Perfluorocarbon Emulsion Contrast Agents: A Mini Review

Perfluorocarbon emulsions offer a variety of applications in medical imaging. The substances can be useful for most radiological imaging modalities; including, magnetic resonance imaging, ultrasonography, computed tomography, and positron emission tomography. Recently, the substance has gained much interest for theranostics, with both imaging and therapeutic potential. As MRI sequences improve and more widespread access to 19F-MRI coils become available, perfluorocarbon emulsions have great potential for new commercial imaging agents, due to high fluorine content and previous regulatory approval as antihypoxants and blood substitutes. This mini review aims to discuss the chemistry and physics of these contrast agents, in addition to highlighting some of the past, recent, and potential applications.

Mitigating isolation: The use of rapid antigen testing to reduce the impact of self-isolation periods

Isolating, either enforced or self-guided, is a well-recognised and used technique in the limitation and reduction of disease spread. This usually balances the societal harm of disease transmission against the individual harm of being isolated and is typically limited to a very small number of individuals. With the widespread transmission of SARS-CoV-2 and requirements to self-isolate when symptomatic or having tested positive, the number of people affected has grown very large causing noticeable individual cost, and disruption to the provision of essential services. With widespread access to reliable rapid antigen tests (also known as LFD or LFTs), in this paper we examine strategies to utilise this testing technology to limit the individual harm whist maintaining the protective effect of isolation. We extend this work to examine how isolation may be improved and mitigate the release of infective individuals into the population caused by fixed time-periods.

Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study

Background The United States (US) Expanded Access Program (EAP) to coronavirus disease 2019 (COVID-19) convalescent plasma was initiated in response to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. While randomized clinical trials were in various stages of development and enrollment, there was an urgent need for widespread access to potential therapeutic agents. The objective of this study is to report on the demographic, geographical, and chronological characteristics of patients in the EAP, and key safety metrics following transfusion of COVID-19 convalescent plasma. Methods and findings Mayo Clinic served as the central institutional review board for all participating facilities, and any US physician could participate as a local physician–principal investigator. Eligible patients were hospitalized, were aged 18 years or older, and had—or were at risk of progression to—severe or life-threatening COVID-19; eligible patients were enrolled through the EAP central website. Blood collection facilities rapidly implemented programs to collect convalescent plasma for hospitalized patients with COVID-19. Demographic and clinical characteristics of all enrolled patients in the EAP were summarized. Temporal patterns in access to COVID-19 convalescent plasma were investigated by comparing daily and weekly changes in EAP enrollment in response to changes in infection rate at the state level. Geographical analyses on access to convalescent plasma included assessing EAP enrollment in all national hospital referral regions, as well as assessing enrollment in metropolitan areas and less populated areas that did not have access to COVID-19 clinical trials. From April 3 to August 23, 2020, 105,717 hospitalized patients with severe or life-threatening COVID-19 were enrolled in the EAP. The majority of patients were 60 years of age or older (57.8%), were male (58.4%), and had overweight or obesity (83.8%). There was substantial inclusion of minorities and underserved populations: 46.4% of patients were of a race other than white, and 37.2% of patients were of Hispanic ethnicity. Chronologically and geographically, increases in the number of both enrollments and transfusions in the EAP closely followed confirmed infections across all 50 states. Nearly all national hospital referral regions enrolled and transfused patients in the EAP, including both in metropolitan and in less populated areas. The incidence of serious adverse events was objectively low (<1%), and the overall crude 30-day mortality rate was 25.2% (95% CI, 25.0% to 25.5%). This registry study was limited by the observational and pragmatic study design that did not include a control or comparator group; thus, the data should not be used to infer definitive treatment effects. Conclusions These results suggest that the EAP provided widespread access to COVID-19 convalescent plasma in all 50 states, including for underserved racial and ethnic minority populations. The study design of the EAP may serve as a model for future efforts when broad access to a treatment is needed in response to an emerging infectious disease. Trial registration ClinicalTrials.gov NCT#: NCT04338360.

Experiences and ways PLWHA deal with their lives

The issue of HIV and AIDS and people living with HIV and AIDS is very sensitive which needs great attention. The population of infected individuals seems not to seek help and health services due to their illness. The barriers which prevent this population experience the meaning of social construction of their illness. The main objective of this study is to understand the day-to-day lives and the ways PLWHA deals with their lives. Qualitative method and participatory action research were used to gather information. The study found out that PLWHA have much to fight for in the complex and frightening areas of HIV research and treatment. Though there have been lacking scientific skills, all PLWHA can bring unique experiences and perspectives to an open discussion. The study concluded that facing the challenges of working with HIV and AIDS–individuals; consider the participatory research approach because it can reach out to individuals, groups and organizations.It was recommended that the ultimate goals of AIDS treatment and research activism are to accelerate scientific research knowledge that contributes towards cure, and to win an early widespread access to treatment for everyone infected with HIV. Developing a well-designed research can help PLWHA learn how to ask themselves different questions and ask if the medical and research establishments will address their concerns. Keywords: Health Services;, seeking behavior; persons living with HIV.

An Exploration of How Women Experience the Process of Intimate Partner Violence in Relationships Characterised by Bi-Directional Aggression.

<p>This qualitative study explored how women in New Zealand experienced the process of intimate partner violence in relationships with men, which were characterised by bi-directional aggression. Using thematic analysis, semi-structured interviews with 11 women who experienced bi-directionally aggressive relationships were analysed and four themes were identified that encompassed 1) the foundations of bi-directional aggression; 2) the nature of bi-directional aggression within the relationship; 3) how the women were stuck in the relationship, and; 4) moving forward. The findings indicate how the vulnerabilities to bi-directional aggression can develop from early life and perpetuate and exacerbate over time in the context of the relationship dynamic. This highlights the need to implement preventive action to support adaptive self-regulation development in young people and families, provide education about bi-directional aggression and widespread access to support and treatment resources for all genders. Further implications and future directions for policy, research and practice regarding bi-directional aggression are discussed.</p>

An Exploration of How Women Experience the Process of Intimate Partner Violence in Relationships Characterised by Bi-Directional Aggression.

<p>This qualitative study explored how women in New Zealand experienced the process of intimate partner violence in relationships with men, which were characterised by bi-directional aggression. Using thematic analysis, semi-structured interviews with 11 women who experienced bi-directionally aggressive relationships were analysed and four themes were identified that encompassed 1) the foundations of bi-directional aggression; 2) the nature of bi-directional aggression within the relationship; 3) how the women were stuck in the relationship, and; 4) moving forward. The findings indicate how the vulnerabilities to bi-directional aggression can develop from early life and perpetuate and exacerbate over time in the context of the relationship dynamic. This highlights the need to implement preventive action to support adaptive self-regulation development in young people and families, provide education about bi-directional aggression and widespread access to support and treatment resources for all genders. Further implications and future directions for policy, research and practice regarding bi-directional aggression are discussed.</p>

In the Eye of the Beholder: Using Photography to Teach Gerontology

Due to the widespread access to smart phones and similar technology, photography and photographic images have become an ever-present part of contemporary social life. Photographic methods are also growing in their use in higher education pedagogy. As a specific application, photography can be a powerful tool to educate students about aging processes and issues that impact older adults. This poster will explore the use of photographic methods and tools to teach and integrate aging-related concepts into gerontology and social work courses, at both undergraduate and graduate levels. Specifically, the use of digital storytelling, photo mapping, photo voice, and photo therapy will be highlighted. Descriptions of and consideration for assignments along with example student projects will be displayed and discussed as will other potential projects and uses of photographic methods. Attention will be paid to how photographic methods can help students explore the diversity and intersection of individual characteristics and experiences with the aging process and how intersectional identities can influence, and be influenced by, aging and external factors and processes.

Music in the Digital World

Digital technologies have impacted and reshaped almost every aspect of 21st-century life, from communication and commerce, to work and leisure, to education and politics. This bibliography represents a collection of scholarship that seeks to detail how varied and ubiquitous digital technologies have reshaped music, and how music has in turn shaped the digital world. Since the first years of the 21st century, widespread access to digital technologies, including social media, smartphones, and Web 2.0 have fundamentally transformed musical aesthetics, creation, performance, consumption, and reception on a global scale. As of October 2020, there are around 4.66 billion active internet users around the globe, nearly all of whom interact with music in one way or another. This bibliography addresses how this “digital world” is implicated in 21st-century digital regimes, and in the global flows and local assemblages of music’s production, circulation, and consumption. Like the technologies themselves, scholarship on music in the digital world is a rapidly shifting field. Readers are encouraged to understand this bibliography as a fluid network of related topics, with substantial thematic overlap between sections. Except when a subject touches on topics unique to this bibliography, the authors have omitted topics covered extensively in other Oxford Bibliographies, including “Film Music,” “Video Game Music,” “Electronic and Computer Music Instruments,” and “Music Technology.”

Application of Machine Learning to Resource Modelling of a Marble Quarry with DomainMCF

Machine learning is constantly gaining ground in the mining industry. Machine learning-based systems take advantage of the computing power of personal, embedded and cloud systems of today to rapidly build models of real processes, something that would have been impossible or extremely time-consuming a couple of decades ago. The widespread access to the internet and the availability of cheap and powerful cloud computing systems led to the development and acceptance of tools to automate resource modelling processes or optimise mine scheduling, using machine learning methodologies. The domain modelling system discussed in this paper, called DomainMCF, has been developed by Maptek, using artificial neural network technology. In the application presented in this paper, DomainMCF is used to model the spatial distribution of marble quality categorical parameters, and the results are combined to produce a final marble quality classification using drillhole and quarry face samples from an operational marble quarry in NE Greece. DomainMCF was made available for this study as a cloud processing service through an early access program for individuals or companies interested in testing its capabilities and suitability in various modelling scenarios and geological settings. The resulting marble product classifications are compared with those produced by the already established classification system that is based on a more conventional estimation method. The produced results show that DomainMCF can be effectively applied to the modelling of marble quality spatial distribution and similar domaining problems.

Digital Entrepreneurship: Public Perception of Barriers, Drivers, and Future

The widespread access to the Internet has undoubtedly changed the way businesses handle their processes and interact with their customers. With the surge of new devices, business models, technologies, and platforms, alongside social media growth and innovative advertising, it became easier to transition from employment to entrepreneurship. The paper aims to assess the public perception of digital entrepreneurship, with a focus on its barriers, drivers, and expectations for the future. The results show that there is a slight agreement with a digital business being easier to establish compared with a traditional one. The driving forces behind starting a digital business are recognized, and the digital environment is considered essential for business growth in the following years. With some exceptions, there are no significant differences between age groups, genders, relationship statuses, levels of education, and/or occupations when rating the barriers, drivers, and expectations for the future of digital entrepreneurship.