scholarly journals Demographic Characteristics of Mothers Who Delivered Children with Birth Defetcs

2018 ◽  
pp. 222-227
Author(s):  
Yudianto B Saroyo ◽  
Christian Wijaya ◽  
Putri M T Marsubin
Keyword(s):  
Retrospective Study ◽  
Birth Weight ◽  
Antenatal Care ◽  
Birth Defects ◽  
Medical Records ◽  
Birth Defect ◽  
Demographic Characteristics ◽  
Comorbid Disease ◽  
Increased Risk

Abstract Objective: to determine the characteristics and background of mothers who delivered neonates with birth defects. Methods: A retrospective study was used by evaluating the medical records of patients with birth defects in Dr. Cipto Mangunkusumo Hospital during the period between September 2014 and June 2016. Results: A total of 67 (1.85%) out of 3,619 infants who were born in Dr. Cipto Mangunkusumo Hospital during the period between September 2014 and June 2016 had birth defects. Forty-seven (70.1%) mothers of the subjects irregularly attend antenatal care. The most frequent maternal comorbid disease in this study was asthma, which was found in 4 (5.97%) mothers of the subjects. 48 (58.7%) subjects had birth weight under 2500 g. Conclusion: In this retrospective study, the main highlight is that 70.1% of the mothers who delivered neonates with birth defects did not attend antenatal care regularly. 58.7% of the neonates with birth defects had low birth weight. This study could be used as base for further research investigating about the role of antenatal care in early detection and/or the planning of delivery for babies with birth defects. Trends in babies with birth defects suggested that fetuses diagnosed with IUGR/SGA should be given special attention, as they were at increased risk for birth defects. Keywords: birth defect, maternal description   Abstrak Tujuan: untuk mengetahui deskripsi/ciri-ciri  dan latar belakang ibu yang melahirkan janin dengan kelainan bawaan. Metode: Studi retrospektif digunakan dengan menggunakan data sekunder rekam medis pasien dengan kelainan bawaan di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo pada periode September 2014-Juni 2016. Hasil: Sejumlah 67 (1.85%) dari 3,619 neonatus didapatkan dengan kelainan bawaan di RSUPN Cipto Mangunkusumo pada periode September 2014-Juni 2016 . Sejumlah 47 (70.1%) ibu dari subjek tidak teratur dalam melakukan kunjungan antenatal care. Penyakit komorbid ibu yang paling banyak ditemukan dalam studi ini adalah asma, yang ditemukan dalam 4 (5.97%) subjek. 48 (58.7%) subyek memiliki berat lahir di bawah 2500 g. Kesimpulan: Pada studi retrospektif ini didapatkan 70.1% ibu yang melahirkan bayi dengan kelainan bawaan tidak melakukan kunjungan antenatal care. Didapatkan bahwa 58,7% bayi yang lahir dengan kelainan bawaan memiliki berat badan lahir rendah (BBLR). Studi ini dapat dijadikan sebagai landasan dilakukannya studi yang lebih besar untuk mengevaluasi peran antenatal care terhadap deteksi dini dan/atau perencanaan persalinan bayi dengan kelainan bawaan. Tren pada bayi dengan kelainan bawaan menunjukkan bahwa janin yang pada antenatal care didapatkan IUGR/SGA patut diperhatikan lebih untuk kecurigaan kemungkinan adanya kelainan bawaan. Kata kunci:   deskripsi ibu,   kelainan bawaan,

scholarly journals Periconceptional folic acid intake in Northwest Russia: a birth registry study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
V A Postoev ◽  
L I Menshikova ◽  
A A Usynina ◽  
A M Grjibovski ◽  
J O Odland
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Birth Defect ◽  
Demographic Factors ◽  
Folic Acid Supplementation ◽  
Demographic Characteristics ◽  
Prenatal Counseling ◽  
Folic Acid Intake ◽  
Birth Registry ◽  
Socio Demographic Factors

Abstract Introduction Periconceptional use of folic acid supplementation is an evidence-based measure of birth defects prevention. The study was aimed to assess effect of periconceptual use of folic acid on birth defect prevalence in Arkhangelsk county and to investigate socio-demographic factors, which are associated with adherence to this preventive measure. Methods A registry-based study was conducted with data from the Arkhangelsk County Birth Registry for 2012-2015. The study population included 57084 pregnancies to calculate the proportion of women taking folic acid and 53340 pregnancy outcomes without missing data to analyze related socio-demographic characteristics. Results The proportion of women followed a folic acid supplementation before pregnancy was 1.3% (95% CI: 1.2-1.4), during pregnancy - 55.8% (95%CI: 54.6-56.4). Such women had less risk to deliver a newborn with any birth defects (OR = 0,84, 95%CI: 0,75 - 0,95). Considering birth defects prevalence of 38,6 per 1000 newborns in Arkhangelsk county, number needed to prevent one case of birth defect was 142,9. Based on multivariate analysis, nulliparous married women with higher education, aged 30 or more, had a higher chance to use folic acid before and during pregnancy. The history of spontaneous abortion in the mother's medical history and the first pregnancy were negatively associated with the probability of folic acid intake both before and during pregnancy. Conclusions The compliance to periconceptional intake of folic acid among women in the region was low. A level of compliance was associated with such socio-demographic factors as age, education, marital status, gravidity and parity. The findings have direct applications in improving prenatal care in Arkhangelsk county and establishing targets for prenatal counseling. Key messages A level of compliance to primary prevention of birth defects is associated with such socio-demographic factors as age, education, marital status, gravidity and parity. Prenatal counseling in terms of birth defects prevention should be based on socio-demographic characteristics of pregnant women.

scholarly journals A retrospective study of predisposing factors and outcome of persistant pulmonary hypertension among newborns at rural tertiary care centre

2020 ◽  
Vol 8 (1) ◽  
pp. 92
Author(s):  
B. C. Yelamali ◽  
Gangadhar S. Mirji ◽  
Mirnalini Rajput
Keyword(s):  
Risk Factors ◽  
Pulmonary Hypertension ◽  
Retrospective Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Birth Asphyxia ◽  
Male Gender ◽  
Predisposing Factors ◽  
Positive Pressure ◽  
Increased Risk

Background: Persistent pulmonary hypertension in newborns (PPHN) remains a significant cause of perinatal morbidity and mortality. Early recognition of factors that increase the risk of PPHN is of great importance in either to prevent or to treat PPHN optimally. Aim was to study the neonatal predisposing factors, profile and outcome of PPHN.Methods: This retrospective study was conducted in level III neonatal care unit, a rural referral centre of North Karnataka, India from January 2018 to April 2020.Results: During the study period a total of 50 infants with PPHN were identified with the incidence of 5.43/1000 live births. Mean gestation age (±SD) was 38.28±2.49 weeks and mean birth weight (±SD) was 2624±512 gm. The most noted risk factors were meconium aspiration syndrome (42%), birth asphyxia (16%), RDS (10%), positive pressure ventilation at birth (52%) and male gender (62%). Out of 50 infants with PPHN, high mortality was seen in low birth weight babies (66.6%). Use of sildenafil showed increased mortality (56.2%) whereas use of surfactant scored better with decreased mortality of 42.8%.Conclusions: Major risk factors for PPHN are MAS, birth asphyxia, RDS and low birth weight. Poor prognosis is seen in male gender, prematurity and CDH with increased risk of mortality. The use of systemic pulmonary vasodilators can be considered with caution and use of surfactant has a role in management of PPHN.

Maternal Thyroid Function, Use of Antithyroid Drugs in Early Pregnancy, and Birth Defects

2019 ◽  
Vol 104 (12) ◽  
pp. 6040-6048 ◽  
Author(s):  
Stine Linding Andersen ◽  
Louise Knøsgaard ◽  
Jørn Olsen ◽  
Peter Vestergaard ◽  
Stig Andersen
Keyword(s):  
Thyroid Function ◽  
Birth Defects ◽  
Early Pregnancy ◽  
Antithyroid Drug ◽  
Maternal Blood ◽  
Antithyroid Drugs ◽  
Birth Cohorts ◽  
Increased Risk ◽  
Maternal Thyroid

Abstract Context Antithyroid drug (ATD) therapy in early pregnancy is associated with birth defects, but more data are needed to substantiate the risk associated with different types of ATD. Furthermore, the role of abnormal maternal thyroid function per se remains unclarified. Objective To evaluate the risk of birth defects associated with the use of ATD in an extended nationwide cohort and the role of abnormal maternal thyroid function in birth cohorts including stored maternal blood samples from early pregnancy. Participants Danish pregnant women and their live-born children, including 1,243,353 children from a Nationwide Register-Based Cohort (NRBC), 1997 to 2016; 8830 children from the Danish National Birth Cohort (DNBC), 1997 to 2003; and 14,483 children from the North Denmark Region Pregnancy Cohort (NDRPC), 2011 to 2015. Main Outcome Measures Birth defects diagnosed before 2 years of age. Results In the NRBC, altogether 2718 (0.2%) children had been exposed to ATD in early pregnancy. The overall frequency of birth defects was 6.7% (95% CI, 6.7% to 6.8%) in nonexposed children and higher after exposure to methimazole/carbimazole (9.6%; 95% CI, 8.2% to 11.2%) and propylthiouracil (8.3%; 95% CI, 6.7% to 10.3%). On the other hand, the frequency of maternal thyroid dysfunction in early pregnancy was similar in the random cohort and in cases of birth defect in the DNBC (12.4 vs 12.6%, P = 0.8) and the NDRPC (15.1 vs 15.4%, P = 0.8). Conclusions Results corroborate an increased risk of birth defects associated with the use of ATD in early pregnancy and suggest that abnormal maternal thyroid function is not a major risk factor for birth defects.

scholarly journals Male Sex and the Risk of Childhood Cancer: The Mediating Effect of Birth Defects

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Erin L Marcotte ◽  
Jeremy M Schraw ◽  
Tania A Desrosiers ◽  
Wendy N Nembhard ◽  
Peter H Langlois ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Birth Defects ◽  
Mediation Analysis ◽  
Birth Defect ◽  
Mediating Effect ◽  
Cancer Type ◽  
Increased Risk ◽  
Causal Pathway ◽  
Male Sex ◽  
Risk Of Cancer

Abstract Background There is a persistent, unexplained disparity in sex ratio among childhood cancer cases, whereby males are more likely to develop most cancers. This male predominance is also seen for most birth defects, which are strongly associated with risk of childhood cancer. We conducted mediation analysis to estimate whether the increased risk of cancer among males is partially explained by birth defect status. Methods We used a population-based birth cohort with linked data from birth certificates, birth defects registries, and cancer registries from Arkansas, Michigan, North Carolina, and Texas. We conducted counterfactual mediation analysis to estimate the natural direct and indirect effects of sex on cancer risk, modeling birth defect status as mediator. State; birth year; plurality; and maternal race and ethnicity, age, and education were considered confounders. We conducted separate analyses limited to cancers diagnosed younger than 1 year of age. Results Our dataset included 10 181 074 children: 15 110 diagnosed with cancer, 539 567 diagnosed with birth defects, and 2124 co-occurring cases. Birth defect status mediated 38% of the association between sex and cancer overall. The proportion mediated varied by cancer type, including acute myeloid leukemia (93%), neuroblastoma (35%), and non-Hodgkin lymphoma (6%). Among children younger than 1 year of age at cancer diagnosis, the proportion mediated was substantially higher (82%). Conclusions Our results suggest that birth defects mediate a statistically significant proportion of the relationship between sex and childhood cancer. The proportion mediated varied by cancer type and diagnosis age. These findings improve our understanding of the causal pathway underlying male sex as a risk factor for childhood cancer.

scholarly journals The correct setting to improve the quality of health care process: a retrospective study in Internal Medicine Department

2018 ◽  
Vol 12 (4) ◽  
pp. 285-295
Author(s):  
Filomena Pietrantonio ◽  
Paola Aperti ◽  
Luca Tonoli ◽  
Elaine Tyndall ◽  
Orietta Meneghetti
Keyword(s):  
Internal Medicine ◽  
Health Care ◽  
Retrospective Study ◽  
Hospital Stay ◽  
Medical Records ◽  
Clinical Severity ◽  
Early Warning Score ◽  
Care Process ◽  
Technical Equipment

The definition of the role of hospitals and communities in terms of the response to patients’ health care needs is essential in the Lombardy region health-care reform development (LR. 23/2015). The stratification of patients according to clinical severity and care complexity for adequate clinical health care, is achieved by delineating care settings, staff standards, required technical equipment and crucial aspects of clinical pathways. An observational and retrospective study at Manerbio Hospital Internal Medicine Unit (IMU) was carried out to define: i) characteristics of IMU patients; ii) role of IMU physician in management of poly-pathological patients; iii) alternative organizational models. After a Literature review, clinical severity was defined by modifying early warning score, complexity and co-morbidities by cumulative illness rating scale (CIRS) and by intensity of care through care intensity index (IIA). All medical records of patients admitted in the first quarter of 2016 were analyzed. A total of 393 medical records were examined: 199 M/194 F, median age 81 years. Critical patients (requiring continuous monitoring using advanced equipment): 27% of the sample (10% with intensive care transfer criteria). Co-morbidity: between 5 and 6 active diseases for most of the sample; 53% with CIRS between 7 and 12. Elevated care intensity (IIA) was found in 46% of the sample, remaining constant throughout hospital stay. Medium stay: 9.35 days. 27% of IMU patients needs subintensive care. About a quarter of patients has unresolved social problems contributing to acute presentations in the emergency room. Agreement on appropriate links between hospital and community care structures is advisable to reduce hospital stay, adequately responding to patients’ needs.

scholarly journals Safety profile of Td vaccination in Indonesian pregnant women: a post-marketing surveillance study

2019 ◽  
Vol 28 (4) ◽  
pp. 322-8
Author(s):  
Hindra Irawan Satari ◽  
Mita Puspita ◽  
Julitasari Sundoro ◽  
Andrijono ◽  
Syafriyal ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Medical Records ◽  
Premature Birth ◽  
Local Reaction ◽  
Arthus Reaction ◽  
Serious Adverse Events ◽  
Post Marketing Surveillance

BACKGROUND The Indonesian Expanded Program of Immunization has implemented tetanus and diphtheria (Td) vaccination to replace the tetanus toxoid vaccine in pregnant women since the year 2016. Td vaccine is administered to protect against diphtheria and tetanus to the mother and her baby as well. This prospective study was conducted to assess the adverse reactions after Td immunization; besides, a retrospective study was conducted to observe the presence of severe local reaction (Arthus reaction), premature birth, and low birth weight history in the medical records of pregnant women who had received Td immunization in the past year. METHODS A prospective observational study was conducted in 200 pregnant women. Local reactions and systemic events occurring within 28 days after immunization were recorded in the diary card and were confirmed by the health worker in the follow-up visit. A retrospective study was also conducted to evaluate 750 medical records of pregnant women who had received Td immunization. The study was conducted fromSeptember 2017 to January 2018. The study has been registered at ClinicalTrials.gov ID: NCT03383653. RESULTS In 185 pregnant women who completed the study, the most common local reaction was pain, occurring in 33.5% of subjects within 24 hours after vaccination. Fever, other systemic reactions, and serious adverse events were not reported during the observation. In the retrospective study, 647 medical records were validated. No Arthus reaction was observed. The prevalence of premature birth was 1.24%, and that of low birth weight was 2.63%, which were below the normal rates. CONCLUSIONS Td vaccination in pregnant women was safe and well-tolerated.

scholarly journals Birth Defects at the Outpatient Department of the Philippine General Hospital from 2000-2010

2017 ◽  
Vol 51 (3) ◽  
Author(s):  
Carmencita D. Padilla ◽  
Melissa Mae P. Baluyot ◽  
Aster Lynn D. Sur ◽  
Roxanne Janica E. Merencilla ◽  
Maria Melanie Liberty B. Alcausin
Keyword(s):  
General Hospital ◽  
Birth Defects ◽  
Medical Records ◽  
Congenital Malformations ◽  
Birth Defect ◽  
The Philippines ◽  
Outpatient Department ◽  
Genital Organ ◽  
Age Group ◽  
Organ Systems

Introduction. Birth defects or congenital anomalies are a major global concern. An estimated 7.9 million children are born worldwide each year. Birth defects are among the top ten leading causes of infant deaths in the Philippines for more than six decades. The objectives of this study were to: 1) determine the frequency of birth defects among patients seen at the Outpatient Department (OPD) of the Philippine General Hospital (PGH) from 2000 to 2010; 2) describe the birth defects by organ systems and presentation (isolated, part of a recognizable syndrome, chromosomal syndrome or multimalformed case); 3) present the distribution of patients by geographic origin; 4) describe the birth defects according to age group and organ system; and 5) compare the data from this study to the previously published report among admitted patients at PGH in the same time period. Methods. Medical records of new patients seen at the PGH OPD from 2000 to 2010 were reviewed. Medical records that included written diagnosis of any of the following International Classification of Diseases (ICD) -10 codes (Q 00 – Q 99, P 35.0, P 83.5, K40, H49.0, H50.0, H50.1, H53.0, H54.42, H54.7, and H55.01) were considered birth defect cases. Results. Out of the 804,410 new patients at the PGH OPD from 2000 to 2010, 12,827 patients (1.59%) had a diagnosis of at least one major structural birth defect. The most common birth defects were cardiovascular, digestive, genital organ and nervous system anomalies. The top 5 anomalies in this report were: congenital malformations of cardiac septa, other congenital malformations not elsewhere classified, cleft palate with cleft lip, congenital hydrocoele, and congenital hydrocephalus. The highest percentage of birth defects were from the < 1 age group (40.3%), followed by the 1 to 4 age group (29%) and the 5 to 9 age group (14.6%). NCR, Region IV-A and Region III had the highest percentages of patients with birth defects, 51.4%, 26.03% and 10.97%, respectively. Conclusion. This study revealed a prevalence of birth defects among PGH OPD patients of 1.59%. The most common birth defects were possibly surgically correctable reflecting the nature of PGH as a referral center. Majority of patients affected were in the under-5 population. The study reflects the importance of a birth defects surveillance to develop policies on strategies that will reduce the burden of morbidity and mortality secondary to preventable birth defects like congenital rubella syndrome that can be aborted by a successful immunization program. The birth defects surveillance will generate data that will support strengthening the regional hospitals with a better complement of specialists and capability for both medical and surgical management of the patients. 

scholarly journals Comparison of Birth Defects in Infants Conceived by Assisted Reproductive Technologies vs. Naturally Conceived Infants in Mashhad, Iran

2015 ◽  
Vol 4 (4) ◽  
pp. 146-50
Author(s):  
Ehsan Shahverdi ◽  
Fatemeh Vahid Roodsari ◽  
Masoomeh Akhavan Saffar
Keyword(s):  
Retrospective Study ◽  
In Vitro Fertilization ◽  
Birth Defects ◽  
Birth Defect ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Vitro Fertilization ◽  
Intra Cytoplasmic Sperm Injection

Background: Assisted reproductive technologies (ART) are known as a treatment for infertility in which oocyte undergoes manipulation outside body. The aim of this study was to study the evaluation of birth defects in infants conceived through assisted reproductive technologies (ART) and compare them with naturally-conceived infants. Materials and Methods: In this retrospective study, four hundred naturally-conceived infants and 400 infants conceived by ARTs between 20 March and 20 November 2012 in Gha’em Hospital and Sheikh Hospital of Mashhad in Iran participated in this study. Infants were evaluated by a pediatrician at the time of birth, 10 days and 40 days after birth. Correlation between the use of IVF and/or ICSI methods and birth defects was evaluated. Results: Of total 800 infants (450 boys and 350 girls), half of the infants were conceived through natural pregnancy, 200(25%) through in-vitro fertilization (IVF) and 200 (25%) intra- cytoplasmic sperm injection (ICSI). In Infants conceived by IVF, 5 cases (2.5%) had a kind of birth defect just similar to those conceived by ICSI; while 4 cases had birth defects in natural pregnancy. There was no significant correlation between the use of IVF and/or ICSI methods in terms of birth defects (P=0.280).Conclusion: We found that using IVF or ICSI methods is not associated with increasing birth defects.[GMJ.2015;4(4):146-50]

scholarly journals Maternal Smoking and Socio-Demographic Characteristics in Correlation with Low Birth Weight: A Turin (Piedmont) Study

2014 ◽  
Vol 53 (3) ◽  
pp. 221-225
Author(s):  
Alice Mannocci ◽  
Claudia Vaschetto ◽  
Leda Semyonov ◽  
Giuseppina Poppa ◽  
Azzurra Massimi ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Maternal Smoking ◽  
Goodness Of Fit ◽  
Univariate Analysis ◽  
Demographic Characteristics ◽  
Smoking During Pregnancy ◽  
Increased Risk

Abstract Introduction. 15 to 25% of women smoke during pregnancy. Scientific evidence suggests that exposure to smoking causes decreased birth weight. The aim of this study was to assess the correlation between smoking during pregnancy, maternal sociodemographic characteristics, and low birth weight. Methods. Data were derived from 1572 questionnaires administered to each woman that gave birth at the Gynecology Teaching Hospital “S. Anna” in Turin (Italy) during the period from 2008 to 2010. Multiple logistic analysis was used to evaluate the association between socio-demographic characteristics and birth weight; the stepwise approach with a “backward elimination” procedure was followed, and the goodness of fit of the model was estimated using the Hosmer-Lemeshow test. Results. The univariate analysis revealed that smoking cigarettes (17%), having a lower educational level (13%), and female sex of the infant (13%) seem to be risk factors, as they increase the risk of having a low birth weight child. Logistic regression analysis showed that gestational age and maternal smoking are the statistically associated variables. Conclusions. The results confirmed that birth weight increases proportionally with the length of the gestational age and that maternal smoking and the child’s sex (female) increase the risk of having a lower birth weight. Logistic regression demonstrated that the association between maternal smoking and low birth weight shows an increased risk for the whole population (OR=2.85), for male (OR=3.45) and for female newborns (OR=2.44)

Sociodemographic risk factors associated with low birthweight in United Arab Emirates

1996 ◽  
Vol 28 (3) ◽  
pp. 339-346 ◽  
Author(s):  
A. Bener ◽  
Y. M. Abdulrazzaq ◽  
A. Dawodu
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Antenatal Care ◽  
United Arab Emirates ◽  
Maternal Smoking ◽  
Low Birthweight ◽  
Multiple Logistic Regression Analysis ◽  
Educational Status ◽  
Increased Risk

SummaryThis case-control study was undertaken to determine socio-demographic risk factors for low birth weight in Al-Ain (United Arab Emirates) over a 12-month period in 1992–93. A total of 3485 live births occurred of which 293 (8·4%) were low birth weight. The risk factors considered were mother's occupation, house conditions, place of residence (urban or rural), maternal smoking habits, antenatal care, availability of help in the home, maternal BMI and educational status. Multiple logistic regression analysis showed that mother's occupation, maternal smoking, antenatal care, and lack of help in the home were associated with increased risk of low birth weight.

Sign in / Sign up

Export Citation Format

Share Document