Use of the vertical rotor to facilitate estrogen and progesterone receptor analysis.

1978 ◽  
Vol 24 (9) ◽  
pp. 1609-1611 ◽  
Author(s):  
L F Hofman ◽  
C Moline ◽  
G McGrath ◽  
E J Barron
Keyword(s):  
Progesterone Receptor ◽  
Gradient Analysis ◽  
Tumor Tissue ◽  
Clinical Laboratory ◽  
Progesterone Receptors ◽  
Sucrose Density Gradient ◽  
Estrogen And Progesterone Receptors ◽  
Vertical Rotor ◽  
Mammary Tumor Tissue ◽  
Estrogen And Progesterone Receptor

Abstract Sucrose density-gradient analysis is one method of identifying specific estrogen and progesterone receptors in mammary tumor tissue. Use of the vertical rotor makes this practical for routine applications in the clinical laboratory by increasing the number of samples that can be run at one time and shortening the centrifuge time from 18 to less than 2 h. The separations and reproducibility compare favorably with those obtained with a swinging-bucket rotor.

scholarly journals American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer

2010 ◽  
Vol 6 (4) ◽  
pp. 195-197 ◽  
Author(s):  
M. Elizabeth H. Hammond ◽  
Daniel F. Hayes ◽  
Antonio C. Wolff ◽  
Pamela B. Mangu ◽  
Sarah Temin
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Progesterone Receptors ◽  
Evidence Based ◽  
Estrogen And Progesterone Receptors ◽  
Testing Performance ◽  
American Society ◽  
Evidence Based Guideline ◽  
Immunohistochemical Testing ◽  
Estrogen And Progesterone Receptor

ASCO and CAP collaborated to produce an evidence-based guideline on estrogen and progesterone receptor testing in breast cancer to produce optimal testing performance.

scholarly journals Investigating the Factors Associated with the Level of Expression of Estrogen and Progesterone Receptors in Patients Suffering from Colorectal Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Saleheh Salehi far ◽  
Maryam Soltani ◽  
Mahmoud Zardast ◽  
Mohammad Reza Ghasemian Moghaddam
Keyword(s):  
Colorectal Cancer ◽  
Drugs Of Abuse ◽  
Progesterone Receptors ◽  
Advanced Stage ◽  
Estrogen And Progesterone Receptors ◽  
Familial History ◽  
Factors Associated ◽  
The Status ◽  
The Mean ◽  
Estrogen And Progesterone Receptor

Background. The present study was performed to investigate the factors related to the expression level of estrogen and progesterone receptor in patients with colorectal cancer. Material and Methods. This crosssectional study was performed on 54 patients suffering from colorectal cancer referring to Imam Reza Hospital in Birjand during 2018-2019. After the biopsy performed during surgery, the specimen was sent for immunohistochemistry, and the status of receptors was determined. Eventually, the data were analyzed by SPSS 22. Results. Out of the 54 patients studied, 64.8% were male. The mean age of the patients was 62.28 ± 14.03 years. The level of expression of beta-estrogen receptors and progesterone receptors had a significant relationship with age, consuming drugs of abuse, and familial history ( P = 0.001 ). Also, the level of expression of estrogen and progesterone receptors of patients with a more advanced stage of cancer was significantly lower ( P = 0.001 ). Conclusion. The extent of expression of estrogen and progesterone receptors affects the progression and prognosis of disease. Thus, through hormone therapy, a step can be taken to reduce the progression and even to treat colorectal cancer.

scholarly journals Association of genetic polymorphisms of estrogen and progesterone receptors and endometriosis: Meta-analysis

2019 ◽  
Vol 11 (1) ◽  
pp. 25-36
Author(s):  
Priscila Prais Carneiro ◽  
Bruna Vicente de Oliveira ◽  
Antonio Marcio Teodoro Cordeiro Silva
Keyword(s):  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Estrogen Receptor Alpha ◽  
Meta Analysis ◽  
Estrogen Receptor Beta ◽  
Progesterone Receptors ◽  
Estrogen And Progesterone Receptors ◽  
Receptor Alpha ◽  
Pubmed Database ◽  
Receptor Beta

Purpose: To investigate the association between polymorphisms in the genes of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor and the genesis of endometriosis. Methods: Systematic review and meta-analysis of articles published fully in the PubMed database, in Portuguese, English, or Spanish, from 2006 to 2017, using the descriptors: “endometriosis,” “polymorphism,” “ESR1,” “ESR2,” “PROGINS,” “rs9340799,” “rs4986938,” and “rs1042838.” Results: A total of 20 studies were included based on the criterion of search for susceptibility to endometriosis related to polymorphisms of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes. Analysis of all polymorphisms found no association with endometriosis. Conclusion: This meta-analysis showed that estrogen receptor alpha, estrogen receptor beta, and progesterone receptor polymorphisms are not related to susceptibility to endometriosis. However, such results may be able to provide more detailed interpretations of how they influence the pathogenesis of endometriosis.

Estrogen and Progesterone Receptors in Human Colorectal Tumour Cells (Study of 70 Cases)

1988 ◽  
Vol 3 (1) ◽  
pp. 41-48 ◽  
Author(s):  
G. Bracali ◽  
A.M. Caracino ◽  
F. Rossodivita ◽  
C. Bianchi ◽  
M.G. Loli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Estrogen Receptors ◽  
Progesterone Receptors ◽  
Human Colorectal Cancer ◽  
Estrogen And Progesterone Receptors ◽  
Colorectal Tumour ◽  
Estrogen Receptor Positive ◽  
Cytochemical Technique

Estrogen and progesterone receptors were studied in 70 cases of human colorectal cancer by a cytochemical technique. 28.5% of the cases were estrogen-receptor positive and 42.8% progesterone-receptor positive. There was no difference between the sexes for estrogen receptors but the women had more tumours with progesterone receptors than men. The presence of receptors is unrelated to the differentiation of the tumour. More colon tumours were positive than those of the sigma and rectum. The concentration of cells with receptors in positive cancer cases tended to be low or medium-low.

Estrogen and progesterone receptor levels are lower in specimens taken from previously biopsied breast tumor tissue

1987 ◽  
Vol 35 (3) ◽  
pp. 197-200 ◽  
Author(s):  
Yoav Sharoni ◽  
Bianca Feldman ◽  
Ilana Inbar ◽  
Ilan Haruzi ◽  
Joseph Levy
Keyword(s):  
Progesterone Receptor ◽  
Breast Tumor ◽  
Tumor Tissue ◽  
Breast Tumor Tissue ◽  
Estrogen And Progesterone Receptor

scholarly journals Features of the gene polymorphism of estrogen and progesterone receptors in women with uterine leiomyoma

2012 ◽  
Vol 61 (3) ◽  
pp. 109-114
Author(s):  
Natalya Sergeevna Osinovskaya ◽  
Tatyana Eduardovna Ivaschenko ◽  
Lyailya Kharryasovna Dzhemlikhanova ◽  
Vladislav Sergeevich Baranov ◽  
Antonina Nicolaevna Tkachenko ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Comparative Analysis ◽  
Progesterone Receptor ◽  
Gene Polymorphism ◽  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Female Reproductive System ◽  
Estrogen And Progesterone Receptors ◽  
Polymorphic Variants ◽  
Female Genital

Uterine Leiomyoma (Leiomyoma) (LM) — benign and most common (incidence 20–45 %) hormone-dependent tumors of female genital organs. Comparative analysis of frequencies of polymorphic variants of genes of estrogen receptor (ERα) and progesterone receptor (PGR) in patients with LM and the population samples was conducted in this work. Also it was investigated their association with clinical manifestation of hyperplastic processes of the female reproductive system. It was founded that the development of LM are not associated with individual polymorphic variants of genes of estrogen receptor and progesterone receptor. This fact does not include their participation in the development of proliferative and hyperplastic processes of the myometrium

scholarly journals Emerging functional roles of nuclear receptors in breast cancer

2017 ◽  
Vol 58 (3) ◽  
pp. R169-R190 ◽  
Author(s):  
Tram B Doan ◽  
J Dinny Graham ◽  
Christine L Clarke
Keyword(s):  
Breast Cancer ◽  
Nuclear Receptors ◽  
Cancer Biology ◽  
Progesterone Receptors ◽  
Metabolic Reprogramming ◽  
Estrogen And Progesterone Receptors ◽  
Functional Roles ◽  
Cancer Migration ◽  
Genomic Technologies ◽  
Estrogen And Progesterone Receptor

Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determining therapeutic strategies. More recently, there is growing evidence supporting the involvement of multiple nuclear receptors other than the estrogen and progesterone receptors, in the regulation of various processes important to the initiation and progression of breast cancer. We review new insights into the mechanisms of action of NRs made possible by recent advances in genomic technologies and focus on the emerging functional roles of NRs in breast cancer biology, including their involvement in circadian regulation, metabolic reprogramming and breast cancer migration and metastasis.

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