scholarly journals 1887. Estimating the Burden of Waterborne Disease in the United States

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S53-S54 ◽  
Author(s):  
Sarah Collier ◽  
Katharine Benedict ◽  
Kathleen Fullerton ◽  
Li Deng ◽  
Jennifer R Cope ◽  
...  

Abstract Background Treatment of drinking water is one of the greatest US public health achievements of the twentieth century and provides a safe, reliable water supply. However, waterborne disease and outbreaks continue to occur, and are associated with a variety of water sources and exposure routes. New estimates of the burden of waterborne disease in the United States will direct prevention activities and set public health goals. Methods We chose 17 waterborne diseases for which domestic waterborne transmission was plausible, substantial burden of illness or death was likely, and data were available. Diseases included were campylobacteriosis, cryptosporidiosis, giardiasis, Legionnaires’ disease, norovirus infection, nontuberculous mycobacteria [NTM] infection, otitis externa, Pseudomonas pneumonia and septicemia, salmonellosis, Shiga toxin-producing E. coli infection, shigellosis, and vibriosis. Adapting previously used methods, disease-specific multipliers were used to adjust the reported/documented number of cases of each disease for under-reporting, under-diagnosis, proportion domestically acquired, and proportion transmitted via water, to generate point estimates with 95% credible intervals (CrI). Data sources included surveillance data, population studies, and expert judgment if no other data were available. We estimated the number of illnesses, ED visits, hospitalizations, and deaths, and costs of ED visits and hospitalizations due to waterborne disease in the United States in 2014. Results 7.2 million waterborne illnesses (CrI 3.9–12.0 million) from the selected diseases occur annually, including 600,000 (CrI 365,000–865,000) ED visits, 120,000 (CrI 85,000–150,000) hospitalizations, and 6,500 deaths (CrI 4,300–8,900) deaths, incurring US$3.2 billion (2014 dollars) in direct healthcare costs. Hospitalizations and deaths were predominantly caused by environmental pathogens commonly associated with biofilm in plumbing systems (NTM, Pseudomonas, Legionella) costing US$2 billion annually. Conclusion Millions of domestically acquired waterborne illnesses from these 17 infections occur in the United States each year, and incur billions of dollars in healthcare costs. Disclosures All Authors: No reported Disclosures.

2010 ◽  
Vol 23 (3) ◽  
pp. 507-528 ◽  
Author(s):  
Gunther F. Craun ◽  
Joan M. Brunkard ◽  
Jonathan S. Yoder ◽  
Virginia A. Roberts ◽  
Joe Carpenter ◽  
...  

SUMMARY Since 1971, the CDC, EPA, and Council of State and Territorial Epidemiologists (CSTE) have maintained the collaborative national Waterborne Disease and Outbreak Surveillance System (WBDOSS) to document waterborne disease outbreaks (WBDOs) reported by local, state, and territorial health departments. WBDOs were recently reclassified to better characterize water system deficiencies and risk factors; data were analyzed for trends in outbreak occurrence, etiologies, and deficiencies during 1971 to 2006. A total of 833 WBDOs, 577,991 cases of illness, and 106 deaths were reported during 1971 to 2006. Trends of public health significance include (i) a decrease in the number of reported outbreaks over time and in the annual proportion of outbreaks reported in public water systems, (ii) an increase in the annual proportion of outbreaks reported in individual water systems and in the proportion of outbreaks associated with premise plumbing deficiencies in public water systems, (iii) no change in the annual proportion of outbreaks associated with distribution system deficiencies or the use of untreated and improperly treated groundwater in public water systems, and (iv) the increasing importance of Legionella since its inclusion in WBDOSS in 2001. Data from WBDOSS have helped inform public health and regulatory responses. Additional resources for waterborne disease surveillance and outbreak detection are essential to improve our ability to monitor, detect, and prevent waterborne disease in the United States.


2021 ◽  
Vol 15 (10) ◽  
pp. e0009878
Author(s):  
Erin R. Whitehouse ◽  
Marissa K. Person ◽  
Catherine M. Brown ◽  
Sally Slavinski ◽  
Agam K. Rao ◽  
...  

Background An evaluation of postexposure prophylaxis (PEP) surveillance has not been conducted in over 10 years in the United States. An accurate assessment would be important to understand current rabies trends and inform public health preparedness and response to human rabies. Methodology/Principle findings To understand PEP surveillance, we sent a survey to public health leads for rabies in 50 U.S. states, Puerto Rico, Washington DC, Philadelphia, and New York City. Of leads from 54 jurisdictions, 39 (72%) responded to the survey; 12 reported having PEP-specific surveillance, five had animal bite surveillance that included data about PEP, four had animal bite surveillance without data about PEP, and 18 (46%) had neither. Although 12 jurisdictions provided data about PEP use, poor data quality and lack of national representativeness prevented use of this data to derive a national-level PEP estimate. We used national-level and state specific data from the Healthcare Cost & Utilization Project (HCUP) to estimate the number of people who received PEP based on emergency department (ED) visits. The estimated annual average of initial ED visits for PEP administration during 2012–2017 in the United States was 46,814 (SE: 1,697), costing upwards of 165 million USD. State-level ED data for initial visits for administration of PEP for rabies exposure using HCUP data was compared to state-level surveillance data from Maryland, Vermont, and Georgia between 2012–2017. In all states, state-level surveillance data was consistently lower than estimates of initial ED visits, suggesting even states with robust PEP surveillance may not adequately capture individuals who receive PEP. Conclusions Our findings suggest that making PEP a nationally reportable condition may not be feasible. Other methods of tracking administration of PEP such as syndromic surveillance or identification of sentinel states should be considered to obtain an accurate assessment.


2008 ◽  
Vol 7 (1) ◽  
pp. 45-54 ◽  
Author(s):  
David Turbow

Contamination of the nearshore marine environment contributes to a high burden of illness among recreational bathers. Disease surveillance activities carried out by local, state, and territorial agencies in the United States are at present voluntary and passive. Several gaps in the existing regulatory framework for beach management and public health protection are highlighted in this paper. The need for disease surveillance of marine bathers is established. A demonstration is made of how surveillance activities can be used to guide risk management and gauge the effectiveness of current water contact standards. Recommendations are offered for agencies to improve surveillance and protect public health. A foundation is presented on which to develop a model marine health code.


2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Marissa L. Zwald ◽  
Kristin M. Holland ◽  
Francis Annor ◽  
Aaron Kite-Powell ◽  
Steven A. Sumner ◽  
...  

ObjectiveTo describe epidemiological characteristics of emergency department (ED) visits related to suicidal ideation (SI) or suicidal attempt (SA) using syndromic surveillance data.IntroductionSuicide is a growing public health problem in the United States.1 From 2001 to 2016, ED visit rates for nonfatal self-harm, a common risk factor for suicide, increased 42%.2–4 To improve public health surveillance of suicide-related problems, including SI and SA, the Data and Surveillance Task Force within the National Action Alliance for Suicide Prevention recommended the use of real-time data from hospital ED visits.5 The collection and use of real-time ED visit data on SI and SA could support a more targeted and timely public health response to prevent suicide.5 Therefore, this investigation aimed to monitor ED visits for SI or SA and to identify temporal, demographic, and geographic patterns using data from CDC’s National Syndromic Surveillance Program (NSSP).MethodsCDC’s NSSP data were used to monitor ED visits related to SI or SA among individuals aged 10 years and older from January 1, 2016 through July 31, 2018. A syndrome definition for SI or SA, developed by the International Society for Disease Surveillance’s syndrome definition committee in collaboration with CDC, was used to assess SI or SA-related ED visits. The syndrome definition was based on querying the chief complaint history, discharge diagnosis, and admission reason code and description fields for a combination of symptoms and Boolean operators (for example, hang, laceration, or overdose), as well as ICD-9-CM, ICD-10-CM, and SNOMED diagnostic codes associated with SI or SA. The definition was also developed to include common misspellings of self-harm-related terms and to exclude ED visits in which a patient “denied SI or SA.”The percentage of ED visits involving SI or SA were analyzed by month and stratified by sex, age group, and U.S. region. This was calculated by dividing the number of SI or SA-related ED visits by the total number of ED visits in each month. The average monthly percentage change of SI or SA overall and for each U.S. region was also calculated using the Joinpoint regression software (Surveillance Research Program, National Cancer Institute).6ResultsAmong approximately 259 million ED visits assessed in NSSP from January 2016 to July 2018, a total of 2,301,215 SI or SA-related visits were identified. Over this period, males accounted for 51.2% of ED visits related to SI or SA, and approximately 42.1% of SI or SA-related visits were comprised of patients who were 20-39 years, followed by 40-59 years (29.7%), 10-19 years (20.5%), and ≥60 years (7.7%).During this period, the average monthly percentage of ED visits involving SI or SA significantly increased 1.1%. As shown in Figure 1, all U.S. regions, except for the Southwest region, experienced significant increases in SI or SA ED visits from January 2016 to July 2018. The average monthly increase of SI or SA-related ED visits was 1.9% for the Midwest, 1.5% for the West (1.5%), 1.1% for the Northeast, 0.9% for the Southeast, and 0.5% for the Southwest.ConclusionsED visits for SI or SA increased from January 2016 to June 2018 and varied by U.S. region. In contrast to previous findings reporting data from the National Electronic Injury Surveillance Program – All-Injury Program, we observed different trends in SI or SA by sex, where more ED visits were comprised of patients who were male in our investigation.2 Syndromic surveillance data can fill an existing gap in the national surveillance of suicide-related problems by providing close to real-time information on SI or SA-related ED visits.5 However, our investigation is subject to some limitations. NSSP data is not nationally representative and therefore, these findings are not generalizable to areas not participating in NSSP. The syndrome definition may under-or over-estimate SI or SA based on coding differences and differences in chief complaint or discharge diagnosis data between jurisdictions. Finally, hospital participation in NSSP can vary across months, which could potentially contribute to trends observed in NSSP data. Despite these limitations, states and communities could use this type of surveillance data to detect abnormal patterns at more detailed geographic levels and facilitate rapid response efforts. States and communities can also use resources such as CDC’s Preventing Suicide: A Technical Package of Policy, Programs, and Practices to guide prevention decision-making and implement comprehensive suicide prevention approaches based on the best available evidence.7References1. Stone DM, Simon TR, Fowler KA, et al. Vital Signs: Trends in State Suicide Rates — United States, 1999–2016 and Circumstances Contributing to Suicide — 27 States, 2015. Morb Mortal Wkly Rep. 2018;67(22):617-624.2. CDCs National Center for Injury Prevention and Control. Web-based Injury Statistics Query and Reporting System (WISQARS). https://www.cdc.gov/injury/wisqars/index.html. Published 2018. Accessed September 1, 2018.3. Mercado M, Holland K, Leemis R, Stone D, Wang J. Trends in emergency department visits for nonfatal self-inflicted injuries among youth aged 10 to 24 years in the United States, 2005-2015. J Am Med Assoc. 2017;318(19):1931-1933. doi:10.1001/jama.2017.133174. Olfson M, Blanco C, Wall M, et al. National Trends in Suicide Attempts Among Adults in the United States. JAMA Psychiatry. 2017;10032(11):1095-1103. doi:10.1001/jamapsychiatry.2017.25825. Ikeda R, Hedegaard H, Bossarte R, et al. Improving national data systems for surveillance of suicide-related events. Am J Prev Med. 2014;47(3 SUPPL. 2):S122-S129. doi:10.1016/j.amepre.2014.05.0266. National Cancer Institute. Joinpoint Regression Software. https://surveillance.cancer.gov/joinpoint/. Published 2018. Accessed September 1, 2018.7. Centers for Disease Control and Prevention. Preventing Suicide: A Technical Package of Policy, Programs, and Practices. 


2020 ◽  
Author(s):  
Ruoyan Sun ◽  
Henna Budhwani

BACKGROUND Though public health systems are responding rapidly to the COVID-19 pandemic, outcomes from publicly available, crowd-sourced big data may assist in helping to identify hot spots, prioritize equipment allocation and staffing, while also informing health policy related to “shelter in place” and social distancing recommendations. OBJECTIVE To assess if the rising state-level prevalence of COVID-19 related posts on Twitter (tweets) is predictive of state-level cumulative COVID-19 incidence after controlling for socio-economic characteristics. METHODS We identified extracted COVID-19 related tweets from January 21st to March 7th (2020) across all 50 states (N = 7,427,057). Tweets were combined with state-level characteristics and confirmed COVID-19 cases to determine the association between public commentary and cumulative incidence. RESULTS The cumulative incidence of COVID-19 cases varied significantly across states. Ratio of tweet increase (p=0.03), number of physicians per 1,000 population (p=0.01), education attainment (p=0.006), income per capita (p = 0.002), and percentage of adult population (p=0.003) were positively associated with cumulative incidence. Ratio of tweet increase was significantly associated with the logarithmic of cumulative incidence (p=0.06) with a coefficient of 0.26. CONCLUSIONS An increase in the prevalence of state-level tweets was predictive of an increase in COVID-19 diagnoses, providing evidence that Twitter can be a valuable surveillance tool for public health.


Author(s):  
Chandan Saini ◽  
Ashish Miglani ◽  
Pankaj Musyuni ◽  
Geeta Aggarwal

Regular inspections are carried out to ensure system conformity by the Food and Drugs Regulatory Authority (FDA) of the United States one of the most stringent regulatory authorities in the world. The inspectors send Form 483 to the management after the inspection, detailing the inappropriate conditions. Because the FDA guidelines are difficult to comply with, a company can contravene the regulations. If any significant infringements can affect the protection, quality, effectiveness, or public health of the drug is identified, the FDA issues advice to the company. Warning Letters (WL) shall be an official notification of non-compliance with federal law within a period to be issued by manufacturer, clinician, distributor, or responsible person in the company. The delivery of a letter has a considerable impact on the company's reputation and position in the market. Inadequate WL reactions could lead to a refusal, import denial, memorandum or even conviction and order. A brief study was conducted in this document of Form 483 and WL for four years (2017–2020) on an understanding the regulatory provisions.


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