Abstract TP85: Impact of Periodontal Disease and -Bacteria on Intracranial Aneurysms

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Shotaro Yoshioka
Keyword(s):  
Periodontal Disease ◽  
Intracranial Aneurysms ◽  
Inflammatory Responses ◽  
Periodontal Diseases ◽  
Gram Negative Bacteria ◽  
Periodontal Pathogens ◽  
Treatment Needs ◽  
Gram Negative ◽  
Periodontal Tissues ◽  
Periodontal Index

Introduction: Periodontal Gram-negative bacteria and their products can initiate inflammatory responses in periodontal tissues with systemic consequences. They are associated with the pathogenesis of atherosclerosis and ischemic stroke. Local inflammation and oxidative stress play a crucial role in the pathophysiology of intracranial aneurysms (IAs). Under the hypothesis that the severity of periodontal disease is associated with the formation and rupture of IAs we assessed which periodontal pathogens contribute to the pathogenesis of IAs. Methods: We enrolled patients with ruptured- (n=5, age 60±11.9) and unruptured IAs (n=13, age 67±6.1) and controls without IAs (n=7, age 58±8.5); their prior informed consent was obtained. The severity of periodontitis was recorded using the community periodontal index (CPI) of the Treatment Needs code. Subgingival plaques (n=23) were evaluated with the quantitative real-time PCR assay to check for the Gram-negative bacteria Aggregatibacter actinomycetemcomitans (Aa), Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia (Pi), Tannerella forsythia, and Porphyromonas gingivalis (Pg). Plasma IgG titers of antibody against Pg, Pi, Aa, and Eikenella corrodens were evaluated by ELISA. Results: The CPI was significantly higher in patients with IAs than the controls (2.7 vs 1.9, p<0.05) and their DNA level of subgingival plaques and their plasma IgG titers of Pg were also higher. Periodontal disease was more severe and the plasma IgG titers of Pg were higher in patients with ruptured- than unruptured IAs, suggesting that Pg is associated not only with the formation but also the rupture of IAs. Conclusions: We present evidence that severe periodontal disease and Pg infection may be involved in the pathophysiology of IAs. The management of periodontal diseases may help to prevent the formation and rupture of IAs.

scholarly journals Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Shotaro Yoshioka ◽  
Takeshi Miyamoto ◽  
Junichiro Satomi ◽  
Yoshiteru Tada ◽  
Kenji Yagi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Periodontal Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Periodontal Pathogens ◽  
Treatment Needs ◽  
Periodontal Index ◽  
Community Periodontal Index ◽  
Positive Rate ◽  
Severe Periodontal Disease ◽  
Subarachnoid Hemorrhages

ABSTRACT BACKGROUND The pathophysiology of subarachnoid hemorrhages (SAHs) due to ruptured intracranial aneurysms (IAs) remains unclear. Although a relationship between SAHs and periodontal disease (PD) has been suggested, the mechanism requires clarification. OBJECTIVE To evaluate the relationship between PD and SAHs and to identify periodontal pathogens associated with SAHs. METHODS This prospective study included consecutive patients with ruptured (n = 11) and unruptured (n = 14) IAs and healthy controls (n = 8). The plasma and plaque subgingival bacterial deoxyribonucleic acid (DNA) levels in PD were evaluated by a dentist using the Community Periodontal Index of Treatment Needs (CPITN). Plasma levels of matrix metalloproteinase (MMP-9), tissue inhibitors of matrix metalloproteinase (TIMP2), and procollagen I were analyzed. RESULTS Patients with ruptured IAs, had significantly higher CPITN scores than the controls, suggesting that ruptured IAs were associated with severe PD. Although no rupture-specific bacteria were identified, the positive rate of plaque subgingival bacterial DNA was significantly higher in patients with severe PD than in those without severe PD. Multivariate logistic regression analysis indicated that bleeding on probing (BOP) was associated with ruptured IAs (odds ratio, 1.10; 95% confidence interval 1.04–1.20; P = .0001). BOP was positively associated with plasma MMP-9 levels and a disequilibrium in the MMP-9/TIMP2 ratio. BOP was negatively correlated with plasma procollagen I levels (P &lt; .05, for each). This suggested that local inflammation with severe PD might have systemic effects and lead to ruptured IAs. CONCLUSION Disequilibrium of plasma protease/anti-protease associated with a high BOP rate in severe PD may be attributable to IA rupture.

scholarly journals MICRO BIOLOGY OF PERIODONTAL DISEASE- A REVIEW

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Jageer Chinna ◽  
Jannat Sharma
Keyword(s):  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Disease Process ◽  
Fusobacterium Nucleatum ◽  
Host Cells ◽  
Bacterial Invasion ◽  
Periodontal Pathogens ◽  
Tissue Destruction ◽  
Campylobacter Rectus ◽  
Periodontal Tissues

Periodontal diseases are inflammatory and destructive diseases of the dentogingival complex associated with specific periodontal pathogens inhabiting periodontal pockets. Periodontal diseases lead to damage of the periodontal tissues supporting the teeth (bone and connective tissue) and affect the quality of life of the affected individuals: poor alimentation, tooth loss, social and financial problems. Although it is generally considered that the disease has multifactorial etiology, data show that some specific Gram-negative microorganisms in the subgingival plaque biofilm play a major role in the initiation and progression of periodontitis. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia form a consortium in the subgingival biofilm and are regarded as the principal periodontopathogenic bacteria. Other microorganisms that have been implicated as predominant species in the disease process are: Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus, Peptostreptococcus migros, Eikenella corrodens. In periodontitis, the initiation of the disease is the colonization of the tissues by these pathogenic species. The next step is bacterial invasion or invasion by pathogenic products into the periodontal tissues, interactions of bacteria or their substances with host cells, and this directly/indirectly causes degradation of the periodontium, resulting in tissue destruction. Keywords: periodontal disease, periodontal pathogens, microbiology.

scholarly journals CONDITION OF PERIODONTAL TISSUES IN PATIENTS WITH DERMATOSES

2018 ◽  
Vol 14 (4) ◽  
pp. 54-57
Author(s):  
Н. Чернышева ◽  
N. Chernyshova ◽  
Сергей Чуйкин ◽  
Sergey Chuykin ◽  
Гузель Акмалова ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Periodontal Diseases ◽  
Complex Treatment ◽  
Adequate Treatment ◽  
Periodontal Tissues ◽  
Periodontal Index ◽  
Oral Lichen

Background. Periodontal disease is one of the most common and complex pathologies in dentistry. It is known frequently damage to the tissues of the periodontal complex with dermatoses. The most relevant among the dermatoses of the mucous membrane of the mouth and the red border of the lips is oral lichen planus. Among the six clinical forms of red flat oral lichen planus and the red border of the lips, the exudative-hyperemic and erosive-ulcerous forms occur most often. Atypical form is much less common than other forms and is often diagnosed by dentists as an inflammatory periodontal disease. At the same time, the pathogenetic mechanisms of inflammatory processes in the gums, which are different in oral lichen planus, are not taken into account, which, accordingly, complicates adequate treatment. Objectives. The aim of the study was to analyze the periodontal status in patients with exudative-hyperemic, erosive-ulcerative and atypical forms of oral lichen planus. Methods. Under our supervision there were 181 patients with oral lichen planus, in whom a simplified Green-Vermillion hygiene index was determined. To assess the state of periodontal used periodontal index according to Russell. Results. When assessing the hygienic condition of the oral cavity, high values were observed in individuals with severe forms of the disease: erosive-ulcerative, exudative-hyperemic. The highest values of the periodontal index were found in patients with atypical, erosive and ulcerative forms of oral lichen planus. Conclusions. The results of the clinical examination of patients with oral lichen planus dictate, first of all, to include in the scheme of complex treatment of it the sanitization of oral cavity and complex treatment of inflammatory periodontal diseases as well.

scholarly journals The Assessment of Periodontal Status and Treatment Needs of the Adult Population Aged 34-44 Residing in Lublin Province and Visiting the Dentist Regularly

2014 ◽  
Vol 124 (2) ◽  
pp. 86-88
Author(s):  
Małgorzata Stodókiewicz ◽  
Joanna Krawczyk ◽  
Jacek Szkutnik ◽  
Marcin Berger
Keyword(s):  
Alveolar Bone ◽  
Periodontal Diseases ◽  
Adult Population ◽  
World Health ◽  
Treatment Needs ◽  
Periodontal Status ◽  
Periodontal Tissues ◽  
Periodontal Index ◽  
Community Periodontal Index ◽  
Health Organization

Abstract Introduction. Periodontitis is a group of inflammatory disorders affecting periodontal tissues. This condition manifests by a progressive destruction of the alveolar bone, subsequently leading to tooth loss. World Health Organization introduced Community Periodontal Index of Treatment Needs in order to gain data regarding periodontal health and treatment needs of people with periodontitis Aim. To evaluate the periodontal status of citizens living in the city of Lublin and its surrounding, using Community Periodontal Index of Treatment Needs (CPITN). Material and methods. Community Periodontal Index of Treatment Needs was used to assess the periodontal status among 180 patients aged 35-44 residing in Lublin and the area around it. Results. Periodontal diseases have been observed in over 90% of the examined population. Treatment need index TN1 has referred to 26.11% of the patients, TN2 – 61.67% and TN3 – 2.22% respectively. Conclusions. Patients who visit the dentist regularly have a better periodontal status as compared to groups randomly selected.

scholarly journals INVESTIGATION OF SPECIES COMPOSITION OF MICROFLORA IN PERIODONTAL POCKETS IN PATIENTS WITH GENERALIZED PERIODONTITIS AND METABOLIC SYNDROME

2021 ◽  
Vol 21 (3) ◽  
pp. 147-150
Author(s):  
T.A. Hlushchenko
Keyword(s):  
Metabolic Syndrome ◽  
Periodontal Disease ◽  
Species Composition ◽  
Periodontal Diseases ◽  
Oral Microbiome ◽  
Periodontal Pathogens ◽  
Periodontal Tissues ◽  
The Metabolic Syndrome ◽  
Microbial Invasion ◽  
Rank One

Among dental diseases, periodontal diseases rank one of the leading places and are considered as the most pressing issues of modern dentistry. The presence of concomitant somatic pathology, in particular, cardiovascular, endocrinological, autoimmune diseases is an important factor that considerably determines the course and prognosis of periodontal disease. Metabolic syndrome is regarded as an urgent social and medical issue due to its high prevalence among the general population and its contribution to the development and progression of cardiovascular disease. The number of reports and scientific interest in the metabolic syndrome has grown up significantly in recent years, but despite the significant number of studies, the oral microbiome in patients with periodontal disease and underlying metabolic syndrome is still remaining insufficiently studied. The aim of this work was to investigate the species composition of the microflora in periodontal pockets and the frequency of excretion of certain types of microorganisms in the acute generalized periodontitis in patients with metabolic syndrome. A microbiological study was performed in 30 people with metabolic syndrome and generalized periodontitis, who formed the main group, and in 30 people with generalized periodontitis without endocrinological pathology, who formed a comparison group. The results of microbiological examination indicate pathological changes in the oral microbiome in the patients with metabolic syndrome demonstrating a predominance of periodontal pathogens. It can be assumed that the components of the metabolic syndrome can initiate and support microbial invasion thus resulting in the inflammatory reaction of periodontal tissues. There is a similarity between pathogenetic mechanisms of metabolic syndrome and periodontal disease that lead to the impairment of all types of metabolism: protein, lipid, mineral, carbohydrate. As a consequence, this contributes to the progressive destruction of oral tissues. The obtained data enable to suggest the dependence between the presence of the patient's metabolic syndrome and the development of intensive damage to periodontal tissues.

scholarly journals Measurements of the optical density of the alveolar process bone tissue of the jaws during periodontal diseases with the use of three-dimensional computed tomography

2012 ◽  
Vol 93 (4) ◽  
pp. 660-662 ◽  
Author(s):  
N N Bondarenko ◽  
E V Balakhontseva
Keyword(s):  
Periodontal Disease ◽  
Bone Tissue ◽  
Optical Density ◽  
Periodontal Diseases ◽  
Three Dimensional ◽  
World Health ◽  
Alveolar Process ◽  
Treatment Needs ◽  
Moderate Severity ◽  
Periodontal Tissues

Aim. To determine the optical density of the alveolar process bone tissue in normal conditions and during various forms of periodontal pathology. Methods. With the use of clinical and radiographic methods examined were 120 patients (with a healthy periodontium, with chronic generalized catarrhal gingivitis of moderate severity, with chronic periodontitis of a mild, moderate and severe degree). On the three-dimensional computer tomograms in each group of patients determined was the optical density of the alveolar process bone tissue from the medial and distal sides of the root of the following teeth 1.6, 1.7, 2.7, 2.6, 3.6, 3.7, 4.7, 4.6, 1.1, 3.1 (the teeth numbers have been recommended by the World Health Organization in order to determine the index of treatment needs of the periodontal disease), and studied were its changes depending on the severity of periodontal disease. Statistical analysis was performed using computer programs «Microsoft Excel», «Biostatistica». Results. In periodontal disease noted was a reduction in the optical density of bone tissue of the alveolar processes of the jaws with a firm relashionship with the severity of disease. In chronic generalized catarrhal gingivitis of moderate severity the optical bone density ranged from 40.445±1.264 to 633.744±5.226 arbitrary units, in mild forms of chronic generalized periodontitis - from -119.664±1.511 to 344.972±4.019, in moderate forms of chronic generalized periodontitis - from -232.589±3.088 to 203.841±1.604, in severe chronic generalized periodontitis - from -464.080±2.398 to -53.991±1.435 arbitrary units. Conclusion. Changes in optical density of bone tissue of the alveolar process of the jaws is an objective criterion for evaluating the status of periodontal tissues, an important diagnostic feature, which also makes it possible to predict the course of the disease and monitor the effectiveness of treatment.

The Effect of Oral Hygiene Instructions On Diabetic Type 2 Male Patients With Periodontal Diseases

2003 ◽  
Vol 4 (3) ◽  
pp. 40-51 ◽  
Author(s):  
Khalid Almas ◽  
Suleman Al-Lazzam ◽  
Abdulla Al-Quadairi
Keyword(s):  
Periodontal Disease ◽  
Oral Hygiene ◽  
Periodontal Diseases ◽  
Treatment Needs ◽  
Diabetic Type ◽  
Periodontal Index ◽  
Male Patients ◽  
Oral Hygiene Instructions ◽  
Type 2 Diabetic

Abstract Periodontal disease and diabetes are two common chronic diseases affecting humans. The aim of this study was to assess the effect of oral hygiene instructions on periodontal disease among type 2 male diabetic Saudi subjects. Sixty subjects completed the study and were divided into three groups of 20: healthy (non-diabetic) with periodontal disease, type 2 diabetic with early or moderate periodontal disease, and type 2 diabetic with advanced periodontitis. The age ranged from 24-64 (42 ± 13.60) years. The subjects were examined at King Saud University, College of Dentistry, Riyadh, Saudi Arabia. Oral hygiene practices and smoking habits were recorded. Oral hygiene instructions given to patients were to use an Oral B medium toothbrush and brush three times daily for 7 days using the by Bass technique for 2 minutes. Fasting blood glucose level (FBGL), gingival crevicular fluid (GCF), community periodontal index of treatment needs (CPITN), and plaque index (Pll) were used to assess patients’ profiles at baseline and at recall visit after 7 days. The results showed there was a significant overall decrease in FBGL, baseline 172.67 mg/dl (±64.69) to recall visit 162.20 (±58.78) P = 0.000, and GCF volume decreased from .4041 µl (±.1260) to .3698 µl (±.1164) P = 0.000. There was a significant reduction in subjects’ CPITN mean scores (from 13.98 (±8.24) to 13.32 (±8.97) P = 0.000), but there was no significant difference in Group 3 with advanced periodontitis, i.e., 22.25 (±1.37) to 22.30 (±1.38). There was more than a 47% reduction in the overall percentage of plaque scores. The decrease ranged from 82.27 (±19.34) to 34.45 (±17.04) at baseline and recall visit respectively. It is concluded oral hygiene instructions (a standardized regimen) has an effect on FBGL, GCF, CPITN, and PlI. It is also concluded CPITN is not very sensitive to assess change in periodontal status over a 7 days period. Further studies are needed among diabetic and healthy subjects with a larger sample size and over a longer period of time. Citation Almas K, Al-Lazzam S, Al-Quadairi A. The Effect of Oral Hygiene Instructions On Diabetic Type 2 Male Patients With Periodontal Diseases. J Contemp Dent Pract 2003 August;(4)3:040-051.

scholarly journals ETIOPATHOGENETIC MECHANISMS OF PERIODONTAL DISEASES AGAINST THE BACKGROUND OF VIRAL LIVER DISSEASES

2021 ◽  
Vol 21 (2) ◽  
pp. 214-219
Author(s):  
H.A. Sichkoriz ◽  
O.M. Slaba ◽  
L.Yu. Minko ◽  
Z.O. Bumbar
Keyword(s):  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Periodontal Pathogens ◽  
Periodontal Tissues ◽  
Immune Mediated ◽  
Hormonal Imbalance ◽  
Viral Aetiology ◽  
Social Challenge ◽  
Significant Impairment ◽  
Oral Presentations

The article presents a review and analysis of relevant available literature sources on etiopathogenetic mechanisms of periodontal disease and liver diseases of viral aetiology, and, in particular, hepatitis B and C viruses. Significant prevalence, pronounced polymorphism of clinical hepatic and extrahepatic manifestations, the incidence rate of liver cirrhosis and hepatocellular carcinoma allows us to consider hepatitis of viral aetiology as a medical and social challenge. Multi-vector liver dysfunctions can cause oral presentations in this group of patients, and in particular, in their periodontal tissues. Viral liver damage is associated with significant impairment of the microbiocenosis in gingival sulcus and periodontal pockets. Dysbiotic changes are characterized by an increase in the number of opportunistic pathogens and anaerobic periodontal pathogens. Exacerbation of dysbiosis along with deterioration of oral hygiene occurs as a consequence of reduced local resistance and hyposalivation due to the sialotropic properties of hepatitis C virus. Significant pathogenetic role in the development of periodontal disease is played by disorders of metabolic and synthetic functions of the liver, as well as hormonal imbalance, metabolic disorders, immune-mediated damage, induction of autoimmune mechanisms and cytokine imbalance. The formation of hepatogenic osteopenia and osteoporosis enhances the loss of bone mass of the alveolar processes in the jaws and, accordingly, the resorption of bone tissue with the further progression of more aggressive forms of generalized periodontitis.

scholarly journals Стоматологічний статус осіб, схильних до регулярного активного куріння

2017 ◽  
Author(s):  
O. Ya. Lavrin ◽  
V. V. Shcherba ◽  
I. Ya. Krynytska
Keyword(s):  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Pathological Process ◽  
Control Group ◽  
Periodontal Tissue ◽  
Active Smoking ◽  
Periodontal Tissues ◽  
Increased Risk ◽  
Periodontal Index ◽  
Central District

Smoking is associated with significantly increased risk of diseases of organs and tissues of the oral cavity, especially periodontal pathology and cancer of the mouth.The aim of the study – to investigate the prevalence, structure and clinical course of periodontal tissue diseases in people prone to regular active smoking.Materials and Methods. A study of 120 visitors who had undergone preventive examinations in the Clinic of Zbarazh Central District Municipal Hospital exposed to regular active smoking was performed. To assess the degree of inflammation in periodontal tissues we used marginally-papillary-alveolar index, periodontal index, the Green-Vermilyon index.Results and Discussion. Dental examination of persons exposed to regular active smoking, revealed periodontal disease in 102 individuals (85.0 %), intact periodont – 18 persons (15.0 %). At the same time, investigation of 30 control individuals showed periodontal disease in 12 persons (40.0 %), clinically healthy periodontal tissue – in 18 persons (60.0 %). PMA index of individuals exposed to regular active smoking, treated as severe gingivitis and was significantly higher than data of the control group in 2.5 times. Average numerical values of periodontal index in patients exposed to regular active smoking answered moderate periodontitis and significantly were higher than data of the control group in 4 times. Oral hygiene status in 62 % of those exposed to regular active smoking, was poor, 7 % – very poor, 22 % – satisfactory, 9 % – good. Average numerical values of Green-Vermilyon index in smokers was significantly higher than data of the control group in 3.1 times.Conclusions. Thus, smoking contributes to increasing of diffuse periodontal diseases and deepening of pathological process.

scholarly journals PERIODONTAL VACCINE- A SHOT IN THE ARM!

2020 ◽  
Vol 8 (10) ◽  
pp. 381-389
Author(s):  
Apeksha Gajghate ◽  
◽  
Salman Ansari ◽  
Rajvir Malik ◽  
Namrata Khetal ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Tooth Loss ◽  
Genetic Factors ◽  
Inflammatory Responses ◽  
Periodontal Diseases ◽  
Treatment Modalities ◽  
Periodontal Pathogens ◽  
Tissue Destruction ◽  
Therapeutic Modalities ◽  
Immune System Dysfunction

Periodontal diseases are immune inflammatory responses induced by dental plaque in which microorganisms harboured within a susceptible periodontium contributes to tissue destruction, bone loss and eventually tooth loss. The etiopathogenesis of periodontal disease is multifactorial which includes host associated factors, genetic factors, immune system dysfunction and environmental factors. Existing treatment modalities have resulted only in arresting the disease progression but have not cured the disease completely, nor do they avert the recurrence. Hence there is a need for therapeutic modalities which may include vaccines targeting periodontal pathogens. Vaccination is induction of immunity by injecting a dead or attenuated form of pathogen. Till date, no pre-emptive modality exists for periodontal disease, the availability of periodontal vaccine would prevent the progression of periodontal diseases. The aim of this review article is to confer the various approaches associated with periodontal vaccine.

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