On-Line Generation of Cyanogen Chloride in Semiautomated Determination of Niacin and Niacinamide in Food Products

1986 ◽  
Vol 69 (3) ◽  
pp. 560-562
Author(s):  
Hoon Ge ◽  
Gary N Oman ◽  
Frank J Ebert
Keyword(s):  
Potassium Cyanide ◽  
Food Products ◽  
Cyanogen Chloride ◽  
Significant Difference ◽  
On Line ◽  
Chloramine T ◽  
Semiautomated Method ◽  
Paired T Test

Abstract The current AOAC procedure for semiautomated determination of niacin specifies the use of externally generated cyanogen bromide. Because of the safety concerns in handling this material, we investigated the use of an alternative system of generating cyanogen chloride in situ, using chloramine-T and potassium cyanide. Recovery studies conducted on 9 different food products yielded average recoveries of 101 %. A repeatability study resulted in a measured coefficient of variation of 2.9%. The AOAC niacin method was compared with this semiautomated method; 115 paired analyses on 8 different food types over 6 separate analytical replications indicated no significant difference by a paired t-test at the 95% confidence level.

Simultaneous Determination of Benzoic Acid and Sorbic Acid in Food Products by CE after On-line Preconcentration by Dynamic pH Junction

2011 ◽  
Vol 73 (11-12) ◽  
pp. 1217-1221 ◽  
Author(s):  
Xinfeng Zhang ◽  
Shuxia Xu ◽  
Yonghua Sun ◽  
Yanyan Wang ◽  
Cheng Wang
Keyword(s):  
Benzoic Acid ◽  
Simultaneous Determination ◽  
Sorbic Acid ◽  
Food Products ◽  
Dynamic Ph Junction ◽  
On Line

Impact of Cytogenetic Abnormalities On Outcome Among Patients with Relapsed/Refractory Multiple Myeloma Treated with Bortezomib: Adverse Effect of 1q21 (CKS1B) Amplification.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 2826-2826
Author(s):  
Hong Chang ◽  
Young Trieu ◽  
Connie Qi ◽  
Wei Xu ◽  
Donna E. Reece
Keyword(s):  
High Risk ◽  
Genetic Factors ◽  
Objective Response ◽  
Cytogenetic Abnormalities ◽  
Significant Difference ◽  
Variate Analysis ◽  
Ortho Biotech ◽  
Duration Of Response

Abstract Abstract 2826 Poster Board II-802 To investigate whether genetic risk factors affect the outcome of relapsed/refractory myeloma patients undergoing bortezomib therapy, we evaluated the clinical features of 85 patients treated with bortezomib and correlated with the high-risk cytogenetic abnormalities as detected by interphase cytoplasmic fluorescence in situ hybridization (cIg-FISH). Forty (47%) patients had an objective response to bortezomib with median progression free (PFS) and overall survivals (OS) of 9.4 and 12.6 months, respectively. cIg-FISH determination of del(13q), del(17p), del(1p21), t(4;14), and amp. (1q21)(CKS1B) was done on 79, 77, 77, 78, and 80 cases and the frequency of their detection was 38%, 22%, 26%, 18%, and 39%, respectively. There was no statistically significant difference in terms of response or duration of response to bortezomib for patients with or without any of the cytogenetic abnormalities. PFS was also comparable among patients with and without the aforementioned genetic markers. However, patients with 1q21(CKS1B) amplification had significantly shorter OS than those without such abnormality (5.3 vs. 24.6 months, p=0.0005). Multi-variate analysis adjusting for all 5 high-risk genetic factors confirmed that 1q21(CKS1B) amplification is an independent risk factor for OS (p=0.008). Improved therapeutic strategies may be required for this subgroup of patients. Disclosures: Reece: Ortho Biotech: Honoraria, Research Funding.

scholarly journals Development and application of a portable instrument for drugs analysis in pharmaceutical preparations

2015 ◽  
Vol 51 (3) ◽  
pp. 699-708
Author(s):  
Paulo Roberto da Silva Ribeiro ◽  
Helena Redigolo Pezza ◽  
Leonardo Pezza ◽  
Liliane Spazzapam Lima ◽  
Matthieu Tubino
Keyword(s):  
Low Cost ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Products ◽  
Ammonium Molybdate ◽  
Quantitative Studies ◽  
Significant Difference ◽  
Drugs Analysis ◽  
And Performance

This article describes the application and performance of an inexpensive, simple and portable device for colorimetric quantitative determination of drugs in pharmaceutical preparations. The sensor is a light detector resistor (LDR) incorporated into a black PTFE cell and coupled to a low-cost multimeter (Ohmmeter). Quantitative studies were performed with captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems. Calibration curves were obtained by plotting the electrical resistance of the LDR against the concentration of the colored species in the ranges 1.84 × 10-4 to 1.29 × 10-3mol L-1 and 5.04 × 10-4 to 2.52 × 10-3 mol L-1 for captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems, respectively, exhibiting good coefficients of determination. Statistical analysis of the results obtained showed no significant difference between the proposed methodologies and the official reported methods, as evidenced by the t-test and variance ratio at a 95% confidence level. The results of this study demonstrate the applicability of the instrument for simple, accurate, precise, fast,in situ and low-cost colorimetric analysis of drugs in pharmaceutical products.

scholarly journals Spectrophotometric determination ofβ-blocker drugs by oxidation with bromate–bromide mixture and its analytical application to pharmaceutical preparations

2011 ◽  
Vol 25 (6) ◽  
pp. 303-315 ◽  
Author(s):  
Akram M. El-Didamony ◽  
Eman A. H. Erfan
Keyword(s):  
Indigo Carmine ◽  
Pharmaceutical Preparations ◽  
Reaction Conditions ◽  
Statistical Comparison ◽  
Spectrophotometric Methods ◽  
Significant Difference ◽  
Optimum Reaction ◽  
Comparison Of The Results

Three visible spectrophotometric methods (A–C) were developed for the analysis of someβ-blocker drugs, namely atenolol (ATE) and timolol (TIM) based on their reactivity with bromine, generated in situ by the action of hydrochloric acid on bromate–bromide mixture. The determination of residual bromine is based on its ability to bleach the indigo carmine dye and measuring the absorbance at 610 nm (method A). Methods B and C involve treating the unreacted bromine with a measured excess of iron (II), the remaining iron (II) is complexed with 1,10-phenanthroline (method B) or with 2,2'-bipyridyl (method C) and measuring the increase in absorbance at 510 and 522 nm, respectively. In all the methods, the amount of bromine reacted corresponding to the drug content. Regression analysis of Beer's plot showed good correlation in the concentration ranges of 0.4–16.4, 0.8–10.4 and 0.4–12.8 µg/ml using methods A–C, respectively, for ATE and 14–38, 12–32 and 14–38 µg/ml using methods A–C, respectively, for TIM. The optimum reaction conditions and other analytical parameters are evaluated. No interference was observed from the additives and the applicability of the methods was tested by analyzing the pharmaceutical preparations containing the investigated drugs. Statistical comparison of the results with those of official methods shows excellent agreement and indicates no significant difference in precision.

scholarly journals An Automated Procedure for the Determination of Total Alkaloids in Cigarette Smoke Using On-line Cyanogen Chloride Generation from Low Hazard Starting Materials

1986 ◽  
Vol 13 (3) ◽  
pp. 151-155
Author(s):  
RG Lidzey ◽  
GP Savage
Keyword(s):  
Cigarette Smoke ◽  
Sodium Hypochlorite ◽  
Cyanogen Bromide ◽  
Potassium Thiocyanate ◽  
Total Alkaloids ◽  
Cyanogen Chloride ◽  
On Line ◽  
Low Toxicity

AbstractAn automated procedure is described for the determination of alkaloids in cigarette smoke using low toxicity reagents. Cyanogen chloride is formed on line from potassium thiocyanate and sodium hypochlorite. The procedure is compared with the previously used cyanogen bromide method which also uses Auto Analyser II methodology.

scholarly journals Influential Factors and Determination of strength of in-situ concrete, using twist-off method.

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Pooria Najarbashi ◽  
Mahmoud Naderi
Keyword(s):  
Low Cost ◽  
Concrete Strength ◽  
Influential Factors ◽  
Laboratory Methods ◽  
Significant Difference ◽  
Site Evaluation ◽  
In Situ Methods ◽  
Very High

Concrete strength represents by far the most critical property of concrete. It represents the mechanical properties of concrete. On-site evaluation of concrete strength remains the fundamental challenge in the condition assessment of existing infrastructure. Although standard laboratory methods can be typically used but most of these testing methods are costly and time-consuming. Among the in-situ methods, the “twist-off ” method with very slight damage is genuinely a convenient, fast and also low-cost technique that provides accurate results for engineers. In this study, the twist-offmethod has been used for the assessment of in-situ strength of the 30 concrete structures in Qazvin in Iran. The results showed structures studied had a strength of 45 to 600 kg/cm2 and the average is about 200 kg/cm2. The observed variation is very high, as well as a significant difference between the compressive strength of the columns, and the floors of the buildings that all indicate non-standard concrete mixing and inadequate control over construction. However, according to the past experience and results of the samples, some recommendations in this regard have been suggested.

In situ microscopy for on-line determination of biomass

1998 ◽  
Vol 60 (1) ◽  
pp. 24-35 ◽  
Author(s):  
C. Bittner ◽  
G. Wehnert ◽  
T. Scheper
Keyword(s):  
On Line

On-line determination of glucose in biotechnological processes: comparison between FIA and an in situ enzyme electrode

1991 ◽  
Vol 18 (1-2) ◽  
pp. 153-160 ◽  
Author(s):  
Claudio Filippini ◽  
Bernhard Sonnleitner ◽  
Armin Fiechter ◽  
Joanne Bradley ◽  
Rolf Schmid
Keyword(s):  
Enzyme Electrode ◽  
On Line ◽  
Biotechnological Processes
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