scholarly journals Periconceptional folic acid intake in Northwest Russia: a birth registry study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
V A Postoev ◽  
L I Menshikova ◽  
A A Usynina ◽  
A M Grjibovski ◽  
J O Odland
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Birth Defect ◽  
Demographic Factors ◽  
Folic Acid Supplementation ◽  
Demographic Characteristics ◽  
Prenatal Counseling ◽  
Folic Acid Intake ◽  
Birth Registry ◽  
Socio Demographic Factors

Abstract Introduction Periconceptional use of folic acid supplementation is an evidence-based measure of birth defects prevention. The study was aimed to assess effect of periconceptual use of folic acid on birth defect prevalence in Arkhangelsk county and to investigate socio-demographic factors, which are associated with adherence to this preventive measure. Methods A registry-based study was conducted with data from the Arkhangelsk County Birth Registry for 2012-2015. The study population included 57084 pregnancies to calculate the proportion of women taking folic acid and 53340 pregnancy outcomes without missing data to analyze related socio-demographic characteristics. Results The proportion of women followed a folic acid supplementation before pregnancy was 1.3% (95% CI: 1.2-1.4), during pregnancy - 55.8% (95%CI: 54.6-56.4). Such women had less risk to deliver a newborn with any birth defects (OR = 0,84, 95%CI: 0,75 - 0,95). Considering birth defects prevalence of 38,6 per 1000 newborns in Arkhangelsk county, number needed to prevent one case of birth defect was 142,9. Based on multivariate analysis, nulliparous married women with higher education, aged 30 or more, had a higher chance to use folic acid before and during pregnancy. The history of spontaneous abortion in the mother's medical history and the first pregnancy were negatively associated with the probability of folic acid intake both before and during pregnancy. Conclusions The compliance to periconceptional intake of folic acid among women in the region was low. A level of compliance was associated with such socio-demographic factors as age, education, marital status, gravidity and parity. The findings have direct applications in improving prenatal care in Arkhangelsk county and establishing targets for prenatal counseling. Key messages A level of compliance to primary prevention of birth defects is associated with such socio-demographic factors as age, education, marital status, gravidity and parity. Prenatal counseling in terms of birth defects prevention should be based on socio-demographic characteristics of pregnant women.

scholarly journals Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study

2019 ◽  
Vol 149 (2) ◽  
pp. 295-303 ◽  
Author(s):  
Thanh T Hoang ◽  
Yunping Lei ◽  
Laura E Mitchell ◽  
Shreela V Sharma ◽  
Michael D Swartz ◽  
...  
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Diet Quality ◽  
Hispanic Women ◽  
Folic Acid Supplementation ◽  
Lactase Deficiency ◽  
Prevention Study ◽  
Folic Acid Intake ◽  
Dietary Folate ◽  
Race Ethnicity

ABSTRACTBackgroundThe risk of neural tube defect (NTD)–affected pregnancies is reduced with adequate folic acid intake during early pregnancy. However, NTDs have been observed among offspring of women with adequate folic acid intake. Some of these women are possibly not absorbing enough folic acid. Because lactase deficiency can lead to poor nutrient absorption, we hypothesized that lactase-deficient women will be at increased risk of having offspring with NTDs.ObjectiveWe examined the association between maternal rs4988235 (a lactase deficiency genetic marker) and NTDs in offspring.MethodsWe conducted a case-control study using data from the National Birth Defects Prevention Study, United States, 1997–2009, restricting to non-Hispanic white (NHW) and Hispanic women. Cases were women with an offspring with an NTD (n = 378 NHW, 207 Hispanic), and controls were women with an offspring without a birth defect (n = 461 NHW, 165 Hispanic). Analyses were conducted separately by race/ethnicity, using logistic regression. Women with the CC genotype were categorized as being lactase deficient. To assess potential effect modification, analyses were stratified by lactose intake, folic acid supplementation, dietary folate, and diet quality.ResultsAmong NHW women, the odds of being lactase deficient were greater among cases compared with controls (OR: 1.37; 95% CI: 1.02, 1.82). Among Hispanic women, the odds of being lactase deficient were significantly lower among cases compared with controls (OR: 0.50, 95% CI: 0.33, 0.77). The association differed when stratified by lactose intake in NHW women (higher odds among women who consumed ≥12 g lactose/1000 kcal) and by dietary folate in Hispanic women (opposite direction of associations). The association did not differ when stratified by folic acid supplementation or diet quality.ConclusionsOur findings suggest that maternal lactase deficiency is associated with NTDs in offspring. However, we observed opposite directions of effect by race/ethnicity that could not be definitively explained.

scholarly journals Effects of Folic Acid Consumption on Newborn Defects and Miscarriage, and Content Uniformity Analysis of Three Different Brands of Folic Acid Tablets Dosage Forms

2019 ◽  
Vol 34 (4) ◽  
pp. 256-264
Author(s):  
Adel B Mohamed ◽  
Azza M Ali ◽  
Samia A Magid
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Folic Acid Supplementation ◽  
Dosage Forms ◽  
The Other ◽  
P Value ◽  
Folic Acid Deficiency ◽  
Content Uniformity ◽  
Acid Consumption ◽  
Taking Action

There is a recent rise in the number of birth defects. This could be related to folic acid deficiency. Folic acid, as an antioxidant, is an important factor in preventing birth defects during embryonic development. This study, via content uniformity measurements and medical history, aimed to investigate the role of folic acid before and during pregnancy and to measure the content uniformity of different brands of folic acid tablets. The statistical study aimed to determine the relationship between folic acid consumption, miscarriage, and anomalies in newborn babies. The study studied a sample of 300 women based on their medical records. There was no significant effect (p-value = 0.143) of folic acid consumption on the frequency of anomalies. On the other hand, there was a high significant relation (p-value = 0.003) between folic acid consumption and miscarriage. The correlation, principally with miscarriage, coincides with previous studies and highlights the importance of folic acid supplementation before and during gestation. Content uniformity measurements were made on three famous folic acid brands (Folic Acid-Nile, Folicum-Julphar and Wockhardt-UK) available at local pharmacies. Measurements on the three folic acid brands were conducted in compliance with the British Pharmacopoeia (BP) (2010) test for content uniformity. Ten tablets from each brand were tested using the UV spectrophotometric method. The results showed that only the first brand name passed the content uniformity test, while the other two brands did not comply with the standards. This result highlights the problem of under-dosing in commercially available folic acid dosage forms, and identifies the need for taking action towards the implementation of quality control on all medical drugs.  

scholarly journals Demographic Characteristics of Mothers Who Delivered Children with Birth Defetcs

2018 ◽  
pp. 222-227
Author(s):  
Yudianto B Saroyo ◽  
Christian Wijaya ◽  
Putri M T Marsubin
Keyword(s):  
Retrospective Study ◽  
Birth Weight ◽  
Antenatal Care ◽  
Birth Defects ◽  
Medical Records ◽  
Birth Defect ◽  
Demographic Characteristics ◽  
Comorbid Disease ◽  
Increased Risk

Abstract Objective: to determine the characteristics and background of mothers who delivered neonates with birth defects. Methods: A retrospective study was used by evaluating the medical records of patients with birth defects in Dr. Cipto Mangunkusumo Hospital during the period between September 2014 and June 2016. Results: A total of 67 (1.85%) out of 3,619 infants who were born in Dr. Cipto Mangunkusumo Hospital during the period between September 2014 and June 2016 had birth defects. Forty-seven (70.1%) mothers of the subjects irregularly attend antenatal care. The most frequent maternal comorbid disease in this study was asthma, which was found in 4 (5.97%) mothers of the subjects. 48 (58.7%) subjects had birth weight under 2500 g. Conclusion: In this retrospective study, the main highlight is that 70.1% of the mothers who delivered neonates with birth defects did not attend antenatal care regularly. 58.7% of the neonates with birth defects had low birth weight. This study could be used as base for further research investigating about the role of antenatal care in early detection and/or the planning of delivery for babies with birth defects. Trends in babies with birth defects suggested that fetuses diagnosed with IUGR/SGA should be given special attention, as they were at increased risk for birth defects. Keywords: birth defect, maternal description   Abstrak Tujuan: untuk mengetahui deskripsi/ciri-ciri  dan latar belakang ibu yang melahirkan janin dengan kelainan bawaan. Metode: Studi retrospektif digunakan dengan menggunakan data sekunder rekam medis pasien dengan kelainan bawaan di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo pada periode September 2014-Juni 2016. Hasil: Sejumlah 67 (1.85%) dari 3,619 neonatus didapatkan dengan kelainan bawaan di RSUPN Cipto Mangunkusumo pada periode September 2014-Juni 2016 . Sejumlah 47 (70.1%) ibu dari subjek tidak teratur dalam melakukan kunjungan antenatal care. Penyakit komorbid ibu yang paling banyak ditemukan dalam studi ini adalah asma, yang ditemukan dalam 4 (5.97%) subjek. 48 (58.7%) subyek memiliki berat lahir di bawah 2500 g. Kesimpulan: Pada studi retrospektif ini didapatkan 70.1% ibu yang melahirkan bayi dengan kelainan bawaan tidak melakukan kunjungan antenatal care. Didapatkan bahwa 58,7% bayi yang lahir dengan kelainan bawaan memiliki berat badan lahir rendah (BBLR). Studi ini dapat dijadikan sebagai landasan dilakukannya studi yang lebih besar untuk mengevaluasi peran antenatal care terhadap deteksi dini dan/atau perencanaan persalinan bayi dengan kelainan bawaan. Tren pada bayi dengan kelainan bawaan menunjukkan bahwa janin yang pada antenatal care didapatkan IUGR/SGA patut diperhatikan lebih untuk kecurigaan kemungkinan adanya kelainan bawaan. Kata kunci:   deskripsi ibu,   kelainan bawaan,

scholarly journals The Influence of Socio-Demographic Factors in Adopting Good Aquaculture Practices: Case of Aquaculture Farmers in Malaysia

2015 ◽  
Vol 8 (9) ◽  
pp. 97 ◽  
Author(s):  
Rozana Samah ◽  
Roslina Kamaruddin
Keyword(s):  
Demographic Factors ◽  
Multiple Linear Regression Model ◽  
Peninsular Malaysia ◽  
Demographic Characteristics ◽  
Primary Data ◽  
Technical Knowledge ◽  
Freshwater Pond ◽  
The Mean ◽  
Socio Demographic Factors ◽  
Brackishwater Pond

<p>This study examined the influence of socio-demographic characteristics on the level of Good Aquaculture Practices (GAqP) among aquaculture farmer in the Northern part of Peninsular Malaysia. Primary data was obtained from survey that was conducted on 121 brackishwater and freshwater pond aquaculture farmer in the states of Kedah and Penang. Descriptive analysis was applied to identify the socio-demographic characteristics of aquaculture farmer and their level of GAqP. Multiple Linear Regression model was used to analyze the relationship between socio-demographic factors and the level of GAqP. The findings has revealed that the level of GAqP among brackishwater pond farmer is satisfactory where almost 84 per cent of farmer practicing GAqP at the level of 60 per cent and above with the mean value of 71.9 per cent. While the mean level of GAqP for freshwater pond farmer was at 50.3 per cent with only 18.6 percent of them practicing GAqP at the level of 60 per cent and above. Age and having technical knowledge related to aquaculture were the main factors that significantly influence to the level of GAqP among aquaculture farmer. Therefore measures related to the enhancement of technical knowledge among aquaculture farmer should be deliberated in the formulation of aquaculture development programs to ensure the sustainable development of aquaculture in Malaysia.</p>

Maternal Folic Acid Intake and Risk of Nonsyndromic Orofacial Clefts: A Hospital-Based Case–Control Study in Bangalore, India

2019 ◽  
Vol 57 (6) ◽  
pp. 678-686
Author(s):  
Vivienne J. Mendonca
Keyword(s):  
Folic Acid ◽  
Case Control Study ◽  
Folic Acid Supplementation ◽  
Folic Acid Intake ◽  
Orofacial Clefts ◽  
Dietary Folate ◽  
Acid Supplementation ◽  
Folic Acid Supplements ◽  
Periconceptional Period ◽  
Control Study

Background: Orofacial clefts are the most common congenital anomaly worldwide. Cleft etiology appears to be multifactorial, with genetic and environmental components. Although periconceptional folic acid supplementation has been shown to be protective for neural tube defects, current evidence for its role in cleft prevention is mixed with few studies from low- and middle-income countries. Aim: To investigate the association between periconceptional folic acid intake and incidence of nonsyndromic orofacial clefts among infants in Bangalore, India. Methods: A hospital-based case–control study (106 cases, 212 controls) utilizing a questionnaire to collect data on prenatal supplements, dietary folate, and potentially confounding factors. Multivariate logistic regression analysis was used to assess relationships between folic acid supplementation and all nonsyndromic clefts, and in separate analyses for cleft lip and/or palate (CL/P) and cleft palate (CP), adjusting for statistically significant variables. Results: A statistically significant protective association was found for separate folic acid supplements (not combined with iron or multivitamins) taken in the periconceptional period and all clefts combined (adjusted odds ratio [OR]: 0.62, 95% confidence interval [CI], 0.45-0.86) and CL/P (adjusted OR: 0.57; 95% CI, 0.38-0.86). Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99). Conclusion: This study provides limited evidence for a protective association of periconceptional folic acid supplementation with nonsyndromic orofacial clefts. The low proportion of mothers taking folic acid supplements in the periconceptional period highlights the need for increased education and awareness regarding prenatal nutrition.

scholarly journals Determinants and Seasonality of Major Structural Birth Defects Among Newborns Delivered at Primary and Referral Hospital of East and West Gojjam Zones, North West Ethiopia 2017- 2018: Case- Control Study

2019 ◽  
Author(s):  
Binalfew Tsehay ◽  
Desalegn Shitie ◽  
Akilog Lake ◽  
Erimiyas Abebaw ◽  
Amisalu Taye ◽  
...  
Keyword(s):  
Birth Defects ◽  
Birth Defect ◽  
Folic Acid Supplementation ◽  
Health Issues ◽  
North West ◽  
Maternal Illness ◽  
West Gojjam ◽  
North West Ethiopia ◽  
History Of ◽  
Maternal Medication

Abstract Objective: Although infant mortality because of birth defect has increased in both developed and developing countries, had not got attention like other health issues at national, regional, or local levels. Documenting the risk factors that influence the occurrence of birth defects and its seasonality will help to inform the community and to develop preventive strategies for the country. Results: Factors associated with higher likelihood of a major structural birth defects included maternal age; neonates born from women living in urban; and in Dega; history of fever during pregnancy; intake of herbal medicine; and drinking alcohol. Counselling for pregnancy preparation and folic acid supplementation was found protective for the likelihood of birth defect. Key words: Birth defect, maternal illness, maternal medication use, environmental exposure

scholarly journals Effect of Iron and Folic Acid Supplementation on Pregnancy outcome at Benghazi, Libya

2020 ◽  
Vol 7 (04) ◽  
pp. 4770-4777
Author(s):  
Fatma Yousuf M. Ziuo ◽  
Aisha Alfituri ◽  
Samia Elzwei ◽  
Abdel Hamid M Senussi
Keyword(s):  
Folic Acid ◽  
Health Status ◽  
Congenital Anomalies ◽  
Folic Acid Supplementation ◽  
Iron Intake ◽  
Significant Relation ◽  
Folic Acid Intake ◽  
Acid Supplementation ◽  
Acid Intake ◽  
Iron And Folic Acid

The aim of the study to assess the effect of iron and folic acid intake during pregnancy on maternal and neonatal health status at delivery at El-jomhoria hospital  in Benghazi 2013.   Material and methods: A descriptive cross-sectional study of delivered mothers at Al-jomhuria hospital in Benghazi during 2013.The sample size was 203 delivered mothers. The Results: The study revealed that 90.6% of pregnant women received folic acid and 89.7% iron.  The study reported a significant effect of iron intake on maternal health status at delivery (odds ratio= 5.9, CI (1.3-26.7). Also, the study reported a significant relation between the incidence and type of congenital anomalies and folic acid intake during pregnancy (X22=9.8 & P=0.007), while reported no significant relation with iron intake. Conclusion: iron and folic acid supplementation can reduce maternal and child complications at delivery and neonatal period. The study recommends pre-pregnancy folic acid intake and iron and folic acid supplementations for every pregnant woman to prevent congenital anomalies and maternal and child complications during delivery.  

scholarly journals Determinants and Seasonality of Major Structural Birth Defects Among Newborns Delivered at Primary and Referral Hospital of East and West Gojjam Zones, North West Ethiopia 2017- 2018: Case- Control Study

2019 ◽  
Author(s):  
Binalfew Tsehay ◽  
Desalegn Shitie ◽  
Akilog Lake ◽  
Erimiyas Abebaw ◽  
Amisalu Taye ◽  
...  
Keyword(s):  
Birth Defects ◽  
Birth Defect ◽  
Folic Acid Supplementation ◽  
Health Issues ◽  
North West ◽  
Maternal Illness ◽  
West Gojjam ◽  
North West Ethiopia ◽  
History Of ◽  
Maternal Medication

Abstract Objective: Although infant mortality because of birth defect has increased in both developed and developing countries, had not got attention like other health issues at national, regional, or local levels. Documenting the risk factors that influence the occurrence of birth defects and its seasonality will help to inform the community and to develop preventive strategies for the country. Results: Factors associated with higher likelihood of a major structural birth defects included maternal age; neonates born from women living in urban; and in Dega; history of fever during pregnancy; intake of herbal medicine; and drinking alcohol. Counselling for pregnancy preparation and folic acid supplementation was found protective for the likelihood of birth defect. Key words: Birth defect, maternal illness, maternal medication use, environmental exposure

scholarly journals Folic Acid Intake and Folate Status and Risk of Cervical Cancer: A Systematic Review and Meta-Analysis from 20 Independent Case-Control Studies and 4 RCTs

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 330-330
Author(s):  
Yuanxing Li ◽  
Aimin Yang ◽  
Wei Wang ◽  
Zhilian Wang ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Folic Acid ◽  
Meta Analysis ◽  
Folate Deficiency ◽  
Folic Acid Supplementation ◽  
Case Control ◽  
Case Control Studies ◽  
Folic Acid Intake ◽  
Acid Supplementation ◽  
Acid Intake

Abstract Objectives Cervical cancer remains a common public health problem, despite its reduced morbidity and mortality. Exploring diverse prevention and treatment methods is essential. The aim of this meta-analysis was to evaluate the association between folic acid intake and status and the risk of cervical cancer, and discuss the feasibility of folic acid supplement. Methods We identified 369 articles via Ovid MEDLINE, Embase, PubMed, Springer, up to January 2019. Inclusion criteria were case-control study or RCT; folate intake or level was determined; outcomes included CIN and/or cervical cancer; correlations between folate and CIN/cervical cancer were studied; original data were obtained or calculated. We also performed these analyses within groups of studies defined by the following design characteristics: disease outcome (cervical intraepithelial neoplasia CIN, cervical cancer CC), samples resource (serum, plasma, red blood cell, diet record), location (European and American countries, Asian countries). All statistical calculations were performed using R Project software. Results Twenty-two case-control studies and four RCTs were included in the meta- analysis. From 22 case-control studies, there was a strong correlation between folate deficiency and risk of CIN or cancer (OR = 1.46, 95% CI [1.30, 1.63]). The overall analysis results were significantly heterogeneous (I2 = 49%, P &lt; 0.01). The location is the main source of heterogeneity. For Asian regions, folate deficiency is a risk factor for CIN and CC (OR = 1.98, 95% CI [1.47, 2.66]; OR = 2.07, 95% CI [1.43, 3.76], respectively); however, for European and American regions, folate deficiency is only associated with CIN, OR = 1.16, 95% CI [1.01, 1.34]. From 4 RCT studies, the results showed that there was no significant correlation between folic acid supplementation and CIN outcome, RR = 1.17, 95% CI [0.90, 1.51]. Conclusions The overall study showed that folate deficiency significantly increased the risk of CIN and cervical cancer. However, the meta-analysis of 4 RCTs did not show the benefit of folic acid supplementation for CIN regression, probably due to the lack of RCTs, large time span, different folic acid supplementation doses, and different judging criteria of CIN. Further research is needed. Funding Sources N/A.

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