Central sensitisation in primary Sjögren Syndrome and its effect on sleep quality

ABSTRACT Objective The aim of the present study is to evaluate the presence and frequency of central sensitisation (CS) in primary Sjögren Syndrome (pSS) and to determine the effect of CS on sleep quality. Materials and Methods In this cross-sectional study, 50 patients diagnosed with pSS between the ages of 18 and 75 were included. The healthy control group was composed of 43 healthcare workers. Each participant underwent a physical examination, and demographic data and the medications they used were recorded. Central sensitisation inventory and Pittsburgh Sleep Quality Index questionnaires were filled in to garner data on CS and sleep quality, respectively, from all participants. Results While central sensitisation inventory >40 was detected in 74% of pSS patients, it was 25.6% in healthy controls, and there is a statistically significant difference between the groups (p < .05). A correlation analysis of the central sensitisation inventory and Pittsburgh Sleep Quality Index values of all participants revealed a statistically significant correlation between all parameters other than the duration of sleep (p < .05). Conclusions CS was found to have a negative effect on sleep quality in patients with pSS. We suggest that the cause of widespread pain seen in patients with pSS as the possible development of CS should be considered.

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Clinical Efficacy of a New Robot-assisted Gait Training System for Acute Stroke Patients

Journal of Medical and Biological Engineering ◽

10.1007/s40846-020-00590-z ◽

2021 ◽

Author(s):

Andy Chien ◽

Fei-Chun Chang ◽

Nai-Hsin Meng ◽

Pei-Yu Yang ◽

Ching Huang ◽

...

Keyword(s):

Sleep Quality ◽

Acute Stroke ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Gait Training ◽

Training System ◽

Control Group ◽

Stroke Patients ◽

Robot Assisted ◽

Significant Difference

Abstract Purpose Robot-assisted gait rehabilitation has been proposed as a plausible supplementary rehabilitation strategy in stroke rehabilitation in the last decade. However, its exact benefit over traditional rehabilitation remain sparse and unclear. It is therefore the purpose of the current study to comparatively investigate the clinical benefits of the additional robot-assisted training in acute stroke patients compared to standard hospital rehabilitation alone. Methods Ninety acute stroke patients (< 3 month) were recruited. All participants received the standard hospital neurorehabilitation comprises 45–60 min sessions daily for 3 weeks. Sixty patients also received an additional 30 min of robot-assisted gait training with the HIWIN MRG-P100 gait training system after each of the standard neurorehabilitation session. Outcome measures included: 1. Berg Balance Scale (BBS); 2. Brunnstrom Stage; 3. Pittsburgh Sleep Quality Index and 4. Taiwanese Depression Questionnaire (TDQ) which were assessed pre-treatment and then after every five training sessions. Results Both groups demonstrated significant improvement pre- and post-treatment for the BBS (robotic group p = 0.023; control group p = 0.033) but no significant difference (p > 0.1) between the groups were found. However, the robotic training group had more participants demonstrating larger BBS points of improvement as well as greater Brunnstrom stage of improvement, when compared to the control group. No significant within and between group statistical differences (p > 0.3) were found for Pittsburgh Sleep Quality Index and Taiwanese Depression Questionnaire. Conclusion The addition of robotic gait training on top of standard hospital neurorehabilitation for acute stroke patients appear to produce a slightly greater improvement in clinical functional outcomes, which is not transferred to psychological status.

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The role of albumin-to-globulin ratio in undifferentiated arthritis: Rheumatoid arthritis versus primary Sjögren syndrome

Archives of Rheumatology ◽

10.46497/archrheumatol.2022.8742 ◽

2021 ◽

Author(s):

Reyhan Köse Çobanoglu ◽

Taşkın Şentürk

Keyword(s):

Rheumatoid Arthritis ◽

Sjögren Syndrome ◽

Control Group ◽

Sjogren Syndrome ◽

Healthy Controls ◽

Undifferentiated Arthritis ◽

Characteristic Analysis ◽

Primary Sjögren Syndrome ◽

Significant Difference ◽

Albumin To Globulin Ratio

Objectives: This study aims to compare initial albumin-to-globulin ratio (AGR) in patients with rheumatoid arthritis (RA) and primary Sjögren syndrome (pSS) presenting with undifferentiated arthritis (UA) and to investigate whether there was a difference in terms of AGR between the two patient groups and healthy controls. Patients and methods: Between January 2019 and December 2019, a total of 177 patients including 96 RA (10 males, 86 females; mean age: 53.6±10.8 years; range, 21 to 74 years) and 81 pSS (5 males, 76 females; mean age: 53.2±14.1 years; range, 23 to 79 years) and 82 healthy controls (20 males, 62 females; mean age: 50.5±13.6 years; range, 20 to 79 years) were included in this case-control study. Demographic characteristics, albumin, and globulin levels of all participants were recorded. The AGR, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-nuclear antibody (ANA), and anti-citrullinated protein antibodies (ACPA) were assessed. Results: The mean AGR was 1.50±0.16 in the control group, 1.48±0.24 in the RA group, and 1.30±0.23 in the pSS group, indicating a significant difference between the pSS and the other two groups (p<0.001). The receiver operating characteristic analysis revealed that the cut-off value for AGR was 1.39 (area under the curve=0.736) with a sensitivity of 0.642 and a specificity of 0.646 (p<0.001). The ESR and CRP values were higher (p<0.001), and ANA (p<0.001) and RF (p=0.003) positivity were lower in the RA group, compared to the pSS group. Conclusion: This study findings indicate that AGR is a helpful tool in the differential diagnosis of RA and pSS presenting with UA at the time of admission, and Sjögren syndrome should be considered in case of AGR ≤1.39.

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Availability of a Flavored Beverage and Impact on Children’s Hydration Status, Sleep, and Mood

Nutrients ◽

10.3390/nu13061757 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1757

Author(s):

Michael R. Szymanski ◽

Gabrielle E. W. Giersch ◽

Margaret C. Morrissey ◽

Courteney L. Benjamin ◽

Yasuki Sekiguchi ◽

...

Keyword(s):

Sleep Quality ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Intervention Group ◽

Urine Osmolality ◽

Urine Specific Gravity ◽

Hydration Status ◽

Control Group ◽

Profile Of Mood States ◽

Urine Color

Euhydration remains a challenge in children due to lack of access and unpalatability of water and to other reasons. The purpose of this study was to determine if the availability/access to a beverage (Creative Roots®) influences hydration in children and, therefore, sleep quality and mood. Using a crossover investigation, 46 participants were randomly assigned to a control group (CON) or an intervention group and received Creative Roots® (INT) for two-week periods. We recorded daily first morning and afternoon urine color (Ucol), thirst perception, and bodyweight of the two groups. Participants reported to the lab once per week and provided first morning urine samples to assess Ucol, urine specific gravity (USG), and urine osmolality (Uosmo). Participants also completed the questionnaires Profile of Mood States-Adolescents (POMS-a) and Pittsburgh Sleep Quality Index (PSQI). Dependent t-tests were used to assess the effects of the intervention on hydration, mood, and sleep quality. Uosmo was greater and Ucol was darker in the control group (mean ± SD) [Uosmo: INT = 828 ± 177 mOsm·kg−1, CON = 879 ± 184 mOsm·kg−1, (p = 0.037], [Ucol:INT = 5 ± 1, CON = 5 ± 1, p = 0.024]. USG, POMS-a, and PSQI were not significant between the groups. At-home daily afternoon Ucol was darker in the control group [INT = 3 ± 1, CON = 3 ± 1, p = 0.022]. Access to Creative Roots® provides a small, potentially meaningful hydration benefit in children. However, children still demonstrated consistent mild dehydration based on Uosmo, despite consuming the beverage.

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Role of Fractalkine in the Pathogenesis of Primary Sjögren Syndrome: Increased Serum Levels of Fractalkine, Its Expression in Labial Salivary Glands, and the Association with Clinical Manifestations

The Journal of Rheumatology ◽

10.3899/jrheum.130892 ◽

2014 ◽

Vol 41 (12) ◽

pp. 2425-2438 ◽

Cited By ~ 7

Author(s):

Jae Ho Lee ◽

Seung-Ki Kwok ◽

Seung Min Jung ◽

Jennifer Lee ◽

Jae-Seon Lee ◽

...

Keyword(s):

Epithelial Cells ◽

Confocal Microscopy ◽

Salivary Glands ◽

Proinflammatory Cytokines ◽

Sjögren Syndrome ◽

Control Group ◽

Sjogren Syndrome ◽

Clinical Effects ◽

Extraglandular Manifestations ◽

Primary Sjögren Syndrome

Objective.To investigate the expression of fractalkine and identify the clinical effects of fractalkine and its receptor (CX3CR1) in patients with primary Sjögren syndrome (pSS).Methods.Serum fractalkine levels were determined by ELISA. Immunohistochemical staining was done to compare the expression of fractalkine and CX3CR1 between salivary glands (SG) of patients with SS and controls. The cells to be merged with fractalkine were evaluated by confocal microscopy. Type of CX3CR1-expressing cells among infiltrating lymphocytes in SG was analyzed by confocal microscopy. Further, associations among fractalkine, proinflammatory cytokines, and clinical profiles were investigated.Results.Serum fractalkine levels in patients with pSS were higher than those in the control group (p = 0.026). SG expression of fractalkine and its receptor was upregulated in patients with pSS compared to that in the controls by immunohistochemistry. Higher histological grade was associated with more fractalkine-positive cells per total epithelial cells. Epithelial cells were the main fractalkine-expressing cell type in the SG. Serum fractalkine levels were significantly correlated with proinflammatory cytokines levels (interleukin 17: r = 0.685, p = 0.029; tumor necrosis factor-α: r = 0.444, p = 0.003), antinuclear antibody (r = 0.349, p = 0.022), and immunoglobulin G levels (r = 0.325, p = 0.044). Serum fractalkine levels in patients with extraglandular manifestations of pSS were significantly higher than in those without extraglandular manifestations (p = 0.026).Conclusion.Fractalkine and CX3CR1 may play a role in the pathogenesis of pSS, including extraglandular manifestations.

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Sleep Quality and Depression in Vitiligo Patients

Eurasian Journal of Family Medicine ◽

10.33880/ejfm.2020090105 ◽

2020 ◽

Vol 9 (1) ◽

pp. 35-41

Author(s):

Aynure Öztekin ◽

Coşkun Öztekin

Keyword(s):

Sleep Quality ◽

Patient Group ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Healthy Control Group ◽

Psychiatric Evaluation ◽

Control Group ◽

Subjective Sleep Quality ◽

Dermatology Clinic ◽

Healthy Control

Aim: Vitiligo is a common disorder that has not only dermatological but also psychological consequences. The aim of this study was to compare depression and sleep quality of vitiligo patients with healthy control group. Methods: In this cross-sectional case-control study, patients admitted to the Dermatology Clinic of Skin and Venereal Diseases Department of Hitit University Erol Olçok Education and Research Hospital between August 2018 and August 2019 were compared with healthy control group. The study included 67 patients and 69 control group participants who were matched for age, sex, marriage status, and education level. The subjects were asked to complete a sociodemographic data form, the Beck Depression Inventory, and the Pittsburgh Sleep Quality Index. Results: The median total Pittsburgh Sleep Quality Index score was higher in the patient group compared with the control group. The median scores for subjective sleep quality, sleep latency, and sleep disturbance were also higher in the patient group compared with the control group. A family history of vitiligo was present in 18 (26.9%) patients. The most common type was acrofacial vitiligo, which was present in 29 (43.3%) patients. Conclusions: Increased probability levels of depression and impaired sleep quality in vitiligo patients suggest that psychiatric evaluation and treatment should be provided for vitiligo patients as a part of a multidisciplinary approach in order to increase the success of the treatment. Keywords: Vitiligo, depression, sleep quality

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1079 Is PTSD In Young Women Associated With Rem Sleep Abnormalities?

SLEEP ◽

10.1093/sleep/zsaa056.1075 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A411-A411

Author(s):

D Martinez ◽

M Yeh ◽

L Oliveira ◽

B Coimbra ◽

A F Mello ◽

...

Keyword(s):

Sleep Quality ◽

Posttraumatic Stress ◽

Young Women ◽

Rem Sleep ◽

Muscle Activity ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Sleep Fragmentation ◽

Control Group ◽

Ptsd Group

Abstract Introduction The increase in violence against young women has a high impact on the prevalence of Posttraumatic stress disorder (PTSD). The lifetime prevalence of PTSD is twice as high in women. However, most studies assessing sleep disturbances in PTSD were conducted predominantly in male samples and combat veterans. Objective: To analyze the sleep of young women with and without PTSD. Hypothesis: Women with PTSD have worse sleep quality, higher arousability, and higher muscle activity during REM sleep. Methods Case-controlled study with young women. Seventy-four women who suffered sexual assault and developed PTSD (DSM-5); and 64 women from the community without PTSD. Women were recruited from the PTSD outpatient clinic (Universidade Federal de São Paulo, Brazil).Clinician-Administered Posttraumatic Stress Scale (CAPS 5), Beck Depression and Anxiety Inventories (BDI) (BAI), full in-lab Polysomnography (PSG), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Índex (PSQI), Fatigue Impact Scale (FIS), and Insomnia Severity Índex (ISI) were applied to all participants. Analysis of variance, regression models, and general linear modeling were used. Results Patients mean age was 28 vs 24 for the control group (p=0.004). CAPS mean score in PTSD-group was 42.5±9.1. BDI, BAI, FIS, PSQI, ISI scores were worse in PTSD-group (p<0.05, all). Pittsburgh Sleep Quality Index (PSQI) score was significantly associated with CAPS 5 independently of depression, fatigue, and sleep fragmentation. The PTSD women had lower total sleep time (p= 0.01) and lower REM sleep percentage (p=0.04). However, the control group had higher arousal index (p=.0.01) and had higher muscle activity during REM sleep (p=0.03) than PTSD. Conclusion Women with PTSD had significantly worse score in PSQI, FIS, and ISI. PSQI score was associated with PTSD severity. However, when PSG results are concerned, we found higher sleep fragmentation in the control group. We speculate that women with PTSD may have felt safer and taken care of in the lab, which might explain the difference between objective and subjective measures of sleep quality in PTSD. Support Acknowledgments: FAPESP: Fundação de Apoio à pesquisa de São Paulo, AFIP: Associação Incentivo a Pesquisa

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Research on Treating Insomnia Accompanied With Depression by Mongolian Medical Warm Acupuncture

Physikalische Medizin Rehabilitationsmedizin Kurortmedizin ◽

10.1055/a-0658-1675 ◽

2018 ◽

Vol 28 (06) ◽

pp. 358-364

Author(s):

Lidao Bao ◽

Sha Li ◽

Qiu Jin ◽

Lengge Si ◽

Agula Bo

Keyword(s):

Sleep Quality ◽

Therapeutic Effect ◽

Quality Index ◽

Rating Scale ◽

Pittsburgh Sleep Quality Index ◽

Depression Scale ◽

Drug Group ◽

Acupuncture Group ◽

Self Rating ◽

Significant Difference

Abstract Objective To observe the therapeutic effect of Mongolian medical warm acupuncture in treating the patients with insomnia accompanied with depression and discuss the mechanism of action of Mongolian medical warm acupuncture in treating insomnia. Method 50 patients with insomnia accompanied with depression were clinically selected and randomly divided into the Mongolian medical warm acupuncture group and the drug group (trazodone) of 25 each. The patients in the Mongolian medical warm acupuncture group were subjected to acupoint stimulation (Xin acupoint, Dinghui acupoint, and Heyi) for 30 min once a day. 100mg of trazodone were administered to the patients in the drug group. The patients in both groups were treated for 4 weeks. The patients in both groups were compared in terms of Pittsburgh sleep quality index, sleep quality, daytime functions, self-rating depression scale etc. Result There was a significant difference in total score of Pittsburgh sleep quality index (PSQI) between the patients in the Mongolian medical warm acupuncture group before treatment (16.83±3.68) and those after treatment (8.18±3.78)(P<0.01). The scores of sleep quality and daytime functions of the patients in the Mongolian medical warm acupuncture group (6.76±2.76) were superior to those in the drug group (5.89±2.87)(P<0.05). The self-rating depression scale (SDS) scores of the patients in the Mongolian medical warm acupuncture group after treatment (0.54±0.89) decreased significantly when compared with those before treatment (P<0.01). There was no significant difference in clinical therapeutic effect between both groups (P=0.0812>0.05). The obvious curative rate in the Mongolian medical warm acupuncture group (75.58%) was significantly superior to that in the drug group (49.77%) (P=0.0382<0.05). The Asberg side effect rating scale (SERS) score in the drug group after treatment (6.11±2.06) was significantly higher than that in the Mongolian medical warm acupuncture group (4.15±1.98) (P<0.05). Conclusion Mongolian medical warm acupuncture has therapeutical effect on insomnia accompanied with depression and Mongolian medical warm acupuncture has better therapeutical effect and fewer side effects than trazodone. Mongolian medical warm acupuncture has certain sedative-hypnotic and anti-depressive effects applies to insomnia accompanied with suppression.

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Benefits of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia: a randomized controlled trial

Clinical Rehabilitation ◽

10.1177/0269215519893107 ◽

2019 ◽

Vol 34 (2) ◽

pp. 242-251 ◽

Cited By ~ 2

Author(s):

Miguel Gómez-Hernández ◽

Tomás Gallego-Izquierdo ◽

Patricia Martínez-Merinero ◽

Daniel Pecos-Martín ◽

Alejandro Ferragut-Garcías ◽

...

Keyword(s):

Sleep Quality ◽

Aerobic Exercise ◽

Quality Index ◽

Analogue Scale ◽

Pittsburgh Sleep Quality Index ◽

Fibromyalgia Impact Questionnaire ◽

Exercise Programme ◽

Moderate Intensity ◽

Control Group ◽

Experimental Group

Objective: To investigate the effects of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia. Design: Randomized controlled trial. Subjects: Sixty-four female patients who were diagnosed with fibromyalgia syndrome based on the American College of Rheumatology criteria were recruited (mean age: 54.27 ± 6.94 years). Interventions: The control group ( n = 32) underwent supervised moderate-intensity cycling (50%–70% of the age-predicted maximum heart rate) three times per week for 12 weeks. The experimental group ( n = 32) underwent the same exercise programme plus a stretching programme once per week for 12 weeks. Main measures: The main measures of this study were sleep quality assessed by the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale, the impact of fibromyalgia on quality of life assessed by the Fibromyalgia Impact Questionnaire, and pain perception assessed by the visual analogue scale at baseline, after 4 weeks, and after 12 weeks. Results: The experimental group experienced significant improvements at 4-week measure compared with control group: Pittsburgh Sleep Quality Index ( P < 0.001); Epworth Sleepiness Scale ( P = 0.002); Fibromyalgia Impact Questionnaire (0.93 ± 7.39, P < 0.001); and visual analogue scale (0.52 ± 0.05, P < 0.001). Also at 12-week measure, experimental group experienced significant improvements compared with control group: Pittsburgh Sleep Quality Index ( P < 0.001), Epworth Sleepiness Scale ( P < 0.001); Fibromyalgia Impact Questionnaire (1.15 ± 9.11, P < 0.001); and visual analogue scale (0.81 ± 0.62, P < 0.001). Conclusion: Adding stretching to a moderate-intensity aerobic exercise programme increased sleep quality, decreased the impact of fibromyalgia on the quality of life, and reduced pain compared with just a moderate-intensity aerobic exercise programme in our sample of women with fibromyalgia.

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Myofunctional Therapy App for Severe Apnea–Hypopnea Sleep Obstructive Syndrome: Pilot Randomized Controlled Trial

JMIR mhealth and uhealth ◽

10.2196/23123 ◽

2020 ◽

Vol 8 (11) ◽

pp. e23123

Author(s):

Carlos O'Connor-Reina ◽

Jose Maria Ignacio Garcia ◽

Elisa Rodriguez Ruiz ◽

Maria Del Carmen Morillo Dominguez ◽

Victoria Ignacio Barrios ◽

...

Keyword(s):

Sleep Quality ◽

Epworth Sleepiness Scale ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Intervention Group ◽

Oxygen Desaturation ◽

Control Group ◽

Desaturation Index ◽

Myofunctional Therapy ◽

Oxygen Desaturation Index

Background Myofunctional therapy has demonstrated efficacy in treating sleep-disordered breathing. We assessed the clinical use of a new mobile health (mHealth) app that uses a smartphone to teach patients with severe obstructive sleep apnea–hypopnea syndrome (OSAHS) to perform oropharyngeal exercises. Objective We conducted a pilot randomized trial to evaluate the effects of the app in patients with severe OSAHS. Methods Forty patients with severe OSAHS (apnea–hypoxia index [AHI]>30) were enrolled prospectively and randomized into an intervention group that used the app for 90 sessions or a control group. Anthropometric measures, Epworth Sleepiness Scale (0-24), Pittsburgh Sleep Quality Index (0-21), Iowa Oral Performance Instrument (IOPI) scores, and oxygen desaturation index were measured before and after the intervention. Results After the intervention, 28 patients remained. No significant changes were observed in the control group; however, the intervention group showed significant improvements in most metrics. AHI decreased by 53.4% from 44.7 (range 33.8-55.6) to 20.88 (14.02-27.7) events/hour (P<.001). The oxygen desaturation index decreased by 46.5% from 36.31 (27.19-43.43) to 19.4 (12.9-25.98) events/hour (P=.003). The IOPI maximum tongue score increased from 39.83 (35.32-45.2) to 59.06 (54.74-64.00) kPa (P<.001), and the IOPI maximum lip score increased from 27.89 (24.16-32.47) to 44.11 (39.5-48.8) kPa (P<.001). The AHI correlated significantly with IOPI tongue and lip improvements (Pearson correlation coefficient −0.56 and −0.46, respectively; both P<.001). The Epworth Sleepiness Scale score decreased from 10.33 (8.71-12.24) to 5.37 (3.45-7.28) in the app group (P<.001), but the Pittsburgh Sleep Quality Index did not change significantly. Conclusions Orofacial exercises performed using an mHealth app reduced OSAHS severity and symptoms, and represent a promising treatment for OSAHS. Trial Registration Spanish Registry of Clinical Studies AWGAPN-2019-01, ClinicalTrials.gov NCT04438785; https://clinicaltrials.gov/ct2/show/NCT04438785

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Myofunctional Therapy App for Severe Apnea–Hypopnea Sleep Obstructive Syndrome: Pilot Randomized Controlled Trial (Preprint)

10.2196/preprints.23123 ◽

2020 ◽

Author(s):

Carlos O'Connor-Reina ◽

Jose Maria Ignacio Garcia ◽

Elisa Rodriguez Ruiz ◽

Maria Del Carmen Morillo Dominguez ◽

Victoria Ignacio Barrios ◽

...

Keyword(s):

Sleep Quality ◽

Epworth Sleepiness Scale ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Intervention Group ◽

Oxygen Desaturation ◽

Control Group ◽

Desaturation Index ◽

Myofunctional Therapy ◽

Oxygen Desaturation Index

BACKGROUND Myofunctional therapy has demonstrated efficacy in treating sleep-disordered breathing. We assessed the clinical use of a new mobile health (mHealth) app that uses a smartphone to teach patients with severe obstructive sleep apnea–hypopnea syndrome (OSAHS) to perform oropharyngeal exercises. OBJECTIVE We conducted a pilot randomized trial to evaluate the effects of the app in patients with severe OSAHS. METHODS Forty patients with severe OSAHS (apnea–hypoxia index [AHI]>30) were enrolled prospectively and randomized into an intervention group that used the app for 90 sessions or a control group. Anthropometric measures, Epworth Sleepiness Scale (0-24), Pittsburgh Sleep Quality Index (0-21), Iowa Oral Performance Instrument (IOPI) scores, and oxygen desaturation index were measured before and after the intervention. RESULTS After the intervention, 28 patients remained. No significant changes were observed in the control group; however, the intervention group showed significant improvements in most metrics. AHI decreased by 53.4% from 44.7 (range 33.8-55.6) to 20.88 (14.02-27.7) events/hour (P<.001). The oxygen desaturation index decreased by 46.5% from 36.31 (27.19-43.43) to 19.4 (12.9-25.98) events/hour (P=.003). The IOPI maximum tongue score increased from 39.83 (35.32-45.2) to 59.06 (54.74-64.00) kPa (P<.001), and the IOPI maximum lip score increased from 27.89 (24.16-32.47) to 44.11 (39.5-48.8) kPa (P<.001). The AHI correlated significantly with IOPI tongue and lip improvements (Pearson correlation coefficient −0.56 and −0.46, respectively; both P<.001). The Epworth Sleepiness Scale score decreased from 10.33 (8.71-12.24) to 5.37 (3.45-7.28) in the app group (P<.001), but the Pittsburgh Sleep Quality Index did not change significantly. CONCLUSIONS Orofacial exercises performed using an mHealth app reduced OSAHS severity and symptoms, and represent a promising treatment for OSAHS. CLINICALTRIAL Spanish Registry of Clinical Studies AWGAPN-2019-01, ClinicalTrials.gov NCT04438785; https://clinicaltrials.gov/ct2/show/NCT04438785

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