How do multiple sclerosis patients’ sickness absence and disability pension level change over time?

Background: Multiple sclerosis (MS) can impact working life, sickness absence (SA) and disability pension (DP). Different types of occupations involve different demands, which may be associated with trajectories of SA/DP among people with MS (PwMS). Objectives: To explore, among PwMS and references, if SA/DP differ according to type of occupation. Furthermore, to examine how trajectories of SA/DP days are associated with type of occupation among PwMS. Methods: A longitudinal nationwide Swedish register-based cohort study was conducted, including 6100 individuals with prevalent MS and 38,641 matched references from the population. Trajectories of SA/DP were identified with group-based trajectory modelling. Multinomial logistic regressions were estimated for associations between identified trajectories and occupations. Results: Increase of SA/DP over time was observed in all occupational groups, in both PwMS and references, with higher levels of SA/DP among PwMS. The lowest levels of SA/DP were observed among managers. Three trajectory groups of SA/DP were identified: Persistently Low (55.2%), Moderate Increasing (31.9%) and High Increasing (12.8%). Managers and those working in Science & Technology, and Economics, Social & Cultural were more likely to belong to the Persistently Low group. Conclusion: Results suggest that type of occupation plays a role in the level and course of SA/DP.

Download Full-text

Multiple sclerosis patients who improve in their disability over time develop less brain atrophy compared to those who remain stable or progress

10.26226/morressier.59a3eda4d462b8028d894d13 ◽

2017 ◽

Author(s):

Emanuele Ghione

Keyword(s):

Multiple Sclerosis ◽

Brain Atrophy ◽

Multiple Sclerosis Patients ◽

Over Time

Download Full-text

Healthcare, Sickness Absence, and Disability Pension Cost Trajectories in the First 5 Years After Diagnosis with Multiple Sclerosis: A Prospective Register-Based Cohort Study in Sweden

PharmacoEconomics - Open ◽

10.1007/s41669-019-0150-3 ◽

2019 ◽

Vol 4 (1) ◽

pp. 91-103 ◽

Cited By ~ 2

Author(s):

Korinna Karampampa ◽

Hanna Gyllensten ◽

Fei Yang ◽

Chantelle Murley ◽

Emilie Friberg ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cohort Study ◽

Sickness Absence ◽

Disability Pension

Download Full-text

Quantitative sensory and motor measures detect change over time and correlate with walking speed in individuals with multiple sclerosis

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2014.11.001 ◽

2015 ◽

Vol 4 (1) ◽

pp. 67-74 ◽

Cited By ~ 17

Author(s):

Kathleen M. Zackowski ◽

Joseph I. Wang ◽

John McGready ◽

Peter A. Calabresi ◽

Scott D. Newsome

Keyword(s):

Multiple Sclerosis ◽

Walking Speed ◽

Change Over Time ◽

Over Time

Download Full-text

Longitudinal changes in sickness absence and disability pension, and associations between disability pension and disease-specific and contextual factors and functioning, in people with multiple sclerosis

Journal of the Neurological Sciences ◽

10.1016/j.jns.2016.05.055 ◽

2016 ◽

Vol 367 ◽

pp. 319-325 ◽

Cited By ~ 10

Author(s):

Charlotte Chruzander ◽

Petter Tinghög ◽

Charlotte Ytterberg ◽

Lotta Widén Holmqvist ◽

Kristina Alexanderson ◽

...

Keyword(s):

Multiple Sclerosis ◽

Sickness Absence ◽

Disability Pension ◽

Contextual Factors ◽

Longitudinal Changes ◽

Disease Specific

Download Full-text

Longitudinal single-cell cytokine responses reveal recurrent autoimmune myelin reactivity in relapsing-remitting multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1191/1352458505ms1165oa ◽

2005 ◽

Vol 11 (3) ◽

pp. 251-260 ◽

Cited By ~ 5

Author(s):

I R Moldovan ◽

R A Rudick ◽

A C Cotleur ◽

S E Born ◽

J-C Lee ◽

...

Keyword(s):

Multiple Sclerosis ◽

Amino Acid ◽

Ex Vivo ◽

Proteolipid Protein ◽

Myelin Proteins ◽

Immune Reactivity ◽

Cytokine Responses ◽

Relapsing Remitting ◽

Multiple Sclerosis Patients ◽

Over Time

The relationship between multiple sclerosis (MS) disease activity and myelin protein-induced cytokine responses over time is not elucidated. We addressed this relationship by examining longitudinal cytokine responses to myelin proteins every three months for one year, in the context of gadolinium (gad)-enhancing brain lesions and of clinical relapses. The ELISPOT assay was used to determine the ex vivo cytokine production in response to nine amino acid long peptides spanning the entire proteolipid protein (PLP) and myelin basic protein (MBP) molecules in relapsing—remitting (RR) MS patients and matched healthy controls. We identified three longitudinal levels of myelin-induced cytokine secretion by adding up the positive responses for all PLP or MBP peptides obtained for five timepoints, at three- month intervals: low reactivity (<200 cumulative cytokine-secreting cells), isolated peptide reactivity (201-450 cumulative cytokine- secreting cells) and recurrent protein-wide bursts of cytokine reactivity (> 451 cumulative cytokine-secreting cells). The majority of MS patients showed recurrent bursts to PLP and MBP. In contrast, controls showed a more even distribution between all levels of cytokine reactivity. The majority of patients with gad-enhancing lesions showed PLP/IFNg and MBP/IFNg recurrent burst responses. This is the first longitudinal study on MS patients in which nine amino acid long myelin peptides are used to reveal the broad range of PLP- and MBP- peptide cytokine reactivity across the whole molecule of these two major myelin proteins. This study also reveals the extremely dynamic nature of the immune reactivity to numerous regions of myelin, which can fluctuate dramatically over time. Such fluctuation could hamper the efficacy of antigen-based therapies for MS.

Download Full-text

Sources and level of income among individuals with multiple sclerosis compared to the general population: A nationwide population-based study

Multiple Sclerosis Journal ◽

10.1177/1352458515570767 ◽

2015 ◽

Vol 21 (13) ◽

pp. 1730-1741 ◽

Cited By ~ 16

Author(s):

Michael Wiberg ◽

Emilie Friberg ◽

Magnus Stenbeck ◽

Kristina Alexanderson ◽

Anders Norlund ◽

...

Keyword(s):

Multiple Sclerosis ◽

General Population ◽

Sickness Absence ◽

Disability Pension ◽

Reference Group ◽

Work Capacity ◽

Population Based ◽

Social Benefits ◽

Unemployment Compensation ◽

Percentage Difference

Introduction: Multiple sclerosis (MS) is associated with reduced work capacity, but there is limited knowledge about MS patients’ sources of income. Objectives: The purpose of this study was to elucidate MS patients’ earnings and social benefits compared to those of the general population. Methods: From nationwide registers of all residents in Sweden aged 21–64 years in 2010 ( n=5,291,764), those with an MS diagnosis ( n=13,979) were compared to a propensity score matched reference group ( n=69,895). Descriptive statistics and regression models were used to estimate the percentage difference between the MS patients and the matched references regarding the following annual incomes: earnings, disability pension, sickness absence, disability allowance, unemployment compensation and social assistance. Results: Both MS patients and the matched references received most of their income from earnings followed by disability pension and sickness absence. MS patients that were diagnosed in 2010 had 15% lower earnings than the matched references, while MS patients diagnosed before 2005 had 38% lower earnings. Corresponding figures regarding summed social benefits were 33% and 130% higher for MS patients, respectively. Conclusion: The results indicate that MS patients are overrepresented, in relative and absolute terms, regarding health-related benefits and have lower levels of earnings. However, the redistributing welfare systems appear to financially compensate the MS patients considerably.

Download Full-text

High prevalence of sickness absence and disability pension among multiple sclerosis patients: a nationwide population-based study

Multiple Sclerosis Journal ◽

10.1177/1352458513488234 ◽

2013 ◽

Vol 19 (14) ◽

pp. 1923-1930 ◽

Cited By ~ 34

Author(s):

Petter Tinghög ◽

Jan Hillert ◽

Linnea Kjeldgård ◽

Michael Wiberg ◽

Anna Glaser ◽

...

Keyword(s):

Multiple Sclerosis ◽

Sick Leave ◽

Disability Pension ◽

Female Gender ◽

Population Based ◽

Disease Modifying Drugs ◽

Modern Health Care ◽

High Prevalence ◽

Widespread Access ◽

Multiple Sclerosis Patients

Introduction: Although multiple sclerosis (MS) often implies substantial disability, there is little knowledge about sick leave and disability pension among MS patients. Objectives: The purpose of this study was to estimate the prevalence rates of sick leave and disability pension among MS patients and to explore how socio-demographics are associated with such rates. Methods: The register data of all people who lived in Sweden in 2005 and were 16–64 years old was used to identify 9721 MS patients and matched controls. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated and effect modifications were evaluated with Wald X2 tests. Results: In 2005, 61.7% of the MS patients were on partial or full disability pension compared to 14.2% among the controls. Of the others, 36.8% had ≥1 sick-leave spell for >14 days during that year. Socio-demographics were similarly associated with sick leave and disability pension among MS patients and controls, with the noteworthy exceptions that female gender and immigration status were less potent risk factors in the MS population ( p<0.05). Conclusion: In spite of widespread access to modern health care including disease-modifying drugs, the majority of MS patients of working ages were on a disability pension. Strategies enabling MS patients to retain their footing in the labour market are needed.

Download Full-text