scholarly journals Do oral amino acid supplements facilitate the healing of rat lung injuries?

2020 ◽  
Vol 58 (5) ◽  
pp. 983-990
Author(s):  
Hasan Ersöz ◽  
İsmail Ağababaoğlu ◽  
İbrahim Taylan ◽  
Ebru Çakır ◽  
Saliha Aksun ◽  
...  
Keyword(s):  
Amino Acid ◽  
Sham Group ◽  
Amino Acid Mixture ◽  
The Other ◽  
Acid Mixture ◽  
Threshold Pressure ◽  
Rat Lung ◽  
Air Leak ◽  
Lung Injuries ◽  
Methyl Butyrate

Abstract OBJECTIVES Prolonged air leaks following lung injury cause extended hospital stays. This study investigated the effect of nutritional supplements containing arginine, glutamine and β-hydroxy β-methyl butyrate, which were theoretically proven to accelerate wound healing, on air leak and wound healing parameters in a rat lung injury model. METHODS Twenty-eight female rats were randomly divided into 4 groups. Experimental groups were given glutamine (Resource Glutamine®) or a mixture of arginine, glutamine and β-hydroxy β-methyl butyrate (Abound®) as a dietary supplement at isonitrogenous and isocaloric doses. On day 3, standard sized lung injuries were created in all rats except the sham group. The rats were sacrificed on day 6, and the lungs were removed for air-leak threshold pressure measurement and histopathological and biochemical analyses. RESULTS Loss of body mass was greater in the glutamine group than in the other groups (P = 0.004). Rats that received the amino acid mixture had better results for mature collagen fibre density (P = 0.002) and inflammation suppression (P = 0.003). The sham group had higher values for air-leak threshold pressure and all other histochemical parameters compared to the other groups. Hydroxyproline level did not differ significantly in any of the groups. CONCLUSIONS Our results indicated that an oral amino acid mixture was effective in the healing of lung injuries. Isolated glutamine supplementation had an adverse impact on body mass. Randomized clinical studies including larger series are needed. Hydroxyproline does not seem to be a suitable marker for this purpose.

Digestibility and nutrient value of palmitoyl-L-lysine derivatives in weanling rats

1977 ◽  
Vol 55 (3) ◽  
pp. 434-438 ◽  
Author(s):  
Christian A. Stephens ◽  
Margaret J. Veen-Baigent ◽  
Alenka Paquet ◽  
G. Harvey Anderson
Keyword(s):  
Weight Gain ◽  
Amino Acid ◽  
Food Intake ◽  
Basal Diet ◽  
Amino Acid Mixture ◽  
The Other ◽  
Acid Mixture ◽  
Lysine Content ◽  
Nutrient Value ◽  
Weanling Rats

α-N,ε-N-Dipalmitoyl-L-lysine, α-N-monopalmitoyl-L-lysine, and ε-N-monopalmitoyl-L-lysine were compared with 18% casein and lysine HCl as sources of lysine in the diets of weanling rats. The lysine derivatives and lysine HCl were added to a basal diet containing 14.1% of an amino acid mixture with no lysine. Weight gain, food intake, plasma lysine, and urine and fecal lysine were determined. Animals fed the basal and lysine derivative diets lost weight over the 10-day study period. They had lower food intake, urine and plasma lysine content, and a higher fecal lysine content than animals fed the other diets. α-N-Monopalmitoyl-L-lysine was absorbed whereas the ε-N-monopalmitoyl-L-lysine and the α-N,ε-N-dipalmitoyl compounds were not.

50. Studies in the Metabolism of the Lactic Acid Bacteria. I. Nitrogen Metabolism. J. G. Davis and A. T. R. Mattick

1932 ◽  
Vol 4 (1) ◽  
pp. 81-90 ◽  
Author(s):  
John Gilbert Davis ◽  
Alexander Torovil Robert Mattick
Keyword(s):  
Lactic Acid ◽  
Growth Factors ◽  
Amino Acid ◽  
Lactic Acid Bacteria ◽  
Amino Nitrogen ◽  
Sole Source ◽  
Amino Acid Mixture ◽  
The Other ◽  
Bacterial Metabolism ◽  
Acid Mixture

1. The true lactic acid bacteria cannot grow in a medium in which the sole source of nitrogen is an amino acid mixture or an ammonium salt.2. The presence of growth factors (yeast extract, marmite and peptones) does not permit the utilisation of this “simple” nitrogen.3. The streptococci grow fastest with those peptones containing the greatest amount of the higher fractions, Bactoproteose being superior to the other peptones tested; the lactobacilli, however, show a considerably greater fermentation rate with those peptones containing most amino nitrogen, Fairchild's being the best. Similarly, the streptococci thrive best upon a peptic casein digest which is about 15 days old, further digestion impoverishing the growth; the lactobacilli, however, grow better the longer the digestion. The significance of these observations is discussed from the aspects of bacterial metabolism, the sequence of flora in ripening cheese, and the preparation of casein digest media.

An open-label, single-center pilot study to test the effects of an amino acid mixture in older patients admitted to internal medicine wards

Nutrition ◽  
2020 ◽  
Vol 69 ◽  
pp. 110588 ◽  
Author(s):  
Francesco Bellanti ◽  
Aurelio Lo Buglio ◽  
Elena Di Stasio ◽  
Giorgia di Bello ◽  
Rosanna Tamborra ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Amino Acid ◽  
Pilot Study ◽  
Older Patients ◽  
Amino Acid Mixture ◽  
Acid Mixture ◽  
Single Center ◽  
Open Label ◽  
Internal Medicine Wards

Choosing A Balanced Amino Acid Mixture

1970 ◽  
Vol 100 (3) ◽  
pp. 380-380 ◽  
Author(s):  
Hans Fisher
Keyword(s):  
Amino Acid ◽  
Amino Acid Mixture ◽  
Acid Mixture

scholarly journals Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response

2015 ◽  
Vol 114 (11) ◽  
pp. 1845-1851 ◽  
Author(s):  
Yean Yean Soong ◽  
Joseph Lim ◽  
Lijuan Sun ◽  
Christiani Jeyakumar Henry
Keyword(s):  
Amino Acids ◽  
Blood Glucose ◽  
Amino Acid ◽  
Glycaemic Index ◽  
Amino Acid Mixture ◽  
Postprandial Blood Glucose ◽  
Acid Mixture ◽  
White Rice ◽  
Amino Acid Mixtures

AbstractConsumption of high glycaemic index (GI) and glycaemic response (GR) food such as white rice has been implicated in the development of type 2 diabetes. Previous studies have reported the ability of individual amino acids to reduce GR of carbohydrate-rich foods. Because of the bitter flavour of amino acids, they have rarely been used to reduce GR. We now report the use of a palatable, preformed amino acid mixture in the form of essence of chicken. In all, sixteen healthy male Chinese were served 68 or 136 ml amino acid mixture together with rice, or 15 or 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of the meal until 60 min after the consumption of the white rice. Subsequent blood samples were taken at 30-min intervals until 210 min. The co-ingestion of 68 ml of amino acid mixture with white rice produced the best results in reducing the peak blood glucose and GR of white rice without increasing the insulinaemic response. It is postulated that amino acid mixtures prime β-cell insulin secretion and peripheral tissue uptake of glucose. The use of ready-to-drink amino acid mixtures may be a useful strategy for lowering the high-GI rice diets consumed in Asia.

Olfactory Conditioning by Association with Histidine-Free or Balanced Amino Acid Loads in Rats†

1973 ◽  
Vol 25 (3) ◽  
pp. 354-359 ◽  
Author(s):  
P. C. Simson ◽  
D. A. Booth
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Amino Acid Mixture ◽  
Conditioned Aversion ◽  
Acid Mixture ◽  
Olfactory Conditioning ◽  
Conditioned Preference ◽  
Gastric Intubation ◽  
Protein Free Diet

An histidine-devoid but otherwise balanced amino acid mixture depressed food intake from 2 hr after its gastric intubation. It induced conditioned aversion to an odour incorporated in a protein-free diet presented for 6 h following intubation. In other rats, a balanced amino acid mixture established conditioned preference for odour presented in the same diet for 6 h following intubation. The degree of preference was considerably less than the degree of aversion.

Liver extract and its free amino acids equally stimulate gastric acid secretion

1980 ◽  
Vol 239 (6) ◽  
pp. G493-G496 ◽  
Author(s):  
E. J. Feldman ◽  
M. I. Grossman
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Free Amino Acid ◽  
Free Amino Acids ◽  
Free Amino ◽  
Liver Extract ◽  
Amino Acid Mixture ◽  
Acid Mixture

Using intragastric titration in dogs with gastric fistulas, dose-response studies were carried out with liver extract and with a mixture of amino acids that matched the free amino acids found in liver extract. All solutions were adjusted to pH 7.0 and osmolality to 290 mosmol x kg-1. Doses are expressed as the sum of the concentrations of all free amino acids. At each dose studied (free amino acid concentration: 2.8, 5.6, 11, 23, and 45 mM), acid secretion in response to the free amino acid mixture was not significantly different from that of liver extract. The peak response to both liver extract and the free amino acid mixture occurred with the 23-mM dose and represented about 60% of the maximal response to histamine. The serum concentrations of gastrin after liver extract and the amino acid mixture were not significantly different. It is concluded that in dogs with gastric fistula, gastric acid secretion and release of gastrin were not significantly different in response to liver extract and to a mixture of amino acids that simulated the free amino acid content of liver extract.

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