High-flow arteriovenous fistula is not associated with increased extracellular volume or right ventricular dysfunction in haemodialysis patients

Author(s):  
David A Jaques ◽  
Andrew Davenport

Abstract Background High-output congestive heart failure secondary to high-flow arteriovenous fistula (AVF) has been reported in haemodialysis (HD) patients. As high-flow AVF (HFA) would be expected to result in fluid retention, we conducted an observational study to characterize the relationship between AVF flow (Qa) and extracellular water (ECW) in HD patients. Methods We measured Qa by ultrasound dilution in prevalent HD outpatients with an AVF in two dialysis centres. The ECW:total body water (TBW) ratio was measured both pre- and post-dialysis by multifrequency bioimpedance analysis. Transthoracic echocardiograms (TTEs) were performed as part of routine clinical management. Results We included 140 patients, mean age 62.7 ± 15.7 years, 60.7% male, 47.9% diabetic and 22.9% with coronary revascularization. Mean Qa was 1339 ± 761 mL/min and 22 (15.7%) patients had HFA defined as Qa >2.0 L/min. Qa was positively associated with an upper arm AVF (P = 0.005), body mass index (P = 0.012) and N-terminal pro-brain natriuretic peptide (NT-proBNP) (P = 0.047) and negatively associated with diabetes (P < 0.001) and coronary revascularization (P = 0.005). The ECW:TBW ratio was positively associated with age (P < 0.001), Davies comorbidity index (P = 0.034), peripheral vascular disease (P = 0.030) and NT-proBNP (P = 0.002) and negatively associated with serum albumin (P < 0.001). Qa was not associated with the ECW:TBW ratio (P = 0.744). TTE parameters were not associated with Qa. Conclusions In our outpatient HD cohort, high AVF flow was not associated with ECW expansion, either pre- or post-dialysis when accounting for potential confounders. By controlling ECW, high access flow should not necessarily be perceived as a threat to cardiovascular physiology.

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Ritu ◽  
Madhu Anand

Parental Modernity is an important aspect for the psycho-social development of the child. The present study aims to study the effect of parental modernity on rejection sensitivity and self-esteem of adolescents and the relationship between rejection sensitivity and self-esteem. The research is carried out on a sample of 240 parents (including 120 fathers and 120 mothers) and their 120 children. For observing the impact of modernity of parents on their children, Individual Modernity Scale was used and administered on father and mother. Rejection Sensitivity Questionnaire and Self-Esteem Inventory were used to measure the rejection sensitivity and self-esteem of children (age ranges from 14 to 19 years). The results suggest that parental modernity has an effect on the rejection sensitivity and personally perceived self of the self – esteem of adolescents. Furthermore, the rejection sensitivity has been found negatively associated with self-esteem.


2016 ◽  
Vol 44 (7) ◽  
pp. 1123-1132 ◽  
Author(s):  
Haishu Qiao ◽  
Yue Xia ◽  
Ying Li

Because bank employees have been found to be especially susceptible to burnout and depression, we explored the relationship between these variables, and examined the moderating effect of perceived employability on the burnout–depression relationship in a sample of Chinese bank employees. As we expected, burnout and perceived employability were, respectively, positively and negatively associated with depression. The results of hierarchical regression and structural equation modeling indicated that perceived employability moderated the relationship between burnout and depression; higher perceived employability was associated with a weaker relationship between burnout and depression. Interventions aimed at developing the perceived employability of Chinese bank employees may help to improve mental health in this group.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ping-Hsun Wu ◽  
Yi-Ting Lin ◽  
Yi-Wen Chiu ◽  
Gabriel Baldanzi ◽  
Jiun-Chi Huang ◽  
...  

AbstractProtein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated. In hemodialysis patients, we investigated the relationship between the free form of IS and PCS and 181 CV-related proteins. First, IS or PCS concentrations were checked, and high levels were associated with an increased risk of acute coronary syndrome (ACS) in 333 stable HD patients. CV proteins were further quantified by a proximity extension assay. We examined associations between the free form protein-bound uremic toxins and the quantified proteins with correction for multiple testing in the discovery process. In the second step, the independent association was evaluated by multivariable-adjusted models. We rank the CV proteins related to protein-bound uremic toxins by bootstrapped confidence intervals and ascending p-value. Six proteins (signaling lymphocytic activation molecule family member 5, complement component C1q receptor, C–C motif chemokine 15 [CCL15], bleomycin hydrolase, perlecan, and cluster of differentiation 166 antigen) were negatively associated with IS. Fibroblast growth factor 23 [FGF23] was the only CV protein positively associated with IS. Three proteins (complement component C1q receptor, CCL15, and interleukin-1 receptor-like 2) were negatively associated with PCS. Similar findings were obtained after adjusting for classical CV risk factors. However, only higher levels of FGF23 was related to increased risk of ACS. In conclusion, IS and PCS were associated with several CV-related proteins involved in endothelial barrier function, complement system, cell adhesion, phosphate homeostasis, and inflammation. Multiplex proteomics seems to be a promising way to discover novel pathophysiology of the uremic toxin.


Pain Medicine ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. e102-e113 ◽  
Author(s):  
Manasi M Mittinty ◽  
Sara Kindt ◽  
Murthy N Mittinty ◽  
Sonia Bernardes ◽  
Annmarie Cano ◽  
...  

Abstract Objective Dyadic coping is a process of coping within couples that is intended not only to support the patient with chronic pain but also to maintain equilibrium in the relationship. This study aims to investigate the effect of patient-perceived and spouse-reported dyadic coping on both the patient and their partner’s relationship quality and anxiety, stress, and depression over time. Methods One hundred thirty-nine couples, with one partner experiencing chronic pain, participated in this study. Spanning three measurements over six months, couples reported on their anxiety, stress, depression, relationship quality, and dyadic coping. Results Patient-perceived supportive dyadic coping was positively associated with both partners’ relationship quality but was negatively associated with spouses’ stress over time. Patient-perceived negative dyadic coping was negatively associated with both partners’ relationship quality and positively associated with patients’ depression and spouses’ depression and stress over time. Spouse-reported supportive dyadic coping showed a positive association with their own relationship quality and a negative association with spouses’ depression at baseline and patients’ depression at three-month follow-up. Spouse-reported negative dyadic coping was negatively associated with their relationship quality at baseline and positively associated with their partner’s anxiety and stress at six-month and three-month follow-up, respectively. Similar inference was observed from the findings of growth curve model. Conclusions As compared with spouse report, patient perception of dyadic coping is a better predictor of both partners’ relationship quality and psychological outcomes over time. Both partners may benefit from early psychosocial intervention to improve their dyadic coping, relationship quality, and psychological outcomes.


2016 ◽  
Vol 31 ◽  
pp. 210.e1-210.e3 ◽  
Author(s):  
Mario D'Amico ◽  
Roberto Miraglia ◽  
Settimo Caruso ◽  
Luigi Maruzzelli ◽  
Kelvin Cortis ◽  
...  

2018 ◽  
Vol 10 (2) ◽  
pp. 70-75 ◽  
Author(s):  
Turgut Karabağ ◽  
Emіne Altuntaş ◽  
Belma Kalaycı ◽  
Bahar Şahіn ◽  
Mustafa Umut Somuncu ◽  
...  

2018 ◽  
Vol 24 (4) ◽  
pp. 387-391
Author(s):  
E. Becher ◽  
P.García Marchiñena ◽  
J. Jaunarena ◽  
D. Santillán ◽  
L. Pérez ◽  
...  

2016 ◽  
Vol 40 (5) ◽  
pp. 459-465 ◽  
Author(s):  
Marina Camodeca ◽  
Gabrielle Coppola

The present study examined whether bullying, defending, and outsider behaviors in preschool children were associated with two conscience aspects (empathic concern and internalization of rules) and with emotion understanding. We also investigated whether emotion understanding moderated the relationship between these dimensions and bullying roles. Participants were 105 children (51 males), aged 36 to 76 months. Bullying roles were assessed through peer nominations. Internalization of rules and empathic concern were observed in classroom and their scores derived from selected Q-Sort items. Emotion understanding was evaluated with the Puppet Interview administered to children. Results showed that empathic concern and internalization of rules were negatively associated with bullying and outsider behaviors, whereas emotion understanding correlated with defending behavior. The interaction between emotion understanding and internalization of rules was also significant: Low scores on rule-compatible conduct were associated with bullying or outsider behavior, in particular for those children with poor emotion understanding.


2002 ◽  
Vol 8 (1) ◽  
pp. 55-60 ◽  
Author(s):  
C. Campos ◽  
R. Piske ◽  
J. Nunes ◽  
S.B. Soares ◽  
J.A. Castro ◽  
...  

A high flow pial arteriovenous fistula in a twenty-years-old girl is described. The arteriovenous communication corresponds to a single hole fistula on the right rolandic area, with a giant venous ectasia. The patient presented seizures and left hemiparesis as symptoms. The fistula was embolized with glue obtaining total occlusion of the shunt. Hypotension was induced and valsalva manoeuver was done during the glue injection to reduce the flow into the fistula, however 26 hours after the procedure the patient bled resulting in a fatal outcome. The purpose of this paper is discuss the presentation of Rendu-Osler-Weber (ROW) in children and the therapeutic guidelines.


2018 ◽  
Vol 58 (10) ◽  
pp. 211-214
Author(s):  
Ippei Kato ◽  
Tomohiro Iwakura ◽  
Koji Toguchi ◽  
Noriko Asakawa

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