scholarly journals Genetic factors controlling the proliferative activity of mouse epidermal melanocytes during the healing of skin wounds.

Genetics ◽  
1988 ◽  
Vol 120 (2) ◽  
pp. 551-558
Author(s):  
T Hirobe
Keyword(s):  
Proliferative Activity ◽  
Genetic Basis ◽  
Genetic Factors ◽  
Skin Wounds ◽  
Wound Edge ◽  
Newborn Mice ◽  
Healing Of Skin Wounds ◽  
The Difference ◽  
F2 Generation ◽  
F1 Generation

Abstract A cut was made on the middorsal skin of newborn mice of strains C57BL/10J, C57BL/10J-A/A, and C3H/He using fine iridectomy scissors. In the epidermis within 1 mm of the wound edge in C57BL/10J and C57BL/10J-A/A, the melanocyte population positive to the dopa reaction as well as the melanoblast-melanocyte population positive to the combined dopa-premelanin reaction increased dramatically until the 3rd day, then gradually decreased. In contrast, the melanocyte population of C3H/He did not increase after wounding, despite that the melanoblast-melanocyte population increased. Pigment-producing melanocytes in mitosis were frequently found in C57BL/10J and C57BL/10J-A/A, but not in C3H/He. The F1, F2, and backcross matings were performed to get some information about the genetic basis of the difference between C57BL/10J and C3H/He. In the F1 generation the offspring from reciprocal crosses exhibited intermediate values in both populations on the 3rd day after wounding. The F2 generation included the C3H/He type, F1 type, and C57BL/10J type in a ratio of 1:2:1 in both populations. Moreover, both reciprocal backcrosses gave 1:1 ratios of parent type to F1 type in both populations. These results indicate that the proliferative activity of mouse epidermal melanocytes during the healing of skin wounds are controlled by semidominant genes.

Shell and Seed Size Relationships in Peanuts1

1981 ◽  
Vol 8 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Ignacio J. de Godoy ◽  
A. J. Norden
Keyword(s):  
Seed Size ◽  
Plant Density ◽  
Wide Distribution ◽  
Seed Length ◽  
Arachis Hypogaea L ◽  
Length Width ◽  
Pericarp Color ◽  
The Difference ◽  
F2 Generation ◽  
F1 Generation

Abstract Three crosses and their reciprocals between peanut (Arachis hypogaea L.) genotypes differing in pod and seed sizes were made to investigate relationships between the pericarp (shell) and seed. Length, width, and weight of the fruit and seed from the F1 generation and selfed parentals were compared. The F2 generation along with plants from the parental lines were grown in the field. The weight, width, and volume of dried fruits and seeds, as well as shell thickness, were obtained from samples of 30 visually mature pods from each plant. Density of fruits and seeds, internal pericarp color, and shelling percentage were also recorded. Length, width, and weight of the F1 seeds tended to be similar to the selfed seeds from the same plants, showing possible maternal influence. The wide distribution in fruit volume obtained among F2 plants is indicative of quantitative inheritance. The larger the difference in fruit and seed size between the parents, the more pronounced was the skewness of the size distributions of the progeny toward the smaller parent. Estimates of pheno-typic correlations for fruit and seed volume were high and positive in most cases. However, fruit density vs fruit volume correlations were essentially negative suggesting that seeds grown inside pods with genetically smaller cavities may be compacted by the shell.

scholarly journals The variability of song variability in zebra finch ( Taeniopygia guttata ) populations

2019 ◽  
Vol 6 (5) ◽  
pp. 190273
Author(s):  
Allison L. Lansverk ◽  
Katie M. Schroeder ◽  
Sarah E. London ◽  
Simon C. Griffith ◽  
David F. Clayton ◽  
...  
Keyword(s):  
Zebra Finch ◽  
Social Behaviour ◽  
Early Life ◽  
Genetic Basis ◽  
Genetic Factors ◽  
Individual Recognition ◽  
Population Level ◽  
Taeniopygia Guttata ◽  
Major Goal ◽  
The Difference

Birdsong is a classic example of a learned social behaviour. Song behaviour is also influenced by genetic factors, and understanding the relative contributions of genetic and environmental influences remains a major goal. In this study, we take advantage of captive zebra finch populations to examine variation in a population-level song trait: song variability. Song variability is of particular interest in the context of individual recognition and in terms of the neuro-developmental mechanisms that generate song novelty. We find that the Australian zebra finch Taeniopygia guttata castanotis ( TGC ) maintains higher song diversity than the Timor zebra finch T. g. guttata ( TGG ) even after experimentally controlling for early life song exposure, suggesting a genetic basis to this trait. Although wild-derived TGC were intermediate in song variability between domesticated TGC populations and TGG , the difference between domesticated and wild TGC was not statistically significant. The observed variation in song behaviour among zebra finch populations represents a largely untapped opportunity for exploring the mechanisms of social behaviour.

scholarly journals Inheritance of rice cold tolerance at the seedling stage

2010 ◽  
Vol 67 (6) ◽  
pp. 669-674 ◽  
Author(s):  
Renata Pereira da Cruz ◽  
Ismael Tiago de Lima Duarte ◽  
Caroline Cabreira
Keyword(s):  
Cold Tolerance ◽  
Genetic Basis ◽  
Oryza Sativa L ◽  
Diallel Analysis ◽  
Cold Tolerant ◽  
Oligogenic Inheritance ◽  
Selection For ◽  
F2 Generation ◽  
F1 Generation ◽  
Desirable Trait

Rice (Oryza sativa L.) cold tolerance at the initial stages of development is a highly desirable trait to be incorporated into the state of Rio Grande do Sul, Brazil, cultivars, but selection for this trait must be performed under controlled temperature conditions, which limits the number of lines that can be evaluated. Knowledge of the inheritance of this trait is important to define breeding strategies. So the aim of this paper was to study the genetic basis of rice cold tolerance at the vegetative stage. Six genotypes with constrasting cold tolerance reactions were crossed in a diallel scheme without the reciprocals. The parents and the F1 and F2 generations were cultivated in a greenhouse until the V4 stage, when they were submitted to 10°C for ten days and evaluated for plant survival after seven days of recovery under normal temperature. The results obtained by the diallel analysis of the F1 generation indicated significance of both additive and non-additive effects, but the general combining ability was more important. The evaluation of the F2 generation revealed oligogenic inheritance with one or two dominant alleles responsible for cold tolerance in the cold tolerant parents and two complementary genes with recessive alleles segregating in the crosses involving sensitive and intermediate genotypes.

scholarly journals Editorial for Special Issue “Genetic Basis and Epidemiology of Myopathies”

2021 ◽  
Vol 22 (4) ◽  
pp. 2152
Author(s):  
Eleni Peristeri ◽  
Efthimios Dardiotis
Keyword(s):  
Genetic Basis ◽  
Genetic Factors ◽  
Special Issue ◽  
Relevant Research ◽  
Future Studies

We are pleased to announce a Special Issue on the Genetic Basis and Epidemiology of Myopathies. This Special Issue is collecting papers pertaining to various lines of research focusing on the genetic basis and the epidemiology of myopathies. The Guest Editors’ note combines the contributing authors’ reviews and findings of relevant research, and we hope that future studies on myopathies will attempt to confirm these findings and, additionally, evaluate supplementary phenotypic and histological expressions of myopathies, as well as genetic factors in their pathogenesis.

Anisotropic Biomimetic Silk Scaffolds for Improved Cell Migration and Healing of Skin Wounds

2018 ◽  
Vol 10 (51) ◽  
pp. 44314-44323 ◽  
Author(s):  
Guozhong Lu ◽  
ZhaoZhao Ding ◽  
Yuanyuan Wei ◽  
Xiaohong Lu ◽  
Qiang Lu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Skin Wounds ◽  
Healing Of Skin Wounds ◽  
Silk Scaffolds

scholarly journals Association between family history and the onset age of essential hypertension in Han population in Shanghai China

2019 ◽  
Author(s):  
li anle ◽  
Qian Peng ◽  
Yue Qin Shao ◽  
Yi Ying Zhang ◽  
Fang Xiang
Keyword(s):  
Essential Hypertension ◽  
Family History ◽  
Genetic Factors ◽  
Nuclear Family ◽  
Age Of Onset ◽  
Control Group ◽  
Case Group ◽  
Onset Age ◽  
Han Population ◽  
The Difference

Abstract Importance Genetic factors are important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. Objective To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. Methods According to l:l matched pairs design，342 precursor of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. Results The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Conclusion Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.

scholarly journals Genetic causes of reproductive problems in the Bosnian women population

2018 ◽  
Vol 9 (5) ◽  
pp. 12-16
Author(s):  
Mirela Mackic-Djurovic ◽  
Dunja Rukavina ◽  
Lejla Ahmetas
Keyword(s):  
Chromosomal Aberrations ◽  
Genetic Factors ◽  
Chromosomal Abnormalities ◽  
Population Sample ◽  
Medical Sciences ◽  
Abnormal Karyotype ◽  
Female Population ◽  
Reproductive Disorder ◽  
The Difference ◽  
Bosnian Women

Background: The causes of infertility and recurrent spontaneous abortions are diverse and numerous – including non-genetic and genetic factors – whereby the importance of genetic factors in pathogenesis of infertility is becoming more and more common. Chromosomal abnormalities and genetic defects can cause reproduction failures, and for this reason genetic analysis can play an important role in reproductive problems research.Aims and Objective: This study aims to determine the type and frequency of chromosomalaberrations in the female population sample, as well as to determine if the difference between groups with and without chromosomal aberrations was statistically significant.Materials and Methods: One hundred women aged 15-46 were included in the study, allhaving different reproductive disorder diagnoses and requiring karyotype analysis in the Sarajevo Medical Faculty Genetic Center. Cytogenetic analysis was performed on the peripheral blood, which was cultured for four days, using GTG banding forchromosomalanalysis.Results: Out of 100 women included in the study, an abnormal karyotype was found in 16 of them (16%). The difference between the frequency of normal and abnormal karyotype in women with reproductive problems identified in this study was found to be statistically significant. The pattern of chromosomal aberrations was similar to that reported in the previous cytogenetic studies with similar inclusion criteria.Conclusion: This fact should be taken in the consideration in order to estimate true etiology of reproductive problems and it is a valuable information in the process of genetic counseling and decision making in assisted reproductive technology.Asian Journal of Medical Sciences Vol.9(5) 2018 12-16

Maternal food restriction in rats of the F0 generation increases retroperitoneal fat, the number and size of adipocytes and induces periventricular astrogliosis in female F1 and male F2 generations

2017 ◽  
Vol 29 (7) ◽  
pp. 1340 ◽  
Author(s):  
A. O. Joaquim ◽  
C. P. Coelho ◽  
P. Dias Motta ◽  
L. F. Felício ◽  
E. F. Bondan ◽  
...  
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Food Restriction ◽  
Bodyweight Gain ◽  
Male Offspring ◽  
Acidic Protein ◽  
Female Rats ◽  
Juvenile Period ◽  
Gfap Expression ◽  
F2 Generation ◽  
F1 Generation

The present study investigated whether male offspring (F2 generation) from female rats (F1 generation) whose mothers (F0 generation) were food restricted during gestation inherit a phenotypic transgenerational tendency towards being overweight and obese in the juvenile period, in the absence of food restriction in the F1/F2 generations. Dams of the F0 generation were 40% food restricted during pregnancy. Bodyweight, the number and size of larger and small hypodermal adipocytes (HAs), total retroperitoneal fat (RPF) weight and the expression of glial fibrillary acidic protein (GFAP) in periventricular hypothalamic astrocytes (PHAs), as determined by immunohistochemistry, were evaluated in both generations. In the female F1 generation, there was low bodyweight gain only during the juvenile period (30–65 days of age), a decrease in the size of small adipocytes, an increase in the number of small adipocytes, an increase in RPF weight and an increase in GFAP expression in PHAs at 90–95 days of age. In males of the F2 generation at 50 days of age, there was increased bodyweight and RPF weight, and a small number of adipocytes and GFAP expression in PHAs. These data indicate that the phenotypic transgenerational tendency towards being overweight and obese was observed in females (F1) from mothers (F0) that were prenatally food restricted was transmitted to their male offspring.

scholarly journals Selection responses for egg production of Fayoumi and Rhode Island Red breeds

2016 ◽  
Vol 19 (1-2) ◽  
pp. 66-73
Author(s):  
ME Haque ◽  
GK Deb ◽  
MN Hasan ◽  
MH Ali
Keyword(s):  
Rhode Island ◽  
Genetic Gain ◽  
Egg Production ◽  
Management Practices ◽  
Selection Responses ◽  
Lower Productivity ◽  
Significant Difference ◽  
F2 Generation ◽  
Foundation Stock ◽  
F1 Generation

This experiment estimated the selection responses for egg production of Fayoumi (Fay) and Rhode Island Red (RIR) breeds. A total of 3000; belonging Fay 2000 & RIR 1000 day old chicks were collected from Egypt and Bangladesh Livestock Research Institute (BLRI), Savar, Dhaka respectively, considered as foundation stock. The chicks were brooded for 5 weeks and reared up to 14 weeks of age providing standard feeding and management. After brooding, 640 Fay and 504 RIR pullets were reared in 40 and 36 individual pens respectively, considering as a family. Finally, 30 and 24 best families of Fay and RIR respectively were selected with 420 Fay and 288 RIR pullets at 15 weeks of age, on the basis of age at 1st egg lay, egg production and fertility. Salmonella and mycoplasma free eggs were collected on the basis of blood test (agglutinate test) from the selected families of both the breeds and hatched out for next generation. The experiment was continued up to 40 weeks of age for each generation. The study revealed that hen day egg production of Fay and RIR was higher in Foundation stock (64.39% in Fay and 68.54% in RIR) than that of F1 generation (58.6% in Fay and 46.8% in RIR) but no significant difference (P > 0.05) was observed for livability between Foundation stock and F1 generation. Reasons for lower productivity in F1 generation may be the poor management practices during growing period. In F2 generation, egg production was higher in both the breeds (64.09% in Fay and 62.05% in RIR) than in F1 generation. Egg production of RIR was not recorded for F3 generation, as their ability to adopt under farmers condition was very poor. However, in F3 generation, egg production of Fay was higher (65.82%) than in F2 generation. Genetic gain in Fay was 0.06%, 0.11% and 0.12% for F1, F2 and F3 generation, respectively. In case of RIR genetic gain was 0.07% in F1 and 0.18% in F2 generation. Due to selection slight genetic gain for egg production was obtained in Fay and RIR but further research with larger stock is needed for better understanding of selection responses of these breeds.Bangladesh J. of Livestock Res. 19(1-2): 66-73, Jan-Dec 2012

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