Effect of endometrial thickness on birthweight in frozen embryo transfer cycles: an analysis including 6181 singleton newborns

2019 ◽  
Vol 34 (9) ◽  
pp. 1707-1715 ◽  
Author(s):  
Jie Zhang ◽  
Hongfang Liu ◽  
Xiaoyan Mao ◽  
Qiuju Chen ◽  
JiQiang Si ◽  
...  
Keyword(s):  
Linear Regression ◽  
Embryo Transfer ◽  
Gestational Age ◽  
Endometrial Thickness ◽  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Frozen Embryo Transfer ◽  
Z Scores ◽  
The Impact ◽  
The Relationship

Abstract STUDY QUESTION Does endometrial thickness (EMT) have an impact on singleton birthweight in frozen embryo transfer (FET) cycles? SUMMARY ANSWER An EMT <8 mm was associated with a lower mean birthweight and gestational age- and gender-adjusted birthweight (Z-scores) of singletons resulting from FET. WHAT IS KNOWN ALREADY Previous studies have examined the impact of EMT on IVF success rates. Little is known, however, regarding the relationship between EMT and neonatal birthweight. STUDY DESIGN, SIZE, DURATION This retrospective study involved singleton live births born to women undergoing frozen-thawed Day 3 embryo transfer during the period from January 2010 to December 2017 at a tertiary care centre. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 6181 women who fulfilled the inclusion criteria were included and were grouped into five groups depending on the EMT: <8 mm, 8–9.9 mm, 10–11.9 mm, 12–13.9 mm and ≥14 mm. EMT between 10 and 11.9 mm was taken as a reference group. Singleton birthweight was the primary outcome measure. A multivariable linear regression analysis was performed to detect a relationship between EMT and newborns' birthweight after controlling for a number of potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE A modest but significant decrease in birthweight was observed in the EMT <8 mm group as compared with groups with EMT ≥10 mm, with a mean difference of 89–108 g. Also, singletons from the EMT <8 mm group (0.24 ± 1.04) had a significantly lower birthweight Z-scores than those from the EMT 10–11.9 mm (0.41 ± 1.02; P = 0.032) or EMT 12–13.9 mm (0.46 ± 1.07; P = 0.004) groups. Further, multiple linear regression analyses indicated that parental BMIs, gestational age, newborn gender, pregnancy complications and EMT <8 mm were all independent predictors of neonatal birthweight. LIMITATIONS, REASONS FOR CAUTION The present study was limited by its retrospective design. Future prospective studies are required to confirm our findings. WIDER IMPLICATIONS OF THE FINDINGS Our findings provided new insight into the relationship between EMT and neonatal outcomes by showing that a thin endometrium is associated with a decrease in singleton birthweight. STUDY FUNDING/COMPETING INTEREST(S) National Key Research and Development Program of China (2018YFC1003000); the National Natural Science Foundation of China (81771533, 81571397, 31770989, 81671520); the China Postdoctoral Science Foundation (2018M630456). The authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER Not applicable.

scholarly journals Impact of maternal age on birthweight in frozen embryo transfer cycles: an analysis including 12565 singleton newborns

2020 ◽  
Author(s):  
Zhexin Ni ◽  
Shuai Sun ◽  
Wen Cheng ◽  
Jin Yu ◽  
Dongxia Zhai ◽  
...  
Keyword(s):  
Linear Regression ◽  
Embryo Transfer ◽  
Gestational Age ◽  
Maternal Age ◽  
Linear Regression Analysis ◽  
Frozen Embryo Transfer ◽  
Maternal Body Mass Index ◽  
Significant Difference ◽  
Z Scores ◽  
The Relationship

Abstract Background Previous studies have investigated the effect of maternal age on assisted reproductive technology (ART) success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Does maternal age have an impact on singleton birthweight in FET cycles?Methods This retrospective study was conducted at a tertiary care centre, involving singleton live births born to women undergoing frozen-thawed embryo transfer during the period from January 2010 to December 2017. A total of 12565 women who fulfilled the inclusion criteria were enrolled and were grouped into four groups according to the maternal age: <30, 30–34, 35–39, and ≥ 40 years old. Maternal age between 30 and 34 years old was taken as a reference group. Singleton birthweight was the key outcome measure. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders.Results A modest decrease but no significant difference in birthweight and gestational age- and gender-adjusted birthweight (Z-scores) was observed in maternal age over 35 years old as compared with group with 30–34 years old. Further, multiple linear regression analyses indicated that maternal body mass index (BMI), embryo developmental stage at transfer, parity, number of embryos transferred, FET endometrial preparation, endometrial thickness, gestational age and newborn gender were all independent predictors of neonatal birthweight.Conclusion Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET.

scholarly journals Impact of maternal age on birthweight in frozen embryo transfer cycles: an analysis including 12565 singleton newborns

2020 ◽  
Author(s):  
Zhexin Ni ◽  
Shuai Sun ◽  
Wen Cheng ◽  
Jin Yu ◽  
Dongxia Zhai ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Maternal Age ◽  
Reference Group ◽  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Frozen Embryo Transfer ◽  
Tertiary Care Centre ◽  
Significant Difference ◽  
Z Scores ◽  
The Relationship

Abstract Background: Previous studies have investigated the effect of maternal age on assisted reproductive technology (ART) success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Does maternal age have an impact on singleton birthweight in FET cycles?Methods: This retrospective study was conducted at a tertiary care centre, involving singleton live births born to women undergoing frozen-thawed embryo transfer during the period from January 2010 to December 2017. A total of 12565 women who fulfilled the inclusion criteria were enrolled and were grouped into four groups according to the maternal age: <30, 30–34, 35-39, and ≥40 years old. Maternal age <30 years old was taken as a reference group. Singleton birthweight was the key outcome measure. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders.Results: A modest decrease but no significant difference in birthweight and gestational age- and gender-adjusted birthweight (Z-scores) was observed in maternal age over 35 years old as compared with group with <30years old. The highest proportions of LBW (4.1%), HBW (1.2%), PTB (5.9%) and very PTB (0.9%) were found in group over 40 years old, but no significant difference was observed among four groups. Additionally, the group with 35-39 years old had the highest very LBW (0.6%) , while the group with 30-34 years old had the lowest SGA (2.7%). However, multivariate analyses revealed that neonatal outcomes including PTB, LBW and SGA were similar between the different maternal age groups.Conclusion: Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET.

The impact of embryo quality on singleton birthweight in vitrified-thawed single blastocyst transfer cycles

2020 ◽  
Vol 35 (2) ◽  
pp. 308-316 ◽  
Author(s):  
Jie Zhang ◽  
Jiaan Huang ◽  
Hongfang Liu ◽  
Bian Wang ◽  
Xiaoyan Yang ◽  
...  
Keyword(s):  
Embryo Quality ◽  
Conflicts Of Interest ◽  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Poor Quality ◽  
Blastocyst Transfer ◽  
Excellent Quality ◽  
Z Scores ◽  
The Impact ◽  
The Relationship

Abstract STUDY QUESTION Does the quality of a single transferred blastocyst affect singleton birthweight in frozen-embryo transfer (FET) cycles? SUMMARY ANSWER The transfer of a poor-quality blastocyst was associated with lower mean birthweight and gestation-adjusted birthweight (Z-scores) when compared with the transfer of an excellent-quality blastocyst during FET cycles. WHAT IS KNOWN ALREADY Embryo quality is a strong predictor of IVF success rates. However, very few studies have examined the effect of embryo quality on singleton birthweight. STUDY DESIGN, SIZE, DURATION This retrospective study involved singleton live births born to women undergoing frozen-thawed single blastocyst transfers during the period from January 2010 to December 2017 at a tertiary care centre. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 1207 women who fulfilled the inclusion criteria were included and were grouped into four groups depending on the blastocyst quality: excellent, good, average and poor. The primary outcome measure was singleton birthweight. The Z-score was employed to calculate the birthweight adjusted for gestational age and newborn gender. Multiple linear regression analysis was performed to investigate the relationship between embryo quality and neonatal birthweight after adjustment for some potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE In the primary multivariable model, singletons from the poor-quality blastocyst group weighed 183.5 g less than those from the excellent-quality blastocyst group (95% CI: −295.1 to −71.9 g, P = 0.001) in terms of mean birthweight after accounting for patient characteristics, IVF treatment parameters, the year of treatment and newborn gender. Likewise, poor-quality blastocyst transfer was associated with lower gestation-adjusted Z-scores than the transfer of excellent-quality blastocysts (β = −0.35, 95% CI: −0.59 to −0.12, P = 0.003). LIMITATIONS AND REASONS FOR CAUTION The current study was limited by its retrospective design and the fact that our analysis was restricted to women with singleton births from single blastocyst transfers. Future prospective studies are required to confirm our findings. WIDER IMPLICATIONS OF THE FINDINGS Our findings provide new insight into the relationship between embryo quality and neonatal outcomes by showing that poor-quality blastocyst transfer was associated with a decrease in singleton birthweight. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by the National Key Research and Development Program of China (grant no. 2018YFC1003000), the National Natural Science Foundation of China (grant nos. 81771533, 81571397 and 31770989), and the China Postdoctoral Science Foundation (Grant no. 2018M630456). The authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER Not applicable.

P–677 Endometrial thickness, endometrial preparation protocol and number of euploid embryos transferred, significantly impact the live birth in frozen embryo transfer cycles

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Liñá. Tegedor ◽  
I Elkhatib ◽  
A Abdala ◽  
A Bayram ◽  
K Ab. Ali ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Embryo Transfer ◽  
Live Birth ◽  
Birth Rate ◽  
Endometrial Thickness ◽  
Live Birth Rate ◽  
Frozen Embryo Transfer ◽  
Endometrial Preparation ◽  
The Impact ◽  
Ploidy Status

Abstract Study question Is the live birth rate (LBR) in euploid frozen embryo transfer (FET) cycles affected by the endometrial thickness (EMT)? Summary answer A significantly higher LBR was observed in patients with an endometrial thickness of at least 7.5mm (46.24% vs. 54.63%) What is known already Parameters assessing the endometrium prior planning a FET include endometrial thickness, pattern and blood flow. The impact of the endometrial thickness on ART outcomes is controversial, with conflicting results published. A recent meta-analysis evaluated whether EMT could predict pregnancy outcomes and suggested that lower EMT was associated with lower incidence of clinical pregnancy rate (CPR), implantation rate (IR) and LBR. Due to heterogeneity of parameters evaluated between different publications, where embryos with unknown ploidy status were transferred, in conjunction with variability of stimulation protocols and the number of embryos transferred, the real effect of the EMT was difficult to infer. Study design, size, duration This was a two-center retrospective observational study including a total of 1522 euploid FET cycles between March 2017 and March 2020 at ART Fertility Clinics Muscat, Oman and Abu Dhabi, UAE. Participants/materials, setting, methods Trophectoderm biopsies were analyzed with Next Generation Sequencing (NGS). Vitrification/warming of blastocysts was performed using Cryotop method (Kitazato). EMT was measured by vaginal ultrasound prior initiating the progesterone administration (± 1 day) and LBR was recorded. Multivariate analysis was performed between LB outcomes and median EMT while controlling for confounding factors. Main results and the role of chance A total of 1522 FET cycles were analyzed: 975 single embryo transfer (SET) and 547 double embryo transfer (DET). The mean age of the patients was 33.38 years with a mean BMI of 27.1 kg/m2. FET were performed in EMT ranging from 3 to 15 mm and 50.52% resulted in a live birth. Though potentially all ranges of EMT were associated with LB, the median EMT in patients with LB was significantly higher than the median EMT of patients without LB (7.6mm vs. 7.4mm; p &lt; 0.001). The dataset was stratified into two groups based on the median EMT (7.5mm): &lt; 7.5mm (n = 744 cycles) and ≥ 7.5mm (n = 778 cycles). A significantly higher live birth rate was observed in ≥ 7.5mm group (46.24% vs. 54.63%. p = 0.0012). In multivariate analysis, EMT, FET endometrial preparation protocol, and number of embryos transferred were the main parameters influencing the chance to achieve LB: OR 1.10 [1.01–1.19], p &lt; 0.015 for the EMT; OR 1.84 [1.47–2.30], p &lt; 0.0001 for Natural Cycle protocol and OR 1.55 [1.25–1.93], p &lt; 0.0001 for DET. Intercept 0.18 [0.07–0.44] p &lt; 0.0002. Female age did not reach significance: OR 1.02 [1.00–1.04], p = 0.056. Limitations, reasons for caution Besides the retrospective nature of the study, the inter-observer variability in EMT assessment between different physicians is a limitation. The physician and embryologist performing the embryo transfer could not been standardized due to the multicenter design of the study. Wider implications of the findings: The EMT in FET may influence the LBR and should be considered as an important factor for the success of embryo transfer cycles. Whether these results can be extrapolated to fresh embryo transfer and to blastocysts with unknown ploidy status, needs further investigation. Trial registration number Not applicable

Linking knowledge sharing to innovative behavior: the moderating role of collectivism

2019 ◽  
Vol 23 (8) ◽  
pp. 1652-1672 ◽  
Author(s):  
Qian Ya Pian ◽  
Hui Jin ◽  
Hui Li
Keyword(s):  
Linear Regression ◽  
Knowledge Sharing ◽  
Linear Regression Analysis ◽  
Social Motivation ◽  
Innovative Behavior ◽  
Moderating Effects ◽  
Content Type ◽  
Epistemic Motivation ◽  
The Impact ◽  
The Relationship

Purpose The purpose of this study is to examine the relationship between behavior-oriented knowledge sharing and innovative behavior and the moderating effects of collectivism on the aforementioned relationship. It also assesses the impact of epistemic motivation and pro-social motivation on behavior-oriented knowledge sharing. Design/methodology/approach Focusing on Chinese context, the study conducts a questionnaire survey to test the research model. Linear regression analysis is used to examine the main effects of the independent variables, and the multi-level linear regression model is used to evaluate the moderating effects of the controlled variables. Findings The findings reveal that epistemic motivation stimulates individual-oriented knowledge sharing and pro-social motivation stimulates organization-oriented knowledge sharing. Organization-oriented knowledge sharing impacts more than individual-oriented knowledge sharing on innovative behavior. Moreover, collectivism is shown to positively moderate the relationship between behavior-oriented knowledge sharing and innovative behavior. Practical implications The study provides evidence that motivation should be significantly considered when sharing knowledge. Managers should prioritize the promotion of employees’ epistemic and pro-social motivation. The study also suggests that encouraging collectivism should be an important objective, as it moderates the relationship between knowledge sharing and innovative behavior positively. Originality/value The study emphasized how individual-oriented and organization-oriented knowledge sharing impacts innovative behavior differently and how collectivism moderates that relationship. It also illustrates how epistemic and pro-social motivation affects behavior-oriented knowledge sharing. The study contributes to a stream of research that links knowledge sharing and innovative behavior.

Multi-Parameter Linear Regression Analysis about the Experimental Results of Pervious Concrete Strength

2013 ◽  
Vol 664 ◽  
pp. 707-713
Author(s):  
Xi Xi He
Keyword(s):  
Linear Regression ◽  
Linear Correlation ◽  
Concrete Strength ◽  
Linear Regression Analysis ◽  
Aggregate Size ◽  
Pervious Concrete ◽  
Natural Logarithm ◽  
Function Relationship ◽  
The Impact ◽  
The Relationship

In this paper, based on 28-day cubic compressive strength fcu and splitting strength fts of pervious concrete with different porosity, aggregate size and of cubic size, correlation analysis was conducted among these three factors and strength using the software of SPSS (Statistical Package for the Social Sciences), in which a logarithmic function was used to do linear regression fitting about the relationship among the three parameters and the strength and then a formula was proposed. The analysis result shows that there is a certain higher-order function relationship between the three influencing factors and the strength, and it is contribute to analysis the impact of three parameters on strength by using natural logarithm to linearize the relationship of parameters. Studies have shown that porosity is the main factor that affects both fcu and fts, and side length of the cube has a significant influence on fts but has no significant linear correlation with fcu. And fts may be more sensitive to cube size on linear correlation than fcu.

P–395 Obstetric and perinatal outcomes of pregnancies resulting from fresh versus frozen embryo transfer – a sibling cohort

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
H Gane. Herman ◽  
Y Mizrachi ◽  
A Shevac. Alon ◽  
Y Farhadian ◽  
O Gluck ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Linear Regression Analysis ◽  
Perinatal Outcomes ◽  
Frozen Embryo Transfer ◽  
Adverse Outcomes ◽  
Obstetric Outcomes ◽  
Multivariate Linear Regression Analysis ◽  
Fresh Transfer

Abstract Study question We aimed to compare obstetric and perinatal outcomes between pregnancies conceived by in vitro fertilization (IVF) with fresh embryo transfer and frozen embryo transfer (FET) in the same women. Summary answer IVF pregnancies following fresh and FET entailed the same obstetric and perinatal outcomes, when compared in the same women. What is known already: There seems to be a difference in adverse outcomes between pregnancies following fresh and FET, as fresh transfer has repeatedly been associated with a higher risk of preterm birth and small for gestational age neonates, and the FET with preeclampsia and large for gestational age neonates. The overall lower incidence of adverse obstetric outcomes in FET may relate to the transfer of an embryo to a uterine environment in the setting of more physiological estradiol level but may also relate to patient characteristics which allow for freezing and subsequent transfer. Study design, size, duration This was a retrospective cohort of 214 deliveries during a 13-year period. Participants/materials, setting, methods The study was performed in a tertiary hospital. The cohort included live singleton deliveries (&gt;24 weeks of gestation) and excluded pregnancies following egg donation. Each fresh transfer IVF pregnancy was matched to a FET pregnancy by the same woman (1:1 ratio). Main results and the role of chance A total of 107 fresh transfer pregnancies were matched to 107 FET pregnancies, in the same women. Mean maternal age was lower in the fresh transfer group compared to the FET group (30.4 vs. 32.5 years, p &lt; 0.001), as was body mass index (BMI) (p = 0.001). A higher rate of nulliparity was noted in fresh transfer pregnancies (64.5% vs. 12.1%, p &lt; 0.001). Mean birthweight was higher in the FET group (3160 vs. 3081 grams, respectively, p &lt; 0.001), although the rates of low birth weight and small for gestational age neonates did not differ between the groups. Preterm deliveries occurred in 10.3% and 9.3% of fresh transfer and FET pregnancies respectively, p = 0.79. On multivariate linear regression analysis, the type of embryo transfer - FET or fresh - was not independently associated with birthweight, after adjustment for women’s age, nulliparity and BMI. Limitations, reasons for caution The study relied on coding in patient files, and thus certain data were missing for analysis, such as paternal identity. In addition, women included had at least two successful IVF pregnancies, and at least one cycle in which embryo freezing was performed. This may confer a selection bias. Wider implications of the findings: Our study of sibling deliveries after fresh and FET, points to a similar prognosis for the main obstetric and perinatal outcomes. This adds to current research which points to similar development of children following fresh and FET and is reassuring for clinicians consulting patients who are eligible for both options. Trial registration number Not applicable

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