scholarly journals Introducing Typhoid Conjugate Vaccine in South Asia: Lessons From the Surveillance for Enteric Fever in Asia Project

2020 ◽  
Vol 71 (Supplement_3) ◽  
pp. S191-S195
Author(s):  
Alice S Carter ◽  
Stephen P Luby ◽  
Denise O Garrett
Keyword(s):  
Conjugate Vaccine ◽  
Large Scale ◽  
Enteric Fever ◽  
World Health ◽  
Health Concern ◽  
Vaccine Introduction ◽  
The World ◽  
Health Organization ◽  
Drug Resistant Strains ◽  
Sanitation Infrastructure

Abstract Enteric fever remains a public health concern in communities lacking sanitation infrastructure to separate sewage from drinking water. To bridge the gap until large-scale civil-engineering projects are implemented in high-burden countries, typhoid conjugate vaccine presents a promising disease-prevention technology. A new typhoid conjugate vaccine was prequalified by the World Health Organization in 2017 and is beginning to be introduced in countries around the world. To help inform vaccine introduction, the Surveillance for Enteric Fever in Asia Project (SEAP) conducts prospective enteric fever surveillance in Bangladesh, Nepal, and Pakistan. This supplement presents findings from Phase II of the study (2016–2019) on burden of disease, clinical presentation, the growing spread of drug-resistant strains, and policy and economic ramifications. These findings are delivered to support policymakers in their deliberations on strategies to introduce typhoid conjugate vaccine as a preventive tool against enteric fever.

Aftermath of Covid -19 Pandemic in the community

2021 ◽  
pp. 498-500
Author(s):  
Sholly. CK
Keyword(s):  
World Health Organization ◽  
Antiviral Treatment ◽  
World Health ◽  
Health Concern ◽  
Severe Illness ◽  
Respiratory Illnesses ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Respiratory Droplets

Novel corona virus (COVID-19) is an infectious condition, which can be spread directly or indirectly from one person to another and causes respiratory illnesses, range from common cold to acute respiratory syndrome. The first cases of this virus were found in Wuhan, China. According to the World Health Organization, COVID-19 is serious health concern and has higher risk for severe illness and spreading rapidly all over the world.This novel coronavirus was named Coronavirus Disease 2019 (COVID-19) by WHO in February 2020. The World Health Organization (WHO) has declared the coronavirus disease 2019 a pandemic, in the year2020 March. A global coordinated effort is needed to stop the further spread of the virus. Among all cases about 92% of the confirmed cases were recorded from China. Initial reports suggest that death rate ranges from 1% to 2% which varies in the study and country. The most of the death have occurred in patients over 50 years of age followed by young children. For the confirmed cases which included both laboratory and clinically diagnosed till now there is no specific antiviral treatment recommended but there is vaccine currently available. Once the virus develops in people, corona viruses can be spread from person to person through respiratory droplets. The viral material hangs out in these droplets and can be breathed into the respiratory tract, where the virus can then lead to an infection. Repercussions of Covid -19 on individuals, families and on front line warriors are countless1.

scholarly journals Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine

2019 ◽  
Vol 69 (Supplement_2) ◽  
pp. S81-S88 ◽  
Author(s):  
Beckie N Tagbo ◽  
Rowan E Bancroft ◽  
Iretiola Fajolu ◽  
Mohammed B Abdulkadir ◽  
Muhammad F Bashir ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Invasive Disease ◽  
Latex Agglutination ◽  
World Health ◽  
Vaccine Introduction ◽  
Vaccine Type ◽  
Health Organization ◽  
Species Specific

Abstract Background Historically, Nigeria has experienced large bacterial meningitis outbreaks with high mortality in children. Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae are major causes of this invasive disease. In collaboration with the World Health Organization, we conducted longitudinal surveillance in sentinel hospitals within Nigeria to establish the burden of pediatric bacterial meningitis (PBM). Methods From 2010 to 2016, cerebrospinal fluid was collected from children <5 years of age, admitted to 5 sentinel hospitals in 5 Nigerian states. Microbiological and latex agglutination techniques were performed to detect the presence of pneumococcus, meningococcus, and H. influenzae. Species-specific polymerase chain reaction and serotyping/grouping were conducted to determine specific causative agents of PBM. Results A total of 5134 children with suspected meningitis were enrolled at the participating hospitals; of these 153 (2.9%) were confirmed PBM cases. The mortality rate for those infected was 15.0% (23/153). The dominant pathogen was pneumococcus (46.4%: 71/153) followed by meningococcus (34.6%: 53/153) and H. influenzae (19.0%: 29/153). Nearly half the pneumococcal meningitis cases successfully serotyped (46.4%: 13/28) were caused by serotypes that are included in the 10-valent pneumococcal conjugate vaccine. The most prevalent meningococcal and H. influenzae strains were serogroup W and serotype b, respectively. Conclusions Vaccine-type bacterial meningitis continues to be common among children <5 years in Nigeria. Challenges with vaccine introduction and coverage may explain some of these finding. Continued surveillance is needed to determine the distribution of serotypes/groups of meningeal pathogens across Nigeria and help inform and sustain vaccination policies in the country.

scholarly journals Hydromorphone in the Management of Cancer-Related Pain: An Update on Routes of Administration and Dosage Forms

2007 ◽  
Vol 10 (4) ◽  
pp. 504 ◽  
Author(s):  
Maansi G. Kumar ◽  
Senshang Lin
Keyword(s):  
Dosage Forms ◽  
World Health ◽  
Health Concern ◽  
Major Health ◽  
Routes Of Administration ◽  
First Choice ◽  
The World ◽  
Rapid Effect ◽  
Synthetic Derivative ◽  
Health Organization

Pain is experienced by a majority of cancer patients. As life expectancy has increased in developed and developing countries, cancer-related pain has become a major health concern. Despite the use of the three-step analgesic ladder proposed by the World Health Organization, pain still remains under treated. Morphine, the gold standard against which all other opioids has been compared is considered the first choice for management of cancer-related pain. However, recently focus has shifted to the use of hydromorphone, a semi-synthetic derivative of morphine, which is more potent, more soluble and has a comparable side-effect profile. This review focuses on the use of hydromorphone for the management of cancer-related pain emphasizing on the various routes of administration as well as dosage forms, and providing a direction for the preference of a particular route depending on the need for a rapid effect and the individual’s situation. Various approaches used to modify the release of hydromorphone from the drug delivery systems with the perspective of improving patient compliance are also being discussed.

scholarly journals Anti-hepatitis C virus seroprevalence in the working age population in Poland, 2004 to 2014

2017 ◽  
Vol 22 (2) ◽  
Author(s):  
Bożena Walewska-Zielecka ◽  
Urszula Religioni ◽  
Grzegorz Juszczyk ◽  
Zbigniew M Wawrzyniak ◽  
Aleksandra Czerw ◽  
...  
Keyword(s):  
Public Health ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
World Health ◽  
Health Concern ◽  
Health Priorities ◽  
The World ◽  
Working Age ◽  
Working Age Population ◽  
Health Organization

Hepatitis C virus (HCV) infection is considered by the World Health Organization (WHO) to be a serious public health concern and one of the major public health priorities. In 2005, it was estimated that there are 185 million anti-HCV positive people in the world, which constitutes 2.8% of the global population. Our study estimates the anti-HCV seroprevalence in the working age population (15–64 years-old), mostly urban and suburban residents, in Poland from 2004 to 2014. The studied group consisted of 61,805 working-age population representatives whose data were obtained from electronic medical records of an outpatient clinic network operating on a countrywide level. Positive anti-HCV test results were obtained in 957 patients, representing 1.5% of the whole population studied throughout the analysed period. The average age of all anti-HCV positive patients was 36.8 years. Analysis of the data suggests that the proportion of anti-HCV positive patients decreased over the study period (mean positive anti-HCV = -0.0017 × year + 3.3715; R2 = 0.7558). In 2004, positive results were noted among 3.2% of patients undergoing HCV antibody tests, but in 2014, the percentage of patients with a positive result stood at 1.1%. The apparent decrease affected men and women similarly. Our study also provides evidence that screening people born before 1965 could be beneficial.

scholarly journals Toward Control? The Prospects and Challenges of Typhoid Conjugate Vaccine Introduction

2019 ◽  
Vol 69 (Supplement_5) ◽  
pp. S408-S411 ◽  
Author(s):  
Megan E Carey ◽  
Zoey I Diaz ◽  
Martin Broadstock ◽  
Roderick Bailey ◽  
Adwoa D Bentsi-Enchill ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Vaccine Development ◽  
Low Cost ◽  
Control Program ◽  
World Health ◽  
Vaccine Hesitancy ◽  
Vaccine Introduction ◽  
Optimal Deployment ◽  
Health Organization ◽  
Communication Planning

Abstract With a newly World Health Organization (WHO)–prequalified typhoid conjugate vaccine (TCV), Gavi funding for eligible countries, and a WHO policy recommendation for TCV use, now is the time for countries to introduce TCVs as part of an integrated typhoid control program, particularly in light of the increasing burden of antimicrobial resistance. Continued vaccine development efforts will lead to secure supply of low-cost vaccines, and ongoing vaccine studies will provide critical vaccine performance data and inform optimal deployment strategies, in both routine use and in outbreak settings. TCV programs should include thoughtful communication planning and community engagement to counter vaccine hesitancy.

Following the directives of World Health Organization: A Hobsons Choice

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Shaima S. Ali Miraj
Keyword(s):  
World Health Organization ◽  
Large Scale ◽  
Financial Burden ◽  
International Health ◽  
Health Agency ◽  
Developed Countries ◽  
World Health ◽  
Effective Control ◽  
The World ◽  
Health Organization

Introduction: Of late several articles in prestigious scientific platforms have shown that, 'COVID-19 has questioned the global health expertise of some developed countries like the USA UK and other European nations as well as the international health agency, the World Health Organization, highlighting that they faltered in managing the crisis during the pandemic. The objective of this article is to highlight the fact that as there was no specific vaccine or treatment at hand, the portfolio available with these nations under the directions of the WHO to counter the measures against COVID19, was limited. There was no other alternative in this time of world’s most unprecedented emergency, and whatever immediate steps were taken to contain the virus spread by the WHO were justified. Methods: Using the available literature on the internet and library sources, a survey of published articles in leading journals of the world have been made to analyse the various articles describing the position of the WHO and its future strategies in dealing with the worlds most unprecedented pandemic. Results and Conclusion: The present communication suggests that a large scale fund allocation in a fixed percentage for Health for All, from every member country’s defence budget can be separately made for substantially replenishing the already depleting funding of the WHO. This will enable an effective control of the global pandemic crisis with significant international cooperation, allowing sharing of the financial burden. The specially created fund can be used under international monitoring for such unprecedented calamities in future. More focus can thus be given to special training of manpower, advancements in the protective equipment, development of vaccines, critical care hospitals and centres on a global basis.

Converting to a Synchronous Virtual Nursing Research Conference Amidst a Pandemic: A Case Study

2021 ◽  
Vol 27 (2) ◽  
pp. 118-124
Author(s):  
Lilian J. Canamo ◽  
Jessica P. Bejar ◽  
Judy E. Davidson
Keyword(s):  
World Health Organization ◽  
Large Scale ◽  
University Of California ◽  
World Health ◽  
User Engagement ◽  
Research Conference ◽  
The World ◽  
Health Organization ◽  
The University

University of California San Diego Health was set to launch its 13th annual Nursing and Inquiry Innovation Conference event in June 2020. However, the Coronavirus Disease 2019 (COVID-19) pandemic placed a barrier to large gatherings throughout the world. Because the World Health Organization designated 2020 as the Year of the Nurse and Midwife, the University committed to continuing the large-scale conference, converting to a virtual event. This article reviews the methodologies behind the delivery of the virtual event and implications for user engagement and learning on the blended electronic platform.

Postscript

2021 ◽  
pp. 411-422
Keyword(s):  
Medical Devices ◽  
Large Scale ◽  
Regulatory Framework ◽  
World Health ◽  
Joint Work ◽  
Infected Blood ◽  
Safety Review ◽  
The World ◽  
Health Organization ◽  
The Uk

This chapter reveals some of the major changes in the European and UK regulatory framework following the UK leaving the EU (Brexit), public health consequences of the supply of infected blood products, and the Covid-19 pandemic. It covers issues that occurred after Brexit, the independent medicines and medical devices safety review, and the UK blood enquiry. It also mentions the Medicines and Healthcare products Regulatory Agency (MHRA) that became the UK’s standalone regulator of medicines and medical devices since 1 January 2021, acting independently in joint work with other international regulators. The chapter elaborates on the UK’s intention to develop a new regulatory framework for medical devices that reflect the Independent Medicines and Medical Devices Safety Review published in July 2020. It highlights the European Medicines Agency’s (EMA) cooperation with the World Health Organization (WHO) on developing potential Covid-19 treatments by facilitating large-scale clinical trials.

World Health Organization

1949 ◽  
Vol 3 (1) ◽  
pp. 163-164
Keyword(s):  
World Health Organization ◽  
Large Scale ◽  
Venereal Disease ◽  
Western Hemisphere ◽  
World Health ◽  
Director General ◽  
Executive Board ◽  
Regional Office ◽  
The World ◽  
Health Organization

The Executive Board of the World Health Organization met in Geneva for its second session from October 25 to November 11, 1948. Some of the more important matters considered from an agenda which comprised more than seventy items included: 1) allocation of $100,000 for an extensive research program on tuberculosis; 2) approval of the report of a committee of experts on venereal disease recommending the large-scale use of penicillin in the treatment of syphilis and calling for WHO to stimulate penicillin production and distribution; 3) authorization to the WHO Director-General to create a Bureau of Medical Supplies to coordinate information and to advise governments on questions concerning the procurement of essential drugs, biological products, and medical equipment; 4) allocation of nearly $1,500,000 for the purpose of giving more direct aid to governments in all parts of the world in the form of field demonstrations and the provision of fellowships for medical and public health personnel; 5) approval of research along lines suggested by the International Congress of Mental Health, including comparative studies, surveys and demonstrations in that field; 6) appointment of Lt. Col. Chandra Mani (India) as director of the WHO Regional Office for South East Asia which was to be established early in 1949 in New Delhi, and 7) authorization to the WHO Director-General to sign a working agreement with the Pan American Sanitary Organization to serve as the WHO regional organization for the Western Hemisphere as soon as fourteen of the twenty-one American republics had completed ratification of the WHO Constitution. The next session of the Executive Board was scheduled for February 21, 1949, also in Geneva.

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