268 Administration of a Bacillus probiotic to sows improves growth response and health of their progeny after weaning

Abstract A Bacillus probiotic administered to sows was evaluated to determine the effect on their litters and subsequent pig growth response during the nursery phase. The study included 500 sows (250 sows/trt) fed a control or treatment diet with two Bacillus subtilis strains administered at 3.7x105 CFU/g of feed beginning three days after mating. Pigs (n=1,100) weaned from the sow phase were divided into 44 pens (22 pens/trt) and fed a common diet to determine the effect of sow treatment on post-weaning growth performance. Fecal samples were collected from a subset of sows (25/trt) at d112 of gestation and d19 of lactation, and from two pigs/pen in the nursery on d3 post-weaning for microbial enumeration. A blood sample was obtained from two pigs/pen on d3 and serum cytokines and the acute phase protein, α-1-acid glycoprotein (AGP) were quantified. Data were analyzed using the MIXED procedure of SAS; sow/litter and pen served as the experimental unit. Litter weaning weights did not differ, but Escherichia coli counts were lower (P≤0.05) on d112 in fecal samples from sows fed Bacillus compared to control sows. Lactic acid bacteria counts were greater (P≤0.01) on d3 post-weaning in pigs weaned from sows fed Bacillus compared to control pigs. Nursery pigs weaned from sows fed the Bacillus probiotic had greater (P≤0.01) ADG and G/F during Phase1 (d 0-11), greater (P≤0.01) ADG and ADFI during Phase3 (d 23-37) and were 0.91 kg heavier (P≤0.01) at the end of the nursery phase (d 51) compared to pigs from control sows. The administration of Bacillus to sows resulted in lower AGP (P≤0.05) and greater tumor necrosis factor-α (P=0.08) serum concentrations on d3 post-weaning and reduced (P≤0.05) the percentage of nursery pigs removed from the trial and placed in invalid pens compared to pigs from control sows. These data indicate that a Bacillus probiotic improves sow health and the lactation environment and has a substantial impact on the subsequent productivity of their progeny.

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Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes

Circulation ◽

10.1161/01.cir.95.5.1247 ◽

1997 ◽

Vol 95 (5) ◽

pp. 1247-1252 ◽

Cited By ~ 208

Author(s):

Tomoyuki Yokoyama ◽

Masayuki Nakano ◽

John L. Bednarczyk ◽

Bradley W. McIntyre ◽

Mark Entman ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Cardiac Myocytes ◽

Tumor Necrosis ◽

Growth Response ◽

Tumor Necrosis Factor Α ◽

Hypertrophic Growth ◽

Adult Cardiac Myocytes ◽

Factor Α ◽

Necrosis Factor

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Transcriptional regulation of the growth-regulated oncogene α gene by early growth response protein-1 in response to tumor necrosis factor α stimulation

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ◽

10.1016/j.bbagrm.2013.07.005 ◽

2013 ◽

Vol 1829 (10) ◽

pp. 1066-1074 ◽

Cited By ~ 17

Author(s):

Soon Young Shin ◽

Jong Min Lee ◽

Yoongho Lim ◽

Young Han Lee

Keyword(s):

Transcriptional Regulation ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Growth Response ◽

Tumor Necrosis Factor Α ◽

Early Growth ◽

Early Growth Response ◽

Factor Α ◽

Necrosis Factor

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Exogenous testosterone modulates tumor necrosis factor-α and acute phase protein responses to repeated endotoxin challenge in steers

Domestic Animal Endocrinology ◽

10.1016/j.domaniend.2005.11.005 ◽

2006 ◽

Vol 31 (4) ◽

pp. 301-311 ◽

Cited By ~ 22

Author(s):

S. Kahl ◽

T.H. Elsasser

Keyword(s):

Tumor Necrosis Factor ◽

Acute Phase ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Acute Phase Protein ◽

Endotoxin Challenge ◽

Phase Protein ◽

Factor Α ◽

Necrosis Factor

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Effects of acanthoic acid on TNF-α gene expression and haptoglobin synthesis

Mediators of Inflammation ◽

10.1080/09629359890938 ◽

1998 ◽

Vol 7 (4) ◽

pp. 257-259 ◽

Cited By ~ 12

Author(s):

H-S. Kang ◽

H. K. Song ◽

J-J. Lee ◽

K-H. Pyun ◽

I. Choi

Keyword(s):

Gene Expression ◽

Biological Function ◽

Acute Phase Protein ◽

Inhibitory Effects ◽

Rt Pcr ◽

Tnf Α ◽

Phase Protein ◽

Factor Α ◽

Necrosis Factor ◽

Acanthoic Acid

Tumour necrosis factor-α (TNF-α) is a major proinflammatory cytokine inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoim mune diseases, and inflammation. Our previous study demonstrated that acanthoic acid, (-)-pimara-9(11), 15-dien19-oic acid, a pimaradiene diterpene isolated fromAcanth opanax koreanum, inhibited TNF-α production. To extend our understanding of inhibitory effects of acanthoic acid on TNF-α production, its effects on TNF-α gene expression was tested. Based on the results from RT-PCR and promoter analysis of TNF-α, it was found that acanthoic acid suppressed TNF-α gene expression. But the same concentration of acanthoic acid had no effect on IL-6 gene expression. Haptoglobin is an acute phase protein which is induced by TNF-α. When liver cells were treated with acanthoic acid, haptoglobin synthesis was blocked by acanthoic acid. These data confirmed that acanthoic acid inhibited gene expression and biological function of TNF-α.

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Early Growth Response Factor-1 Mediates Prostaglandin E2-dependent Transcriptional Suppression of Cytokine-induced Tumor Necrosis Factor-α Gene Expression in Human Macrophages and Rheumatoid Arthritis-affected Synovial Fibroblasts

Journal of Biological Chemistry ◽

10.1074/jbc.m414067200 ◽

2005 ◽

Vol 280 (10) ◽

pp. 9536-9546 ◽

Cited By ~ 33

Author(s):

Wissam H. Faour ◽

Nada Alaaeddine ◽

Arturo Mancini ◽

Qing Wen He ◽

Dragan Jovanovic ◽

...

Keyword(s):

Tumor Necrosis ◽

Growth Response ◽

Tumor Necrosis Factor Α ◽

Synovial Fibroblasts ◽

Early Growth ◽

Response Factor ◽

Early Growth Response ◽

Transcriptional Suppression ◽

Factor Α ◽

Necrosis Factor

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In vivo changes in plasma acute phase protein levels in the rat induced by slow release of IL-1, IL-6 and TNF

Mediators of Inflammation ◽

10.1155/s0962935192000085 ◽

1992 ◽

Vol 1 (1) ◽

pp. 39-44 ◽

Cited By ~ 8

Author(s):

E. J. Lewis ◽

A. D. Sedgwick ◽

T. H. P. Hanahoe

Keyword(s):

Acute Phase ◽

Acute Phase Protein ◽

Continuous Release ◽

Protein Levels ◽

Phase Protein ◽

Interleukin 1Α ◽

Factor Α ◽

Higher Doses ◽

Necrosis Factor

Administration of large doses of cytokines by injection is required to induce changes in acute phase protein levels. Comparisons were made in the rat of the effects of administering recombinant human cytokines by injection with continuous release from implanted osmotic minipumps. Continuous release of interleukin-1β (0.2–2.1 ng h-1) induced dose-related changes in the plasma levels of albumin, seromucoid proteins, haptoglobin and caeruloplasmin; interleukin-1α had similar effects but required higher doses (2–21 ng h-1). Tumour necrosis factor α (50 ng h-1) only significantly increased seromucoid levels, whereas IL-6 (3–30 ng h-1) induced haptoglobin and caeruloplassynthesis. This method provides a better technique for studying the in rive effects of cytokines which may be relevant to the release mechanisms in inflammation.

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