Hemopyrrole and kryptopyrrole are absent from the urine of schizophrenics and normal persons.

1978 ◽  
Vol 24 (2) ◽  
pp. 230-233 ◽  
Author(s):  
P L Gendler ◽  
H A Duhan ◽  
H Rapoport
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Detection Limit ◽  
Methylene Chloride ◽  
Acute Intermittent Porphyria ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

Abstract We describe a method for detecting hemopyrrole and kryptopyrrole in urine, with a detection limit of 100 mug/liter (1 part in 10(7)). Urine is thoroughly extracted with methylene chloride and the extract is concentrated and examined by gas chromatography and gas chromatography-mass spectrometry. No hemopyrrole or kryptopyrrole could be detected in 52 samples, from 17 controls, 29 schizophrenics, and six persons with acute intermittent porphyria.

Detection of ethanol in urine of abstaining alcoholics

1987 ◽  
Vol 65 (6) ◽  
pp. 1225-1227 ◽  
Author(s):  
B. K. Tang
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Detection Limit ◽  
Ethanol Concentration ◽  
Gas Chromatography Mass Spectrometry ◽  
Simple Method ◽  
Low Concentration ◽  
Control Subjects ◽  
Chromatography Mass Spectrometry ◽  
Alcoholic Drinks

A simple method using gas chromatography – mass spectrometry was developed to determine a low concentration of ethanol in urine. The detection limit was 0.02 mM ethanol. A mean ± SD ethanol concentration in urine of 0.21 ± 0.17 mM was measured in 11 alcoholics after 14 days abstention, a level at least 10 times higher than that of control subjects who had no alcoholic drinks during a period of 7 days prior to the test.

scholarly journals Development and Validation of a Gas Chromatography/Mass Spectrometry Procedure for Confirmation of Para-Toluenesulfonamide in Edible Fish Fillet Tissue

2004 ◽  
Vol 87 (5) ◽  
pp. 1098-1108 ◽  
Author(s):  
Olutosin R Idowu ◽  
Philip J Kijak ◽  
Jeffery R Meinertz ◽  
Larry J Schmidt
Keyword(s):  
Mass Spectrometry ◽  
Aqueous Solution ◽  
Gas Chromatography ◽  
Methylene Chloride ◽  
Fish Tissue ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Chloramine T ◽  
Development And Validation ◽  
Edible Fish

Abstract Chloramine-T is a disinfectant being developed as a treatment for bacterial gill disease in cultured fish. As part of the drug approval process, a method is required for the confirmation of chloramine-T residues in edible fish tissue. The marker residue that will be used to determine the depletion of chloramine-T residues from the edible tissue of treated fish is para-toluenesulfonamide (p-TSA), a metabolite of chloramine-T. The development and validation of a procedure for the confirmation of p-TSA is described. Homogenized fish tissue is dried by mixing with anhydrous sodium sulfate, and the mixture is extracted with methylene chloride. The extract is passed through a silica gel solid-phase extraction column, from which p-TSA is subsequently eluted with acetonitrile. The acetonitrile extract is evaporated, and the oily residue is dissolved in hexane. The hexane solution is shaken with fresh acetonitrile. The acetonitrile solution is evaporated and the residue is redissolved in dilute potassium hydroxide solution. The aqueous solution is extracted with methylene chloride to further remove more of the fat co-extractive. The aqueous solution is reacted with pentafluorobenzyl bromide in presence of tetrabutylammonium hydrogensulfate. The resulting di-(pentafluorobenzyl) derivative of p-TSA is analyzed by gas chromatography/mass spectrometry. This method permits the confirmation of p-TSA in edible fish tissue at 20 ppb.

scholarly journals Determination of Bisphenol A in Sewage Effluent and Sludge by Solid-Phase and Supercritical Fluid Extraction and Gas Chromatography/Mass Spectrometry

2000 ◽  
Vol 83 (2) ◽  
pp. 290-298 ◽  
Author(s):  
Hing-Biu Lee ◽  
Thomas E Peart
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Detection Limit ◽  
Bisphenol A ◽  
Solid Phase ◽  
Gas Chromatography Mass Spectrometry ◽  
Method Detection Limit ◽  
Chromatography Mass Spectrometry ◽  
Standard Deviations

Abstract Methods have been developed for the determination of bisphenol A (BPA) residues in municipal sewage and sludge samples. BPA in wastewater samples was enriched with a C18 solid-phase extraction cartridge, eluted with acetone, and converted to the pentafluoropropionyl derivative. For sludge samples, BPA was acetylated and extracted with supercritical carbon dioxide. In both cases, BPA-d16 was used as a surrogate to monitor extraction efficiency. Final analyses of derivatized sample extracts were performed by gas chromatography/mass spectrometry operating in the electron impact mode. For water samples, mean recoveries and standard deviations were 89 ± 6, 94 ± 4, and 85 ± 7% at fortification levels of 1, 0.1, and 0.025 μg/L, respectively, with a method detection limit of 0.006 μg/L. For solid waste samples, mean recoveries and standard deviations were 93 ± 5 and 92 ± 6% at fortification levels of 2.5 and 0.25 μg/g, respectively, and the method detection limit was 0.05 μg/g. For the Canadian samples under investigation, concentrations of BPA ranged from 49.9 to 0.031 μg/L in sewage influent and effluent, and from 36.7 to 0.104 μg/g in sludge.

scholarly journals GAS CHROMATOGRAPHY AND MASS SPECTROMETRY OF THE ETHANOLIC EXTRACT OF NEST MATERIAL OF MUD DAUBER WASP, SCELIPHRON CAEMENTARIUM

2018 ◽  
Vol 11 (7) ◽  
pp. 234
Author(s):  
Susheela P ◽  
Rosaline Mary ◽  
Radha R
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Methylene Chloride ◽  
Ethanolic Extract ◽  
Chemical Compounds ◽  
Biological Properties ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectrometry Analysis ◽  
Chromatography Mass Spectrometry

Objective: The objective of the present study was to determine the chemical compounds present in the nests of the mud dauber wasp, Sceliphron caementarium.Methods: Gas chromatography-mass spectrometry analysis of the nest samples was carried out by standard procedures. The resultant compounds were compared with the database of the National Institute Standard and Technology (NIST), WILEY8, FAME.Results: The results of the gas chromatography-mass spectrometry analysis of the concentrated ethanol extract revealed the presence of chemical compounds such as methylene chloride, 1, 1’:3’, 1’’-Terphenyl, 5’-Phenyl, Di N Decylsulfone, Eicosanoic acid, 1, 2-Bis (Trimethylsilyl) Benzene, and Androstane-11, 17-Dione, 3-[(Trimethylsilyl) Oxy]-, 17-[O-(Phenylmethyl) O.Conclusion: The compounds identified were found to have biological properties such as anti-inflammatory, antibacterial, and antifungal, and further study of these isolated compounds may prove their medicinal importance in future.

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