Dactylitis

2018 ◽  
Author(s):  
Ignazio Olivieri ◽  
Enrico Scarano ◽  
Salvatore D’Angelo ◽  
Carlo Palazzi ◽  
Angela Padula
Keyword(s):  
The Other ◽  
Clinical Aspects ◽  
Imaging Methods ◽  
Composite Scores

This chapter covers dactylitis, or ‘sausage-shaped’ digits. As the types of dactylitis depends on the tissues involved and the type of involvement, ‘false’ dactylitis is discussed, and the manifestation of diffuse swelling in spondyloarthritis (SpA) is differentiated from the other forms. Clinical aspects and imaging methods are described, followed by clinimetric assessment and the development of composite scores such as CPDAI and PASDAS. Finally, therapies are described.

Platelet Models and Their Possible Usefulness in the Study of Migraine Pathogenesis

Cephalalgia ◽  
1995 ◽  
Vol 15 (4) ◽  
pp. 265-271 ◽  
Author(s):  
G D'Andrea ◽  
AR Cananzi ◽  
F Perini ◽  
L Hasselmark
Keyword(s):  
Primary Headache ◽  
The Other ◽  
Clinical Aspects ◽  
Metabolic Characteristics ◽  
Dense Bodies ◽  
Migraine Pathogenesis ◽  
Serotonin Turnover ◽  
The One

Platelets may be linked to migraine. On the one hand they are activated during the migraine attack and thus may participate in the pathogenesis of the disorder (the nature of this activation is still unknown). In order to understand this platelet anomaly, we discuss the data available in the literature. In particular, we review recent in vitro studies of a-granules and dense bodies secretion, and aggregation induced by collagen and PAF. On the other hand, platelets share many metabolic characteristics with serotonergic neurons and endothelial cells. Accordingly, platelets have been used to investigate the possible role of serotonin turnover and nitric oxide function in migraine. In both cases, the data obtained have shown peculiar abnormalities that may explain pathogenetic and clinical aspects of primary headache.

scholarly journals Systemic inflammation in patients with Takotsubo syndrome: a review of mechanistic and clinical implications

2021 ◽  
Author(s):  
Kenan Yalta ◽  
Ertan Yetkin ◽  
Tulin Yalta
Keyword(s):  
Systemic Inflammation ◽  
Acute Coronary Syndromes ◽  
The Other ◽  
Clinical Aspects ◽  
Clinical Implications ◽  
Takotsubo Syndrome ◽  
Inflammation Markers ◽  
Therapeutic Implications ◽  
Coronary Syndromes ◽  
General Perspective

Over recent decades, systemic inflammation  as  quantified  with  inflammation  markers  or  indices has been extensively  investigated  in the setting of  various  cardiovascular  conditions  including heart failure (HF),  acute coronary syndromes (ACS). In contrast, systemic inflammation  in patients with  takotsubo syndrome (TTS) has been an underrated  phenomenon in clinical practice. On the other hand, experimental and clinical data  have been  rapidly  accumulating  in the recent years  regarding   pathogenetic, prognostic as well as therapeutic implications of  systemic inflammation in TTS.  Accordingly, the present article  aims to provide a general perspective  on mechanistic and  clinical aspects of  systemic  inflammation in the setting of  TTS.

Heredity and Environment in Finger and Palm Prints Progress report

1970 ◽  
Vol 19 (1-2) ◽  
pp. 157-159 ◽  
Author(s):  
P. Parisi ◽  
G. Alciati ◽  
M. Di Bacco
Keyword(s):  
Statistical Methods ◽  
Chromosomal Aberrations ◽  
Progress Report ◽  
The Other ◽  
Large Impact ◽  
Clinical Aspects ◽  
Other Hand ◽  
Definition Of ◽  
Quantitative Definition

Recent years have witnessed a growing interest in dermatoglyphics: an increasing number of associations between dermatoglyphic alterations and different diseases (especially chromosomal aberrations) are actually being reported, which is of particular concern to human and medical geneticists, as well as to clinicians and pediatricians.Having been shown to undergo practically complete genetic conditioning, fingerprints are also being applied, by different authors, to the diagnosis of zygosity in twins.On the other hand, although, on account of available data, a large impact of heredity may be assumed in their determination, dermatoglyphics as a whole still fail to find a clear genetic definition.Furthermore, with respect to clinical aspects and applications, a clear quantitative definition of dermatoglyphic alterations, and therefore of dermatoglyphic normality and its variability, is still needed.Last, but not least, a wider and generalized application of dermatoglyphics to the diagnosis of zygosity in twins would require a clear, morphological and genetic, quantitative definition of each trait, as well as the introduction of simple and standardized statistical methods for calculating the probabilities of monozygosity and dizygosity.

ABO Haemolytic Disease of the Newborn, by E. R. Gold, M.D. and N. R. Butler, M.D., F.R.C.P., D.C.H. Baltimore: The Williams & Wilkins Company, 1972, 212 pp., $15.75

PEDIATRICS ◽  
1974 ◽  
Vol 53 (4) ◽  
pp. 593-593
Author(s):  
Jerold F. Lucey
Keyword(s):  
The Other ◽  
Clinical Aspects ◽  
Hemolytic Disease ◽  
Haemolytic Disease ◽  
Source Book ◽  
Abo Incompatibility ◽  
Laboratory Techniques ◽  
History Of ◽  
Staff Research ◽  
Wilkins Company

This is a compact, up-to-date (1972), thorough, source book. It contains more information on ABO incompatibility than most physicians need or may want to know. Approximately one third of the book's 212 pages are devoted to clinical aspects of the problem. The other two thirds is concerned with serology, laboratory techniques, and the history of hemolytic disease. The book is clearly written and would be particularly appropriate for house staff, research fellows, and consulting physicians who want a concise, accurate, authoritative reference.

scholarly journals Chasing Future Feelings: A Practice-led Experiment with Emergent Digital Materialities of Heritage

2021 ◽  
Vol 19 (2) ◽  
pp. 149-165
Author(s):  
Tracy Ireland ◽  
Tessa Bell
Keyword(s):  
Laser Scanning ◽  
3D Visualization ◽  
The Other ◽  
High Fidelity ◽  
Digital Photogrammetry ◽  
Imaging Methods ◽  
Digital Heritage ◽  
Digital Materiality ◽  
Experimental Project ◽  
Oblique Approach

High-fidelity imaging methods such as laser scanning and digital photogrammetry have captured public and professional audiences in a flurry of optimistic discourse about their capacities as forms of preservation and of archaeological recording and interpretation. With technical finesse and mastery, endangered heritage can, it is argued, be captured, re-materialized, and recovered from the forces that threaten it. As the plot concerning our ‘digital futures’ thickens, we discuss here an experimental project that offers an oblique approach to the practice of 3D visualization, one that subverts the dominance of neutral, technical field engagements. We examine digital materiality by exploring digital heritage objects as both method and site of ethnographic encounter. Orbiting the ruins of Asinou, an abandoned village in the Troodos Mountains of Cyprus, with our ‘low-tech’ equipment, we sought to observe the conditions of the ‘in-between’ of two makeshift forms, each as ‘real’ as the other. We focus our thinking on the tensions of translation that play on the surface of our technically crude digital assemblages, as spaces of generative potential for speculations about encounters with emerging digital materialities, their affective capacities and status as future heritage objects.

Survival of gastric cancer (GC) patients is not determined by the predominant genomic ancestry (PGA): Results from an ethnically admixed Brazilian cohort of GC patients.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15588-e15588
Author(s):  
Helano C. Freitas ◽  
Luiza Ferreira Araujo ◽  
Diana Noronha Nunes ◽  
Maria D. Begnami ◽  
Thais Fernanda Bartelli ◽  
...  
Keyword(s):  
Overall Survival ◽  
Clinical Characteristics ◽  
Disease Free Survival ◽  
Tumor Location ◽  
The Other ◽  
Cancer Center ◽  
Clinical Aspects ◽  
The Difference ◽  
And Gender ◽  
Brazilian Cohort

e15588 Background: Clinical characteristics, treatment response and overall survival of GC patients differ between Asian and non-Asian countries. Here we evaluated the possible associations between PGA, clinical characteristics and survival in an admixed GC Brazilian cohort. Methods: We included 112 GC pts diagnosed and treated at AC Camargo Cancer Center (São Paulo, Brazil) before 2013. The study was approved by local IRB. Genomic DNA was used for capture-based enrichment of a customized gene panel including 99 genes. Libraries were sequenced in the NextSeq 500 platform (Illumina), using paired-end reads (2x75bp). Ancestries were determined through a set of ancestry informative markers (AIMs), covered by target and off-target reads, described by Elhaik et al. (2014). Results: An average of 406 AIMs were recovered from the available samples, revealing average ancestries was as follows: 55.4% European, 27.7% Asian, 8.9% African; 8% of subjects were highly admixed (HA; < 50% of any ancestry). We found no association between PGA and age at diagnosis (p = 0.58), tumor location (p = 0.34), Lauren (p = 0.24) and staging (p = 0.68). There was an association between PGA and gender (p = 0.04) and a marginal association between PGA and EBV (p = 0.056). BRCA2 was the only gene enriched in the Asian subgroup, compared to the other groups combined (p = 0.009). The median follow-up time was 95 months. We found no differences in median overall survival (OS) (p = 0.4) or disease-free survival (DFS) (p = 0.6) according to PGA. The HA subgroup presented worst survival outcomes compared to the other groups aggregated (mOS 34m; 95%CI 5-80 x mOS 71m; 95% CI 44-85, respectively), but the difference was not statistically significant (HR 1,73; 95% CI 0.74-4.05; p = 0.2). Even for patients with > 75% AIMs for any given ancestry, we found no differences in OS between Europeans (n = 25; mOS 86m; 95%CI 80-NA), Asians (n = 22; mOS 83m; 95%CI 51-NA) and Africans (n = 5; mOS 67m; 95%CI 22-NA), p = 0.4. Conclusions: The most prevalent ancestries in this Brazilian GC cohort were European, followed by Asian and African. Although we found associations between ancestry and a few clinical aspects, PGA was not associated with survival.

Sign in / Sign up

Export Citation Format

Share Document