scholarly journals SELECTION BY FERTILITY IN DROSOPHILA PSEUDOOBSCURA

Genetics ◽  
1974 ◽  
Vol 77 (3) ◽  
pp. 559-564
Author(s):  
Wyatt W Anderson ◽  
Takao K Watanabe
Keyword(s):  
Balancing Selection ◽  
Low Frequency ◽  
Chromosomal Polymorphism ◽  
Intermediate Frequency ◽  
Male Mating ◽  
Female Fecundity ◽  
Differential Fertility ◽  
High Frequencies ◽  
Differential Viability ◽  
Males And Females

ABSTRACT Fertility, the component of selection due to female fecundity and male mating success, differed significantly among the ST/ST, ST/AR, and AR/AR karyotypes in experimental populations and varied with karyotypic frequency. In relation to ST/AR, ST/ST females and males had higher fertilities at low frequency; AR/AR males and females were at a significant fertility disadvantage at intermediate frequency, while at low and at high frequencies their fertilities matched or exceeded that of the heterokaryotype. These fertility differences were comparable in size to viability differences previously reported for D. pseudoobscura karyotypes. Differential fertility seems likely to be an important element, perhaps just as important as differential viability, in the balancing selection that maintains the chromosomal polymorphism in this species.

scholarly journals An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components

2017 ◽  
Author(s):  
Nathaniel P. Sharp ◽  
Aneil F. Agrawal
Keyword(s):  
Genetic Variance ◽  
Balancing Selection ◽  
Statistical Tests ◽  
Balance Model ◽  
Male Mating ◽  
Deleterious Mutations ◽  
Fitness Component ◽  
Fitness Components ◽  
Female Fecundity ◽  
Mutational Variance

ABSTRACTDespite decades of research, the factors that maintain genetic variation for fitness are poorly understood. Mutation selection balance will always contribute to standing variance, but it is unclear what fraction of the variance in a typical fitness component can be explained by mutation-selection balance and whether fitness components differ in this respect. In theory, the level of standing variance in fitness due to mutation-selection balance can be predicted using the rate of fitness decline under mutation accumulation, and this prediction can be directly compared to the actual standing variance observed. This approach allows for controlled statistical tests of the sufficiency of the mutation-selection balance model, and could be used to identify traits or populations where genetic variance is maintained by factors beyond mutation-selection balance. For example, some traits may be influenced by sexually antagonistic balancing selection, resulting in an excess of standing variance beyond that generated by deleterious mutations. To encourage the application of this approach, we describe the underlying theory and use it to test the mutation selection balance model for three traits in Drosophila melanogaster. We find some evidence for non-mutational variance in male mating success and female fecundity relative to larval viability, which is consistent with balancing selection on sexual fitness components. Finally, we discuss the theoretical and practical limitations to this approach, and discuss how to apply it successfully.

scholarly journals Selection responses of means and inbreeding depression for female fecundity in Drosophila melanogaster suggest contributions from intermediate-frequency alleles to quantitative trait variation

2007 ◽  
Vol 89 (2) ◽  
pp. 85-91 ◽  
Author(s):  
BRIAN CHARLESWORTH ◽  
TAKAHIRO MIYO ◽  
HELEN BORTHWICK
Keyword(s):  
Drosophila Melanogaster ◽  
Inbreeding Depression ◽  
Quantitative Trait ◽  
Balancing Selection ◽  
Evolutionary Genetics ◽  
Intermediate Frequency ◽  
Female Fecundity ◽  
Deleterious Alleles ◽  
The Mean ◽  
Change In Mean

SummaryThe extent to which quantitative trait variability is caused by rare alleles maintained by mutation, versus intermediate-frequency alleles maintained by balancing selection, is an unsolved problem of evolutionary genetics. We describe the results of an experiment to examine the effects of selection on the mean and extent of inbreeding depression for early female fecundity in Drosophila melanogaster. Theory predicts that rare, partially recessive deleterious alleles should cause a much larger change in the effect of inbreeding than in the mean of the outbred population, with the change in inbreeding effect having an opposite sign to the change in mean. The present experiment fails to support this prediction, suggesting that intermediate-frequency alleles contribute substantially to genetic variation in early fecundity.

scholarly journals An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components

2018 ◽  
Vol 285 (1890) ◽  
pp. 20181864 ◽  
Author(s):  
Nathaniel P. Sharp ◽  
Aneil F. Agrawal
Keyword(s):  
Genetic Variance ◽  
Balancing Selection ◽  
Statistical Tests ◽  
Balance Model ◽  
Male Mating ◽  
Male Mating Success ◽  
Deleterious Mutations ◽  
Fitness Component ◽  
Fitness Components ◽  
Female Fecundity

Despite decades of research, the factors that maintain genetic variation for fitness are poorly understood. It is unclear what fraction of the variance in a typical fitness component can be explained by mutation-selection balance (MSB) and whether fitness components differ in this respect. In theory, the level of standing variance in fitness due to MSB can be predicted using the rate of fitness decline under mutation accumulation, and this prediction can be directly compared to the standing variance observed. This approach allows for controlled statistical tests of the sufficiency of the MSB model, and could be used to identify traits or populations where genetic variance is maintained by other factors. For example, some traits may be influenced by sexually antagonistic balancing selection, resulting in an excess of standing variance beyond that generated by deleterious mutations. We describe the underlying theory and use it to test the MSB model for three traits in Drosophila melanogaster . We find evidence for differences among traits, with MSB being sufficient to explain genetic variance in larval viability but not male mating success or female fecundity. Our results are consistent with balancing selection on sexual fitness components, and demonstrate the feasibility of rigorous statistical tests of the MSB model.

Pre-Stall Waves: Precursors to Stall Inception in a Contra-Rotating Axial Fan

2020 ◽  
Author(s):  
Manas Madasseri Payyappalli ◽  
A. M. Pradeep
Keyword(s):  
Low Frequency ◽  
Intermediate Frequency ◽  
Axial Fan ◽  
Frequency Spectra ◽  
Low Frequencies ◽  
Stall Inception ◽  
High Frequencies ◽  
Inflow Condition ◽  
Design Speed ◽  
High Frequency Waves

Abstract Stall in a compressor or a fan is often associated with pre-stall waves, that could act as precursors. The present study aims to understand in detail the pre-stall waves leading to instabilities in a low aspect ratio, low hub-tip ratio contra-rotating axial fan. Apart from a clean inflow condition, experiments on the contra-rotating fan are also carried out for two radial distortion conditions, namely, hub-radial and tip-radial distortions, and three circumferential distortion conditions, namely, simple-circumferential, hub-complex-circumferential and tip-complex-circumferential distortions. The results primarily concluded that operating rotor-2 at a speed higher than the design speed could possibly suppress the pre-stall disturbances. Towards the fully developed stall, the waves that are associated with low frequencies speed up and thus these waves become intermediate frequency waves. The fluid phenomena that trigger the stall are associated with high frequencies and these subsequently stretch to low frequencies at the onset of fully developed stall. The low-frequency waves and high frequency waves compromise to reach an intermediate frequency range during the fully developed stall. Further, it is observed that disturbances associated with low frequencies as well as high frequencies co-exist during the fully developed stall regime. There is also a region in the frequency spectra where no disturbances are excited and this region appears to be a “no excitation zone”. This paper thus concludes that there possibly exists a mechanism through which the energy is transferred between different frequencies during the pre-stall and fully developed stall regimes.

scholarly journals Fitness of allozyme variants in Drosophila pseudoobscura: II. Selection at the Est-5, Odh and Mdh-2 loci

1974 ◽  
Vol 24 (2) ◽  
pp. 137-149 ◽  
Author(s):  
Dragoslav Marinković ◽  
Francisco J. Ayala
Keyword(s):  
Allelic Variation ◽  
Balancing Selection ◽  
Natural Populations ◽  
Superior Performance ◽  
Adult Survival ◽  
Drosophila Pseudoobscura ◽  
Male Mating ◽  
Female Fecundity ◽  
Single Genotype ◽  
Fitness Parameters

SUMMARYWe have studied the effects on fitness of allelic variation at three gene loci (Est-5, Odh, and Mdh-2)coding for enzymes in Drosophila pseudoobscura. Genotype has a significant effect on fitness for all six parameters measured (female fecundity, male mating capacity, egg-to-adult survival under near-optimal and under competitive conditions, and rate of development under near-optimal and under competitive conditions). No single genotype is best for all six fitness parameters; rather, genotypes with superior performance during a certain stage of the life-cycle may have low fitness at some other stage, or in different environmental conditions. Heterozygotes are sometimes best when all fitness parameters are considered. There are significant interactions between loci. The various forms of balancing selection uncovered in our experiments may account for the polymorphisms occurring in natural populations of D. pseudoobscura at the three loci studied.

The Effects of the sphragis on male and female genitalia in Acraea (Nymphalidae) butterflies

2020 ◽  
Vol 22 ◽  
Author(s):  
Shannon L Summers ◽  
Akito Y Kawahara ◽  
Ana P. S. Carvalho
Keyword(s):  
Interspecific Variation ◽  
Sperm Storage ◽  
Male Mating ◽  
Museum Collections ◽  
Storage Organ ◽  
Mating Plug ◽  
Males And Females ◽  
Comparison And Analysis ◽  
Imagej Software ◽  
Sexually Antagonistic Coevolution

Male mating plugs have been used in many species to prevent female re-mating and sperm competition. One of the most extreme examples of a mating plug is the sphragis, which is a large, complex and externalized plug found only in butterflies. This structure is found in many species in the genus Acraea (Nymphalidae) and provides an opportunity for investigation of the effects of the sphragis on the morphology of the genitalia, which is poorly understood. This study aims to understand morphological interspecific variation in the genitalia of Acraea butterflies. Using specimens from museum collections, abdomen dissections were conducted on 19 species of Acraea: 9 sphragis bearing and 10 non-sphragis bearing species. Genitalia imaging was performed for easier comparison and analysis and measurements of genitalia structures was done using ImageJ software. Some distinguishing morphological features in the females were found. The most obvious difference is the larger and more externalized copulatory opening in sphragis bearing species, with varying degrees of external projections. Females of the sphragis bearing species also tend to have a shorter ductus (the structure that connects the copulatory opening with the sperm storage organ) than those without the sphragis. These differences may be due to a sexually antagonistic coevolution between the males and females, where the females evolve larger and more difficult to plug copulatory openings and the males attempt to prevent re-mating with the sphragis.

scholarly journals Rheology of rounded mammalian cells over continuous high-frequencies

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Gotthold Fläschner ◽  
Cosmin I. Roman ◽  
Nico Strohmeyer ◽  
David Martinez-Martin ◽  
Daniel J. Müller
Keyword(s):  
High Frequency ◽  
Mammalian Cells ◽  
Mechanical Response ◽  
Cell Mass ◽  
Low Frequency ◽  
Mass Measurements ◽  
High Frequencies ◽  
Polymer Relaxation ◽  
Continuous Frequency ◽  
Rheological Experiments

AbstractUnderstanding the viscoelastic properties of living cells and their relation to cell state and morphology remains challenging. Low-frequency mechanical perturbations have contributed considerably to the understanding, yet higher frequencies promise to elucidate the link between cellular and molecular properties, such as polymer relaxation and monomer reaction kinetics. Here, we introduce an assay, that uses an actuated microcantilever to confine a single, rounded cell on a second microcantilever, which measures the cell mechanical response across a continuous frequency range ≈ 1–40 kHz. Cell mass measurements and optical microscopy are co-implemented. The fast, high-frequency measurements are applied to rheologically monitor cellular stiffening. We find that the rheology of rounded HeLa cells obeys a cytoskeleton-dependent power-law, similar to spread cells. Cell size and viscoelasticity are uncorrelated, which contrasts an assumption based on the Laplace law. Together with the presented theory of mechanical de-embedding, our assay is generally applicable to other rheological experiments.

scholarly journals Nucleotide Variation at theCHALCONE ISOMERASELocus inArabidopsis thaliana

Genetics ◽  
2000 ◽  
Vol 155 (2) ◽  
pp. 863-872 ◽  
Author(s):  
Helmi Kuittinen ◽  
Montserrat Aguadé
Keyword(s):  
Nucleotide Diversity ◽  
Direct Relationship ◽  
Selective Sweep ◽  
Balancing Selection ◽  
Neutral Theory ◽  
Low Frequency ◽  
The Other ◽  
Nucleotide Variation ◽  
Rapid Population Growth ◽  
History Of

AbstractAn ~1.9-kb region encompassing the CHI gene, which encodes chalcone isomerase, was sequenced in 24 worldwide ecotypes of Arabidopsis thaliana (L.) Heynh. and in 1 ecotype of A. lyrata ssp. petraea. There was no evidence for dimorphism at the CHI region. A minimum of three recombination events was inferred in the history of the sampled ecotypes of the highly selfing A. thaliana. The estimated nucleotide diversity (θTOTAL = 0.004, θSIL = 0.005) was on the lower part of the range of the corresponding estimates for other gene regions. The skewness of the frequency spectrum toward an excess of low-frequency polymorphisms, together with the bell-shaped distribution of pairwise nucleotide differences at CHI, suggests that A. thaliana has recently experienced a rapid population growth. Although this pattern could also be explained by a recent selective sweep at the studied region, results from the other studied loci and from an AFLP survey seem to support the expansion hypothesis. Comparison of silent polymorphism and divergence at the CHI region and at the Adh1 and ChiA revealed in some cases a significant deviation of the direct relationship predicted by the neutral theory, which would be compatible with balancing selection acting at the latter regions.

scholarly journals Extended High Frequencies Provide Both Spectral and Temporal Information to Improve Speech-in-Speech Recognition

2020 ◽  
Vol 24 ◽  
pp. 233121652098029
Author(s):  
Allison Trine ◽  
Brian B. Monson
Keyword(s):  
Speech Recognition ◽  
Pure Tone ◽  
Recognition Performance ◽  
Low Frequency ◽  
Exploratory Analysis ◽  
Temporal Information ◽  
Significant Benefit ◽  
Head Orientation ◽  
Spectral Structure ◽  
High Frequencies

Several studies have demonstrated that extended high frequencies (EHFs; >8 kHz) in speech are not only audible but also have some utility for speech recognition, including for speech-in-speech recognition when maskers are facing away from the listener. However, the contribution of EHF spectral versus temporal information to speech recognition is unknown. Here, we show that access to EHF temporal information improved speech-in-speech recognition relative to speech bandlimited at 8 kHz but that additional access to EHF spectral detail provided an additional small but significant benefit. Results suggest that both EHF spectral structure and the temporal envelope contribute to the observed EHF benefit. Speech recognition performance was quite sensitive to masker head orientation, with a rotation of only 15° providing a highly significant benefit. An exploratory analysis indicated that pure-tone thresholds at EHFs are better predictors of speech recognition performance than low-frequency pure-tone thresholds.

scholarly journals The challenging SED of AP Librae

2011 ◽  
Vol 7 (S284) ◽  
pp. 411-413 ◽  
Author(s):  
David Sanchez ◽  
Berrie Giebels ◽  
Pascal Fortin ◽  
Keyword(s):  
Spectral Energy Distribution ◽  
Broad Band ◽  
Low Frequency ◽  
Theoretical Models ◽  
Intermediate Frequency ◽  
High Energy ◽  
Spectral Energy ◽  
Broad Band Emission ◽  
Band Emission ◽  
Bl Lac

AbstractMatching the broad-band emission of active galaxies with the predictions of theoretical models can be used to derive constraints on the properties of the emitting region and to probe the physical processes involved. AP Librae is the third low frequency peaked BL Lac (LBL) detected at very high energy (VHE, E>100GeV) by an Atmospheric Cherenkov Telescope; most VHE BL Lacs (34 out of 39) belong to the high-frequency and intermediate-frequency BL Lac classes (HBL and IBL). LBL objects tend to have a higher luminosity with lower peak frequencies than HBLs or IBLs. The characterization of their time-averaged spectral energy distribution is challenging for emission models such as synchrotron self-Compton (SSC) models.

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