scholarly journals Metachronous pleuropulmonary blastoma in an adult patient with endometrial cancer: a case report

2019 ◽  
Vol 2019 (6) ◽  
Author(s):  
Sagar Bhalerao ◽  
Aditya Adhav ◽  
Sucheta Gandhe ◽  
Rajnish Nagarkar
Keyword(s):  
Endometrial Cancer ◽  
Adult Patient ◽  
Primary Tumour ◽  
Common Finding ◽  
Pleuropulmonary Blastoma ◽  
Second Primary ◽  
Pulmonary Blastoma ◽  
The Past ◽  
First Case ◽  
Second Primary Tumour

Abstract Pulmonary blastoma is a rare form of lung cancer with a reported incidence of 0.25–0.55 of primary pulmonary cancers. Pleuropulmonary blastoma (PPB) is a common finding in children while it is rarely found in adults. In the past few years, the incidence of a second primary tumour has increased to 3.5% followed by third primary tumour at 0.5% and fourth tumour at 0.3%. The clinical significance of diagnosing and distinguishing a secondary primary tumour is often challenging. As per our knowledge, this is the first case of metachronous PPB in an adult patient previously diagnosed with endometrial cancer.

Simultaneous double laryngeal tumours: a diagnostic and therapeutic challenge

2021 ◽  
Vol 14 (2) ◽  
pp. e239797
Author(s):  
Fergus Cooper ◽  
Rafael Moleron ◽  
Andrea Chapman ◽  
Muhammad Shakeel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Soft Tissue ◽  
Histological Analysis ◽  
Primary Tumour ◽  
Second Primary ◽  
Soft Tissue Tumours ◽  
Rare Presentation ◽  
Laryngeal Tumours ◽  
Second Primary Tumour

Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies. He subsequently underwent laryngectomy for treatment of this tumour but, unexpectedly, the histological analysis of the laryngectomy specimen revealed a second primary tumour in the larynx—a squamous cell carcinoma (SCC). The patient had further treatment with neck radiotherapy. Three years after treatment, there are no signs of recurrence of either tumour. This case report discusses the very few similar cases of leiomyosarcoma coexisting with SCC in the larynx, collating the evidence surrounding the treatment of this rare presentation.

scholarly journals Gene Expression-Based Approaches in Differentiation of Metastases and Second Primary Tumour

2010 ◽  
Vol 3 (2) ◽  
pp. 255-261 ◽  
Author(s):  
Tõnu Vooder ◽  
Kristjan Välk ◽  
Raivo Kolde ◽  
Retlav Roosipuu ◽  
Jaak Vilo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Primary Tumour ◽  
Second Primary ◽  
Second Primary Tumour

Second primary tumour following retinoblastoma

1989 ◽  
Vol 103 (7) ◽  
pp. 690-691 ◽  
Author(s):  
D. C. Berridge ◽  
A. Hitchcock ◽  
P. J. Bradley ◽  
L. Kapila
Keyword(s):  
Optic Nerve ◽  
Submandibular Gland ◽  
Radiation Field ◽  
Mucoepidermoid Carcinoma ◽  
Primary Tumour ◽  
Stage Iv ◽  
Second Primary ◽  
Radiation Fields ◽  
Second Primary Tumours ◽  
Second Primary Tumour

AbstractReported is a child who at the age of 18 months had presented with a left retinoblastoma. The lesion had involved the optic nerve (Stage IV), and was successfully treated by enucleation and radiotherapy. The radiation field did not include the mandible or the submandibular triangle. He was followed up until he left the area aged 11 years. He represented aged 12 years with a progressive swelling of the left submandibular gland. Histology of the surgically excised submandibular gland revealed a mucoepidermoid carcinoma of the submandibular gland. This case highlights the need for continual surveillance in survivors of retinoblastoma, as second primary tumours occur both within and outside of previous radiation fields. The clinical association between retinoblastoma and mucoepidermoid carcinoma of the submandibular gland has not been previously reported.

Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy

2007 ◽  
Vol 122 (6) ◽  
pp. 623-627 ◽  
Author(s):  
Y Suoglu ◽  
M Guven ◽  
E Kiyak ◽  
M Enoz
Keyword(s):  
Overall Survival ◽  
Anterior Commissure ◽  
Primary Tumour ◽  
Univariate Analysis ◽  
Thyroid Cartilage ◽  
Second Primary ◽  
Partial Laryngectomy ◽  
Supracricoid Partial Laryngectomy ◽  
Second Primary Tumour ◽  
Minimal Invasion

AbstractCancerous involvement of the pre-epiglottic space has been known for many years to be an important prognostic factor. The aim of this study was to investigate the prognostic value of pre-epiglottic space invasion, according to the degree of invasion (i.e. absence, minimal or gross), and to assess the oncological suitability for supracricoid partial laryngectomy in patients with supraglottic laryngeal carcinomas. This study included 52 patients with squamous cell carcinomas of the supraglottic and glotto-supraglottic larynx, treated with supracricoid partial laryngectomy–cricohyoidopexy, between 1992 and 2001. Clinical and histopathological parameters were evaluated. Pre-epiglottic space invasion was seen in 35 patients (67.3 per cent); there was gross invasion in seven patients and minimal invasion in 28. Neoplastic invasion of the anterior commissure was seen in 18 patients (34.6 per cent) and thyroid cartilage involvement in eight (15.4 per cent). Neoplastic spread through the extralaryngeal tissues was not seen in any patient. The five-year overall survival was 71.5 per cent for patients with gross pre-epiglottic space invasion, 82.2 per cent for those with minimal pre-epiglottic space invasion, and 76.4 per cent for those without pre-epiglottic space invasion. It was observed that gross or minimal pre-epiglottic space invasion did not have a statistically significant effect on survival. Univariate analysis showed that nodal positivity was associated with a poor prognosis. None of the other parameters analysed showed a statistically significant relationship with survival. Four (7.6 per cent) patients had local laryngeal recurrence. Distant metastasis and a second primary tumour were detected in three (5.8 per cent) and four (7.6 per cent) patients, respectively. The five-year overall survival and cause-specific survival were 78.8 and 82 per cent, respectively. Supracricoid partial laryngectomy with cricohyoidopexy can safely be performed in supraglottic and glotto-supraglottic carcinomas with minimal or gross invasion of the pre-epiglottic space which have no extralaryngeal spread. Nodal status is an important predictor affecting survival.

USCAP Specialty Conference, Case 1: Type I Pleuropulmonary Blastoma

2005 ◽  
Vol 8 (1) ◽  
pp. 77-84 ◽  
Author(s):  
D. Ashley Hill
Keyword(s):  
Bronchogenic Cyst ◽  
Pleuropulmonary Blastoma ◽  
Malignant Neoplasms ◽  
Pulmonary Blastoma ◽  
Type I ◽  
Distinct Entity ◽  
The Past ◽  
The World ◽  
Mesenchymal Cystic Hamartoma ◽  
Cystic Hamartoma

Pleuropulmonary blastoma (PPB) was defined in 1988 by Manivel et al. in a series describing 11 intrathoracic pulmonary neoplasms in young children [1]. The PPB is a unique peripheral pulmonary or pleural-based tumor of childhood that is characterized in its earliest form as a bland-appearing multiloculated cyst with small foci of tumor cells and in later forms as mixed and predominantly primitive, overtly malignant neoplasms [2,3]. Prior to the introduction of the PPB as a distinct entity, this tumor had been reported in the literature as pulmonary blastoma, sarcoma arising in mesenchymal cystic hamartoma, embryonal sarcoma, malignant mesenchymoma, primary pulmonary rhabdomyosarcoma and rhabdomyosarcoma arising in congenital adenomatoid malformation or bronchogenic cyst. Over the past 15 years, PPB has come to be recognized in centers around the world. With the establishment of the Pleuropulmonary Blastoma Registry by Jack Priest, MD, and colleagues, there has been improved understanding of this rare pediatric neoplasm. The registry Web site serves as an important resource for physicians and families ( http://www.ppbregistry.org ).

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