83 Burn Injuries in Sub-Saharan Africa: A Global Burden of Disease Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S57-S58
Author(s):  
Zachary J Collier ◽  
Priyanka Naidu ◽  
Katherine J Choi ◽  
Christopher H Pham ◽  
Tom Potokar ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Data Exchange ◽  
Burn Injuries ◽  
Sub Saharan Africa ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Targeted Interventions ◽  
Burn Care ◽  
Life Years ◽  
Sub Saharan

Abstract Introduction Over 1 million burns occur in Sub-Saharan Africa (SSA) each year leading to significant morbidity and mortality. Financial constraints, social stigma, political strife, inaccessible healthcare facilities, limited perioperative resources, and low workforce capacity results in steep barriers to obtaining timely and effective burn care. This study set out to better define the burn burden as well as the age and gender-related disparities within SSA, to identify specific sub-regions and countries that would benefit most from targeted interventions to enhance burn care. Methods Data for all 46 SSA countries were acquired from the 2017 Global Burden of Disease (GBD17) database of the Global Health Data Exchange. Information regarding fire, heat, and hot substance-related injuries was derived from 17,792 data sources to estimate burn-related incidence, deaths, and Disability Adjusted Life Years (DALYs) by year, sex, age, and location from 1990 to 2017. Summative statistics were created for burn incidence, deaths, DALYs, and mortality ratio (deaths: incidence; %). Spatial mapping was performed to identify burn burden for specific regions and countries. Results An estimated 28,127,199 burns occurred in SSA from 1990–2017. On average, SSA accounted for 16% of worldwide burns, 21% of burn deaths, and 25% of DALYs. Furthermore, the mortality rate was 2.2 times the global average and remained nearly double the entire 27-year period. While all SSA regions had higher incidence, deaths, and DALYs compared to the global cohort, the Southern SSA region consistently had the highest incidence (211 cases per 100,000), deaths (7 per 100,000), and DALYs (355 years per 100,000) throughout the time period, with Lesotho, Swaziland, and Zimbabwe having the highest rates. In contrast to gender similarities globally for burn indicators, all regions within SSA showed higher incidence rates (144 vs 136 cases per 100,000), deaths (5.4 vs 4.7 deaths per 100,000), and DALYs (289 vs 272 years per 100,000) for men than women when age standardized. Conclusions With an estimated 1.4 million burn injuries in 2017, SSA accounted for over 15% of all worldwide burns and 20% of global burn deaths. Although all trended rates improved over the years for each country, they were consistently worse and slower to improve in all regions of SSA compared to the rest of the world. While both Central and Southern SSA regions had the greatest burn burden, burns in Central SSA more significantly impacted those under 5 years whereas Southern SSA saw the greatest burden on the 15–49-year age group.

scholarly journals Physiotherapy in the management of non-communicable diseases: facing the challenge

2005 ◽  
Vol 61 (2) ◽  
Author(s):  
J. M. Frantz
Keyword(s):  
Burden Of Disease ◽  
Health Resources ◽  
Communicable Diseases ◽  
Sub Saharan Africa ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Non Communicable Diseases ◽  
Epidemiological Changes ◽  
Rising Incidence ◽  
Sub Saharan

There is mounting evidence of the rising incidence and prevalence of non-communicable diseases in developing countries. Governments are facing serious challenges in health care due to the rising trends in non-communicable diseases as a result of demographic and epidemiological changes, as well as economic globalization. Cardiovascular disease, cancers, diabetes, respiratory disease, obesity andother non-communicable conditions now account for 59 percent of the 56.5 million global deaths annually, and almost half, or 46 percent, of the global burden of disease. It is estimated that by 2020, non-communicable diseases will account for 60% of the global burden of disease. The burden of non-communicable diseases in sub-Saharan Africa is already substantial, and patients with these conditions make significant demands on health resources. How do these changes affect physiotherapists? This paper aims to highlight the need for physiotherapists to shift their focus from curative to preventive care in order to face the challenge of non-communicable diseases.

scholarly journals Unintentional injuries in Mexico, 1990–2017: findings from the Global Burden of Disease Study 2017

2020 ◽  
Vol 26 (Supp 1) ◽  
pp. i154-i161
Author(s):  
Martha Híjar ◽  
Ricardo Pérez-Núñez ◽  
Elisa Hidalgo-Solórzano ◽  
Bernardo Hernández Prado ◽  
Rosario Valdez-Santiago ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Unintentional Injury ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Unintentional Injuries ◽  
Targeted Interventions ◽  
Life Years ◽  
Injury Burden ◽  
Disease Study ◽  
Incident Cases

BackgroundTo date, the burden of injury in Mexico has not been comprehensively assessed using recent advances in population health research, including those in the Global Burden of Disease Study 2017 (GBD 2017).MethodsWe used GBD 2017 for burden of unintentional injury estimates, including transport injuries, for Mexico and each state in Mexico from 1990 to 2017. We examined subnational variation, age patterns, sex differences and time trends for all injury burden metrics.ResultsUnintentional injury deaths in Mexico decreased from 45 363 deaths (44 662 to 46 038) in 1990 to 42 702 (41 439 to 43 745) in 2017, while age-standardised mortality rates decreased from 65.2 (64.4 to 66.1) in 1990 to 35.1 (34.1 to 36.0) per 100 000 in 2017. In terms of non-fatal outcomes, there were 3 120 211 (2 879 993 to 3 377 945) new injury cases in 1990, which increased to 5 234 214 (4 812 615 to 5 701 669) new cases of injury in 2017. We estimated 2 761 957 (2 676 267 to 2 859 777) disability-adjusted life years (DALYs) due to injuries in Mexico in 1990 compared with 2 376 952 (2 224 588 to 2 551 004) DALYs in 2017. We found subnational variation in health loss across Mexico’s states, including concentrated burden in Tabasco, Chihuahua and Zacatecas.ConclusionsIn Mexico, from 1990 to 2017, mortality due to unintentional injuries has decreased, while non-fatal incident cases have increased. However, unintentional injuries continue to cause considerable mortality and morbidity, with patterns that vary by state, age, sex and year. Future research should focus on targeted interventions to decrease injury burden in high-risk populations.

scholarly journals The Global Burden of Shigella and Enterotoxigenic E. coli: Results from the Global Burden of Disease Study 2016

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S365-S365 ◽  
Author(s):  
Ibrahim Khalil
Keyword(s):  
Burden Of Disease ◽  
Population Attributable Fraction ◽  
Sub Saharan Africa ◽  
Enterotoxigenic Escherichia Coli ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Life Years ◽  
Disease Study ◽  
Children Under 5

Abstract Background Diarrhea is the seventh leading cause of death globally, responsible for more than 1,600,000 deaths in 2016 and nearly 90% of these deaths occurred in sub-Saharan Africa and South Asia. The Global Burden of Disease Study (GBD) is an annual effort to produce and refine estimates of diarrheal disease burden attributable to Shigella spp., enterotoxigenic Escherichia coli (ETEC), and other enteric pathogens. Methods We used a counter-factual approach to estimate deaths, incidence, years of life lost (YLLs), years living with disability (YLDs), and total disability adjusted life years (DALYs) attributable to diarrhea and its etiologies, including Shigella and ETEC. To estimate the burden of diarrhea etiologies, we conducted a systematic review of the proportion of diarrheal cases positive for each pathogen and modeled these data using a Bayesian meta-regression tool called DisMod-MR. This tool generates estimates of the pathogen distribution for national and some subnational geographies, all age groups, and for both sexes from 1990 to 2016. We used these estimates, in conjunction with odds ratios for diarrhea given pathogen detection from the Global Enteric Multicenter Study, to calculate the population attributable fraction for each pathogen. Results In 2016, Shigella was responsible for 75,000 deaths among children under-5 and 270,000 deaths among all ages and ETEC was responsible for 22,000 deaths among children under-5 and 60,000 deaths among all ages. Shigella and ETEC ranked second and fourth with regard to pathogen contributions to global diarrheal deaths. Conclusion The global burden of disease attributable to Shigella and ETEC is substantial. GBD 2016 estimates on the age- and location-specific impact of Shigella and ETEC enable evidence-based decision making regarding interventions to reduce the burden of these pathogens. Our findings call for accelerated efforts for the development of vaccines against ETEC and Shigella. Disclosures All authors: No reported disclosures.

scholarly journals Global, Regional, and National Burden of Chronic Myeloid Leukemia, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017

2020 ◽  
Vol 10 ◽  
Author(s):  
Qingqing Lin ◽  
Liping Mao ◽  
Li Shao ◽  
Li Zhu ◽  
Qingmei Han ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Burden Of Disease ◽  
Myeloid Leukemia ◽  
Sub Saharan Africa ◽  
Global Burden Of Disease ◽  
Accurate Information ◽  
Global Burden ◽  
Life Years ◽  
Incidence And Mortality ◽  
Incident Cases

BackgroundWith the advent of tyrosine kinase inhibitors (TKIs), the prognosis of chronic myeloid leukemia (CML) seems to have dramatically improved over the last two decades. Accurate information of the global burden of CML is critical for direct health policy and healthcare resource allocation in the era of high-cost TKI therapy.ObjectiveThis study aimed to evaluate the health burden of CML at global, regional, and national levels from 1990 to 2017.MethodsWe collected data of CML between 1990 and 2017 from the Global Burden of Disease (GBD) study 2017 including, annual incidence, disease-related mortality, and disability-adjusted life-years (DALY), and the corresponding age-standardized rates (ASRs). To summarize the results, countries were categorized by sociodemographic index (SDI) quintiles and 21 GBD regions.ResultsIn 2017, an estimated 34,179 [95% Uncertainty Interval (UI), 31,516–36,714) incident cases of CML were recorded, and 24,054 (95%UI, 22,233–26,072) CML-related deaths were reported worldwide. Both, the age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) steadily decreased from 1990 to 2017, with estimated annual percentage changes (EAPCs) of −2.39 (95%UI, −8.13–3.71) and −2.74 (95%UI, −9.31–4.31), respectively. The global incidence and mortality of CML in males were higher than that in females. The ASRs varied substantially across regions, with the highest burden in Andean Latin America, Central Sub-Saharan Africa, and Southeast Asia. Besides, the ASRs decreased most obviously in the high-SDI regions compared to non-high-SDI regions. Moreover, the lower the SDI, the higher was the proportion of deaths in the younger age groups.ConclusionDespite the decreasing trends of ASRs of CML from 1990 to 2017, the health-related burden of CML remains a challenge for the low-SDI regions. These findings highlight that appropriate strategies should be adopted in low-SDI countries to reduce the ASRs of CML.

scholarly journals Quantifying changes in global health inequality: the Gini and Slope Inequality Indices applied to the Global Burden of Disease data, 1990–2017

2019 ◽  
Vol 4 (5) ◽  
pp. e001500 ◽  
Author(s):  
Fridolin Steinbeis ◽  
Dzintars Gotham ◽  
Peter von Philipsborn ◽  
Jan M Stratil
Keyword(s):  
Global Health ◽  
Health Inequality ◽  
Burden Of Disease ◽  
Disease Burden ◽  
International Health ◽  
Sub Saharan Africa ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Relative Inequality ◽  
Life Years

BackgroundThe major shifts in the global burden of disease over the past decades are well documented, but how these shifts have affected global inequalities in health remains an underexplored topic. We applied comprehensive inequality measures to data from the Global Burden of Disease (GBD) study.MethodsBetween-country relative inequality was measured by the population-weighted Gini Index, between-country absolute inequality was calculated using the population-weighted Slope Inequality Index (SII). Both were applied to country-level GBD data on age-standardised disability-adjusted life years.FindingsAbsolute global health inequality measured by the SII fell notably between 1990 (0.68) and 2017 (0.42), mainly driven by a decrease of disease burden due to communicable, maternal, neonatal and nutritional diseases (CMNN). By contrast, relative inequality remained essentially unchanged from 0.21 to 0.19 (1990–2017), with a peak of 0.23 (2000–2008). The main driver for the increase of relative inequality 1990–2008 was the HIV epidemic in Sub-Saharan Africa. Relative inequality increased 1990–2017 within each of the three main cause groups: CMNNs; non-communicable diseases (NCDs); and injuries.ConclusionsDespite considerable reductions in disease burden in 1990–2017 and absolute health inequality between countries, absolute and relative international health inequality remain high. The limited reduction of relative inequality has been largely due to shifts in disease burden from CMNNs and injuries to NCDs. If progress in the reduction of health inequalities is to be sustained beyond the global epidemiological transition, the fight against CMNNs and injuries must be joined by increased efforts for NCDs.

scholarly journals Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016

2020 ◽  
Vol 77 (3) ◽  
pp. 142-150 ◽  
Author(s):  
Keyword(s):  
Occupational Exposure ◽  
Respiratory Disease ◽  
Burden Of Disease ◽  
Population Attributable Fraction ◽  
Occupational Exposures ◽  
Chronic Respiratory Disease ◽  
Sub Saharan Africa ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Life Years

ObjectivesThis paper presents detailed analysis of the global and regional burden of chronic respiratory disease arising from occupational airborne exposures, as estimated in the Global Burden of Disease 2016 study.MethodsThe burden of chronic obstructive pulmonary disease (COPD) due to occupational exposure to particulate matter, gases and fumes, and secondhand smoke, and the burden of asthma resulting from occupational exposure to asthmagens, was estimated using the population attributable fraction (PAF), calculated using exposure prevalence and relative risks from the literature. PAFs were applied to the number of deaths and disability-adjusted life years (DALYs) for COPD and asthma. Pneumoconioses were estimated directly from cause of death data. Age-standardised rates were based only on persons aged 15 years and above.ResultsThe estimated PAFs (based on DALYs) were 17% (95% uncertainty interval (UI) 14%–20%) for COPD and 10% (95% UI 9%–11%) for asthma. There were estimated to be 519 000 (95% UI 441,000–609,000) deaths from chronic respiratory disease in 2016 due to occupational airborne risk factors (COPD: 460,100 [95% UI 382,000–551,000]; asthma: 37,600 [95% UI 28,400–47,900]; pneumoconioses: 21,500 [95% UI 17,900–25,400]. The equivalent overall burden estimate was 13.6 million (95% UI 11.9–15.5 million); DALYs (COPD: 10.7 [95% UI 9.0–12.5] million; asthma: 2.3 [95% UI 1.9–2.9] million; pneumoconioses: 0.58 [95% UI 0.46–0.67] million). Rates were highest in males; older persons and mainly in Oceania, Asia and sub-Saharan Africa; and decreased from 1990 to 2016.ConclusionsWorkplace exposures resulting in COPD, asthma and pneumoconiosis continue to be important contributors to the burden of disease in all regions of the world. This should be reducible through improved prevention and control of relevant exposures.

scholarly journals Burden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017

2019 ◽  
Vol 7 (10) ◽  
pp. e1375-e1387 ◽  
Author(s):  
Hebe N Gouda ◽  
Fiona Charlson ◽  
Katherine Sorsdahl ◽  
Sanam Ahmadzada ◽  
Alize J Ferrari ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Communicable Diseases ◽  
Sub Saharan Africa ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Non Communicable Diseases ◽  
Sub Saharan ◽  
Disease Study

Abstract 062: Global Patterns Of Mean Systolic Blood Pressure Over Three Decades: Results From The Global Burden Of Disease 2019 Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Saate S Shakil ◽  
Catherine O Johnson ◽  
Gregory A Roth ◽  
Christian A Razo
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Burden Of Disease ◽  
High Income ◽  
Sub Saharan Africa ◽  
Asia Pacific ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Sub Saharan ◽  
Over Time

Background: Atherosclerotic cardiovascular disease and its risk factors are increasing globally. We estimated global and regional mean levels of systolic blood pressure (SBP) for the Global Burden of Disease (GBD) 2019 study. Methods: Mean SBP in mm Hg was estimated by age (adults >25 years), sex, location and year using all available population-based health surveys and studies that systematically measured brachial blood pressure. Estimates were produced using a Bayesian statistical model, spatiotemporal Gaussian process regression, which produces a smoothed time series from 1990 to 2019, borrowing strength over space and time, then aggregates to GBD regions. Each point in the figure represents age- and sex-specific mean SBP for one of 21 GBD regions, color coded by the 7 GBD super regions; black triangles denote global mean SBP. We report 95% uncertainty intervals in brackets. Results: Globally, mean SBP increased with age, peaking at 75-84 years, followed by a plateau and slight decline amongst oldest adults. In adults >60 in 1990 and >70 in 2019, females had higher SBP than males globally; this difference declined over time. In 1990, mean SBP was highest among females in Central Europe aged 60-64 (150 [147- 154]) and High-income Asia Pacific aged 80-84 (150 [147 - 152]), and in males aged 80-84 in Western Europe (150 [147-152]) and High-income Asia Pacific (148 [146 - 150]). By 2019, mean SBP was highest among adults aged 80-84 in Western and Southern Sub-Saharan Africa for both females (150 [136 - 164]; 149 [142 - 156], respectively), and males (145 [140 - 150]; 144 [136 - 153], respectively). Conclusions: SBP increased globally with age and was higher in older women than men. The 5-year age group with highest estimated SBP shifted over time from parts of Europe and High-income Asia Pacific to parts of Sub-Saharan Africa. Elevated SBP remains a major health risk for the world’s population, suggesting a need for increased investments in understanding its etiologies and how to treat and eventually prevent it as a cause of disease.

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