scholarly journals 192. Epidemiology, Microbiological Characteristics and Clinical Outcomes of Invasive Blood Stream Infections of Group B Streptococcal Isolates From Qatar

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S203-S204
Author(s):  
Maisa Ali ◽  
Mohammed Alamin ◽  
Gawahir Ali ◽  
Khalid Alzubaidi ◽  
Bashir Ali ◽  
...  
Keyword(s):  
Young Adults ◽  
Clinical Outcomes ◽  
Streptococcus Agalactiae ◽  
Blood Stream Infection ◽  
The Elderly ◽  
Blood Stream ◽  
High Cure ◽  
Presenting Symptoms ◽  
Microbiological Characteristics ◽  
Group B

Abstract Background Group B Streptococci (GBS) or Streptococcus agalactiae colonize humans genitourinary and gastrointestinal tracts particularly of females. The pathogen is capable of causing invasive disease primarily in infants, pregnant and postpartum women as well as the elderly and patients with comorbidities. There is paucity of studies of the disease with regional differences in prevalence and presentation of invasive blood stream infection (BSI). In this study, we aim to assess prevalence, microbiological characteristics as well as clinical outcomes of invasive GBS disease from all ages groups at Hamad Medical Corporation (HMC), Qatar. Methods A retrospective study was conducted on all patients with microbiologically confirmed GBS bacteraemia between January 2015–March 2019. Demographic, microbiological characteristics as well as clinical data were extracted from hospital information system. Results Out of 196 confirmed cases of GBS blood stream infection, 63.7 % were females (125/196) of whom 44.8 % were pregnant (56/125), 53.6 % (30/56) were colonized while 36.3 % (71/196) were males. There were three distinct age group populations, paediatric less than 4 years of age at 35.7 %, young adults 25-34 (20.9 %) and the elderly > 65 year (17.4 %). Presenting symptoms were mild with fever recognised in only 53 % of cases (104/196) while 89% of cases had low Pitt bactermia score of 0-2. Microbiological characteristic using disc diffusion tests demonstrated all isolates were universally sensitive to penicillin (100%, 196/196) with significant resistance to clindamycin at 28.6 % (56/196) and erythromycin at 49 % (96/196) of which 34.4 % (33/96) had inducible clindamycin resistance. Clinical outcome showed high cure rate of 87.25% (171/196) with low complications at 8.76 % (17/196) and 4% (8/196) 30-day mortality. Antibiotic sensitivity profile for GBS isolates Conclusion Streptococcus agalactiae blood stream infection in Qatar is common in females, affects the very young, young adults and the elderly. Almost half of affected pregnant women are colonized. The organism remains universality sensitive to pencilling with significant resistance to clindamycin and erythromycin. Patients presents with mild symptoms with high cure rates, low complications and safe outcome for the majority of cases. Disclosures All Authors: No reported disclosures

scholarly journals Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics

2019 ◽  
Vol 13 (4) ◽  
pp. e0007293 ◽  
Author(s):  
M. John Albert ◽  
Dieter Bulach ◽  
Wadha Alfouzan ◽  
Hidemasa Izumiya ◽  
Glen Carter ◽  
...  
Keyword(s):  
Blood Stream Infection ◽  
Blood Stream ◽  
Microbiological Characteristics

Incidence and serotype characterisation ofStreptococcus agalactiaein a Portuguese hospital

2017 ◽  
Vol 71 (6) ◽  
pp. 508-513 ◽  
Author(s):  
Ana Mafalda Pinto ◽  
Tamegão Aires Pereira ◽  
Valquíria Alves ◽  
António Araújo ◽  
Olga Maria Lage
Keyword(s):  
Retrospective Study ◽  
Pregnant Women ◽  
Streptococcus Agalactiae ◽  
Neonatal Sepsis ◽  
Pathogenic Agent ◽  
Live Births ◽  
The North ◽  
Microbiological Characteristics ◽  
Group B

AimsStreptococcus agalactiae,commonly known as group BStreptococcus(GBS), has been recognised as a worldwide causative pathogenic agent of neonatal sepsis, meningitis and pneumonia. To better understand the behaviour ofS. agalactiaein pregnant women from a hospital from the North of Portugal, retrospective analyses were performed to describe epidemiological, clinical and microbiological characteristics of the isolates obtained.MethodsBased on laboratorial records and the hospital’s patient files, a 6-year retrospective study was performed to analyseS. agalactiaeisolates from screened pregnant women between 35 and 37 weeks of gestation and hospitalised neonates from pregnant women between 24 and 41 weeks of gestation admitted in Hospital Pedro Hispano. Serotype characterisation was also performed in 67 GBS strains.ResultsIn 6692 pregnant women between 35 and 37 weeks of gestation screened between 2011 and 2016, a total of 1377S. agalactiaeisolates (21%) were found. A high percentage (40%) of unknown colonisation status among hospitalised neonates from pregnant women between 24 and 41 weeks of gestations was also found. The incidence of neonatal sepsis was 8.7 (95% CI 7.0 to 10.8) cases per 1000 live births. Regarding serotype characterisation, serotype III (22.4%) was the most frequent, followed by serotype Ia (19.4%) and serotypes Ib and V (both with 17.9%).ConclusionHigh epidemiological values of GBS colonisation and incidence were found in this study. In Portugal studies on the epidemiology and behaviour ofS. agalactiaeremain limited, reinforcing the importance and need forS. agalactiaescreening across the country.

scholarly journals Control of Streptococcal Infections: Is a Common Vaccine Target Achievable Against Streptococcus agalactiae and Streptococcus pneumoniae

2021 ◽  
Vol 12 ◽  
Author(s):  
Edmund Bedeley ◽  
Andrea Gori ◽  
Dorothy Yeboah-Manu ◽  
Kanny Diallo
Keyword(s):  
Streptococcus Pneumoniae ◽  
Streptococcus Agalactiae ◽  
Vaccine Development ◽  
Genomic Sequence ◽  
Group B Streptococcus ◽  
The Elderly ◽  
Pneumococcal Infections ◽  
Antibiotics Use ◽  
Life Threatening ◽  
Group B

Both Streptococcus agalactiae [group B streptococcus (GBS)] and Streptococcus pneumoniae (pneumococcus) remain significant pathogens as they cause life threatening infections mostly in children and the elderly. The control of diseases caused by these pathogens is dependent on antibiotics use and appropriate vaccination. The introduction of the pneumococcal conjugate vaccines (PCVs) against some serotypes has led to reduction in pneumococcal infections, however, the subsequent serotype switching, and replacement has been a serious challenge. On the other hand, no vaccine is yet licensed for use in the control of GBS diseases. In this review, we provide an overview of the history and global disease burden, disease pathophysiology and management, vaccines update, and the biology of both pathogens. Furthermore, we address recent findings regarding structural similarities that could be explored for vaccine targets across both mucosal pathogens. Finally, we conclude by proposing future genomic sequence comparison using the wealth of available sequences from both species and the possibility of identifying more related structural components that could be exploited for pan-pathogen vaccine development.

scholarly journals COMPARISION OF FREQUENCY OF INFECTION BETWEEN INTERNAL JUGULAR AND FEMORAL VEIN DOUBLE LUMEN HEMODIALYSIS CATHETER IN CHRONIC KIDNEY DISEASE (CKD) PATIENTS

2021 ◽  
Vol 71 (3) ◽  
pp. 993-95
Author(s):  
Saif Ullah Khan ◽  
Muhammad Amir ◽  
Ali Javed ◽  
Shazia Nisar ◽  
Shazia Nisar ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Duration ◽  
Blood Stream Infection ◽  
Femoral Vein ◽  
Blood Stream ◽  
Military Hospital ◽  
Double Lumen ◽  
Group A ◽  
Group B

Objective: To compare the frequency of infection between internal jugular and femoral vein double lumen haemodialysis catheter in chronic kidney disease (CKD) patients. Study Design: Comparative prospective study. Place and Duration of Study: Department of Medicine, Combined Military Hospital, Peshawar, from Jan to Jun 2018. Methodology: A total of 400 patients (200 patients in each group) were included in this study. After insertion of catheter the patients were divided into 2 groups, group-A (jugular) and group-B (femoral) by lottery method and followed for development of catheter related blood stream infection (CRBI) within two weeks after its insertion. Results: Mean age of the patients was 51.68 ± 13.29 and 50.89 ± 14.31 years in group-a and b, respectively. In group-A 193 (96.5%) and in group-B 196 (98%) patients presented with chronic kidney disease duration of <4 years, in group-A 7 (3.5%) and in group-B 4 (2%) patients presented with chronic kidney disease duration of >5 years. In both groups, 65 (32.5%) were diabetic. Catheter related blood stream infection (CRBSI) was found in 13 (6.5%) and 8 (14%) in group-A & B, respectively. Conclusion: Infection frequently complicates double lumen catheters used for haemodialysis and infections are more frequent in patients with femoral vein catheter as compared to internal jugular vein.

Blood Stream Infection in Patients on Venovenous Extracorporeal Membrane Oxygenation for Respiratory Failure

2018 ◽  
Vol 39 (07) ◽  
pp. 871-874 ◽  
Author(s):  
Soo Jin Na ◽  
Chi Ryang Chung ◽  
Hee Jung Choi ◽  
Yang Hyun Cho ◽  
Jeong Hoon Yang ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Extracorporeal Membrane Oxygenation ◽  
Bloodstream Infection ◽  
Clinical Outcomes ◽  
Median Time ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Blood Transfusions ◽  
Membrane Oxygenation ◽  
Venovenous Extracorporeal Membrane Oxygenation

Bloodstream infection (BSI) occurred in 21 of 121 patients (17%) receiving venovenous extracorporeal membrane oxygenation within the median time of 6 days after initiation (interquartile range, 4–19 days). Longer duration of arterial catheterization and more blood transfusions were independently associated with BSI, which is associated with poor clinical outcomes.Infect Control Hosp Epidemiol 2018;1–4

scholarly journals Management of arteriovenous malformations in the elderly: a single-center case series and analysis of outcomes

2016 ◽  
Vol 125 (1) ◽  
pp. 145-151 ◽  
Author(s):  
Aqueel H. Pabaney ◽  
Kevin A. Reinard ◽  
Max K. Kole ◽  
Donald M. Seyfried ◽  
Ghaus M. Malik
Keyword(s):  
Clinical Outcomes ◽  
Arteriovenous Malformations ◽  
Case Series ◽  
Patient Characteristics ◽  
The Elderly ◽  
Treatment Modalities ◽  
Presenting Symptoms ◽  
Complete Obliteration ◽  
Henry Ford ◽  
Receive Treatment

OBJECT Treatment of brain arteriovenous malformations (bAVMs) in the elderly remains a challenge for cerebrovascular surgeons. In this study the authors reviewed the patient characteristics, treatments, angiographic results, and clinical outcomes in 28 patients over 65 years of age who were treated at Henry Ford Hospital between 1990 and 2014. METHODS The bAVM database at the authors’ institution was queried for records of elderly patients with bAVMs, and data regarding patient demographics, presenting symptoms, bAVM angioarchitecture, treatment modalities, angiographic results, clinical outcomes, and treatment complications were tabulated and analyzed. RESULTS There were 9 male (32%) and 19 female (68%) patients, with an average age ( ± SD) of 73.0 ± 6.95 years. The most common symptoms on presentation were hemorrhage (36%) and headaches (18%). The bAVMs were equally distributed between the supra- and infratentorial compartments. The most common Spetzler-Martin grade was II, observed in 57% of the patients. Eleven patients (39.3%) underwent resection, 4 patients (14.3%) received standalone radiation therapy, and 13 patients (46%) did not receive treatment or were managed expectantly. Four patients (14.3%) were lost to follow-up. Complete bAVM obliteration was achieved in 87% of the treated patients. None of the patients who received any form of treatment died; the overall mortality rate was 3.6%. CONCLUSIONS Surgical management of bAVMs in the elderly can result in complete obliteration and acceptable clinical outcomes.

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