scholarly journals 404. COVID-19 Normality Rate: Criteria for Optimal Time to Return to In-person Learning

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S303-S304
Author(s):  
Carlos Starling ◽  
Jackson Machado-Pinto ◽  
Unaí Tupinambás ◽  
Estevão Urbano Silva ◽  
Bráulio R G M Couto

Abstract Background The COVID-19 pandemic created the most severe global education disruption in history. According to UNESCO, at the peak of the crisis over 1.6 billion learners in more than 190 countries were out of school. After one year, half of the world’s student population is still affected by full or partial school closures. Here we investigated whether or not it is possible to build a multivariate score for dynamic school decision-making specially in scenarios without population-scale RT-PCR tests. Methods Normality rate is based on a COVID-19 risk matrix (Table 1). Total score (TS) is obtained by summing the risk scores for COVID-19, considering the six parameters of the pandemic in a city. The COVID-19 Normality Rate (CNR) is obtained by linear interpolation in such a way that a total score of 30 points is equivalent to a 100% possibility of normality and, in a city with only six total points would have zero percent chance of returning to normality: CNR = (TS – 6)/24 (%). The criteria for opening and closing schools can be defined based on the percentages of return to normality (Table 2). Table 1. Limits for each parameter of the risk matrix and "normality" scores in relation to COVID-19: the lower the risk, higher is the “normality” score. Table 2. Criteria for opening and closing schools in a city according to the COVID-19 Normality Rate. Results at June 3rd, 2021, we evaluated all 5,570 Brazilian cities (Figure 1): 2,708 cities (49%) with COVID-19 normality rate less than 50% (full schools closure), 2,223 cities (40%) with normality rate between 50% and 70% (in-person learning only for 5 years and 8 months-old children), 583 with normality rate between 71% and 80% (in-person learning extended to children age 12 years and less), 583 cities (1%) with normality rate between 81% to 90% (in-person learning extended to the student population age 18 years), and just one city with 92% COVID-19 normality rate (in-person learning extended to all the student population). We calculated the COVID-19 normality rate between January and May, 2021, in four countries: Brazil, USA, UK, and Italy (Figure 2). At Jun, 3rd, 2021, percentage of people fully vaccinated in Brazil varied from 0% to 69%, an average of 11%. Figure 1. COVID-19 Normality Rate in 5,570 cities in Brazil, Jun/03/2021. Figure 2. COVID-19 Normality Rate between January and May, 2021: comparison among Brazil, USA, UK, and Italy. Conclusion COVID-19 vaccination programs take several months to implement. Besides fully vaccination of the population, it is important to check if people became really safe from the virus. The COVID-19 Normality Rate is a double check multivariate score that can be used as a criteria for optimal time to return to in-person learning safely. Disclosures All Authors: No reported disclosures

Author(s):  
Luca Pingani ◽  
Sara Evans-Lacko ◽  
Sandra Coriani ◽  
Silvia Ferrari ◽  
Maria Filosa ◽  
...  

The primary aim is to describe the changes in the knowledge of mental health conditions, the attitudes toward the mentally ill, and the intended behaviour towards people with mental illness among the entire student population of the third year of a degree course in Psychology. A total of 570 students attended a seminar on stigma towards mental illness and were invited to complete an online survey which collected data on sociodemographic characteristics and three validated questionnaires evaluating different aspects of stigma at three different time points (pre-intervention, post-intervention, and at one year follow up). A total of 253 students (44.39%) completed the questionnaires at t0, t1, and t2. The mean age of the sample was 23.7 (SD = ±5.89), and 86.96% (n = 220) were females. Between t0 and t1, a statistically significant improvement was observed for all three outcomes, while the intended behaviour outcome was no longer significant between t1 and t2 (Z = −0.70; p = 0.48). Females and who participated live at the seminar maintained a significant knowledge of mental illness and a better attitude toward community mental health care. The effects of the seminar focused on reducing stigma tended to diminish over time at one year follow-up, particular in relation to intended behaviour.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Codina ◽  
M De Antonio ◽  
E Santiago-Vacas ◽  
M Domingo ◽  
E Zamora ◽  
...  

Abstract Background Heart failure (HF) contemporary management has significantly improved over the past two decades leading to better survival. How application of the contemporary HF management guidelines affects the risk of death estimated by available web-based risk scores is not elucidated. Objective To assess changes in mortality risk prediction after a after a 12-month management period in a multidisciplinary HF Clinic. Methods Out of 1,689 consecutive patients with HF admitted at our ambulatory HF Clinic from May 2006 to November 2018, those who completed one year follow-up were considered for the study. Patients without NTproBNP measurement or with more than 3 missing variables for risk estimation were excluded. Three contemporary web-based HF risk scores were evaluated: MAGGIC-HF, Seattle HF Model (SHFM) and the Barcelona Bio-HF Calculator containing NTproBNP (BCN Bio-HF). Risk of all-cause death at one year and at 3 years were calculated at baseline and re-evaluated after 12-month management in a multidsisciplinary HF Clinic. Wilcoxon paired data test was used to compare changes in mortality risk estimation over time and test equality of matched pairs for comparing estimated change among tools. 442 patients used to derive the Barcelona Bio-HF Calculator were excluded for discrimination purposes. Results 1,157 patients were included (age 65.7±12.7 years, 70.4% men). A significant reduction in mortality risk estimation was observed with the three HF risk scores evaluated at 12-months (Table). The BCN Bio-HF model showed significantly different changes in risk estimation, fact that indeed was partnered with numerically better discrimination. AUC at 1 and 3 years, respectively, were: BCN Bio-HF (0.773 and 0.775), MAGGIC HF (0.686 and 0.748) and SHFM (0.773 and 0.739). Conclusions The three web-based risk scores evaluated showed a significant reduction in mortality risk estimation after 12 month management in a multidisciplinary HF Clinic. The BCN Bio-HF score showed higher reduction in estimated risk, together with better discrimination, likely because it incorporates contemporary treatment and use of biomarkers. Funding Acknowledgement Type of funding source: None


2018 ◽  
Vol 12 (supplement_1) ◽  
pp. S240-S241
Author(s):  
N Imperatore ◽  
A Rispo ◽  
A Testa ◽  
L Bucci ◽  
G Luglio ◽  
...  

JRSM Open ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 205427041561129
Author(s):  
Daniela Cassar Demarco ◽  
Alexandros Papachristidis ◽  
Damian Roper ◽  
Ioannis Tsironis ◽  
Jonathan Byrne ◽  
...  

2020 ◽  
Vol 20 (09) ◽  
pp. 2040002
Author(s):  
MONAN WANG ◽  
HAIYANG LUO ◽  
QI CUI

Based on the standard Marching Cubes (MC) algorithm, this paper proposes an improved MC algorithm. First, the original 15 topological configurations in the MC algorithm are increased to 24, which effectively avoid the generation of voids phenomenon. To further improve the speed of three-dimensional (3D) reconstruction, in this paper, the midpoint selection method is used instead of the linear interpolation method, and the 24 configurations are divided into three types. Each class corresponds to a thread. The multi-thread parallel processing is used to improve the calculation speed. The critical region is used to realize multi-thread synchronization, and then we designed a protocol mapping table according to the idea of the message mapping table. The function pointer is triggered by macro. Processing function is called by function pointer and completes the encapsulation of the protocol mapping table, which maintains the opening and closing principle of the class and ensures the scalability of the class. Through the improved MC algorithm accuracy verification and reconstruction speed verification, it is concluded that the improved MC algorithm can make up for the voids problem. By comparing the calculation time under the two platforms of Windows and Linux, the reconstruction speed of the improved MC algorithm is approximately 30% faster than the standard MC algorithm and 40% faster than the Masala algorithm. Finally, the algorithm is applied to the medical image 3D reconstruction system, and the accuracy and applicability of the algorithm are demonstrated by two sets of examples.


1979 ◽  
Vol 135 (6) ◽  
pp. 535-543 ◽  
Author(s):  
P. J. Huxley ◽  
D. P. Goldberg ◽  
G. P. Maguire ◽  
V. A. Kincey

SummaryRecent studies have suggested that psychosocial factors play an important part in the prediction of the course of minor psychiatric disorders. Fifty-nine new psychiatric out-patients suffering from minor disorders were assessed, using standardized clinical and social interviews, and 52 were followed up after one year and the clinical assessment repeated. Social and clinical factors were equally important predictors of the number of months ill in the survey year, but social and constitutional variables were superior in the prediction of percentage change in symptoms over the year.The results of correlation, factor and multiple regression analyses suggest that the course of minor psychiatric disorder is best predicted by three sets of variables which are, in order of importance, the patient's material social circumstances, his clinical symptoms and his ‘genetic risk’ scores.


2010 ◽  
Vol 18 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Ciaran M. Skerry ◽  
Bernard P. Mahon

ABSTRACTDespite successful mass vaccination programs, whooping cough remains a significant cause of neonatal mortality. Immunity induced by current vaccines wanes in adolescence, requiring additional immunizations to prevent resurgence. There is a need for a new generation of vaccines capable of conferring long-lasting immunity from birth. Recently, a live, attenuated whooping cough vaccine, BPZE1, has been developed. Here, an established murine immunization model was used to examine the induction and longevity of immunological memory. In this predictive model, BPZE1 conferred a level of protection against virulent bacterial challenge comparable to that conferred by recovery from prior infection, up to 1 year after immunization. One year after immunization with BPZE1, a pertussis-specific persistent response, with high levels of gamma interferon (IFN-γ), could be detected from spleen cells restimulated with inactivatedBordetella pertussis. BPZE1 induced low levels of interleukin-17 (IL-17) and no IL-10 or IL-5. BPZE1 immunization induced long-lasting, efficacious memory B-cell and specific antibody responses dominated by IgG2a, which were boosted by subsequent challenge. Finally, the antibody induced by BPZE1 was functionally relevant and could clear a virulentB. pertussisinfection in antibody-deficient mice following passive transfer. This study suggests that BPZE1 is capable of conferring a high level of long-lived effective protection against virulentB. pertussis.


2021 ◽  
Vol 2 (1) ◽  
pp. 5-6
Author(s):  
Peter Black

Rarely has the transition from one year to the next been so eagerly anticipated as when we said goodbye (and good riddance!) to 2020 and ushered in 2021. We all would like a return to our “old” lives as they were in 2019. The launch of global vaccination programs against the SARS-CoV-2 virus makes the light at the end of the tunnel clearly visible.


Author(s):  
B. Balarabe-Musa ◽  
N. T. Dabo

Introduction: Nigeria had planned to introduce the rotavirus vaccine in the National Immunisation Programme in 2014, but this has yet to be done. Nigeria has the continent's highest mortality due to diarrhoeal diseases with little information on specific, prevalent genotypes. Aim: The study's main objectives were to identify the predominant rotavirus genotypes and examine the effects of existing local vaccination programs on prevailing rotavirus genotypes and on preventing rotavirus diarrhoea. Methodology: A one-year prospective descriptive study of children under 5 with acute diarrhoea was conducted from June 2018 to May 2019. Children with acute diarrhoea attending Asokoro District Hospital, Abuja. Children without diarrhoea were also recruited as a control group. Rotavirus ELISA and RNA extraction were done with commercially available kits, and positive samples were subjected to RT-PCR and electrophoresis to determine VP7 (G) and VP4 (P) genotypes. Results: Rotavirus-ELISA was positive among 231 (17.8%) children with diarrhoea and 29 (2.2%) of controls, with November, December. The predominant VP7 genotypes was G1 (n=116, 50.2%) followed by G9 (n=66, 28.5%). Viral Protein, VP4 (P) was mostly P [8] (n=143, 74.8%) followed by P [4] (n=21, 10.9%). The predominant genotype combinations found were G1 P [8] (n=108, 46.7%), G9 P [8] (n=62, 26.8%), and G2 P [4] (n=18, 7.7%). Very few mixed infections were found in the study, 2 (0.8%). Among 94 unvaccinated children with rotavirus isolates that were genotyped, G1 P [8] (n=88, 49.4%) and G9 P [8] (n=43, 24.1%) were predominant.  Among 32 vaccinated children, G1 P [8] (n=13, 40.2%) and G9 P [8] (n=9, 28.1%) were predominant. Conclusion: The emergence of new genotypes such as G 12 P [4] found in this study emphasize the need for continued prospective monitoring of rotavirus at the molecular level to detect new threats to vaccine programs in future.


Sign in / Sign up

Export Citation Format

Share Document