scholarly journals 1370Introducing network analysis to measure early life adversity

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Tjeerd Rudmer De Vries ◽  
Iris Arends ◽  
Naja Hulvej Rod ◽  
Albertine J. Oldehinkel ◽  
Ute Bültmann

Abstract Focus of Presentation Many studies have investigated associations between early life adversity (ELA) and outcomes across the life course. A defining characteristic of ELA is its complex nature, as many individual adverse experiences (e.g., parental mental health problems, financial difficulties) co-occur and interact over time. Commonly used methods for measuring ELA have not been able to elucidate pathways through which individual AEs are associated with each other during early life. We propose using network analysis to overcome this research gap. Findings Figure 1 shows the conditional associations between AEs in childhood and adolescence in an undirected network model, based on empirical data from the longitudinal TRAILS cohort. First, we found that the network model allows us to explain co-occurrences between AEs. For example: the co-occurrence of parental illness and financial difficulties in childhood is likely due to parental unemployment. Second, we identified which AEs are associated over time, e.g., familial conflicts in childhood and adolescence are strongly associated, the latter being associated with parental divorce in adolescence. Conclusions/Implications These findings add to the literature by providing insight into how individual AEs are conditionally associated, in distinct developmental periods and over time. The findings can be used in future research on pathways between AEs and guide the development of interventions. Key messages Undirected network models are a promising alternative approach to measuring ELA that can provide insight into pathways through which AEs co-occur and interact over time.

2021 ◽  
pp. 1-16
Author(s):  
Courtenay L. Kessler ◽  
Suzanne Vrshek-Schallhorn ◽  
Susan Mineka ◽  
Richard E. Zinbarg ◽  
Michelle Craske ◽  
...  

Abstract Early life adversity influences the diurnal cortisol rhythm, yet the relative influence of different characteristics of adversity remains unknown. In this study, we examine how developmental timing (childhood vs. adolescence), severity (major vs. minor), and domain of early life adversity relate to diurnal cortisol rhythms in late adolescence. We assessed adversity retrospectively in early adulthood in a subsample of 236 participants from a longitudinal study of a diverse community sample of suburban adolescents oversampled for high neuroticism. We used multilevel modeling to assess associations between our adversity measures and the diurnal cortisol rhythm (waking and bedtime cortisol, awakening response, slope, and average cortisol). Major childhood adversities were associated with flatter daily slope, and minor adolescent adversities were associated with greater average daily cortisol. Examining domains of childhood adversities, major neglect and sexual abuse were associated with flatter slope and lower waking cortisol, with sexual abuse also associated with higher cortisol awakening response. Major physical abuse was associated with higher waking cortisol. Among adolescent adversities domains, minor neglect, emotional abuse, and witnessing violence were associated with greater average cortisol. These results suggest severity, developmental timing, and domain of adversity influence the association of early life adversity with stress response system functioning.


Pertussis ◽  
2018 ◽  
pp. 87-99
Author(s):  
Jodie McVernon ◽  
Hester de Melker

Over the past 60 years, pertussis vaccines have been implemented in national immunization programme schedules at a variety of ages. All countries administer the vaccine as an infant primary series, but the number and exact timing of these doses differ, as do the number and timing of booster doses. In consequence, short-term direct protection of age-appropriately immunized children varies by schedule. This variability influences vaccine impact on the burden of disease, because the risk of severe morbidity and mortality is greatest in early life and decreases thereafter. In addition, vaccine-derived immunity wanes over time, meaning that longer intervals between doses are predicted to increase the risk of breakthrough infections throughout childhood and adolescence, fuelling ongoing transmission and cyclic epidemics. The duration of protection following vaccination is substantially shorter than following infection, although absolute estimates vary widely across populations and studies.


SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A304-A305
Author(s):  
Francisco Marquez ◽  
Andrea Decker ◽  
Jennifer Taber ◽  
Mengya Xia ◽  
Matthew Cribbet

Abstract Introduction Individuals with early life adversity (ELA) experience a greater likelihood of sleep disturbance. Sleep disturbance is a hypothesized mechanism underlying the association between ELA and adverse health outcomes. However, it is unclear whether sleep disturbance presents differently in individuals with ELA when compared to individuals without ELA. Network analysis provides an analytic framework to examine the relationships and magnitudes of association between symptoms of sleep disturbance. Using a network framework, we investigated the differences in sleep disturbance symptoms between individuals with ELA and individuals without ELA. Methods College students (N=507; age=18±1, Female=72%) completed demographic measures, the Childhood Trauma Questionnaire (CTQ), and the Pittsburgh Sleep Quality Index using an online data collection platform from March-December 2020. Using clinical cutoffs, individuals with ELA were separated from individuals without ELA. Using the Pittsburgh Sleep Quality Index (PSQI; alpha=0.79), sleep disturbance was assessed. Two 7-node ELA-specific networks were generated using raw values for the 7 components of the PSQI. To assess network accuracy, stability coefficients were estimated using the ‘bootnet’ and ‘qgraph’ packages in R. The strength of association between each component and all other components of sleep disturbance were estimated using expected influence (EI). Network structures and measures of EI were examined for differences between exposure groups. Results Overall, the average global PSQI score was 7.50±3.37. Individuals with ELA had larger global PSQI scores when compared to individuals without ELA (8.18 versus 6.97, t=3.8, p<0.001, d=0.37). For individuals with ELA, sleep quality, duration, and efficiency were most associated with other symptoms of sleep disturbance. For individuals without ELA, subjective sleep quality, sleep latency, and daytime dysfunction were most related to other symptoms of sleep disturbance. Individuals with ELA demonstrated a more interrelated network structure, with greater raw measures of EI in most components of the PSQI. Conclusion For individuals with ELA, duration and efficiency strongly underly sleep disturbance. Moreover, most symptoms had greater measures of EI in individuals with ELA when compared to individuals without ELA, suggesting that symptoms of sleep disturbance may be more likely to co-occur in individuals with ELA. Future research may explore the utility of these symptoms in predicting adverse health outcomes. Support (if any):


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S576-S577
Author(s):  
Claudia Recksiedler ◽  
Boris Cheval ◽  
Stefan Sieber ◽  
Robert S Stawski ◽  
Stephane Cullati

Abstract Research documented the impact of marital transitions—particularly marital loss—on depression in old age, yet its severity depends multiple factors. Individuals’ capability to cope with transitions depends on available resources and previous exposure to stressors, such as early-life adversity, which buffers or aggravates the impact of marital transitions on later-life depression. Although studies documented the pivotal link between early-life adversity and negative health trajectories, our study is the first attempt to examine whether early-life adversity influences the relationship between prospectively-tracked, later-life marital transitions and depression. We drew data from SHARE, which samples individuals aged 50+ across Europe (N = 13,258; 2004-2016). Using multilevel linear models, we found that women who became widowed had higher levels of depression compared to coupled and single women, but experienced lower increases in depression over time. After adjusting for early-life and adulthood SES, losing a partner remained significantly associated with depression. Life-course SES was associated with levels of depression, yet interactions between marital transitions and SES were not, with some exceptions: single women who reported difficulties in their ability to make ends meet experience higher increases of depression over time. Overall, results were similar for men. Interactions between family transitions and SES were again not significant, with a few exceptions for single men: those born in more childhood conditions, and those with high education, had lower levels of depression. We interpret and discuss our findings through the lens of life-course and stress-resiliency perspectives and in light of changing family dynamics for this age group.


2019 ◽  
Vol 12 (3) ◽  
pp. 353-384 ◽  
Author(s):  
Muriel Norde ◽  
Sarah Sippach

Libfixes are parts of words that share properties with both blends, compounds and affixes. They are deliberate formations, often with a jocular character, e.g. nerdalicious ‘delicious for nerds’, or scientainment ‘scientific entertainment’. These are not one-off formations – some libfixes have become very productive, as evidenced by high type frequency in a single corpus. Libfix constructions are particularly interesting for a network analysis for three reasons: they do not always have discrete morpheme boundaries, they feature a wide variety of bases (including phrases, as in give-me-a-break-o-meter), and they may be the source of back formations such as infotain. In this paper, we present a corpus-based analysis of eight English libfixes (cracy, fection, flation, gasm, licious, (o-)meter, tainment, and tastic), detailing their formal and semantic properties, as well as their differences and similarities. We argue that libfixes are most fruitfully analysed in a Bybeean network model, in which nodes are connected on the basis of phonological similarity, which allows for both fully compositional and non-compositional constructions to be linked without an exhaustive analysis into morphemes.


2019 ◽  
Author(s):  
Mary Elizabeth Zinn ◽  
Edward Huntley ◽  
Daniel Keating

Introduction. Early life adversity (ELA) can result in negative health-outcomes, including psychopathology. Evidence suggests that adolescence is a critical developmental period for processing ELA. Identity formation, which is crucial to this developmental period, may moderate the effect between ELA and psychopathology. One potential moderating variable associated with identity formation is Prospective Self, a latent construct comprised of future-oriented attitudes and behaviors.Methods. Participants are from the first wave of an ongoing longitudinal study designed to characterize behavioral and cognitive correlates of risk behavior trajectories. A community sample of 10th and 12th grade adolescents (N = 2017, 55% female) were recruited from nine public school districts across eight Southeastern Michigan counties in the United States. Data were collected in schools during school hours or after school via self-report, computer-administered surveys. Structural equation modeling was used in the present study to assess Prospective Self as a latent construct and to evaluate the relationship between ELA, psychopathology, and Prospective Self.Results. Preliminary findings indicated a satisfactory fit for the construct Prospective Self. The predicted negative associations between Prospective Self and psychopathology were found and evidence of moderation was observed for externalizing behavior problems, such that the effects of ELA were lower for individuals with higher levels of Prospective Self. Conclusion. These results support the role of Prospective Self in conferring resilience against externalizing behavior problems associated with ELA among adolescents. Keywords: Adolescence, Adverse Childhood Experiences, Psychopathology, Self-concept, Adolescent Health, Early Life Adversity


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