scholarly journals Myo-inositol supplementation in women of reproductive age with subclinical hypothyroidism and obesity on the background of vitamin D deficiency

2021 ◽  
Vol 17 (5) ◽  
pp. 443-447
Author(s):  
N.V. Pasyechko ◽  
V.M. Kulchinska ◽  
S.V. Kadubets
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Autoimmune Thyroiditis ◽  
Subclinical Hypothyroidism ◽  
Thyroid Diseases ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
The Impact ◽  
Basic Treatment

Background. In recent years, thyroid diseases occupy the top places in the structure of the endocrine pathology. There exists a tight functional relationship between the thyroid and reproductive systems, which leads to a high probability of the development of combined disorders in one of these links of homeostasis. The problem of reproductive health disorders is of particular concern around the world and is relevant to the study of the impact of thyroid diseases on both fertility and pregnancy, especially in conditions of comorbidity. The purpose of the study was to investigate the effect of myo-inositol on the reproductive function of women with subclinical hypothyroidism on the background of autoimmune thyroiditis and obesity. Materials and methods. The study included 98 patients aged 18–40 years with subclinical hypothyroidism, overweight, or obesity on the background of autoimmune thyroiditis. They were randomly subdivided into two groups. Patients of the first group (n = 49) before the basic treatment received myo-inositol at a dose of 2000 mg/day and cholecalciferol at a dose of 2000 IU/day. Patients of the second group (n = 49) before the basic treatment received only cholecalciferol at a dose of 2000 IU/day. Results. Vitamin D deficiency was observed in 90.81 % of women with subclinical hypothyroidism, and vitamin D insufficiency in 9.19 %. A negative correlation was found between the level of 25(OH)D and the level of TPO-Ab (r = –0.189; p < 0.05). There was a weak negative correlation between the level of 25(OH)D and the level of the HOMA-IR (r = –0.168; p < 0.05). The administration of myo-inositol together with vitamin D led to a significant increase in the content of 25(OH)D, as well as to a decrease in the titer of TPO-Ab. Conclusions. The positive effect of myo-inositol drugs together with vitamin D on the functional state of the thyroid gland, on the level of TPO-Ab and HOMA-IR in women of reproductive age with subclinical hypothyroidism and obesity has been established.

scholarly journals Vitamin D deficiency in women of reproductive age, options for correction

2018 ◽  
pp. 18-22 ◽  
Author(s):  
A. Z. Khashukoeva ◽  
T. N. Savchenko ◽  
M. I. Agaeva ◽  
Z. A. Agaeva ◽  
G. O. Andreasyan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reproductive Age ◽  
Women Of Reproductive Age

The level of vitamin D and its relationship with the amount of fatty tissue and adipocytokine content in the women of reproductive age

2013 ◽  
Vol 58 (6) ◽  
pp. 19-23 ◽  
Author(s):  
T. L. Karonova ◽  
E. N. Grineva ◽  
E. P. Mikheeva ◽  
O. D. Belyaeva ◽  
E. I. Krasil’nikova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Weight ◽  
Waist Circumference ◽  
Negative Correlation ◽  
Distribution Patterns ◽  
Reproductive Age ◽  
Fatty Tissue ◽  
Women Of Reproductive Age ◽  
25 Hydroxy Vitamin D ◽  
The Relationship

The patients with obesity are known to suffer 25-hydroxy vitamin D (25(OH)D) deficiency, but the relationship between these two conditions remains unclear. The blood 25(ON)D levels in practically healthy women were compared with the amount and distribution patterns of the fatty tissue and with the content of plasma adipocytokines. The absence or deficit of vitamin D was documented in 61.3% of the women included in the present study. They exhibited negative correlation between 25(ON) D levels and body weight. The patients with obesity were characterized by correlation between the 25(ON)D levels and waist circumference, body weight, BMI, and the amount of fatty tissue. The women of reproductive age with the reduced blood 25(ON)D level (OR 1.86 [0.88—3.95]; CI 95%) or 25(ON)D deficiency (OR 2.23 [1.03—4.80]; CI 95%) were at a higher risk of development of obesity compared with the women in whom the 25(ON)D levels were in excess of 75 nmol/l. The study confirmed correlations between adypocytokine levels and the amount of fatty tissue even though it failed to demonstrate a significant relationship between the levels of adipocytokines and vitamin D.

scholarly journals Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

2017 ◽  
Vol 61 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Vinicius Medina Lopes ◽  
Joaquim Roberto Costa Lopes ◽  
Jean Pierre Barguil Brasileiro ◽  
Ingrid de Oliveira ◽  
Ricardo Peclat Lacerda ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reproductive Age ◽  
Women Of Reproductive Age

scholarly journals The Prevalence of Hypovitaminosis D and Its Associated Risk Factors Among Women of Reproductive Age in Saudi Arabia: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 11 ◽  
pp. 1179562X1876788 ◽  
Author(s):  
Riyadh A Alzaheb
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Hypovitaminosis D ◽  
Reproductive Age ◽  
Vitamin D Status ◽  
Women Of Reproductive Age ◽  
Associated Risk Factors

Vitamin D deficiency is currently a worldwide epidemic. Middle Eastern countries, including Saudi Arabia, have high vitamin D deficiency prevalence, most prominently among women, despite their plentiful year-round sunshine. Previous research investigating vitamin D status among Saudi women of reproductive age (15-49 years) is scarce, and no study has used a nationally representative sample, so this review quantified overall hypovitaminosis D prevalence among women in Saudi Arabia and explored the associated risk factors. The Web of Science, Scopus, and Medline databases were searched for prior studies in Saudi Arabia exploring vitamin D status among women of reproductive age, published between January 1, 2000 and May 25, 2017. Data were extracted from the identified studies, and a random effects model meta-analysis established the overall hypovitaminosis D prevalence. The initial search yielded 223 possibly relevant articles; 13 were confirmed as eligible, with samples totaling 2877 women aged between 15 and 49 years. Meta-analysis revealed a mean serum 25-hydroxyvitamin D, 25(OH)D, level of 13.1 ng/mL (95% confidence interval [CI]: 11.6-14.6) and an overall prevalence of hypovitaminosis D, defined as 25(OH)D < 30 ng/mL, of 77.4% (95% CI: 63.2-87.3), mostly due to insufficient sunlight exposure and low dietary vitamin D intake. There is therefore a need for a national strategy to raise vitamin D levels among women in Saudi Arabia by advising them on natural vitamin D sources, and recommending the timing and duration of sun exposure, while also defining a national approach to vitamin D fortification and supplementation.

scholarly journals High Prevalence and Its Influencing Factors of Vitamin D Deficiency Among Women of Reproductive Age in Central China (P10-119-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yuan Zhang ◽  
Xinming Song ◽  
Lifang Jiang ◽  
Jilei Wu ◽  
Gong Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Influencing Factors ◽  
Reproductive Age ◽  
Central China ◽  
Women Of Reproductive Age ◽  
Hydroxyvitamin D ◽  
Funding Sources ◽  
Nutrition Research ◽  
Research And Education

Abstract Objectives To examine the prevalence and its influencing factors of vitamin D deficiency. among women of reproductive age in central China. Methods A total of 1151 women of reproductive age were from an established Women's Reproductive Health Cohort Study, and their exposure factors, blood samples were collected between 2009 and 2010 in four counties of Henan Province, China. Pregnancy outcomes were followed up and a nested case control study was performed reproductive to estimate prevalence and its influencing factors of vitamin D deficiency according to serum 25-hydroxyvitamin D [25(OH)D] < 26.0 ng/mL. Results The prevalence of Vitamin D deficiency among women of reproductive age in central China was 61.5%. Significant determinants of serum 25(OH)D deficiency among women of reproductive age in central China were nutrition supplement (aOR 0.53, 95% CI 0.40–0.71), intake frequency of eggs (aOR 1.61, 95%CI 1.11–2.33) and fruits (aOR 2.50, 95% CI 1.43–4.37), Hemoglobin (aOR 2.25, 95% CI 1.38–3.66), gravidity (aOR 1.79,95% CI:1.27–2.51), family annual income (aOR 1.48, 95% CI 1.11–1.98) and passive smoking (aOR 1.56, 95% CI :1.20–2.03). Conclusions Vitamin D deficiency among women of reproductive age in central China should have high degree of concern, we should pay more attention on the nutritional status improvement and health education of women of reproductive age in central China. Funding Sources National Natural Science Foundation of China; Dietary Nutrition Research and Education Fund of Danone Nutrition Center. Supporting Tables, Images and/or Graphs

scholarly journals Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Xue Zhou ◽  
Ben Li ◽  
Chao Wang ◽  
Zhihong Li
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
Hs Crp ◽  
The Impact

Objective: To investigate the effect of vitamin D deficiency on the levels of thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPO-Ab), interleukin-1 (IL-1) and high-sensitivity C-reactive protein (hs-CRP) in pregnant women with early pregnancy complicated by subclinical hypothyroidism. Methods: A total of 172 pregnant women with subclinical hypothyroidism in the first trimester diagnosed and treated in a given hospital from August 2014 to May 2018 were selected, and their levels of vitamin D were determined. Depending on the abnormality of their vitamin D levels, the study participants were divided into two groups: the study group (vitamin D≤20 ng/L) and the control group (vitamin D>20 ng/L). The levels of TSH, TPO-Ab, IL-1 and hsCRP in the two groups were measured. Results: The levels of TSH, hsCRP and TPO-Ab in the study group were significantly higher than those in the control group (P < 0.05). The comparison between the two groups in terms of IL-1 showed no statistically significant difference. Conclusion: Vitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. The mechanism may be associated with the impact of vitamin D deficiency on hs-CRP and other body inflammation indicators, as well as on thyroid autoantibodies and other immune indicators, but has no effect on IL-1 levels. doi: https://doi.org/10.12669/pjms.36.6.1982 How to cite this:Zhou X, Li B, Wang C, Li Z. Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.1982 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

2019 ◽  
Vol 8 (3) ◽  
pp. 1115
Author(s):  
Amrita Sandhu ◽  
Ruchira Nautiyal ◽  
Vinit Mehrotra ◽  
Sanober Wasim
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Serum Vitamin ◽  
Related Factors ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Impact

Background: Maternal and fetal vitamin D deficiency has nowadays emerged as a frequent morbidity. Adequate vitamin D concentrations during pregnancy are necessary to maintain neonatal calcium homeostasis, bone maturation and mineralization. Objectives of this study were to evaluate serum vitamin D concentration in mothers and its correlation with neonatal cord blood vitamin D at the time of delivery and to study the impact of hypovitaminosis on neonatal anthropometry. Effect of related factors like calcium (Ca), alkaline phosphatase (ALP) and parathyroid hormone (PTH) on maternal vitamin D levels were to be evaluated.Methods: Cross sectional study was done on a total of 220 healthy uncomplicated antenatal females with singleton pregnancy attending labor room at the time of delivery. Maternal and neonatal cord blood samples were drawn in the delivery room and analyzed. Neonatal anthropometry was recorded. Correlations among various maternal and neonatal factors were studied.Results: Widespread vitamin D deficiency was observed in expectant subjects and neonates with 70.91% having deficient levels which were also reflected in newborns (71.82%). Maternal ALP (r= -0.5503, p=0.000) bears a weak negative correlation (p<0.05), maternal serum Ca positive correlation (r = 0.7486, p=0.000) and plasma PTH levels a negative correlation (r = -2.084, p=0.000) with hypovitaminosis. No significant correlation was observed between neonatal anthropometry and vitamin D levels.Conclusions: High prevalence of hypovitaminosis was observed among pregnant women and their neonates in this study. A positive linear relationship was seen between maternal and cord blood vitamin D (r 0.974, p 0.0001).

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