scholarly journals Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics

2019 ◽  
Vol 13 (4) ◽  
pp. e0007293 ◽  
Author(s):  
M. John Albert ◽  
Dieter Bulach ◽  
Wadha Alfouzan ◽  
Hidemasa Izumiya ◽  
Glen Carter ◽  
...  
Keyword(s):  
Blood Stream Infection ◽  
Blood Stream ◽  
Microbiological Characteristics

scholarly journals 192. Epidemiology, Microbiological Characteristics and Clinical Outcomes of Invasive Blood Stream Infections of Group B Streptococcal Isolates From Qatar

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S203-S204
Author(s):  
Maisa Ali ◽  
Mohammed Alamin ◽  
Gawahir Ali ◽  
Khalid Alzubaidi ◽  
Bashir Ali ◽  
...  
Keyword(s):  
Young Adults ◽  
Clinical Outcomes ◽  
Streptococcus Agalactiae ◽  
Blood Stream Infection ◽  
The Elderly ◽  
Blood Stream ◽  
High Cure ◽  
Presenting Symptoms ◽  
Microbiological Characteristics ◽  
Group B

Abstract Background Group B Streptococci (GBS) or Streptococcus agalactiae colonize humans genitourinary and gastrointestinal tracts particularly of females. The pathogen is capable of causing invasive disease primarily in infants, pregnant and postpartum women as well as the elderly and patients with comorbidities. There is paucity of studies of the disease with regional differences in prevalence and presentation of invasive blood stream infection (BSI). In this study, we aim to assess prevalence, microbiological characteristics as well as clinical outcomes of invasive GBS disease from all ages groups at Hamad Medical Corporation (HMC), Qatar. Methods A retrospective study was conducted on all patients with microbiologically confirmed GBS bacteraemia between January 2015–March 2019. Demographic, microbiological characteristics as well as clinical data were extracted from hospital information system. Results Out of 196 confirmed cases of GBS blood stream infection, 63.7 % were females (125/196) of whom 44.8 % were pregnant (56/125), 53.6 % (30/56) were colonized while 36.3 % (71/196) were males. There were three distinct age group populations, paediatric less than 4 years of age at 35.7 %, young adults 25-34 (20.9 %) and the elderly > 65 year (17.4 %). Presenting symptoms were mild with fever recognised in only 53 % of cases (104/196) while 89% of cases had low Pitt bactermia score of 0-2. Microbiological characteristic using disc diffusion tests demonstrated all isolates were universally sensitive to penicillin (100%, 196/196) with significant resistance to clindamycin at 28.6 % (56/196) and erythromycin at 49 % (96/196) of which 34.4 % (33/96) had inducible clindamycin resistance. Clinical outcome showed high cure rate of 87.25% (171/196) with low complications at 8.76 % (17/196) and 4% (8/196) 30-day mortality. Antibiotic sensitivity profile for GBS isolates Conclusion Streptococcus agalactiae blood stream infection in Qatar is common in females, affects the very young, young adults and the elderly. Almost half of affected pregnant women are colonized. The organism remains universality sensitive to pencilling with significant resistance to clindamycin and erythromycin. Patients presents with mild symptoms with high cure rates, low complications and safe outcome for the majority of cases. Disclosures All Authors: No reported disclosures

Healthcare associated infections caused by non-fermenting Gram negative rods (NFGNR): six years of experience of a tertiary hospital

2013 ◽  
Vol 7 (2) ◽  
pp. 06-12
Author(s):  
Zahidul Hasan ◽  
Md. Kamrul Islam ◽  
Arifa Hossain
Keyword(s):  
Blood Stream Infection ◽  
Tertiary Care ◽  
Blood Stream ◽  
Tertiary Hospital ◽  
Healthcare Associated Infections ◽  
Care Hospital ◽  
Gram Negative ◽  
Acinetobacter Spp ◽  
Tract Infections ◽  
Healthcare Associated

Recently non-fermenting Gram negative rods (NFGNR) are playing an important role in healthcare associated infections. This observational study in a tertiary care hospital of Dhaka city conducted during 01August 2007 to 30 June 2013 found that 34.8% isolated organisms from patients with healthcare associated infections were NFGNR. Majority (74.3 %) of these infections were occurring inside critical care areas. Pseudomonas and Acinetobacter together constituted 79.6% of the total NFGNR whereas Burkholderia cephacia complex (15.4%), Stenotrophomonas (4.3%) and Chryseobacterium species (0.7%) combined constituted remaining 20.4%. Out of total NFGNRs, Pseudomonas was responsible for highest number of catheter associated urinary tract infections (55.6%), ventilator associated pneumonia (46.3%), respiratory tract infection (65.8%) and surgical site infection (70.6%). Blood stream infection was predominantly caused by Burkholderia cephacia complex (33.5%) and Acinetobacter spp. (39.5%). Other than colistin most of the organisms were resistant to antibiotics commonly recommended for NFGNR.DOI: http://dx.doi.org/10.3329/bjmm.v7i2.19326 Bangladesh J Med Microbiol 2013; 07(02): 6-12

scholarly journals Is it cost effective to use a 2% chlorhexidine wipes bath to reduce central-line associated blood stream infection? A quasi-experimental study

2021 ◽  
Vol 25 (1) ◽  
pp. 101538
Author(s):  
Diego Feriani ◽  
Ercilia Evangelista Souza ◽  
Larissa Gordilho Mutti Carvalho ◽  
Aline Santos Ibanes ◽  
Eliana Vasconcelos ◽  
...  
Keyword(s):  
Experimental Study ◽  
Blood Stream Infection ◽  
Cost Effective ◽  
Blood Stream ◽  
Central Line ◽  
Quasi Experimental

scholarly journals 250. Blood Stream Infections (BSI) in Pediatric Neuroblastoma High Risk: Emphasis on Viridans Group Streptococci (VGS) Bacteremia

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S124-S125
Author(s):  
Muayad Alali ◽  
Joseph Hageman
Keyword(s):  
High Risk ◽  
Solid Tumors ◽  
Induction Chemotherapy ◽  
Blood Stream Infection ◽  
Lymphoblastic Leukemia ◽  
Blood Stream ◽  
High Risk Group ◽  
Related Complication ◽  
High Risk Factors ◽  
Viridans Group Streptococci

Abstract Background Febrile neutropenia’s (FN) literature has focused on acute leukemia and undergoing allogeneic stem cell transplantation (SCT) as high risk factors for microbiological documented infection (MDI) and blood stream infection (BSI). Comprehensive studies on in pediatric Neuroblastoma high risk (NB-HR) who receive highly myelosuppressive therapy are lacking. Methods We conducted a retrospective medical record review of pediatric patients who received any oncology care at UCM Comer Children’s Hospitals.with a diagnosis of FN who had at least 1 blood culture obtained and one of the following underlying diagnoses (AML, lymphoblastic leukemia ALL), NB-HR, and other solid tumors (ST). SCT patients were excluded from study. We reviewed pathogens isolated from blood cultures (BCx) and determined whether they were pathogens or contaminants using IDSA guidelines. Comparative analyses of BSI rates between NB-HR and other underlying diagnoses were done. Results A total of 560 FN episodes (FNEs) were identified in 230 patients. FNEs occurred in NB-HR were 102 in 77 patients. Fifty-seven percent of patients developed one or more BSI or MDI during induction chemotherapy. The mean age was 11.0 (SD=6.5) years. True BSI occurred in 138 (24.6%) of FN episodes. The organisms that were most frequently isolated from were viridans group streptococci (VGS) (25%). The highest rate of BSI occurred among FNEs with AML (44/115, 37%) followed by NB-HR 26/110 (25%) Table1. Overall BSI rate in NB-HR group is higher than other solid tumors (25 vs 17%, P=0.03). In subset analysis, VGS bacteremia was highest among FNEs with AML and NB-HR compared with ALL (8.7 and 8.8 % vs 6%) P< 0.04 and P=0.02 respectively. Notably, the gram positive/ gram negative (GP/GN ratio) in NB-HR compared with ST was significantly higher (OR =2.26, CI 95% 1.5–7.8, P< 0.01), this was likely due to a higher VGS rate (8.8% vs 2%, OR=4.2, P < 0.01). Rate of GN-BSI are same in each of ALL,HR-NB and ST. Conclusion Our large Neuroblastoma cohort showed that NB-HR during induction chemotherapy are higher risk for VGS bacteremia, compared with other solid tumors. Further prospective studies are needed to investigate infection related complication in this high risk group and possible improved morbidity and mortality. Disclosures All Authors: No reported disclosures

scholarly journals Central Line-Associated Blood Stream Infection During COVID-19 Pandemic

2021 ◽  
Author(s):  
Fatima Aldawood ◽  
Aiman El-Saed ◽  
Mohammed Al Zunitan ◽  
Majed Alshamrani
Keyword(s):  
Blood Stream Infection ◽  
Blood Stream ◽  
Central Line

scholarly journals Recurrent thrombosis of an arteriovenous fistula as a complication of COVID-19 in a chronic hemodialysis patient: A case report

2021 ◽  
pp. 112972982110008
Author(s):  
Joao Pedro Teixeira ◽  
Sara A Combs ◽  
Jonathan G Owen
Keyword(s):  
Arteriovenous Fistula ◽  
Hemodialysis Patient ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Chronic Hemodialysis ◽  
Risk Of Death ◽  
Catheter Directed Thrombolysis ◽  
Intravenous Heparin ◽  
Increased Risk ◽  
End Stage

Patients with end-stage kidney disease are at increased risk of death from coronavirus disease 2019 (COVID-19). In addition, severe COVID-19 has been associated with an increased risk of arterial and venous thromboses. In this report, we describe the case of a hemodialysis patient who developed an otherwise-unexplained thrombosis of an arteriovenous fistula during a symptomatic COVID-19 infection. Despite prompt treatment with three technically successful thrombectomies along with systemic intravenous heparin and two rounds of catheter-directed thrombolysis with tissue plasminogen activator, the fistula rapidly re-thrombosed each time and he required tunneled dialysis catheter placement. He subsequently required admission for hypoxemia from COVID-19 pneumonia and ultimately developed a catheter-related blood stream infection that likely contributed to his death. As the fistula had been previously well functioning and no angiographic explanation for the thrombosis was found, we speculate in this case the recurrent thromboses were related to the hypercoagulable state characteristic of severe COVID-19. Interventionalists performing hemodialysis access procedures should be aware of the prothrombotic state associated with COVID-19 and should consider it when deliberating how to best plan and approach access interventions in patients with symptomatic COVID-19.

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