Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1.

Abstract The activity of the yeast transcriptional activator HAP1 is controlled by heme and the heme effect is mediated through the heme domain of HAP1. In this report, we show that HAP1 activity is significantly reduced in strains deleted of TUP1 or SSN6, and addition of a heme analog does not allow HAP1 to regain its full activity. Deletion of the heme domain alleviates the requirement for TUP1/SSN6. The results suggest that TUP1/SSN6 have a positive effect on the activity of HAP1 and this effect is mediated through the heme domain. Although TUP1/SSN6 generally repress transcription of many genes, our data indicate they may have positive effect on the expression of certain genes.

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Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.90.7.2851 ◽

1993 ◽

Vol 90 (7) ◽

pp. 2851-2855 ◽

Cited By ~ 24

Author(s):

L. Zhang ◽

O. Bermingham-McDonogh ◽

B. Turcotte ◽

L. Guarente

Keyword(s):

Dna Binding ◽

Transcriptional Activator ◽

Heme Domain

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Histone variant H2A.Z antagonizes the positive effect of the transcriptional activator CPC1 to regulate catalase-3 expression under normal and oxidative stress conditions

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2018.05.003 ◽

2018 ◽

Vol 121 ◽

pp. 136-148 ◽

Cited By ~ 7

Author(s):

Qing Dong ◽

Yajun Wang ◽

Shaohua Qi ◽

Kexin Gai ◽

Qun He ◽

...

Keyword(s):

Oxidative Stress ◽

Transcriptional Activator ◽

Histone Variant ◽

Stress Conditions ◽

Positive Effect ◽

And Oxidative Stress

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Vibrational Coherence Spectroscopy of the Heme Domain in the CO-Sensing Transcriptional Activator CooA

Journal of the American Chemical Society ◽

10.1021/ja206152m ◽

2011 ◽

Vol 133 (46) ◽

pp. 18816-18827 ◽

Cited By ~ 16

Author(s):

Venugopal Karunakaran ◽

Abdelkrim Benabbas ◽

Hwan Youn ◽

Paul M. Champion

Keyword(s):

Transcriptional Activator ◽

Vibrational Coherence ◽

Heme Domain ◽

Coherence Spectroscopy

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Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000440 ◽

2016 ◽

Vol 86 (3-4) ◽

pp. 127-151 ◽

Cited By ~ 3

Author(s):

Zeshan Ali ◽

Zhenbin Wang ◽

Rai Muhammad Amir ◽

Shoaib Younas ◽

Asif Wali ◽

...

Keyword(s):

Chemical Structure ◽

Review Paper ◽

Heart Diseases ◽

Folk Medicine ◽

Active Role ◽

Current Review ◽

Different Types ◽

Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

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Working Memory, Mental Prospection, Time Orientation, and Cognitive Insight

Journal of Individual Differences ◽

10.1027/1614-0001/a000111 ◽

2013 ◽

Vol 34 (3) ◽

pp. 159-169 ◽

Cited By ~ 4

Author(s):

Sevtap Cinan ◽

Aslı Doğan

Keyword(s):

Working Memory ◽

Structural Equation ◽

Factor Model ◽

Time Orientation ◽

Equation Modeling ◽

Cognitive Insight ◽

Confirmatory Factor ◽

Negative Effect ◽

Positive Effect ◽

Three Factor

This research is new in its attempt to take future time orientation, morningness orientation, and prospective memory as measures of mental prospection, and to examine a three-factor model that assumes working memory, mental prospection, and cognitive insight are independent but related higher-order cognitive constructs by using confirmatory factor analysis (CFA). The three-factor model produced a good fit to the data. An alternative one-factor model was tested and rejected. The results suggest that working memory and cognitive insight are distinguishable, related constructs, and that both are distinct from, but negatively associated with, mental prospection. In addition, structural equation modeling (SEM) showed that working memory had a strong positive effect on cognitive insight and a moderate negative effect on mental prospection.

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Employees’ Critical Thinking, Leaders’ Inspirational Motivation, and Voice Behavior

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000193 ◽

2018 ◽

Vol 17 (1) ◽

pp. 33-41 ◽

Cited By ~ 4

Author(s):

Jing Jiang ◽

Ang Gao ◽

Baiyin Yang

Keyword(s):

Critical Thinking ◽

Field Study ◽

Voice Behavior ◽

Research And Practice ◽

Inspirational Motivation ◽

Positive Effect

Abstract. This study uses implicit voice theory to examine the influence of employees’ critical thinking and leaders’ inspirational motivation on employees’ voice behavior via voice efficacy. The results of a pretest of 302 employees using critical thinking questionnaires and a field study of 273 dyads of supervisors and their subordinates revealed that both employees’ critical thinking and leaders’ inspirational motivation had a positive effect on employees’ voice and that voice efficacy mediates the relationships among employees’ critical thinking, leaders’ inspirational motivation, and employees’ voice. Implications for research and practice are discussed.

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