scholarly journals Early-Life Socioeconomic Status and Mortality in Later Life: An Integration of Four Life-Course Mechanisms

2014 ◽  
Vol 69 (3) ◽  
pp. 451-460 ◽  
Author(s):  
Tetyana Pudrovska ◽  
Benedicta Anikputa
Keyword(s):  
Socioeconomic Status ◽  
Life Course ◽  
Early Life ◽  
Later Life

scholarly journals Life Course Socioeconomic Status and Later Life Alzheimer’s Disease-Related Neuropathological Lesions

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 164-164
Author(s):  
Sarah Tom ◽  
Amol Mehta ◽  
Stepanie Izard ◽  
Paul Crane ◽  
David Bennett ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Socioeconomic Status ◽  
Life Course ◽  
Early Life ◽  
Parental Education ◽  
Brain Aging ◽  
Late Life ◽  
Later Life ◽  
Braak Stage

Abstract While higher life course socioeconomic status (SES) is associated with lower Alzheimer’s Disease (AD) risk, relationships with AD-related neuropathological lesions are unclear. We hypothesize that high SES in early, mid and late life will be associated with lower frequency of AD-related pathological lesions. The Rush Memory and Aging Project is a cohort of 2025 people age ≥ 65 years from Northeastern Illinois recruited 1997 – 2018; 972 participants died. We created binary variables for Braak stage (0-II versus III-VI), NIA-Reagan score (low likelihood/no AD pathology versus high/intermediate likelihood), presence of microinfarcts and, separately, macroinfarcts, and life course SES based on median for late life (baseline income), midlife (income at age 40 years), and early life (composite of parental education and number of siblings). Logistic regression models adjusted for ages at baseline and death, sex, presence of APOE-Ɛ4 alleles, and separately, vascular factors and education. Of 761 participants with relevant data, 69% were women, and mean ages at baseline and death were 83 + 6 years and 90 + 6 years, respectively. High early life SES was related to lower frequency of AD pathology (OR= 0.69, 95% CI 0.50, 0.96) and macroinfarcts (OR= 0.69, 95% CI 0.51, 0.94). Results were similar when adjusting for vascular factors; adjustment for education modestly attenuated these associations. Mid-life and late life SES were not associated with AD-related neuropathological lesions. High early life SES was related to lower frequency of AD pathology and macroinfarct presence. Environment during early development may influence later life brain aging.

scholarly journals Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Saira Khan ◽  
K. Y. Wolin ◽  
R. Pakpahan ◽  
R. L. Grubb ◽  
G. A. Colditz ◽  
...  
Keyword(s):  
Body Size ◽  
Benign Prostatic Hyperplasia ◽  
Life Course ◽  
Early Life ◽  
Prostate Volume ◽  
Late Life ◽  
Later Life ◽  
Normal Weight ◽  
Prostatic Hyperplasia ◽  
The Life Course

Abstract Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. Conclusions We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia.

scholarly journals Early-life circumstances and the risk of function-limiting long-term conditions in later life

2020 ◽  
Vol 11 (2) ◽  
pp. 157-180
Author(s):  
Matthew H. Iveson ◽  
Chris Dibben ◽  
Ian J. Deary
Keyword(s):  
Life Course ◽  
Cognitive Ability ◽  
Early Life ◽  
Economic Status ◽  
Functional Limitation ◽  
Later Life ◽  
Socio Economic Status ◽  
Childhood Cognitive Ability ◽  
The Life Course

Older adults are particularly prone to function-limiting health issues that adversely affect their well-being. Previous work has identified factors from across the life course –childhood socio-economic status, childhood cognitive ability and education – that predict later-life functional outcomes. However, the independence of these contributions is unclear as later-in-the-life-course predictors are themselves affected by earlier ones. The present study capitalised on the recent linkage of the Scottish Mental Survey 1947 with the Scottish Longitudinal Study, using path analyses to examine the direct and indirect associations between life-course predictors and the risk of functional limitation at ages 55 (N = 2,374), 65 (N = 1,971) and 75 (N = 1,534). The odds of reporting a function-limiting long-term condition increased across later life. At age 55, reporting a functional limitation was significantly less likely in those with higher childhood socio-economic status, higher childhood cognitive ability and higher educational attainment; these associations were only partly mediated by other predictors. At age 65, adult socio-economic status emerged as a mediator of several associations, although direct associations with childhood socio-economic status and childhood cognitive ability were still observed. At age 75, only childhood socio-economic status and adult socio-economic status directly predicted the risk of a functional limitation, particularly those associated with disease or illness. A consistent pattern and direction of associations was observed with self-rated health more generally. These results demonstrate that early-life and adult circumstances are associated with functional limitations later in life, but that these associations are partly a product of complex mediation between life-course factors.

What role for the ‘long arm of childhood’ in social gradients in health? An international comparison of high-income contexts

2020 ◽  
Author(s):  
Steven A. Haas ◽  
Zhangjun Zhou ◽  
Katsuya Oi
Keyword(s):  
Life Course ◽  
Early Life ◽  
Economic Status ◽  
Functional Limitation ◽  
Later Life ◽  
High Income ◽  
Childhood Health ◽  
Relative Contribution ◽  
Early Life Factors

Social gradients in health have been a focus of research for decades. Two important lines of social gradient research have examined (1) international variation in their magnitude and (2) their life course / developmental antecedents. The present study brings these two strands together to explore the developmental origins of educational gradients in health. We leverage data spanning 14 high-income contexts from the Health and Retirement Study and its sisters in Europe. We find that early-life health and socio-economic status consistently attenuate educational gradients in multimorbidity and functional limitation. However, the relative contribution of early-life factors to gradients varies substantially across contexts. The results suggest that research on social gradients, and population health broadly, would benefit from the unique insights available from a conceptual and empirical approach that integrates comparative and life course perspectives.<br /><br />Key messages<br /><ul><li>The magnitude of educational gradients in later life health depend, in part, on childhood health and socioeconomic circumstances.</li><br /><li>The role of early life factors in educational gradients in health varies substantially across high income contexts.</li></ul>

scholarly journals Early-Life Socioeconomic Status and Adult Physiological Functioning: A Life Course Examination of Biosocial Mechanisms

2017 ◽  
Vol 63 (2) ◽  
pp. 87-103 ◽  
Author(s):  
Yang Claire Yang ◽  
Karen Gerken ◽  
Kristen Schorpp ◽  
Courtney Boen ◽  
Kathleen Mullan Harris
Keyword(s):  
Socioeconomic Status ◽  
Life Course ◽  
Early Life

scholarly journals Early Life Circumstances and Cognitive Aging: Longitudinal Evidence From China Health and Retirement Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 62-62
Author(s):  
Zhuoer Lin ◽  
Xi Chen
Keyword(s):  
Socioeconomic Status ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Early Life ◽  
Cognitive Deficit ◽  
Later Life ◽  
Health Conditions ◽  
Childhood Socioeconomic Status ◽  
Life Circumstances

Abstract Objectives: This study examines the long-term relationship between early life circumstances and later life cognitive aging. In particular, we differentiate the long-term effects of early life circumstances on level of cognitive deficit and rate of cognitive decline. Methods: Cognitive trajectories were measured using three waves of China Health and Retirement Longitudinal Surveys (CHARLS 2011-2015). Linear mixed-effect model was used to decompose the individual level of cognitive deficit and rate of cognitive change in a sample of Chinese middle-aged and older adults 45-90 years of age (N=6,700). These two dimensions of cognition were matched to four domains of early life circumstances using CHARLS Life History Survey (2014), including childhood socioeconomic status, neighborhood environment, social relationships and health conditions. Their associations were examined by linear regressions. Stratification analysis was further conducted to investigate the mediating effect of education on early life circumstances and cognitive aging. Results: Childhood socioeconomic status, childhood friendship and early life health conditions were significantly associated with both the level of cognitive deficit and rate of decline. In contrast, the community environment, including childhood neighborhood safety and social cohesion, only affected the baseline level of cognitive deficit; and childhood relationship with parents only affected the rate of cognitive decline. Moreover, education was found to be a mediating factor of these relationships. Conclusion: Exposure to disadvantaged early life circumstances have significant negative effects on later life cognitive deficit as well as rate of cognitive decline. Nevertheless, these long-term impacts can be partially ameliorated by higher educational attainment.

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