scholarly journals Determination of Sodium Azide in Beverages by Ion Chromatography

2000 ◽  
Vol 83 (6) ◽  
pp. 1410-1414 ◽  
Author(s):  
Harumi Oshima ◽  
Eiji Ueno ◽  
Isao Saito ◽  
Hiroshi Matsumoto
Keyword(s):  
Detection Limit ◽  
Sample Preparation ◽  
Sodium Hydroxide ◽  
Ion Chromatography ◽  
Sodium Azide ◽  
Convenient Method ◽  
Sodium Hydroxide Solution ◽  
Hydrazoic Acid ◽  
Suppressed Conductivity Detection

Abstract A convenient method for determination of sodium azide in beverages using ion chromatography is described. This method combines the specificity for azide with a simple sample preparation using a bubble and trap apparatus that removes any interferences. Sodium azide in a sample was acidified, and the azide was converted to the volatile hydrazoic acid, which was trapped in 2.5mM sodium hydroxide solution. Determination was performed by isocratic ion chromatography using suppressed conductivity detection. Calibration curves were linear for 0.5 to 20 μg/mL sodium azide and the detection limit was 0.05 μg/mL. Recoveries of sodium azide from spiked samples (10.0 μg/g) were more than 82.6%. The method was then used to analyze various beverages.

The determination of nitrate and sulphate in 50% sodium hydroxide solution by ion-chromatography

Talanta ◽  
1988 ◽  
Vol 35 (3) ◽  
pp. 245-247 ◽  
Author(s):  
Jarl M. Petersen ◽  
Hanne G. Johnsen ◽  
Walter Lund
Keyword(s):  
Sodium Hydroxide ◽  
Ion Chromatography ◽  
Sodium Hydroxide Solution ◽  
Hydroxide Solution

A New Micromethod for Determination of Protein in Cerebrospinal Fluid and Urine

1973 ◽  
Vol 19 (11) ◽  
pp. 1265-1267 ◽  
Author(s):  
Michael A Pesce ◽  
Carl S Strande
Keyword(s):  
Cerebrospinal Fluid ◽  
Detection Limit ◽  
Sodium Hydroxide ◽  
Trichloroacetic Acid ◽  
Gamma Globulin ◽  
Sodium Hydroxide Solution ◽  
Micro Scale ◽  
Dilute Sodium Hydroxide ◽  
Ponceau S

Abstract We developed a new micro-scale procedure for determination of protein in cerebrospinal fluid and urine. The sample (50 µl) is mixed with a trichloroacetic acid—Ponceau S dye solution. The proteins, together with a proportional amount of dye, are precipitated and the red precipitate is dissolved in dilute sodium hydroxide solution, giving a violet-colored solution. This color, linearly proportional to the amount of protein present (up to 150 mg/dl), is measured spectrophotometrically at 560 nm. By varying the sample size alone, protein concentrations up to 1500 mg/dl can be measured. The detection limit for the method is 2 mg/dl of sample. Precipitation of the proteins is independent of temperature and albuminbinding compounds, and is not appreciably affected by the albumin—gamma globulin ratio.

scholarly journals Determination of Genotoxic Azide Impurity in Cilostazol API by Ion Chromatography with Matrix Elimination

Separations ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 162
Author(s):  
Boglárka Páll ◽  
Zsuzsa Gyenge ◽  
Róbert Kormány ◽  
Krisztián Horváth
Keyword(s):  
Sample Preparation ◽  
Ion Chromatography ◽  
Sodium Azide ◽  
Limit Of Detection ◽  
Active Pharmaceutical Ingredient ◽  
Liquid Extraction ◽  
Limit Of Quantification ◽  
Positive Effects ◽  
Liquid Liquid Extraction

Cilostazol is a commonly used active pharmaceutical ingredient (API) to treat and reduce the symptoms of intermittent claudication in peripheral vascular disease. Recently, it was found to be a potential medicine in the effective treatment of COVID-19. In addition to the positive effects of this API, genotoxic sodium azide is used in the synthesis of cilostazol that can appear in the API. In this work, a method was developed for the determination of sodium azide (as azide anion) in cilostazol API at 7.5 ppm limit level by using ion chromatography (IC) and liquid–liquid extraction (LLE) sample preparation. The liquid–liquid extraction allows the application of high sample concentrations. Because of the low limit concentration (7.5 ppm), 500 mg sample was dissolved in 5 mL solvent. By using LLE for sample preparation, the huge amount of cilostazol was omitted and column overload was avoided. The developed method was validated in accordance with the relevant guidelines. Specificity, accuracy, precision, limit of detection and limit of quantification parameters were evaluated. The calculated limit of detection was 0.52 ppm (S/N:3) and the limit of quantification was 1.73 ppm (S/N:10) for sodium azide. The recovery of the sodium azide was 102.4% and the prepared solutions were stable in the sample holder for 24 h.

Colorimetric Determination of Oxyphenisatin and Oxyphenisatin Diacetate in Pharmaceutical Preparations

1964 ◽  
Vol 47 (4) ◽  
pp. 688-692
Author(s):  
Antoine Major
Keyword(s):  
Aqueous Solution ◽  
Organic Solvent ◽  
Silver Nitrate ◽  
Sodium Hydroxide ◽  
Column Chromatography ◽  
Sodium Hydroxide Solution ◽  
Pharmaceutical Preparations ◽  
Colorimetric Determination ◽  
Hydroxide Solution

Abstract A method is described which will quantitatively determine 0.1 mg oxyphenisatin or the diacetate in various pharmaceutical preparations. After removal of interferences by organic solvent extractions from aqueous solution and partition column chromatography, the reaction of oxyphenisatin (diacetate) with silver nitrate in alcoholic sodium hydroxide solution produces a violet solution, which follows Beer’s law (1—15 μg per ml). The method was satisfactorily applied to the assay of commercial tablets, liquids, and powders with recoveries, as per cent found of declared, in the range 95—101%.

Determination of Cl- in Concrete Materials by Ion Chromatography

2016 ◽  
Vol 680 ◽  
pp. 52-55
Author(s):  
Hong Yan Guan ◽  
Jian Jun Ding ◽  
Zhong Bao Guo ◽  
Ming Yu Wang ◽  
Yi Fei Mei
Keyword(s):  
Detection Limit ◽  
Ion Chromatography ◽  
Potential Method ◽  
Concrete Cover ◽  
Chloride Ions ◽  
Accurate Analysis ◽  
Chromatography Method ◽  
Concrete Materials ◽  
Corrosion Of Steel

The determination of chloride ions in concrete materials accurately is far and away crucial, since chloride ions can cause corrosion of steel and concrete cover off. The conventional potential method and silver nitrate titration method usually show features of simple operation and short duration, nevertheless, they are not suitable for accurate analysis for concrete attributing to their low accuracy and detection limit. In this paper, an ion chromatography method was presented to determine chlorine in concrete materials. Concrete samples were pre-processed and then extracted with distilled water. The extraction solutions were purified on a 0.22 μm filter membrane, an On Guard SPE-RP column and a SPE-H column sequentially for eliminating undissolved substance, organisms and metal ions before ion chromatographic analysis. The chromatographic separation was performed on a Dionex ICS-1000 Chromatographic using 25.0 mmol/L KOH solutions as mobile phase at 1.0 mL/min. Results show that the detection limit of the method was 0.004 mg/L. The linear relationship of the external Cl- standard solutions was 0.9994, and the sample analytical RSD was 0.44%.

Simple Colorimetric Method for Determination of Acetaminophen

1980 ◽  
Vol 63 (6) ◽  
pp. 1189-1190
Author(s):  
Ramesh T Sane ◽  
Sudhir S Kamat
Keyword(s):  
Elevated Temperature ◽  
Sodium Hydroxide ◽  
Sodium Hydroxide Solution ◽  
Colorimetric Method ◽  
Hydroxide Solution

Abstract A simple colorimetric method for the determination of acetaminophen is described. The method is based on the measurement of a crimson complex formed when acetaminophen is treated with 10% sodium hydroxide solution at elevated temperature. Compounds such as phenacetin, aspirin, caffeine, oxyphenbutazone, barbiturates, hydantoins, and dextropropoxyphen which are present in various formulations containing acetaminophen do not interfere. The method is sensitive to concentrations as low as 25 μg acetaminophen/mL.

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