scholarly journals Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health Study

2009 ◽  
Vol 25 (1) ◽  
pp. 119-124 ◽  
Author(s):  
C. Keller ◽  
R. Katz ◽  
M. J. Sarnak ◽  
L. F. Fried ◽  
B. Kestenbaum ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Inflammatory Biomarkers ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Association of Serum Uromodulin With ESKD and Kidney Function Decline in the Elderly: The Cardiovascular Health Study

2019 ◽  
Vol 74 (4) ◽  
pp. 501-509 ◽  
Author(s):  
Dominik Steubl ◽  
Petra Buzkova ◽  
Pranav S. Garimella ◽  
Joachim H. Ix ◽  
Prasad Devarajan ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Kidney Function Decline

The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: The Cardiovascular Health Study

2006 ◽  
Vol 187 (2) ◽  
pp. 372-377 ◽  
Author(s):  
Jie J. Cao ◽  
Joshua I. Barzilay ◽  
Do Peterson ◽  
Teri A. Manolio ◽  
Bruce M. Psaty ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Subclinical Atherosclerosis ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Silent Brain MRI Infarcts and Subsequent Stroke Type In the Cardiovascular health Study

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 363-363
Author(s):  
Charles B Bernick ◽  
Lewis H Kuller ◽  
Will T Longstreth ◽  
Corinne Dulberg ◽  
Teri A Manolio ◽  
...  
Keyword(s):  
Hemorrhagic Stroke ◽  
Cardiovascular Health ◽  
Brain Mri ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Prior History ◽  
Mri Scans ◽  
Cranial Mri ◽  
Silent Mri

P136 Objective: Silent infarcts seen on cranial MRI scans are a risk factor for subsequent clinical stroke in the elderly. This study examines the type of clinical strokes seen in those with silent infarcts. Methods: Cranial MRI examination was completed on 3324 Cardiovascular Health Study (CHS) participants aged 65+ who were without a prior history of clinical stroke. Incident strokes were identified over an average follow-up of 4 years and classified as hemorrhagic or ischemic. Ischemic strokes were further subdivided into lacunar, cardioembolic, atherosclerotic or other/unknown. Results: Silent MRI infarcts >3mm were found in approximately 28% (n=923). Of these, 7% (n=67) subsequently had a clinically evident stroke. The characteristics of the silent MRI infarcts in those who sustained an incident stroke were as folows: 56 had only subcortical infarcts, of which 55 were <20mm; 4 had only cortical infarcts; and 7 had both cortical and subcortical infarcts. Of those with only subcortical silent MRI infarcts, 16% (n=9) went on to a hemorrhagic stroke and 84% (n=47) sustained an ischemic stroke. The ischemic strokes were subtyped as 12 cardioembolic, 3 lacunar, 2 atherosclerotic and 30 unknown/other. Considering only those with cortical silent infarcts, either alone or in combination with subcortical infarcts, there was 1 hemorrhagic stroke and 10 ischemic strokes. Half of the ischemic strokes were cardioembolic and half were unknown type. Conclusion: Elderly individuals with silent subcortical infarcts who go onto subsequent stroke may be at risk not only for lacunar infarcts but also cardioembolic or hemorrhagic strokes.

Factor V Leiden Is not a Risk Factor for Arterial Vascular Disease in the Elderly: Results from the Cardiovascular Health Study

1998 ◽  
Vol 79 (05) ◽  
pp. 912-915 ◽  
Author(s):  
Mary Cushman ◽  
Frits R. Rosendaal ◽  
Bruce M. Psaty ◽  
E. Francis Cook ◽  
J. Valliere ◽  
...  
Keyword(s):  
Risk Factor ◽  
Arterial Thrombosis ◽  
Cardiovascular Health ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Factor V ◽  
Incident Cases

SummaryCoagulation factor V Leiden is a risk marker for venous thrombosis. For arterial thrombosis no large study to date has included population-based elderly patients. The Cardiovascular Health Study is a longitudinal study of 5,201 men and women over age 65. With 3.4-year follow-up, we studied 373 incident cases of myocardial infarction (MI), angina, stroke, or transient ischemic attack (TIA), and 482 controls. The odds ratios for each event with heterozygous factor V Leiden were: MI, 0.46 (95% CI 0.17 to 1.25); angina, 1.0 (95% CI 0.45 to 2.23); stroke, 0.77 (95% CI 0.35 to 1.70); TIA, 1.33 (95% CI 0.5 to 3.55); any outcome, 0.83 (95% CI 0.48 to 1.44). Adjustment for cardiovascular risk factors did not change relationships. In older adults factor V Leiden is not a risk factor for future arterial thrombosis.

Hemoglobin Decline and Health Outcomes in the Elderly: the Cardiovascular Health Study

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3448-3448
Author(s):  
Neil A Zakai ◽  
Benjamin French ◽  
Alice Arnold ◽  
Anne Newman ◽  
Linda F. Fried ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Baseline Risk ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Logistic Regression Models ◽  
Concurrent Development ◽  
Adjusted Logistic Regression

Abstract Introduction: Anemia is associated with increased morbidity and mortality in the elderly, though the risk factors for and the consequences of hemoglobin (HGB) decline are poorly characterized. Methods: We studied 5201 men and women ≥65 participating in the Cardiovascular Health Study. The cohort was followed biannually and had baseline and repeat hemograms 3 years later. HGB decline was defined as >1g/dL HGB drop, or incident anemia at 3 years by WHO criteria. Results: 4006 participants survived to 3 years and had two HGB measures. The median HGB change was −0.2g/dL (IQR-0.8, 0.1). 961 (24%) participants had a >1g/dL HGB drop and 335 (8%) developed incident anemia. The left side of the table presents adjusted logistic regression models of baseline risk factors for HGB decline. Those with baseline cardiovascular disease (CVD), diabetes and kidney disease were more likely to develop >1g/dL HGB drop while only baseline kidney disease was associated with incident anemia. The table also shows the adjusted risk of HGB decline with concurrent development of co-morbid conditions. A >1g/dL drop in HGB was more likely in those who concurrently developed incident CVD, hypertension or inflammation. Incident anemia was more likely in participants with concurrent development of kidney disease or inflammation. Both incident anemia and a HGB drop >1g/dL were associated with subsequent 9-year mortality adjusting for age, race, gender, year 3 HGB, hypertension, CVD, diabetes, and renal disease; HRs (95% CI) 1.4 (1.2, 1.6) and 1.2 (1.1, 1.4) respectively. Discussion: Among studied factors, baseline CVD, diabetes and kidney disease were risk factors for >1g/dL HGB drop while only baseline kidney disease was a risk factor for incident anemia. Incident CVD and hypertension were associated concurrently with >1g/dL HGB drop while kidney disease was associated with concurrent incident anemia. Inflammation development was the strongest risk factor accompanying HGB decline. HGB decline, especially a 1g/dL drop, was associated with subsequent mortality irrespective of HGB concentration. These data suggest that small HGB changes not captured by the WHO anemia criteria are associated with poor health outcomes and that inflammation is a major correlate of HGB decline in the elderly. Table: Risk Factors for HGB Decline in Age-, Race-, Gender, and Baseline HGB-Adjusted Logistic Regression Models Baseline Risk Factors for HGB Decline Risk of HGB Decline with Concurrent Conditions HGB Drop >1g/dL Incident Anemia HGB Drop >1g/dL Incident Anemia CVD 1.2 (1.1, 1.4) 1.0 (0.8, 1.3) 1.3 (1.1, 1.6) 1.0 (0.7, 1.3) Hypertension 1.1 (0.99, 1.3) 1.1 (0.8, 1.2) 1.4 (1.1, 1.7) 1.1 (0.8, 1.5) Diabetes 1.3 (1.1, 1.5) 1.1 (0.8, 1.4) 0.9 (0.6, 1.4) 0.8 (0.4, 1.7) Kidney Disease (GFR <60ml/min/1.73m2) 1.2 (1.0, 1.3) 1.3 (1.1, 1.7) 1.1 (0.8, 1.4) 1.5 (1.0, 2.1) Inflammation CRP ≥10mg/dL or WBC≥15×109/mm3 1.0 (0.8, 1.3) 1.3 (0.99 1.8) 2.3 (1.8, 2.8) 2.3 (1.8, 3.0)

Congestive Heart Failure in the Elderly: The Cardiovascular Health Study

2004 ◽  
Vol 13 (2) ◽  
pp. 61-68 ◽  
Author(s):  
Sunil T. Mathew ◽  
John S. Gottdiener ◽  
Dalane Kitzman ◽  
Gerard Aurigemma ◽  
Julius M. Gardin
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Cognition and the Risk of Hospitalization for Serious Falls in the Elderly: Results From the Cardiovascular Health Study

2010 ◽  
Vol 65A (11) ◽  
pp. 1242-1249 ◽  
Author(s):  
D. B. Welmerink ◽  
W. T. Longstreth ◽  
M. F. Lyles ◽  
A. L. Fitzpatrick
Keyword(s):  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study
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