First Report of Aedes albopictus (Diptera: Culicidae) in District Mirpur, Azad Jammu and Kashmir, Pakistan

2020 ◽  
Author(s):  
Aliya Jabeen ◽  
Jamil A Ansari ◽  
Aamer Ikram ◽  
Mumtaz Ali Khan ◽  
Moin Iqbal Qaisrani ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Aedes Albopictus ◽  
Water Storage ◽  
Northern Pakistan ◽  
Jammu And Kashmir ◽  
First Report ◽  
Primary Vector ◽  
Storage Containers ◽  
Himalaya Mountains

Abstract Our article documents the presence of Aedes albopictus (Skuse) from urban and rural locations in the lower Himalaya Mountains, northern Pakistan. Larvae were collected from graveyards, junkyards, plant nurseries, parks, and houses. Used tires, bird drinking pots, and water storage containers were the most common containers used by this mosquito. In the absence of Aedes aegypti (L.) (Diptera: Culicidae), Ae. albopictus appears to be the primary vector of recent dengue virus outbreaks.

scholarly journals PERAN GEN STRUKTURAL, GEN NON-STRUKTURAL, DAN UNTRANSLATED REGION DALAM PERAKITAN VIRUS DENGUE

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Meiranty C. Pangerapan ◽  
Beivy J. Kolondam
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Aedes Albopictus ◽  
Untranslated Region ◽  
Rna Virus ◽  
Virus Genome ◽  
Interferon Response ◽  
Endoplasmic Reticulum Membrane ◽  
Structural Genes

Abstract: Dengue virus is a single-stranded RNA virus that belongs to Flaviviridae family. This virus causes dengue fever which is transmitted by Aedes aegypti dan Aedes albopictus. There are four serotypes of dengue virus; all of them can cause dengue fever. Understanding the genomics of dengue virus is important for research and diagnostics. The genome of dengue virus is 11 kilo-base long. It consists of 5’-untranslated region (5’-UTR), three structural genes (coding capsid protein, pre-membrane/membrane, and envelope), seven non-structural genes (coding NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 proteins) and 3’-UTR. Non-structural genes are encoding proteins of viral RNA replication, interferon response, viral assembly and secretion, endoplasmic reticulum membrane invagination induction, immune-mediator induction, and RNA 5’-caping.Keywords: dengue virus, genome, structural genes, non-structural genes, untranslated region.Abstrak: Virus dengue merupakan virus RNA beruntai tunggal yang termasuk dalam famili Flaviviridae. Virus ini adalah penyebab penyakit demam berdarah dengue yang ditransmisikan melalui nyamuk Aedes aegypti dan Aedes albopictus. Ada empat serotipe virus dengue yang telah dikenal secara luas yang ada semuanya dapat menimbulkan penyakit demam berdarah. Pemahaman tentang genomik virus dengue sangat penting untuk pengembangan penelitian dan juga untuk keperluan diagnostik. Genom virus dengue memiliki panjang 11 kilo basa. Genomnya tersusun atas 5’-untranslated region (5’-UTR), tiga gen struktural (mengodekan protein kapsid, premembran/membran dan amplop), tujuh gen non-struktural (mengodekan protein NS1, NS2A, NS2B, NS3, NS4A, NS4B dan NS5) dan 3’-UTR. Gen-gen non-struktural mengodekan protein untuk replikasi RNA virus, respon interferon, perakitan, sekresi partikel virus, menginduksi invaginasi membran retikulum endoplasma, induksi imunomediator dan penambahan tudung pada ujung 5’ RNA.Kata kunci: virus dengue, genom, gen struktural, gen non-struktural, untranslated region

scholarly journals Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes Aegypti Kir1 (AeKir) Channel and Larvicides

2020 ◽  
Author(s):  
Christopher D. Aretz ◽  
Sujay V. Kharade ◽  
Keagan S. Chronister ◽  
Erick J. Martinez Rodriguez ◽  
Peter M. Piermarini ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Chemical Compounds ◽  
Mechanisms Of Action ◽  
Kir Channel ◽  
Primary Vector ◽  
Resistant Strains ◽  
New Compounds

We have discovered new chemical compounds that are characterized as Kir channel inhibitors of the Aedes aegypti mosquito. This is important as the Ae. aegypti mosquito is the primary vector for Zika virus (ZIKV), Dengue virus (DENV) and chikungunya virus (CHIKV). Traditional mosquitocides are plagued with significant resistance and developing new compounds with novel mechanisms of action are vitally important. Lastly, we show that our compounds are potent larvicides against pyrethroid-susceptible and pyrethroid-resistant strains.

scholarly journals The Mosquito Immune System and the Life of Dengue Virus: What We Know and Do Not Know

Pathogens ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 77 ◽  
Author(s):  
Debica Mukherjee ◽  
Sandeepan Das ◽  
Feroza Begum ◽  
Sweety Mal ◽  
Upasana Ray
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Aedes Aegypti ◽  
Dengue Virus ◽  
Aedes Albopictus ◽  
Blood Meal ◽  
Mosquito Vector ◽  
Preventive Strategies ◽  
Immune Control ◽  
The Family

Flaviviruses are largely transmitted to humans by their arthropod vectors such as mosquitoes or ticks. The dengue virus (DENV) is one of the members of the family Flaviviridae and is the causative agent of dengue fever. In the mosquito vector, DENV enters through viremic blood meal and replicates in the mid-gut. Newly formed virion particles circulate to various mosquito organs and get transmitted to the next host in subsequent bites. Aedes aegypti and Aedes albopictus have intricate immune control to allow DENV production at a sub-pathogenic level. In the mosquito, antimicrobial peptides (AMP) and RNA inference (RNAi) are the two main antiviral strategies used against DENV. Apart from innate immunity, mosquito resident microbes play a significant role in modulating DENV replication. In this review, we discuss different immune mechanisms and preventive strategies that act against DENV in two of its vectors: Aedes aegypti and Aedes albopictus.

scholarly journals Sylvatic dengue virus type 4 in Aedes aegypti and Aedes albopictus mosquitoes in an urban setting in Peninsular Malaysia

2019 ◽  
Vol 13 (11) ◽  
pp. e0007889
Author(s):  
Nur Alia Johari ◽  
Kenny Voon ◽  
Shen Yung Toh ◽  
Lokman Hakim Sulaiman ◽  
Ivan Kok Seng Yap ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Virus Type ◽  
Aedes Albopictus ◽  
Peninsular Malaysia ◽  
Urban Setting

Relationship between Aedes aegypti production and occurrence of Escherichia coli in domestic water storage containers in rural and sub-urban villages in Thailand and Laos

Acta Tropica ◽  
2013 ◽  
Vol 126 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Nsa Dada ◽  
Nanthasane Vannavong ◽  
Razak Seidu ◽  
Audrey Lenhart ◽  
Thor Axel Stenström ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Aedes Aegypti ◽  
Water Storage ◽  
Domestic Water ◽  
Storage Containers ◽  
Urban Villages
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