scholarly journals Estimated and projected burden of multiple sclerosis attributable to smoking and childhood and adolescent high body-mass index: a comparative risk assessment

2020 ◽  
Author(s):  
Julia Pakpoor ◽  
Klaus Schmierer ◽  
Jack Cuzick ◽  
Gavin Giovannoni ◽  
Ruth Dobson
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Body Mass ◽  
Early Life ◽  
Time Lag ◽  
Early Adulthood ◽  
High Body Mass Index ◽  
High Body ◽  
High Bmi

Abstract Background Smoking and childhood and adolescent high body-mass index (BMI) are leading lifestyle-related risk factors of global premature morbidity and mortality, and have been associated with an increased risk of developing multiple sclerosis (MS). This study aims to estimate and project the proportion of MS incidence that could be prevented with elimination of these risk factors. Methods Prevalence estimates of high BMI during childhood/adolescence and smoking in early adulthood, and relative risks of MS, were obtained from published literature. A time-lag of 10 years was assumed between smoking in early adulthood and MS incidence, and a time-lag of 20 years was assumed between childhood/adolescent high BMI and MS incidence. The MS population attributable fractions (PAFs) of smoking and high BMI were estimated as individual and combined risk factors, by age, country and sex in 2015, 2025 and 2035 where feasible. Results The combined estimated PAFs for smoking and high BMI in 2015 were 14, 11, 12 and 12% for the UK, USA, Russia and Australia in a conservative estimate, and 21, 20, 19 and 16% in an independent estimate, respectively. Estimates for smoking are declining over time, whereas estimates for high early life BMI are rising. The PAF for high early life BMI is highest in the USA and is estimated to increase to 14% by 2035. Conclusions Assuming causality, there is the potential to substantially reduce MS incidence with the elimination of lifestyle-related modifiable risk factors, which are the target of global public health prevention strategies.

Temporal trend of early pregnancy high body mass index in Australian women: risk factors and outcomes

2021 ◽  
Vol 29 (1) ◽  
pp. 10-18
Author(s):  
Marjan Khajehei ◽  
Hassan Assareh
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Early Pregnancy ◽  
High Body Mass Index ◽  
Tertiary Hospital ◽  
Reproductive Age ◽  
Smoking During Pregnancy ◽  
High Body ◽  
High Bmi

Background There is a shift toward the increasing weight gain among women of reproductive age. Aim To assess changes in the prevalence of high body mass index (BMI) (including both overweight and obese) in early pregnancy in Australian women, and its risk factors and association with selected birth outcomes from 2011–2017. Methods Records of pregnant women who received antenatal care and gave birth at an Australian tertiary hospital during 2011–2017 were evaluated and trends of high BMI were investigated. Results The risk of high BMI at early pregnancy increased by 3% annually and rose from 37% in 2011 to 44% in 2017. The risk of high BMI was greater in women who were more than 35 years old, multiparous, were smoking during pregnancy, and who had neurological disorders. High maternal BMI was associated with greater risks of having assisted conception, caesarean section and larger neonate. Conclusion The rate of high BMI in early pregnancy increased between 2011–2017.

scholarly journals Assessing the Cost-Effectiveness of Interventions That Simultaneously Prevent High Body Mass Index and Eating Disorders

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2313
Author(s):  
Long Khanh-Dao Le ◽  
Phillipa Hay ◽  
Jaithri Ananthapavan ◽  
Yong Yi Lee ◽  
Cathrine Mihalopoulos
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Eating Disorders ◽  
Cost Effectiveness ◽  
Body Mass ◽  
High Body Mass Index ◽  
High Body ◽  
Effective Interventions ◽  
The Cost ◽  
High Bmi

Eating disorders (ED) are among the top three most common debilitating illnesses in adolescent females, while high Body Mass Index (BMI) is one of the five leading modifiable risk factors for preventable disease burden. The high prevalence of eating and weight-related problems in adolescence is of great concern, particularly since this is a period of rapid growth and development. Here, we comment on the current evidence for the prevention of EDs and high BMI and the importance of assessing the cost-effectiveness of interventions that integrate the prevention of EDs and high BMI in this population. There is evidence that there are effective interventions targeted at children, adolescents and young adults that can reduce the prevalence of risk factors associated with the development of EDs and high BMI concurrently. However, optimal decision-making for the health of younger generations involves considering the value for money of these effective interventions. Further research investigating the cost-effectiveness of potent and sustainable integrated preventive interventions for EDs and high BMI will provide decision makers with the necessary information to inform investment choices.

High Body Mass Index and Posttransplant Weight Gain Are Not Risk Factors for Kidney Graft and Patient Outcome

2007 ◽  
Vol 39 (7) ◽  
pp. 2205-2207 ◽  
Author(s):  
R. Marcén ◽  
A. Fernández ◽  
J. Pascual ◽  
J.L. Teruel ◽  
J.J. Villafruela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Patient Outcome ◽  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
High Body Mass Index ◽  
Kidney Graft ◽  
High Body

Smoking and High Body Mass Index: Risk Factors for Advanced Interval Polyps

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S160
Author(s):  
Aliya Khan ◽  
Divya Bhatt ◽  
Paul Gomez ◽  
Lauren S. Cole ◽  
Richard Gerkin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
High Body Mass Index ◽  
High Body

scholarly journals High body mass index in children with sickle cell disease: a retrospective single-centre audit

2018 ◽  
Vol 2 (1) ◽  
pp. e000302 ◽  
Author(s):  
Rachael Hall ◽  
Kate Gardner ◽  
David C Rees ◽  
Subarna Chakravorty
Keyword(s):  
Body Mass Index ◽  
Sickle Cell Disease ◽  
Disease Severity ◽  
Body Mass ◽  
Sickle Cell ◽  
High Body Mass Index ◽  
Cell Disease ◽  
Admission Rates ◽  
High Body ◽  
High Bmi

ObjectiveTo assess the prevalence of high body mass index (BMI) in children with sickle cell disease and assess correlation between BMI and disease severity.DesignRetrospective chart review followed by statistical analysis.SettingA single tertiary paediatric clinic in inner city London.PatientsAll patients with sickle cell disease, including homozygous haemoglobin (HbSS) and compound heterozygous Hb (HbSC), age 2–18 years receiving clinical care at the centre, were included in the study.InterventionsHeight and weight measurements, steady-state laboratory blood tests, hospital admission rates, adjunct therapy such as hydroxycarbamide or blood transfusions and obstructive sleep apnoea (OSA) data were obtained from the hospital electronic patient records.Main outcome measuresTo study the prevalence of high BMI and to identify any correlation between BMI and disease severity.Results385 patients were included. 64 children (17%) were overweight or obese, of which a significantly higher number of children with HbSC were obese or overweight (23 out of 91, 25%) compared with those with HbSS (36 out of 273, 13%), p≤0.001. No correlation was found between high BMI and presence of OSA, and markers of disease severity such as admission rates, fetal haemoglobin or lactate dehydrogenase levels.ConclusionsHigh BMI did not correlate with disease severity in this cohort of patients with sickle cell disease. Obesity was more prevalent in females and those with HbSC. Further prospective studies are needed to determine long-term effects of BMI in disease severity and outcome.

PS02.154: RISK FACTORS FOR WEIGHT LOSS 1 MONTH AFTER ESOPHAGECTOMY FOR ESOPHAGEAL CANCER

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 165-165
Author(s):  
Hiromi Mohizuki ◽  
Shinji Mine ◽  
Takashi Nakahama ◽  
Masayuki Watanabe ◽  
Naoki Hiki
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Weight Loss ◽  
Esophageal Cancer ◽  
Body Weight ◽  
Body Mass ◽  
Odds Ratio ◽  
High Body Mass Index ◽  
Body Weight Loss ◽  
High Body

Abstract Background Post-operative body weight loss (BWL) of patients who underwent esophagectomy is common. One month after esophagectomy, some patients lose weight remarkably, and others not. If preoperative or operative risk factors influencing body weight loss are identified, it will be possible that nutritional intervention is given to the patient having these risk factors. Methods In our department, the dietician stays in a surgical ward for nutritional management of patients. Ninety-two patients who underwent esophagectomy for esophageal cancer in 2016 were reviewed. Pre-operative and operative factors were correlated with post-operative BWL. The cut-off value of BWL 1 month after esophagectomy was defined with 75 percentile. Results The median body weight change was -4.8% (-18.5% ∼11.7%). The patients were divided into two groups; 24 patients with ≥ 7.3% of BWL (severe BWL group) and 68 with < 7.3% of BWL (mild BWL group). Patients’ characteristics or post-operative morbidities were not statistically different in these 2 groups. The incidence of patients with reconstruction using a colon or jejunum was higher in severe BWL group. Pre-operative body weight, body mass index, and the value of prealbumin was higher in severe BWL group. On postoperative 14 day, the patients in severe BWL group were likely to have lower energy intake per kilogram of pre-operative body weight. On multivariate analysis, high body mass index [odds ratio = 5.90; 95% confidence interval (CI) = 1.03–47.8; P = 0.046], upper location of tumor [odds ratio = 3.38; 95%, CI = 1.04–11.4; P = 0.043] were independently associated with severe BWL at 1 month after surgery. Conclusion High body mass index of ≥ 25, upper location of tumor were unfavorable risk factors for weight loss 1 month after esophagectomy for esophageal cancer. Disclosure All authors have declared no conflicts of interest.

scholarly journals Global burden of obesity

2017 ◽  
Vol 1 (1) ◽  
pp. 45
Author(s):  
Muhammad Jawad Hashim
Keyword(s):  
Body Mass Index ◽  
Health Promotion ◽  
Body Mass ◽  
Conflicts Of Interest ◽  
Temporal Trends ◽  
High Body Mass Index ◽  
Sub Saharan Africa ◽  
Global Burden ◽  
High Body ◽  
High Bmi

Global burden of obesity Introduction The burden of nutritional disorders is increasing despite advances in scientific research and health promotion. Nutritional disorders include excess body mass conditions especially obesity (body mass index [BMI] > 30 kg/m2) and being overweight (BMI > 25 and < 30 kg/m2). These conditions are now considered as precursors to several diseases including diabetes, heart disease, musculoskeletal disorders as well as psychiatric illnesses. We studied the global burden of obesity to assess temporal trends and regional variations of this highly prevalent nutritional disorder. Methods We used the Global Burden of Disease database from the Institute of Health Metrics (www.healthdata.org) at the University of Washington, Seattle. This database collates data from a very large number of studies and census figures to generate regional estimates for health statistics. We analyzed the data from 1990 to 2015 using global averages for years lived with disability (YLD). The primary risk factor analyzed was ‘High body-mass index’. The effect of high BMI on all causes of health reduction (including diabetes) were studied for temporal (1990 to 2015) and regional/national patterns. Results The global of burden of diseases due to high BMI is rising continuously, from 213 YLDs per 100,000 in 1990 to 388 YLDs in 2015. A high burden of YLDs was seen in developed regions including North America and Australasia. Northern Europe and Middle East were also disproportionately affected. Areas with low rates of YLDs from obesity included sub-Saharan Africa, south Asia and south east Asia. Marked increases in the rates per 100,000 populations were seen over 1990 to 2015 in countries such as Fiji, USA, Egypt and Ukraine. The burden of suffering is higher among women than men. Conclusion The global burden of suffering due to illnesses caused by high body mass index is continuing to rise. Existing public health measures appear to be ineffective and more efficacious nutritional education and health promotion strategies are urgently needed. Conflicts of interest disclosure: no external or commercial funding source, and no holding of significant equity in a company relevant to the study.

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