THE DISTRIBUTION OF MUTANT ALLELES IN A SUBDIVIDED POPULATION

Genetics ◽  
1980 ◽  
Vol 95 (2) ◽  
pp. 503B-523B
Author(s):  
Montgomery Slatkin

ABSTRACT The results are presented from a simulation study of the spatial distribution of mutant alleles in a subdivided population. Statistical measures of the spatial pattern are defined in such a way that the same quantities could be measured in a geographic survey of allele frequencies in natural populations. Two types of quantities are discussed in this paper: (1)the occupancy distribution provides information on the presence or absence of the mutant in different numbers of demes; and (2) the conditional frequency distribution provides information about the extent of local differentiation when the mutant is present in different numbers of demes. Properties of these distributions are found for different types of natural selection acting on the mutant. Some results are presented for the same statistical measures based on samples of individuals from a fraction of the total number of demes. The simulation results for intermediate levels of the migration rates are compared with analytic results obtained on the limits of high and low migration rates. The main conclusion is that these measures of the spatial distribution of mutants in a subdivided population have simple properties that could provide a new perspective on data from natural populations.

Author(s):  
Mohammad Maleki ◽  
Kevin Soria

Beach litter is a worldwide problem that has several negative effects. A first step in preventing an environmental hazard is to determine and model the level of contamination. In this paper, geostatistical simulation is used to model two main forms of beach litter (cigarette butts and sharp items) in one of the most contaminated beaches in Antofagasta, Chile. A hundred realizations of cigarette butts and broken glass are generated to emulate their joint spatial distribution. The simulation results are used to classify the beach into different areas with respect to the risk of injury by broken glass and the level of contamination by cigarette butts. The models obtained can be used by local authorities in beach clean-up programs and by visitors to beaches in choosing the safest and cleanest areas. The results demonstrate the capability of geostatistical simulation algorithms to model different types of beach litter.


2012 ◽  
Vol 2309 (1) ◽  
pp. 114-126 ◽  
Author(s):  
Dhafer Marzougui ◽  
Cing-Dao (Steve) Kan ◽  
Kenneth S. Opiela

The National Crash Analysis Center (NCAC) at the George Washington University simulated the crash of a 2,270-kg Chevrolet Silverado pickup truck into a standard 32-in. New Jersey shape concrete barrier under the requirements of Test 3–11 of the Manual for Assessing Safety Hardware (MASH). The new, detailed finite element (FE) model for the Chevrolet Silverado was used as the surrogate for the MASH 2270P test vehicle. An FE model of the New Jersey barrier was drawn from the array of NCAC hardware models. The primary objective of this analysis was to simulate the crash test conducted to evaluate how this commonly used, NCHRP 350–approved device would perform under the more rigorous MASH crashworthiness criteria. A secondary objective was to use newly developed verification and validation (V&V) procedures to compare the results of the detailed simulation with the results of crash tests undertaken as part of another project. The crash simulation was successfully executed with the detailed Silverado FE model and NCAC models of the New Jersey concrete barrier. Traditional comparisons of the simulation results and the data derived from the crash test suggested that the modeling provided viable results. Further comparisons employing the V&V procedures provided a structured assessment across multiple factors reflected in the phenomena importance ranking table. Statistical measures of the accuracy of the test in comparison with simulation results provided a more robust validation than previous approaches. These comparisons further confirmed that the model was able to replicate impacts with a 2270P vehicle, as required by MASH.


2018 ◽  
Vol 22 (8) ◽  
pp. 4425-4447 ◽  
Author(s):  
Manuel Antonetti ◽  
Massimiliano Zappa

Abstract. Both modellers and experimentalists agree that using expert knowledge can improve the realism of conceptual hydrological models. However, their use of expert knowledge differs for each step in the modelling procedure, which involves hydrologically mapping the dominant runoff processes (DRPs) occurring on a given catchment, parameterising these processes within a model, and allocating its parameters. Modellers generally use very simplified mapping approaches, applying their knowledge in constraining the model by defining parameter and process relational rules. In contrast, experimentalists usually prefer to invest all their detailed and qualitative knowledge about processes in obtaining as realistic spatial distribution of DRPs as possible, and in defining narrow value ranges for each model parameter.Runoff simulations are affected by equifinality and numerous other uncertainty sources, which challenge the assumption that the more expert knowledge is used, the better will be the results obtained. To test for the extent to which expert knowledge can improve simulation results under uncertainty, we therefore applied a total of 60 modelling chain combinations forced by five rainfall datasets of increasing accuracy to four nested catchments in the Swiss Pre-Alps. These datasets include hourly precipitation data from automatic stations interpolated with Thiessen polygons and with the inverse distance weighting (IDW) method, as well as different spatial aggregations of Combiprecip, a combination between ground measurements and radar quantitative estimations of precipitation. To map the spatial distribution of the DRPs, three mapping approaches with different levels of involvement of expert knowledge were used to derive so-called process maps. Finally, both a typical modellers' top-down set-up relying on parameter and process constraints and an experimentalists' set-up based on bottom-up thinking and on field expertise were implemented using a newly developed process-based runoff generation module (RGM-PRO). To quantify the uncertainty originating from forcing data, process maps, model parameterisation, and parameter allocation strategy, an analysis of variance (ANOVA) was performed.The simulation results showed that (i) the modelling chains based on the most complex process maps performed slightly better than those based on less expert knowledge; (ii) the bottom-up set-up performed better than the top-down one when simulating short-duration events, but similarly to the top-down set-up when simulating long-duration events; (iii) the differences in performance arising from the different forcing data were due to compensation effects; and (iv) the bottom-up set-up can help identify uncertainty sources, but is prone to overconfidence problems, whereas the top-down set-up seems to accommodate uncertainties in the input data best. Overall, modellers' and experimentalists' concept of model realism differ. This means that the level of detail a model should have to accurately reproduce the DRPs expected must be agreed in advance.


Author(s):  
Carla J. Harper ◽  
Jean Galtier ◽  
Thomas N. Taylor ◽  
Edith L. Taylor ◽  
Ronny Rößler ◽  
...  

ABSTRACTDocumented evidence of fungi associated with Mesozoic ferns is exceedingly rare. Three different types of fungal remains occur in a portion of a small, permineralised fern stem of uncertain systematic affinities from the Triassic of Germany. Exquisite preservation of all internal tissues made it possible to map the spatial distribution of the fungi in several longitudinal and transverse sections. Narrow, intracellular hyphae extend through the entire cortex, while wide hyphae are concentrated in the cortical intercellular system adjacent to the stele and leaf traces. Hyphal swellings occur in the phloem and adjacent cortex, while moniliform hyphae (or chains of conidia) are present exclusively in parenchyma adjacent to the stele. No host response is recognisable, but host tissue preservation suggests that the fern was alive during fungal colonisation. The highest concentration of fungal remains occurs close to the stele and leaf traces, suggesting that the fungi either utilised the vascular tissues as an infection/colonisation pathway or extracted nutrients from these tissues. This study presents the first depiction of fungal distribution throughout a larger portion of a fossil plant. Although distribution maps are useful tools in assessing fungal associations in relatively small, fossil plants, preparing similar maps for larger and more complex fossils would certainly be difficult and extremely arduous.


2020 ◽  
Author(s):  
Emma L. M. Lewington ◽  
Stephen J. Livingstone ◽  
Chris D. Clark ◽  
Andrew J. Sole ◽  
Robert D. Storrar

Abstract. We identify and map traces of subglacial meltwater drainage around the former Keewatin Ice Divide, Canada from ArcticDEM data. Meltwater tracks, tunnel valleys and esker splays exhibit several key similarities, including width, spacing, their association with eskers and transitions to and from different types, which together suggest they form part of an integrated drainage signature. We collectively term these features 'meltwater corridors' and propose a new model for their formation, based on observations from contemporary ice masses, of pressure fluctuations surrounding a central conduit. We suggest that eskers record the imprint of a central conduit and meltwater corridors the interaction with the surrounding distributed drainage system. The widespread aerial coverage of meltwater corridors (5–36 % of the bed) provides constraints on the extent of basal uncoupling induced by basal water pressure fluctuations and variations in spatial distribution and evolution of the subglacial drainage system, which will modulate the ice dynamic response.


Demography ◽  
2020 ◽  
Vol 57 (6) ◽  
pp. 2143-2167
Author(s):  
Ridhi Kashyap ◽  
Julia Behrman

AbstractSon preference has been linked to excess female under-5 mortality in India, and considerable literature has explored whether parents invest more resources in sons relative to daughters—which we refer to as explicit discrimination—leading to girls’ poorer health status and, consequently, higher mortality. However, this literature has not adequately controlled for the implicit discrimination processes that sort girls into different types of families (e.g., larger) and at earlier parities. To better address the endogeneity associated with implicit discrimination processes, we explore the association between child sex and postneonatal under-5 mortality using a sample of mixed-sex twins from four waves of the Indian National Family Health Survey. Mixed-sex twins provide a natural experiment that exogenously assigns a boy and a girl to families at the same time, thus controlling for selectivity into having an unwanted female child. We document a sizable impact of explicit discrimination on girls’ excess mortality in India, particularly compared with a placebo analysis in sub-Saharan Africa, where girls have a survival advantage. We also show that explicit discrimination weakened for birth cohorts after the mid-1990s, especially in northern India, but further weakening has stalled since the mid-2000s, thus contributing to understandings of how the micro-processes underlying the female mortality disadvantage have changed over time.


2019 ◽  
Vol 30 (08) ◽  
pp. 1950052
Author(s):  
Feng Hu ◽  
Jin-Li Guo ◽  
Fa-Xu Li ◽  
Hai-Xing Zhao

Hypernetworks are ubiquitous in real-world systems. They provide a powerful means of accurately depicting networks of different types of entity and will attract more attention from researchers in the future. Most previous hypernetwork research has been focused on the application and modeling of uniform hypernetworks, which are based on uniform hypergraphs. However, random hypernetworks are generally more common, therefore, it is useful to investigate the evolution mechanisms of random hypernetworks. In this paper, we construct three dynamic evolutional models of hypernetworks, namely the equal-probability random hypernetwork model, the Poisson-probability random hypernetwork model and the certain-probability random hypernetwork model. Furthermore, we analyze the hyperdegree distributions of the three models with mean-field theory, and we simulate each model numerically with different parameter values. The simulation results agree well with the results of our theoretical analysis, and the findings indicate that our models could help understand the structure and evolution mechanisms of real systems.


2020 ◽  
Vol 14 (3) ◽  
pp. 296-302
Author(s):  
Hans Thomas Maier ◽  
Oliver Schmiedbauer ◽  
Hubert Biedermann

Rising complexity in industrial asset and maintenance management due to more volatile business environments and megatrends like Industry 4.0 has led to the need for a new perspective on these management domains. The Lean Smart Maintenance (LSM) philosophy, which focuses on both the efficient (lean) and the learning (smart) organization was introduced during the past few years, and a corresponding maturity model (MM) has been developed to guide organizations on their way to asset and maintenance excellence. This paper discusses use cases, in which the usability and the generic aspect of the LSM MM are validated by using data from three different asset management assessment projects in organizations with different types of production. Research results show that the LSM MM can be used as a basis for management system improvement, independent of production types such as one-of-a-kind industry, mass production and continuous production.


2010 ◽  
Vol 19 (04) ◽  
pp. 535-541 ◽  
Author(s):  
FENGHUAN HAO ◽  
RUI WANG ◽  
JIA WANG

We demonstrate a design method of focusing-control device, which consists of single metallic nano-slit surrounded with the grooves at the metal exit surface. According to the principle of the constructive interference, the grooves are positioned to scatter the SPPs to the radiation lights with desired phases. The role of SPPs in the focusing control is investigated, by applying the design method in the four different types of metal film. The simulation results indicate that the focusing effects are dependant on the types of metal film, the metal film which supports the SPPs with a long propagation length can form an apparent focus spot, and the reason is discussed.


2018 ◽  
Vol 63 (1-2) ◽  
pp. 5-19
Author(s):  
Martina Ohlídalová ◽  
Karel Křenek ◽  
Jana Tvrzníková ◽  
Michal Pech ◽  
Radka Šefců

In 2017, the National Museum commemorated the bicentenary of the discovery of the Manuscript of Dvůr Králové and the Manuscript of Zelená Hora by further material research into both works and especially by an exhibition of their originals. The main aims of this research into the manuscripts included the documentation and evaluation of their current physical condition and the mapping of the effect of the microchemical analyses performed in the context of the disputes over the authenticity of the manuscripts between the middle of the 19th century and the 1970s. For the achievement of these objectives, a detailed documentation of all the pages of the manuscripts in different types of lighting (visible direct, lateral, transmitted, ultraviolet, infrared), optical microscopy, and the identification of the degradation productions of damaged places by means of X-ray fluorescence analysis and Raman spectroscopy were used. This provided new information on the current physical condition of the manuscripts and documentation of the damage caused by historical microchemical testing. In addition, some previously unpublished historical tests were identified, thus offering a new perspective on some current damage of the two manuscripts.


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