Salvage Procedures

2018 ◽  
pp. 307-322
Author(s):  
Joaquin Sanchez-Sotelo
Keyword(s):  
Surgical Technique ◽  
Surgical Procedures ◽  
Glenohumeral Joint ◽  
Resection Arthroplasty ◽  
Successful Management ◽  
The Many ◽  
And Function ◽  
Surgical Option

The many surgical procedures summarized in previous chapters allow successful management of most shoulder conditions and result in improved pain, motion, and function. However, salvage procedures that sacrifice the glenohumeral joint or the scapulothoracic joint represent the best surgical option for a few patients. These salvage procedures are uncommon, but shoulder surgeons need to be familiar with their indications, surgical technique, and reported outcomes. This chapter addresses glenohumeral arthrodesis, scapulothoracic arthrodesis, and glenohumeral resection arthroplasty.

scholarly journals Surgical Management of Complications after Dexamethasone Implant

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Giancarlo Sborgia ◽  
Alfredo Niro ◽  
Francesco D’Oria ◽  
Alessandra Galeone ◽  
Luigi Sborgia ◽  
...  
Keyword(s):  
Surgical Management ◽  
Surgical Procedures ◽  
Case Series ◽  
Implant Removal ◽  
Surgical Approaches ◽  
Dexamethasone Implant ◽  
Successful Management ◽  
Ocular Complications ◽  
Management Of Complications ◽  
And Function

Purpose. To report surgical management of ocular complications occurred after dexamethasone (DEX) implant (Ozurdex®) injection. Methods. Retrospective interventional case series. Results. Different surgical procedures including viscoexpression to manage the migration of the implant into the anterior chamber, “phaco-rolling” technique for the intralenticular injection, and vitrectomy with implant removal for an acute endophthalmitis were performed. Successful management of different complications after DEX implant by using individualized surgical approaches was observed. Conclusions. Early and targeted surgical management is required in selected cases of ocular complications after DEX implant. The implant removal was needed to preserve ocular anatomy and function.

Capsular Interposition Arthroplasty for Severe Hallux Rigidus

1997 ◽  
Vol 18 (2) ◽  
pp. 68-70 ◽  
Author(s):  
William G. Hamilton ◽  
Martin J. O'Malley ◽  
Francesca M. Thompson ◽  
Paul E. Kovatis
Keyword(s):  
Metatarsophalangeal Joint ◽  
Hallux Rigidus ◽  
Resection Arthroplasty ◽  
Equal Length ◽  
Interposition Arthroplasty ◽  
Bone Resection ◽  
First Metatarsophalangeal Joint ◽  
And Function ◽  
Surgical Option

Thirty patients (37 feet) with severe hallux rigidus underwent resection arthroplasty of the first metatarsophalangeal joint with our modification (reattachment of the extensor hood and extensor brevis to the flexor hallucis brevis as a capsular interposition arthroplasty, with minimal bone resection). Pain and function were significantly improved. Transfer metatarsalgia was not seen. All patients had at least 4/5 plantarflexion strength and averaged 50° of dorsiflexion. In patients with severe hallux rigidus and nearly equal length of first and second metatarsals, capsular interpostion arthroplasty offers a surgical option that relieves pain without sacrificing motion or strength.

scholarly journals Spanning the gap: unraveling RSC dynamics in vivo

2021 ◽  
Author(s):  
Heinz Neumann ◽  
Bryan J. Wilkins
Keyword(s):  
Cell Cycle ◽  
Posttranslational Modifications ◽  
Transcriptional Activation ◽  
Binding Mode ◽  
Binding Modes ◽  
Binding Domains ◽  
Binding Interface ◽  
The Many ◽  
And Function

AbstractMultiple reports over the past 2 years have provided the first complete structural analyses for the essential yeast chromatin remodeler, RSC, providing elaborate molecular details for its engagement with the nucleosome. However, there still remain gaps in resolution, particularly within the many RSC subunits that harbor histone binding domains.Solving contacts at these interfaces is crucial because they are regulated by posttranslational modifications that control remodeler binding modes and function. Modifications are dynamic in nature often corresponding to transcriptional activation states and cell cycle stage, highlighting not only a need for enriched spatial resolution but also temporal understanding of remodeler engagement with the nucleosome. Our recent work sheds light on some of those gaps by exploring the binding interface between the RSC catalytic motor protein, Sth1, and the nucleosome, in the living nucleus. Using genetically encoded photo-activatable amino acids incorporated into histones of living yeast we are able to monitor the nucleosomal binding of RSC, emphasizing the regulatory roles of histone modifications in a spatiotemporal manner. We observe that RSC prefers to bind H2B SUMOylated nucleosomes in vivo and interacts with neighboring nucleosomes via H3K14ac. Additionally, we establish that RSC is constitutively bound to the nucleosome and is not ejected during mitotic chromatin compaction but alters its binding mode as it progresses through the cell cycle. Our data offer a renewed perspective on RSC mechanics under true physiological conditions.

THE CRITICALLY ILL CHILD: SICKLE CELL DISEASE CRISES AND THEIR MANAGEMENT

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 629-635
Author(s):  
Howard A. Pearson ◽  
Louis K. Diamond
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Mutant Gene ◽  
Point Of View ◽  
Clinical Aspects ◽  
Cell Disease ◽  
Form And Function ◽  
Heterozygous Form ◽  
The Many ◽  
And Function

This brief review, being limited in scope to the recognition and management of the life-threatening and painful crises in infants and children with sickle-cell disease, has not even touched on the intriguing mystery of the molecular basis for the sickling phenomenon–how one amino-acid substitution (gene controlled) in the beta chain sequence of 146 amino acids can cause such serious disruption in form and function; or how this mutation occurred in the first place and why it has persisted in contrast to the rapid disappearance of many other deleterious mutants. Nor has there been even mention of the many milder symptoms, signs, and complications due to the presence of Hb. S., either in the homozygous (disease-producing) state or heterozygous form when found in combination with other hereditary hemoglobin defects. The accumulated knowledge about this mutant gene, its biochemical effects, and geographic distribution is enormous. From a fundamental scientific standpoint, sickle cell disease is one of the best understood of human afflictions. However, from a practical point of view treatment of the patient himself is often only symptomatic and palliative. Nevertheless, prompt and effective therapy of the myriad manifestations of sickle cell disease can effectively reduce morbidity and mortality. The pediatrician who cares for black children in his practice should be familiar with the cardinal diagnostic and clinical aspects of sickle cell disease and its crises.

Stabilized resection arthroplasty by an anterior approach in trapeziometacarpal arthritis: Results and surgical technique

1996 ◽  
Vol 21 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Dominique T. Le Viet ◽  
Luc Kerboull ◽  
Laurent A. Lantieri ◽  
Dale E. Collins
Keyword(s):  
Surgical Technique ◽  
Anterior Approach ◽  
Resection Arthroplasty

scholarly journals The ups and downs of working with industry to collect fishery-dependent data: the Irish experience

2011 ◽  
Vol 68 (8) ◽  
pp. 1670-1678 ◽  
Author(s):  
Colm Lordan ◽  
Macdara Ó Cuaig ◽  
Norman Graham ◽  
Dominic Rihan
Keyword(s):  
Scientific Data ◽  
Dependent Data ◽  
Management Systems ◽  
Project Design ◽  
Critical Aspect ◽  
Successful Management ◽  
Joint Research ◽  
Time Horizons ◽  
Fisheries Policy ◽  
The Many

Abstract Lordan, C., Ó Cuaig, M., Graham, N., and Rihan, D. 2011. The ups and downs of working with industry to collect fishery-dependent data: the Irish experience. – ICES Journal of Marine Science, 68: 1670–1678. Working with the fishing industry to collect fishery-dependent data for scientific and advisory purposes is essential in most countries, but despite the many advantages of working with fishers, it is not without challenges. The objectives and the ups and downs of 16 recent projects in Ireland are described, and four case studies are discussed in detail. Some common themes that characterize both successful and unsuccessful experiences are identified. One critical aspect is industry's sometimes unrealistic time-horizons and expectations when engaging in scientific data collection. Detailed communication of objectives, procedures, results, and relevance not only to industry representatives, but also to vessel owners and crew, is required throughout the life cycle of a project. For some projects, there is a clear need to include incentives in the design, but for others this is less critical. The critical needs for ongoing quality control and assurance, validation of data, and appropriate project design are discussed, along with the link between successful management systems and participatory research. Finally, comment is provided on how the expected reforms of the EU's Common Fisheries Policy will place new demands on joint research.

The expanding world of metabolic enzymes moonlighting as RNA binding proteins

2021 ◽  
Author(s):  
Nicole J. Curtis ◽  
Constance J. Jeffery
Keyword(s):  
Gene Expression ◽  
Regulatory Networks ◽  
Binding Proteins ◽  
Molecular Mechanisms ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Molecular Structures ◽  
Intermediary Metabolism ◽  
The Many ◽  
And Function

RNA binding proteins play key roles in many aspects of RNA metabolism and function, including splicing, transport, translation, localization, stability and degradation. Within the past few years, proteomics studies have identified dozens of enzymes in intermediary metabolism that bind to RNA. The wide occurrence and conservation of RNA binding ability across distant branches of the evolutionary tree suggest that these moonlighting enzymes are involved in connections between intermediary metabolism and gene expression that comprise far more extensive regulatory networks than previously thought. There are many outstanding questions about the molecular structures and mechanisms involved, the effects of these interactions on enzyme and RNA functions, and the factors that regulate the interactions. The effects on RNA function are likely to be wider than regulation of translation, and some enzyme–RNA interactions have been found to regulate the enzyme's catalytic activity. Several enzyme–RNA interactions have been shown to be affected by cellular factors that change under different intracellular and environmental conditions, including concentrations of substrates and cofactors. Understanding the molecular mechanisms involved in the interactions between the enzymes and RNA, the factors involved in regulation, and the effects of the enzyme–RNA interactions on both the enzyme and RNA functions will lead to a better understanding of the role of the many newly identified enzyme–RNA interactions in connecting intermediary metabolism and gene expression.

KAJIAN ORNAMEN GORGA DI RUMAH ADAT BATAK TOBA (Studi Kasus : Di Kawasan Desa Wisata Tomok, Huta Siallagan dan Huta Bolon Di Kabupaten Samosir)

2019 ◽  
Vol 2 (1) ◽  
pp. 1-14
Author(s):  
Dearma A Saragih ◽  
Yulianto Yulianto ◽  
Raimundus Pakpahan
Keyword(s):  
Comparative Research ◽  
Research Method ◽  
Toba Batak ◽  
Historical Heritage ◽  
The Many ◽  
Almost All ◽  
And Function ◽  
Meaning And Function ◽  
House Building

One of the interesting cultural potentials to be studied is traditional houses. This traditional house has its own uniqueness in every area. One of the uniqueness can be seen from the many ornaments in it. Diversity has its own meaning and function. Ornaments is one of the historical heritage of Indonesia where almost all the tribes in Indonesia can be found various kinds of ornaments that reflect the techniques of each region in Indonesia. Ornament Batak Toba is one of the many ornaments that exist in this country Indonesia. Toba Batak ornament can be found in North Sumatera Province precisely in Samosir regency which always apply Toba Batak ornament as decoration or as identity in important building for Batak Toba, for example in traditional house building in Huta Siallagan, Tomok Village and Huta Bolon.This research is classified in research using descriptive-comparative research method, doing the study by comparing the existing ornaments in these three villages with theories about Ornaments Gorga Rumah Adat Batak Toba, then do the analysis of the condition in accordance with the theory used as a reference

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