P598. Dietetic intervention and nutritional status in adult patients with Crohn’s disease: preliminary results

This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn’s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18–65 years with CD were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ± 14 years and a BMI of 23.2 ± 3.7 kg/m2. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor. Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings.

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Bone turnover and nutritional status in Crohn's disease: relationship to circulating mononuclear cell function and response to fish oil and antioxidants

Proceedings of The Nutrition Society ◽

10.1079/pns2005419 ◽

2005 ◽

Vol 64 (2) ◽

pp. 183-191 ◽

Cited By ~ 11

Author(s):

T. M. Trebble

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Nutritional Status ◽

Bone Turnover ◽

Fish Oil ◽

Body Mass ◽

Adult Patients ◽

Inflammatory Activity ◽

Epa And Dha ◽

Ifn Γ

Crohn's disease is associated with osteoporosis, malnutrition and altered function of peripheral blood mononuclear cells (PBMC). The responses of circulating immune cells and extra-intestinal manifestations to increased inflammatory activity and to modulation by dietary supplementation are uncertain. The relationships between disease status, bone turnover and body mass and composition, PBMC function and fatty acid availability have been investigated in patients with Crohn's disease. The availability of n-3 and n-6 PUFA is altered in adult patients and interferon (IFN)-γ production by PBMC is lower. Increased inflammatory activity is associated with increased bone resorption in adult patients and decreased body mass in paediatric patients. In healthy male subjects there is a proportionate relationship between supplementary intake of EPA and DHA (0.3–2.0 g as fish oil/d) in combination with antioxidants (vitamins A, C and E and Se) and incorporation into plasma phospholipids and PBMC, and a non-linear relationship with PBMC synthesis of TNF-α, IL-6 and prostaglandin E2 (decrease) and IFN-γ (increase). In adults with Crohn's disease high-dose fish oil (2.7 g EPA+DHA/d) in combination with antioxidants (vitamins A, C and E and Se) increases the EPA and DHA content of PBMC and decreases the production of IFN-γ by PBMC, but is not associated with effects on bone turnover or nutritional status.

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Assessment of Nutritional Status of Patients With Crohn's Disease

Case Medical Research ◽

10.31525/ct1-nct03871634 ◽

2019 ◽

Author(s):

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Nutritional Status

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The Effect of Oral Polymeric Diet Enriched With TGF-beta 2 (Modulen) on Clinical Response and Mucosal Healing in Adult Patients With Newly Diagnosed Crohn's Disease

Case Medical Research ◽

10.31525/ct1-nct04233463 ◽

2020 ◽

Author(s):

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Clinical Response ◽

Mucosal Healing ◽

Adult Patients ◽

Newly Diagnosed ◽

Tgf Beta ◽

Beta 2

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Positive impact of blocking tumor necrosis factor α on the nutritional status in pediatric Crohn’s disease patients

International Journal of Colorectal Disease ◽

10.1007/s00384-008-0578-x ◽

2008 ◽

Vol 24 (1) ◽

pp. 19-25 ◽

Cited By ~ 23

Author(s):

A. Diamanti ◽

M. S. Basso ◽

M. Gambarara ◽

B. Papadatou ◽

F. Bracci ◽

...

Keyword(s):

Crohn’S Disease ◽

Tumor Necrosis Factor ◽

Crohn's Disease ◽

Nutritional Status ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Positive Impact ◽

Factor Α ◽

Necrosis Factor

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30 OC Ciprofloxacin versus mesalazine in the prevention of postoperative recurrence of Crohn's disease: Preliminary results

Digestive and Liver Disease ◽

10.1016/s1590-8658(02)90320-8 ◽

2002 ◽

Vol 34 ◽

pp. A84

Author(s):

A. Resegotti ◽

B. Demarchi ◽

G.I. Avagnina ◽

N. Sapone ◽

A. Giustetto ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Postoperative Recurrence ◽

Preliminary Results

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P.2 Influence of localisation of crohn's disease on nutritional status and intestinal absorption

Clinical Nutrition ◽

10.1016/s0261-5614(83)80110-1 ◽

1983 ◽

Vol 2 ◽

pp. 57

Author(s):

H. Lochs ◽

R. Pötzi ◽

P. Ferenci ◽

M. Egger-Schöld ◽

H. Pamperl

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Nutritional Status ◽

Intestinal Absorption

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Systematic Analysis of the Impact of Diagnostic Delay on Bowel Damage in Paediatric Versus Adult Onset Crohn’s Disease

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz065 ◽

2019 ◽

Vol 13 (10) ◽

pp. 1334-1342 ◽

Cited By ~ 10

Author(s):

Alain Schoepfer ◽

Jessica Santos ◽

Nicolas Fournier ◽

Susanne Schibli ◽

Johannes Spalinger ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Diagnostic Delay ◽

Perianal Fistula ◽

Adult Patients ◽

Adult Onset ◽

Systematic Analysis ◽

Internal Fistula ◽

The Impact

Abstract Background and Aims Length of diagnostic delay is associated with bowel strictures and intestinal surgery in adult patients with Crohn’s disease [CD]. Here we assessed whether diagnostic delay similarly impacts on the natural history of paediatric CD patients. Methods Data from the Swiss IBD Cohort Study were analysed. Frequency of CD-related complications [bowel stenosis, perianal fistula, internal fistula, any fistula, resection surgery, fistula/abscess surgery, any complication] at diagnosis and in the long term [up to 30 years after CD diagnosis] was compared between paediatric patients [diagnosed <18 years] and adult patients [diagnosed ≥18 years] using multivariate Cox proportional hazard regression modelling. Results From 2006 to 2016, 387 paediatric and 1163 adult CD patients were included. Median [interquartile range: IQR] diagnostic delay was 3 [1–9] for the paediatric and 6 [1–24] months for the adult group, respectively. Adult onset CD patients presented at diagnosis more frequently with bowel stenosis [p <0.001] and bowel surgery [p <0.001] compared with paediatric CD patients. In the long term, length of diagnostic delay was significantly associated with bowel stenosis [p = 0.001], internal fistula [p = 0.038], and any complication [p = 0.024] in the adult onset CD population. No significant association between length of diagnostic delay and CD-related outcomes in the long term was observed in the paediatric population. Conclusions Adult CD patients have longer diagnostic delay compared with paediatric CD patients and present at diagnosis more often with bowel stenosis and surgery. Length of diagnostic delay was found to be predictive for CD-related complications only in the adult but not in the paediatric CD population.

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