scholarly journals Beverage Consumption and Longitudinal Changes in Lipid Concentrations and Incident Dyslipidemia in U.S. Adults: The Framingham Heart Study (P18-017-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Danielle Haslam ◽  
Gina Peloso ◽  
Mark Herman ◽  
Josee Dupuis ◽  
Alice Lichtenstein ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
P Value ◽  
Linear Regression Models ◽  
Mixed Effect ◽  
Beverage Consumption ◽  
Sweetened Beverages ◽  
Heart Study ◽  
Low Hdl

Abstract Objectives Limited data are available on the prospective relationship between beverage consumption and plasma lipid and lipoprotein concentrations in population-based studies. Two major sources of sugar in the US diet are sugar-sweetened beverages (SSB; sodas and fruit drinks) and 100% fruit juices (FJ). Low-calorie sweetened beverages (LCSB) are common replacements for SSB and FJ. Methods Fasting plasma triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) concentrations were measured at up to 5 exams in the Framingham Heart Study offspring and up to 2 exams in generation 3 cohorts (1998–2005; N = 6730). Consumption of SSB, FJ, and LCSB were estimated from food frequency questionnaires and intakes were categorized. Mixed-effect linear regression models were used to examine changes in lipid concentrations, and Cox proportional hazard models were used to estimate hazard ratios (HR) for incident dyslipidemia, adjusting for potential confounding factors. Results were statistically significant at a Bonferroni-corrected P-value < 0.017 (0.05/3 outcomes). Results In multivariate-adjusted models, SSB intake was associated with smaller mean 4-year changes in HDL-C [high (>1 serving/day) vs. low intake category (<1 serving/month) (H vs. L): β ± SE: −1.0 ± 0.3 mg/dl, p trend < 0.0001] and greater mean 4-year changes in TG concentrations (H vs. L: β ± SE: 5.7 ± 2.1 mg/dl, p trend = 0.0003), along with a higher incidence of low HDL-C [H vs. L HR (95% CI): 1.64 (1.06–2.54), p for trend = 0.01] and high TG concentrations [H vs. L HR (95% CI): 1.46 (1.05–2.03); p trend = 0.009]. LCSB intake was associated with a higher incidence of low HDL-C [H vs. L HR (95% CI): 1.38 (1.02–1.86), p trend = 0.01] and high LDL-C concentrations [H vs. L HR (95% CI): 1.19 (1.00–1.41); p trend = 0.01]. No other significant associations between beverage consumption and lipid concentrations or incident dyslipidemia were observed. Conclusions SSB intake was associated with changes in HDL-C and TG concentrations and higher risk of dyslipidemia, suggesting that SSB consumption should be limited. LCSB intake was not associated with changes in lipid concentrations, but higher intake was associated with risk of dyslipidemia. Thus, limiting LCSB intake is recommended based on these study findings. Funding Sources NIH, AHA, and ARS, USDA.

Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population

2021 ◽  
Vol 53 (02) ◽  
pp. 105-111
Author(s):  
Dongdong Zhang ◽  
Cheng Cheng ◽  
Yan Wang ◽  
Yuan Xue ◽  
Yiming Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rural Population ◽  
Density Lipoprotein ◽  
Cubic Spline ◽  
Lipoprotein Cholesterol ◽  
Linear Regression Models ◽  
Hydroxyvitamin D ◽  
Linear Association ◽  
25 Hydroxyvitamin D

AbstractThere is a paucity of data on the relation between serum 25-hydroxyvitamin D [25(OH)D] concentration and cardiometabolic biomarkers in the Chinese population. To comprehensively and quantitatively examine the association of 25(OH)D and cardiometabolic traits, we conducted a cross-sectional study in the Chinese rural population. Serum 25(OH)D and eight cardiometabolic biomarkers were measured in 1714 individuals from Henan province, China. Scatter plot was used to visualize the distribution and correlation of 25(OH)D and cardiometabolic indicators. Moreover, multivariate linear regressions and restricted cubic spline (RCS) functions were performed to examine the quantitative association between the serum 25(OH)D and cardiometabolic parameters. The median serum 25(OH)D level was 19.94 ng/ml in all participants, with an estimated 50.12% presenting vitamin D deficiency. Serum 25(OH)D level showed significantly modest association with cardiometabolic parameters (p<0.05) except for diastolic blood pressure (r=0.03, p=0.22). Multiple linear regression models showed that 25(OH)D concentration was positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with low-density lipoprotein cholesterol (LDL-C) and fasting serum glucose (GLU). The results of restricted cubic spline models indicated a positively linear association of 25(OH)D with HDL-C (p for overall<0.001, p for nonlinearity=0.191) and a negatively linear association with GLU (p for overall=0.024, p for nonlinearity=0.095). Overall, vitamin D deficiency was very common among Chinese rural population living near the 34 degrees north latitude. Besides, there were significant association between 25(OH)D concentrations and cardiometabolic biomarkers including HDL-C and GLU levels. Future longitudinal studies and randomized trials are warranted to clarify the causal relationship.

“Isolated” Low High-Density Lipoprotein Cholesterol

1997 ◽  
Vol 31 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Vickie M Wilt ◽  
John G Gums
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Lifestyle Modification ◽  
Density Lipoprotein ◽  
Additional Treatment ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Estrogen Replacement ◽  
Review Articles ◽  
Low Hdl

OBJECTIVE: To present information on the function, structure, and importance of high-density lipoprotein cholesterol (HDL-C) and to evaluate the current literature regarding the controversy of managing patients with an “isolated” low HDL-C concentration. DATA SOURCE: A MEDLINE search was performed (1966–June 1996) to identify English-language clinical and review articles pertaining to HDL-C. Some articles were identified through the bibliography of selected articles. STUDY SELECTION: All articles were considered for possible inclusion in the review. Pertinent information, as judged by the authors, was selected for discussion. DATA EXTRACTION: Important historical lipid studies, recent review articles, and clinical trials involving therapy for HDL-C were evaluated. DATA SYNTHESIS: The structure, function, and measurement of HDL-C and the state of an isolated low HDL-C are discussed for background. Lifestyle modification measures to increase HDL-C, medications to avoid, estrogen replacement, and lipid-altering agents used to raise an isolated low HDL-C are presented. CONCLUSIONS: An isolated low HDL-C concentration poses a risk for coronary heart disease. The management of this state is controversial. The first step in management is in agreement with experts and includes lifestyle modification (e.g., weight reduction, diet, smoking cessation, aerobic exercise). Estrogen replacement therapy and discontinuance of drugs that secondarily lower HDL-C are additional treatment options. The use of lipid-altering agents has been used in some patients. Nicotinic acid appears to be an effective agent for an isolated low HDL-C. A large clinical trial evaluating the effect of treating an isolated low HDL-C for primary and secondary prevention of coronary events is needed.

Association between different types of plant-based diet and dyslipidemia in Korean adults

2021 ◽  
pp. 1-17
Author(s):  
Nara Shin ◽  
Jihye Kim
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Multivariable Logistic Regression Analysis ◽  
Nutrition Survey ◽  
Korean Adults ◽  
Different Types ◽  
Low Hdl ◽  
Nationally Representative ◽  
Using Data

Abstract This study investigated the association between the different types of plant-based diets and dyslipidemia in Korean adults using data from the nationally representative sample. Using the 2012-2016 Korea National Health and Nutrition Survey data, a total of 14,167 adults (≥19 years old) participated in this study. Dietary intake was assessed by a semi-quantitative food frequency questionnaire. Three different plant-based diet indices (overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), unhealthful plant-based diet index (uPDI)), were calculated. Dyslipidemia and its components (hypertriglyceridemia, hypercholesterolemia, low high-density lipoprotein cholesterol (HDL-C), high low-density lipoprotein cholesterol (LDL-C), use of anti-hyperlipidemia agent) were measured. Multivariable logistic regression analysis was used to examine the associations between plant-based diet and dyslipidemia and individual lipid disorders. Totally, 47% of overall population had dyslipidemia. Individual in the highest quintile of uPDI had 22% greater odds of dyslipidemia (95% CI: 1·05, 1·41) and 48 % higher odds of hypertriglyceridemia (95% CI: 1·21, 1·81) and 16% higher odds of low HDL-C (OR: 1·16, 95% CI: 1·00, 1·35) than those in the lowest quintile of uPDI. PDI was associated with 16 % higher odds of low HDL-C and hPDI were associated with 25% lower odds of high LDL-C. However, Neither PDI nor hPDI was significantly associated with the prevalence of dyslipidemia. Greater adherence to unhealthful plant-based diets was associated with greater odds of the dyslipidemia and its components suggesting the importance of the quality of plant-based diet in South Korean adults for dyslipidemia prevention.

scholarly journals Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

2008 ◽  
Vol 2 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Stavroulla Xenophontos ◽  
Marilena Hadjivassiliou ◽  
Alexandros Karagrigoriou ◽  
Nafsika Demetriou ◽  
George Miltiadous ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Greek Cypriot ◽  
Low Hdl ◽  
First Time ◽  
Control Study

This study was carried out in Greek Cypriot males to identify risk factors that predispose to myocardial infarction (MI). Genetic and lipid risk factors were investigated for the first time in a Greek Cypriot male case-control study.Contrary to other studies, mean low density lipoprotein cholesterol did not differ between cases and controls. High density lipoprotein cholesterol on the other hand, although within normal range in cases and controls, was significantly higher in the control population. In agreement with many other studies, smoking was significantly more prevalent in cases compared with controls. In pooled cases and controls, smokers had a significantly lower HDL-C level compared with non-smokers. The frequency of the IL-13 R130Q homozygotes for the mutation (QQ), as well as the mutant allele were significantly higher in cases compared with controls. The IL-13 R130Q variant, or another locus, linked to it, may increase the risk of MI.

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