scholarly journals High Prevalence of Vitamin D Insufficiency in Black and White Pregnant Women Residing in the Northern United States and Their Neonates

2007 ◽  
Vol 137 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Lisa M. Bodnar ◽  
Hyagriv N. Simhan ◽  
Robert W. Powers ◽  
Michael P. Frank ◽  
Emily Cooperstein ◽  
...  
2008 ◽  
Vol 198 (2) ◽  
pp. 261-269 ◽  
Author(s):  
Rene F Chun ◽  
John S Adams ◽  
Martin Hewison

Our perception of the vitamin D system continues to evolve. Recent studies have re-evaluated the parameters for adequate vitamin D status in humans, revealing a high prevalence of insufficiency in many populations throughout the world. Other reports have highlighted the potential consequences of vitamin D insufficiency beyond established effects on bone homeostasis. Most notably, there is now strong evidence of a role for vitamin D in modulating innate and adaptive immunities, with insufficiency being linked to infectious disease and other immune disorders. To date, signaling pathways for these new responses to vitamin D have been based on established endocrine models for active 1,25-dihydroxyvitamin D, despite present evidence for more localized, intracrine modes of action. In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid.


2022 ◽  
Vol 226 (1) ◽  
pp. S774
Author(s):  
Jessica C. Fields ◽  
Justin S. Brandt ◽  
Hillary L. Graham ◽  
Jennifer Zeitlin ◽  
Cande V. Ananth

2010 ◽  
Vol 202 (5) ◽  
pp. 436.e1-436.e8 ◽  
Author(s):  
Adit A. Ginde ◽  
Ashley F. Sullivan ◽  
Jonathan M. Mansbach ◽  
Carlos A. Camargo

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43868 ◽  
Author(s):  
Stefanie Vandevijvere ◽  
Sihame Amsalkhir ◽  
Herman Van Oyen ◽  
Rodrigo Moreno-Reyes

2017 ◽  
Vol 152 (5) ◽  
pp. S370
Author(s):  
Sangmin (Sarah) Lee ◽  
Amy Metcalfe ◽  
Yvette Leung ◽  
Maitreyi Raman ◽  
Catherine Field ◽  
...  

2008 ◽  
Vol 99 (6) ◽  
pp. 1330-1334 ◽  
Author(s):  
Jean Woo ◽  
Christopher W. K. Lam ◽  
Jason Leung ◽  
Winny Y. Lau ◽  
Edith Lau ◽  
...  

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring – Beijing in the north (latitude 39° north) and Hong Kong (latitude 22° north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no further suppression of PTH. Finally, we examined whether dietary Ca intake influences this relationship. Non-pregnant women aged 18–40 years (n 441) were recruited between February and June. Fasting blood was collected and dietary intakes were assessed using 5 d food records. Mean serum 25-hydroxyvitamin D concentration was lower in Beijing than Hong Kong women (29 v. 34 nmol/l; P < 0·001). Vitamin D deficiency ( ≤  25 nmol/l) was indicated in 40 % of Beijing and 18 % of Hong Kong women, and over 90 % of women in both cities were insufficient ( ≤ 50 nmol/l). Mean Ca and vitamin D intakes were 478 mg/d and 2·0 μg/d, respectively. The relationship between 25-hydroxyvitamin D concentration and PTH was linear throughout the range with a slope of − 0·36 (different from 0; P < 0·001; R 0·26), with no apparent threshold. There was no influence of Ca intake on the relationship between 25-hydroxyvitamin D and PTH concentration. Vitamin D deficiency is common and insufficiency is very common in non-pregnant women in Hong Kong and Beijing during spring. Serum 25-hydroxyvitamin D was inversely associated with PTH with no apparent threshold. Strategies such as vitamin D fortification or supplementation may be required.


PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e47264 ◽  
Author(s):  
Han-Kui Lu ◽  
Zeng Zhang ◽  
Yao-Hua Ke ◽  
Jin-Wei He ◽  
Wen-Zhen Fu ◽  
...  

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