scholarly journals Irritable bowel syndrome-like symptoms in treated microscopic colitis patients compared with controls: a cross-sectional study

2019 ◽  
Vol 8 (5) ◽  
pp. 374-380
Author(s):  
Jenny Pagoldh ◽  
David Lundgren ◽  
Ole B Suhr ◽  
Pontus Karling
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rating Scale ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Microscopic Colitis ◽  
Faecal Calprotectin ◽  
Cross Sectional ◽  
Control Subjects ◽  
Gastrointestinal Symptom Rating Scale ◽  
Irritable Bowel

Abstract Background The prevalence of irritable bowel syndrome (IBS)-like symptoms is high in untreated patients with microscopic colitis (MC), but there is uncertainty of the prevalence of IBS-like symptoms in treated patients. We assessed the degree of IBS-like symptoms in patients with MC in comparison to control subjects, and investigated the association between IBS-like symptoms and faecal calprotectin (FC) in MC patients. Methods Patients with an established MC diagnosis (n = 57) were compared to sex- and age-matched controls (n = 138) for scores in the GSRS-IBS (Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome) and HADS (Hospital Anxiety Depression Scale). In MC patients, an FC level was simultaneously analysed. Results The median interval from MC diagnoses to the time the subjects participated in the study was 5.5 years (25th–75th percentiles; 4.5–9.5 years). The total GSRS-IBS score, subscores for abdominal pain, bloating, and diarrhoea were significantly higher in MC patients compared to controls (all P < 0.001). There was a significant correlation between FC levels and reported bowel frequency (P = 0.023), but there was no correlation between FC levels and GSRS-IBS scores. Patients with MC had significantly higher scores on anxiety (HADS-A) (P < 0.001) and used more selective serotonin-reuptake-inhibitor drugs (P = 0.016) than the control subjects. However, only the control subjects (not the patients with MC) showed significant correlations between GSRS-IBS scores and HADS scores. Conclusions Patients with MC reported more IBS-like symptoms and anxiety than control subjects but neither FC levels nor symptoms of affectivity were significantly correlated with IBS-like symptoms.

scholarly journals Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Laura Prospero ◽  
Giuseppe Riezzo ◽  
Michele Linsalata ◽  
Antonella Orlando ◽  
Benedetta D’Attoma ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Barrier Function ◽  
Rating Scale ◽  
Psychological Symptoms ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Fatty Acid Binding ◽  
Gastrointestinal Symptom Rating Scale ◽  
Gi Symptoms ◽  
Irritable Bowel

Abstract Background Irritable bowel syndrome (IBS) is characterised by gastrointestinal (GI) and psychological symptoms (e.g., depression, anxiety, and somatization). Depression and anxiety, but not somatization, have already been associated with altered intestinal barrier function, increased LPS, and dysbiosis. The study aimed to investigate the possible link between somatization and intestinal barrier in IBS with diarrhoea (IBS-D) patients. Methods Forty-seven IBS-D patients were classified as having low somatization (LS = 19) or high somatization (HS = 28) according to the Symptom Checklist-90-Revised (SCL-90-R), (cut-off score = 63). The IBS Severity Scoring System (IBS-SSS) and the Gastrointestinal Symptom Rating Scale (GSRS) questionnaires were administered to evaluate GI symptoms. The intestinal barrier function was studied by the lactulose/mannitol absorption test, faecal and serum zonulin, serum intestinal fatty-acid binding protein, and diamine oxidase. Inflammation was assessed by assaying serum Interleukins (IL-6, IL-8, IL-10), and tumour necrosis factor-α. Dysbiosis was assessed by the urinary concentrations of indole and skatole and serum lipopolysaccharide (LPS). All data were analysed using a non-parametric test. Results The GI symptoms profiles were significantly more severe, both as a single symptom and as clusters of IBS-SSS and GSRS, in HS than LS patients. This finding was associated with impaired small intestinal permeability and increased faecal zonulin levels. Besides, HS patients showed significantly higher IL-8 and lowered IL-10 concentrations than LS patients. Lastly, circulating LPS levels and the urinary concentrations of indole were higher in HS than LS ones, suggesting a more pronounced imbalance of the small intestine in the former patients. Conclusions IBS is a multifactorial disorder needing complete clinical, psychological, and biochemical evaluations. Trial registration: https://clinicaltrials.gov/ct2/show/NCT03423069.

scholarly journals Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

2021 ◽  
Vol 11 (1) ◽  
pp. 35
Author(s):  
Zahra A. Barandouzi ◽  
Joochul Lee ◽  
Kendra Maas ◽  
Angela R. Starkweather ◽  
Xiaomei S. Cong
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Alpha Diversity ◽  
Diversity Indices ◽  
Cross Sectional Study ◽  
Caffeine Intake ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Food Components ◽  
Irritable Bowel

The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.

scholarly journals Irritable Bowel Syndrome Among University Students in Jordan

2019 ◽  
Author(s):  
Amjad Al-Shdaifat ◽  
Anwar Al-Kassar ◽  
Asgeir Johannessen ◽  
Zaid Al-Dabbagh ◽  
Mohamed Al-Ethawi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
University Students ◽  
Multivariable Analysis ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Rome Iii Criteria ◽  
Cross Sectional ◽  
Rome Iii ◽  
Irritable Bowel ◽  
Hashemite University

Abstract Background Irritable bowel syndrome (IBS) is one of the commonest diagnosed gastrointestinal disorders (GI) in primary care and gastroenterology practices. This study aimed to explore the prevalence of IBS, and identify associated factors, among university students in Jordan. Methods A cross-sectional study was conducted among students at the Hashemite University in Jordan. A validated, confidential, self-administered data collection questionnaire was used for the collection of personal and sociodemographic data, and the Rome III criteria were used to define IBS. Logistic regression analysis was done to identify factors associated with IBS. Results A total of 198 students participated in the study, of whom 163 had complete data and could be assessed by the Rome III criteria. The age range of the students was 18 to 35 years, and 91 (55.8%) were women. Overall, 26 (16.0%) of the respondents were diagnosed with IBS. Poor sleep (Adjusted Odds Ratio [AOR] 3.9; 95% confidence interval [CI] 1.5-10.4; p<0.01), being married (AOR 7.6; 95% CI 2.0-28.8; p<0.01) and a family history of IBS (AOR 2.9; 95% CI 1.1-7.7; p=0.03) were independently associated with IBS in multivariable analysis. Conclusion IBS was common among otherwise healthy university student in Jordan. Lifestyle factors such as poor sleep appeared to be associated with IBS symptoms.

scholarly journals Predictive value of alarm symptoms in Rome IV irritable bowel syndrome: A multicenter cross-sectional study

2022 ◽  
Vol 10 (2) ◽  
pp. 563-575
Author(s):  
Qian Yang ◽  
Zhong-Cao Wei ◽  
Na Liu ◽  
Yang-Lin Pan ◽  
Xiao-Sa Jiang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Predictive Value ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Irritable Bowel ◽  
Rome Iv

scholarly journals Prevalence of Organic Colonic Lesions by Colonoscopy in Patients Fulfilling ROME IV Criteria of Irritable Bowel Syndrome

2018 ◽  
Vol 56 (209) ◽  
pp. 487-492 ◽  
Author(s):  
Mukesh Sharma Paudel ◽  
Amrendra Kumar Mandal ◽  
Barun Shrestha ◽  
Nandu Silwal Poudyal ◽  
Sudhamshu KC ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Histopathological Examination ◽  
Malignant Lesion ◽  
Recurrent Abdominal Pain ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Irritable Bowel ◽  
Histopathology Examination ◽  
Rome Iv ◽  
Organic Lesions

Introduction: Irritable bowel syndrome occurs as recurrent abdominal pain that is related to defecation and associated with change in frequency and/or form of stool. Few Patients with IBS may have organic lesions detectable at colonoscopy. Methods: A cross sectional study was carried out in 140 consecutive patients of IBS fulfilling the ROME IV criteria. The study was conducted in Gastroenterology unit, Department of Medicine, Bir hospital, Kathmandu from July 2016 to September 2017. All patients underwent full colonoscopy along with biopsy from sigmoid colon and any visibly abnormal areas. Results: The average age of patients was 37.5 years with 76 (52.8%) males. Forty-two (30%) had IBS-D, 36 (26%) had IBS-C, 31 (22%) had IBS-M and 31 (22%) had IBS-U. Dyspepsia was seen in 16 (11.4%) and fear of TB/Malignancy/IBD was seen in 27 (19.2%). Organic lesions were seen in 39 (27.85%) patients. Nonspecific colitis was seen in 10 (7.1%) followed by ileal erosions in 7 (5%), polyps in 8 (5.7%), hemorrhoids in 6 (4.2%) and diverticula in 3 (2.1%). Only one (0.71%) patient had microscopic colitis and one (0.71%) had malignant lesion seen at histopathological examination. Females with IBS-D had more organic findings than males (P=0.03, RR=4.13, 95% CI=1.21-15.71). Conclusions: The prevalence of organic lesions in patients with IBS fulfilling ROME IV criteria is 27%. Dyspepsia is the most common comorbidity and fear of TB/malignancy/IBD is the most common reason for seeking health care. Females with IBS-D have a higher risk of detecting organic lesions by colonoscopy and histopathology examination.

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