scholarly journals SERUM VITAMIN B 12 AND DEPRESSIVE SYMPTOMS: A LONGITUDINAL STUDY AMONG OLDER ADULTS

2016 ◽  
Vol 56 (Suppl_3) ◽  
pp. 36-36
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Vitamin B 12

scholarly journals Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4 year longitudinal study

2021 ◽  
pp. 1-22
Author(s):  
Eamon Laird ◽  
Aisling M. O’Halloran ◽  
Anne M Molloy ◽  
Martin Healy ◽  
Belinda Hernandez ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Regression Models ◽  
Plasma Concentrations ◽  
Depression Scale ◽  
Community Dwelling ◽  
Vitamin B ◽  
Folate Status ◽  
Antidepressant Use

Abstract The objective was to examine the prospective relationship between folate and vitamin B12 (B12) status and incident depressive symptoms in a representative cohort of community-dwelling older people. This was a longitudinal study utilising the Irish Longitudinal Study on Aging (n =3,849 aged ≥50 years) and investigated the relationship between blood plasma folate and B12 levels at baseline (wave 1) and incident depressive symptoms at 2 and 4 years (waves 2 and 3). Participants with depression at wave 1 were excluded. A score ≥9 on the Center for Epidemiologic Studies Depression Scale-8 at wave 2 or 3 was indicative of incident depressive symptoms. Plasma B12 and folate concentrations were determined by microbiological assay. B12 status profiles (pmol/l) were defined as: <185, deficient-low; 185 - <258, low normal; >258 - 601, normal and >601 high. Folate status profiles (nmol/l) were defined as: ≤10.0, deficient-low; >10 - 23.0, low normal; >23.0 - 45.0, normal; >45.0, high. Logistic regression models reporting odds ratios were used to analyse the longitudinal association of B-vitamin categories with incident depression. Both B12 and folate plasma concentrations were lower in the group with incident depressive symptoms vs. non depressed (folate: 21.4 vs. 25.1 nmol/L; P=0.0003); (B12: 315.7 vs. 335.9 pmol/L; P=0.0148). Regression models demonstrated that participants with deficient-low B12 status at baseline had a significantly higher likelihood of incident depression four years later (odds ratio 1.51, 95% CI 1.01-2.27, P=0.043). This finding remained robust after controlling for relevant covariates including physical activity, chronic disease burden, vitamin D status. cardiovascular disease and antidepressant use. No associations of folate status with incident depression were observed. Older adults with deficient-low B12 status had a 51% increased likelihood of developing depressive symptoms over 4 years. Given the high rates of B12 deficiency, these findings are important and highlight the need to further explore the low cost benefits of optimising vitamin B12 status for depression in older adults.

scholarly journals Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time

2010 ◽  
Vol 92 (2) ◽  
pp. 330-335 ◽  
Author(s):  
Kimberly A Skarupski ◽  
Christine Tangney ◽  
Hong Li ◽  
Bichun Ouyang ◽  
Denis A Evans ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Vitamin B ◽  
Longitudinal Association ◽  
Vitamin B 12 ◽  
Over Time

scholarly journals A Combined Nutrition and Exercise Intervention Influences Serum Vitamin B-12 and 25-Hydroxyvitamin D and Bone Turnover of Healthy Chinese Middle-Aged and Older Adults

2020 ◽  
Vol 150 (8) ◽  
pp. 2112-2119
Author(s):  
Inge Groenendijk ◽  
Ruth Chan ◽  
Jean Woo ◽  
Sherlin Ong ◽  
Panam Parikh ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Exercise Intervention ◽  
Intervention Group ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Middle Aged ◽  
Vitamin B 12 ◽  
Turnover Markers

ABSTRACT Background Hong Kong faces several public health problems including malnutrition and osteoporosis. Considering the typical Chinese diet and overall low physical activity levels of Chinese adults, timely interventions to improve nutritional status and bone health are needed. Objectives We examined the effects of a nutrition plus exercise intervention on serum vitamin B-12 and 25-hydroxyvitamin D [25(OH)D], bone turnover markers, and parathyroid hormone (PTH) concentrations in apparently healthy Chinese middle-aged and older adults. Methods In this 24-wk randomized controlled trial, 180 Chinese adults (85 women, mean ± SD age: 61 ± 6 y) were randomly assigned to receive a fortified milk supplement (2 × 30 g/d) and an exercise program (2 × 1 h/wk including resistance, balance, and aerobic training) or no intervention. The primary outcome was physical performance. In this article we analyzed the secondary outcomes serum vitamin B-12 and 25(OH)D concentrations, assessed at baseline, 12 wk, and 24 wk. Also, bone turnover markers and PTH concentrations were studied. Linear mixed models evaluated group differences over time. Results A significant time × group interaction (P &lt; 0.001) was found for serum vitamin B-12 and 25(OH)D concentrations and the bone turnover markers, but not for serum PTH concentrations (P = 0.09). The intervention increased mean ± SD vitamin B-12 concentrations from baseline (345 ± 119 pmol/L) to 24 wk (484 ± 136 pmol/L), whereas concentrations remained stable within the control. For 25(OH)D concentrations, the intervention group had a greater increase from baseline (54.7 ± 14.2 nmol/L) to 24 wk (80.1 ± 19.2 nmol/L) than the control (60.6 ± 15.2 compared with 65.6 ± 14.6 nmol/L). The ratio of the net effect of bone formation and resorption was greater in the intervention group, suggesting less bone remodeling, irrespective of sex. Conclusions A fortified milk supplement and exercise intervention successfully improved vitamin B-12 and 25(OH)D concentrations as well as the balance of bone turnover markers of Chinese middle-aged and older adults. This trial was registered at trialregister.nl as NTR6214.

scholarly journals Low Vitamin B-12 Intake and Status Are More Prevalent in Hispanic Older Adults of Caribbean Origin Than in Neighborhood-Matched Non-Hispanic Whites

2002 ◽  
Vol 132 (7) ◽  
pp. 2059-2064 ◽  
Author(s):  
Laurinda L. Kwan ◽  
Odilia I. Bermudez ◽  
Katherine L. Tucker
Keyword(s):  
Older Adults ◽  
Vitamin B ◽  
Vitamin B 12

scholarly journals Role of white matter hyperintensities, hemoglobin and vitamin B‐12 on cognitive decline: Two‐year follow‐up data from the Tata Longitudinal Study of Ageing (TLSA)

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Aditi Balakrishnan ◽  
Vivek Tiwari ◽  
M.L. Abhishek ◽  
Naren P. Rao ◽  
Vijayalakshmi Ravindranath ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
Vitamin B ◽  
Vitamin B 12

High Serum Folate Concentrations Are Associated with Decreased Risk of Mortality among Japanese Adults

2021 ◽  
Author(s):  
Sanmei Chen ◽  
Takanori Honda ◽  
Jun Hata ◽  
Satoko Sakata ◽  
Yoshihiko Furuta ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Serum Vitamin ◽  
Mthfr C677t ◽  
Serum Folate ◽  
Vitamin B ◽  
Mthfr C677t Polymorphism ◽  
Japanese Adults ◽  
All Cause Mortality ◽  
Vitamin B 12

ABSTRACT Background Folate and vitamin B-12 are essential nutrients for normal cell growth and replication, but the association of serum folate and vitamin B-12 concentrations with mortality risk remains uncertain. Objective This study was performed to investigate the associations of serum folate and vitamin B-12 concentrations with mortality risk and test whether the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism modifies these associations. Methods A total of 3050 Japanese community residents aged ≥40 y were prospectively followed-up for mortality between 2002 and 2012. Cox proportional hazards models and restricted cubic splines were used to estimate HRs and 95% CIs of mortality. Results During a median follow-up period of 10.2 y, 336 participants died. Higher serum folate concentrations were associated with lower risks of all-cause mortality [multivariable-adjusted HR: 0.73; 95% CI: 0.56, 0.96 for the second tertile (8.8–12.2 nmol/L; median 10.4 nmol/L) and HR: 0.61; 95% CI: 0.46, 0.80 for the third tertile (≥12.5 nmol/L; median 15.6 nmol/L) serum folate concentrations compared with the first tertile (≤8.6 nmol/L; median 7.0 nmol/L)]. This association remained significant in all sensitivity analyses. Spline analyses showed a steady decline in all-cause mortality risk with increasing serum folate concentrations up to 20–25 nmol/L. This association persisted regardless of the MTHFR C677T genotypes. For serum vitamin B-12, the multivariable-adjusted HR of 1.32 (95% CI: 0.97, 1.79) of all-cause mortality was marginally significantly greater in the first tertile compared with the second tertile. This association was attenuated and nonsignificant after the exclusion of participants with a history of cardiovascular disease or cancer, or participants aged ≥85 y at baseline, or deaths in the first 3 y of follow-up. Conclusions Serum folate concentrations were inversely associated with the risk of all-cause mortality in Japanese adults. Serum vitamin B-12 concentrations were not consistently associated with all-cause mortality risk after accounting for reverse-causation bias.

scholarly journals Interpretation of vitamin B-12 and folate concentrations in population-based surveys does not require adjustment for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

2020 ◽  
Vol 111 (4) ◽  
pp. 919-926 ◽  
Author(s):  
Melissa F Young ◽  
Junjie Guo ◽  
Anne Williams ◽  
Kyly C Whitfield ◽  
Sabiha Nasrin ◽  
...  
Keyword(s):  
Survey Design ◽  
Serum Vitamin ◽  
Correlation Coefficients ◽  
Population Based ◽  
Reproductive Age ◽  
Serum Folate ◽  
Vitamin B ◽  
Cross Sectional ◽  
Population Prevalence ◽  
Vitamin B 12

ABSTRACT Background Vitamin B-12 and folate deficiencies in women and children have important public health implications. However, the evidence is conflicting and limited on whether the influence of inflammation on biomarker concentrations may be sufficiently and consistently influenced by inflammation to require adjustment for interpreting concentrations or estimating population prevalence of deficiencies. Objective We examined correlations between concentrations of the inflammation biomarkers C-reactive protein (CRP) and α1-acid glycoprotein (AGP) and serum vitamin B-12 and serum and RBC folate among nonpregnant women of reproductive age (WRA; 15–49 yr) and preschool children (PSC; 6–59 mo). Methods We analyzed cross-sectional data from 16 nationally representative nutrition surveys conducted in WRA (n = 32,588) and PSC (n = 8,256) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project. Spearman correlations between CRP or AGP and vitamin B-12 or folate concentrations were examined, taking into account complex survey design effects. Results Correlations between inflammation and vitamin B-12 or folate were weak, with no clear pattern of association in either WRA or PSC. Correlation coefficients between CRP and vitamin B-12 for WRA and PSC ranged from −0.25 to 0.16, and correlations between AGP and vitamin B-12 ranged between −0.07 and 0.14. Similarly, correlations between CRP and serum folate ranged from −0.13 to 0.08, and correlations between AGP and serum folate between −0.21 and 0.02. Only 3 surveys measured RBC folate, and among them, correlations for WRA ranged from −0.07 to 0.08 for CRP and −0.04 for AGP (1 country). Conclusions Based on the weak and inconsistent correlations between CRP or AGP and vitamin B-12 or folate biomarkers, there is no rationale to adjust for inflammation when estimating population prevalence of vitamin B-12 or folate deficiencies in WRA or PSC.

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