical problems, the study of biochemical blood parameters is of paramount importance. A great interest in various aspects of this issue is not accidental, since the transport function of the blood largely depends on it and, consequently, the efficient delivery of oxygen, glucose, amino acids, fats, vitamins, mineral salts, hormones, mediators, antibodies and metabolites to the micro-zones in the tissues. The purpose of this article is to study the hematological status and the state of the red blood cell membrane in women of reproductive age suffering from iron deficiency anemia (IDA). Iron deficiency anemia (IDA) is a combination of clinical and hematological symptoms characterized by impaired hemoglobin formation due to iron deficiency in serum and bone marrow, as well as the development of trophic disorders in the organs and tissues. During the study, a complete blood count was performed using an enzyme-linked immunosorbent assay, using the kits produced by JSC Vector-Best, and the Kamyshnikov method. Based on the results of the study of the erythrocyte sorption capacity (ESC) in women of reproductive age with IDA, it was established that this parameter is 1.2 times higher than that in the control group. The development of anemia is associated with significant changes in the osmotic stability of the erythrocytes, which results in an increase in the proportion of both unstable and high-resistance erythrocytes. The scientific novelty of the article is that the authors established the key parameters for iron deficiency anemia detection.

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Vitamin D deficiency and iron deficiency anemia in women in menopausal transition period. Clinical case

GYNECOLOGY ◽

10.26442/20795696.2020.5.200446 ◽

2020 ◽

Vol 22 (5) ◽

pp. 87-90

Author(s):

Nina A. Tatarova ◽

Margarita S. Airapetian

Keyword(s):

Vitamin D ◽

Iron Deficiency ◽

Vitamin D Deficiency ◽

Iron Deficiency Anemia ◽

Transition Period ◽

Water Soluble ◽

Menopausal Transition ◽

Deficiency Anemia ◽

Drug Of Choice ◽

Increased Risk

Vitamin D is a regulator of immune response, and plays a role in the development of cardiovascular diseases, insulin resistance and diabetes mellitus, obesity, autoimmune disorders, iron binding, anemia, respiratory viral and other diseases. In addition, vitamin D deficiency contributes to the chronicity of infections and an increased risk for number of oncological pathology. The developing immunosuppression in women with iron deficiency anemia in the menopausal transition period does not allow to fully compensate for iron deficiency with monotherapy if vitamin D deficiency is present. The drug of choice in this situation is micellized (water-soluble) vitamin D3(Aquadetrim).

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Prevalence of 25-Hydroxyvitamin D Deficiency in Korean Patients with Anemia

Blood ◽

10.1182/blood.v120.21.5164.5164 ◽

2012 ◽

Vol 120 (21) ◽

pp. 5164-5164

Author(s):

Eun-Hyung Yoo ◽

Hyun-Jung Cho

Keyword(s):

Vitamin D ◽

Iron Deficiency ◽

Vitamin D Deficiency ◽

Iron Deficiency Anemia ◽

Cellular Proliferation ◽

World Health ◽

Deficiency Anemia ◽

Korean Patients ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Abstract Abstract 5164 Background: Vitamin D deficiency is a very common health problem in Korea. Vitamin D has been suggested to have an important role on nonskeletal functions including cellular proliferation and differentiation, muscle function, immunity and erythropoiesis. Recent studies have been reported that vitamin D deficiency had associated with iron deficiency anemia, anemia of chronic kidney disease, and anemia of inflammation. In this study, we investigated the prevalence of vitamin D deficiency in Korean patients with anemia and also analyzed the association between vitamin D status and specific subtypes of anemia. Methods: A total of 147 anemic patients (median age 66 years, range 19∼91 years) and 300 nonanemic controls (median age 60 years, range 29∼87 years) were included. Anemia was defined according to World Health Organization (WHO) criteria. Serum 25- hydroxyvitamin D [25(OH)D] was measured using electrochemiluminescence immunoassay. The deficiency of 25(OH)D was defined as <20 ng/mL and severe deficiency was defined as <10 ng/mL. We compared serum 25(OH)D levels based on the presence and subtypes of anemia. Results: The prevalence of 25(OH)D deficiency was 74% (109/147) and 70% (210/300) in anemic (median Hb 9. 6 g/dL) and nonanemic group (median Hb 14. 3 g/dL), respectively. The prevalence of severe 25(OH)D deficiency was significantly higher in anemic group than in nonanemic group [44. 8% (66/147) vs 11. 7% (35/300), P<0. 0001] Odds ratio for severe 25(OH)D deficiency in anemic patients was 6. 17 (95% CI 3. 820–9. 965, P<0. 0001). The prevalence of 25(OH)D deficiency was not different between iron deficiency anemia (IDA) group and anemia of chronic disease (ACD) group. However, the serum 25(OH)D levels of ACD patients were lower than those of IDA patients in male (median 25(OH)D 14. 34 ng/mL vs 23. 04 ng/mL, P=0. 04). Conclusion: This study demonstrates that severe vitamin D deficiency is associated with anemia in Korea. Although vitamin D deficiency is also very common in nonanemic Korean population, anemia is related to much worse vitamin D deficient status. Multiple factors including poor nutritional status and potential roles of vitamin D on inflammation and erythropoiesis might be considered. Disclosures: No relevant conflicts of interest to declare.

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The Anemia Syndrome in Contemporary Women: an Unsolved Worldwide Problem. A Therapeutic Approach

Doctor Ru ◽

10.31550/1727-2378-2020-19-8-20-24 ◽

2020 ◽

Vol 19 (8) ◽

pp. 20-24

Author(s):

V.E. Radzinsky ◽

◽

A.V. Solovyeva ◽

N.G. Fedotov ◽

◽

...

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Iron Deficiency Anemia ◽

Ferric Hydroxide ◽

Abnormal Uterine Bleeding ◽

First Trimester ◽

Uterine Bleeding ◽

Reproductive Age ◽

Deficiency Anemia ◽

Women Of Reproductive Age

Objective of the Review: To set forth the frequency and prevalence of the anemia syndrome in non-pregnant and pregnant women and approaches to treating this disorder. Key Points: Anemia syndrome is the most common health problem in contemporary women. The leading cause of iron deficiency in women of reproductive age is abnormal uterine bleeding (AUB). Anemia in women significantly reduces their ability to work and quality of life, and increases the rates and severity of complications in pregnant women and parturients. It is also a significant contributor to maternal mortality and fetal and neonatal morbidity. Treating anemia in pregnant women presents certain challenges. In the period between the first trimester and delivery, there is an 8-fold increase in the requirement for iron; therefore, hemoglobin levels return to normal slowly. The active ingredient of Ferrum Lek is a ferric hydroxide polymaltose complex, which is as effective as medications containing ferrous sulfate, but is significantly better tolerated by patients and easier to use. The active transport of iron allows its controlled absorption from the polymaltose complex, minimizing the risk of an increase in serum levels of iron not bound to transferrin. This ensures that this medication is very safe and eliminates the risk of overdose or poisoning. Conclusion: Anemia syndrome is the most common type of homeostatic imbalance in women of reproductive age. It most often results from frequent and abundant uterine bleeding (AUB). Therefore, an obstetrician-gynecologist plays the leading role in identifying menstrual disorders and choosing therapies to reduce blood loss. A gynecologist will also work with an internist (hematologist) in treating iron deficiency anemia. Keywords: anemia syndrome, iron deficiency anemia, abnormal uterine bleeding, ferric hydroxide polymaltose complex.

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